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1. 发明授权

US3885078A Hydrogel laminates and method of manufacturing thereof 失效
标题翻译：水凝胶层压板及其制造方法
公开(公告)号：US3885078A
公开(公告)日：1975-05-20
申请号：US20123671
申请日：1971-11-22
申请人： CESKOSLOVENSKA AKADEMIE VED
发明人： WICHTERLE OTTO , KLIMENT KAREL
IPC分类号： A61K9/70 , A61L15/60 , B01D69/12 , C08J9/28 , B32B3/26 , B32B7/02
CPC分类号： C08J9/28 , A61K9/70 , A61L15/60 , B01D69/125 , Y10T428/249991 , Y10T428/31536 , Y10T428/31797 , Y10T428/31928 , C08L33/04
摘要： A comparatively thick sheet of a spongy hydrogel, made, e.g., by polymerizing ethylene glycol monomethacrylate in presence of less than 2 percent of a cross-linking agent and more than 60 percent of water, is laminated with a much thinner sheet of the same or similar, but homogeneous hydrogel, either from one side or from both sides. Alternatively, one external layer may be less hydrophilic or fully hydrophobic. The lamination is carried out so that the external thin layer is made on a glass or other smooth pad, either by polymerizing a cross-linked or linear polymer thereon, or by casting a thin layer of a dissolved linear polymer. Then a monomer mixture for spongy hydrogel is cast onto the first layer and polymerized. A sandwich structure is obtained if the monomer mixture for spongy hydrogel is cast between two pads provided with a thin homogeneous polymer layer. Hydrogel laminates and sandwich structures are useful, e.g., for surgical and cosmetic purposes, for filtering liquids, etc.
摘要翻译：在例如通过在少于2％的交联剂和大于60％的水存在的情况下聚合乙二醇单甲基丙烯酸酯制成的比较厚的海绵状水凝胶片与其更薄的片材层压，类似但均匀的水凝胶，从一侧或从两侧。或者，一个外层可以较不亲水或完全疏水。进行层压，使得外部薄层通过在其上聚合交联或线性聚合物或通过浇铸溶解的线性聚合物的薄层而制成在玻璃或其它平滑垫上。然后将海绵状水凝胶的单体混合物浇铸到第一层上并聚合。如果用于海绵状水凝胶的单体混合物浇铸在设置有薄均匀聚合物层的两个垫之间，则获得三明治结构。水凝胶层压材料和夹层结构在例如手术和化妆用途中是有用的，用于过滤液体等。

2. 发明授权

US3597473A Method of purifying ethyleneglycol methacrylate 失效
标题翻译：纯化乙烯基甲基丙烯酸酯的方法
公开(公告)号：US3597473A
公开(公告)日：1971-08-03
申请号：US3597473D
申请日：1968-05-14
申请人： CESKOSLOVENSKA AKADEMIE VED
发明人： CHROMECEK RICHARD , WICHTERLE OTTO , GAVRILOVA IVA , VACIK JIRI
IPC分类号： C07C69/54
CPC分类号： C07C67/52 , C07C67/58 , C07C69/54
摘要： IF ETHYLENEGLYCOL MONOMETHACRYLATE IS CONTAMINATED WITH ETHYLENEGLCOL DIMETHACRYLATE, THE DIESTER CAN BE REMOVED LARGELY BY CRYSTALLIZATION OF THE MONOESTER FROM A NORMALLY LIQUID SOLVENT MEDIUM AT A TEMPERATURE BELOW THE MELTING POINT OF THE DIESTER, TYPICALLY -20* TO -50* C. IF THE CRUDE MATERIAL CONTAINS MUCH ETHYLENEGLYCOL, THE ESTERS MAY BE SEPARATED FROM THE GLYCOL BY DISSOLVING THE MIXTURE IN WATER AND SALTING THE ESTERS OUT AS AN ORGANIC PHASE WHICH MAY BE FURTHER PURIFIED BY DISTILLATION OR BY LOW-TEMPERATURE CRYSTALLIZATION.

3. 发明授权

US3476499A Selectively light absorbing contact lens 失效
标题翻译：选择光吸收接触镜
公开(公告)号：US3476499A
公开(公告)日：1969-11-04
申请号：US3476499D
申请日：1965-01-04
申请人： CESKOSLOVENSKA AKADEMIE VED
发明人： WICHTERLE OTTO
IPC分类号： B29D11/00 , D06P1/00 , D06P3/00 , G02B1/04 , G02C7/02 , G03C1/496 , D06P3/52
CPC分类号： B29D11/00903 , B29D11/00 , B29D11/00317 , D06P1/0076 , D06P3/00 , G02B1/043 , G02C7/046 , G03C1/496

4. 发明授权

US3679504A Method of forming color effects in hydrogel contact lenses and ophthalmic prostheses 失效
标题翻译：在水凝胶接触镜中形成颜色效应的方法和光学性质
公开(公告)号：US3679504A
公开(公告)日：1972-07-25
申请号：US3679504D
申请日：1969-03-26
申请人： CESKOSLOVENSKA AKADEMIE VED
发明人： WICHTERLE OTTO
IPC分类号： G02C7/04 , B29D11/00 , D06P3/00 , G02B1/04 , G02C7/02 , B32B31/00
CPC分类号： B29D11/00317 , B29D11/0073 , D06P3/00 , G02B1/043 , G02C7/021 , Y10S623/901 , Y10S623/92
摘要： OBJECT OF THE INVENTION IS A METHOD OF FORMING COLOR EFFECTS IN HYDROGEL CONTACT LENSES AND OPHTHALMIC PROSTHESES, WHEREIN THE COLORED PATTERN IS FORMED BETWEEN AT LEAST TWO TRANSPARENT HYDROGEL LAYERS, BOUND TOGETHER BY POLYMERIZING BETWEEN THEM A MONOMER MIXUTRE FORMING THE SAME OR SIMILAR HYDROGEL. A HOMOGENEOUS TRANSPARENT THIN COVERING LAYER OF HYDROGEL IS FIRST FORMED ON A REGULAR SURFACE OF A SMOOTH PAD. THE DESIRED COLORED PATTERN IS THEN FORMED BETWEEN IT AND THE CONCAVE SURFACE OF A LENS OR THAT OF AN OPHTHALMIC PROSTHESIS, BEING EITHER LAID BETWEEN THEM AS A THIN FOIL OR CREATED ON EITHER THE SAID CONCAVE SURFACE OR SAID COVERING LAYER, THE LAST MENTIONED EMBODIMENT BEING PREFERRED. THE BOND BETWEEN THE LENS OR PROSTHESIS AND THE COVERING LAYER IS REALIZED BY PUTTING A DROP OF INITATED MONOMER MIXTURE BETWEEN THEM AND PRESSING THEM SLIGHTLY TOGETHER SO THAT THE EXCESS OF THE MONOMER MIXTURE IS EXPRESSED. THE COLORED PATTERN IS PREFERABLY FORMED USING COLORS, DYESTUFFS OR PIGMENTS WHICH ARE INSOLUBLE IN WATER AND IN MONOMER MIXTURE. THE FINISHED LENS OR PROSTHESIS IS THEN REMOVED FROM THE PAD BY SWELLING THE WHOLE IN A SWELLING LIQUID SUCH AS WATER OR ALCOHOL AND KEPT IN STERILE PHYSIOLOGIC SOLUTION.

5. 发明授权

US3660545A Method of centrifugally casting thin edged corneal contact lenses 失效
标题翻译：离心铸造方法切割加工的角接触镜
公开(公告)号：US3660545A
公开(公告)日：1972-05-02
申请号：US3660545D
申请日：1970-11-04
申请人： CESKOSLOVENSKA AKADEMIE VED
发明人： WICHTERLE OTTO
IPC分类号： B29C41/04 , B29C41/42 , B29C41/50 , B29D11/00 , B29D11/02 , C08F20/62
CPC分类号： B29D11/02 , B29C41/045 , B29C41/42 , B29C41/50 , B29D11/00057 , B29D11/00115 , B29K2105/0002 , B29L2011/0041 , B29L2031/76 , C08F20/62
摘要： A CORNEAL CONTACT LENS IS MADE BY POLYMERIZING A CATALYZED MIXTURE OF ACRYLATES AND/OR METHACRYLATES OF POLYHYDRIC ALCOHOLS WITH A WATER MISCIBLE SOLVENT IN A MOLD CAVITY HAVING A SPHERICALLY CONCAVE BOTTOM SURFACE AND BEING ROTATED ABOUT AN AXIS PERPENDICUAR TO THAT SURFACE AT A SPEED TO PRODUCE AN EXPOSED CONCAVE SURFACE OF THE

POLYMERIZATION MIXTURE, WHICH IS SUFFICIENTLY DIFFERENT FROM A PARABOLOID SHAPE BECAUSE OF SURFACE TENSION EFFECTS TO HAVE A CENTER EFFECTIVE AS A CORRECTIVE LENS.

6. 发明授权

US3499862A Method of preparing shape retaining bodies of organic polymer hydrogels 失效
标题翻译：制备有机聚合物水凝胶形状保持体的方法
公开(公告)号：US3499862A
公开(公告)日：1970-03-10
申请号：US3499862D
申请日：1966-05-23
申请人： CESKOSLOVENSKA AKADEMIE VED
发明人： WICHTERLE OTTO
IPC分类号： C08F2/00 , C08F2/02 , C08F36/20 , C08F47/12
CPC分类号： C08F36/20 , Y10S524/916

7. 发明授权

US3551556A Carriers for biologically active substances 失效
标题翻译：生物活性物质载体
公开(公告)号：US3551556A
公开(公告)日：1970-12-29
申请号：US3551556D
申请日：1967-01-06
申请人： CESKOSLOVENSKA AKADEMIE VED
发明人： KLIMENT KAREL , VACIK JIRI , OTT ZDENEK , MAJKUS VLADIMIR , STOY VLADIMIR , STOL MIROSLAV , WICHTERLE OTTO
IPC分类号： A61K9/20 , A61K9/22 , A61K9/26 , C08F36/20 , A61K27/12
CPC分类号： A61K9/2027 , C08F36/20
摘要： Drugs are released gradually to a living organism after oral ingestion, through a layer of non-ionogenic, neutral hydrogel of a polymer of ethylene glycol methacrylate or similar monomer cross-linked sufficiently to make the polymer insoluble in all gastro intestinal liquids.
摘要翻译：口服摄入后，药物通过一层非离子发生的中性水凝胶的乙二醇甲基丙烯酸酯或类似单体的交联剂充分交联以使聚合物不溶于所有胃肠液体，逐渐释放到生物体内。

8. 发明授权

US3542907A Method of temporarily deforming hydrophilic contact lenses,grinding and polishing 失效
标题翻译：临时变形液压接触镜，研磨抛光方法
公开(公告)号：US3542907A
公开(公告)日：1970-11-24
申请号：US3542907D
申请日：1967-02-15
申请人： CESKOSLOVENSKA AKADEMIE VED
发明人： WICHTERLE OTTO
IPC分类号： B24B13/00 , G02C7/04 , B25D11/00 , B29C17/12
CPC分类号： B24B13/0025 , G02C7/04

9. 发明授权

US3915172A Capillary drain for glaucoma 失效
标题翻译：青光眼毛细血管
公开(公告)号：US3915172A
公开(公告)日：1975-10-28
申请号：US34447773
申请日：1973-03-26
申请人： CESKOSLOVENSKA AKADEMIE VED
发明人： WICHTERLE OTTO , KREJCI LUBOMIR
IPC分类号： A61F9/007 , A61L29/04 , A61L29/14 , A61M25/00 , A61M27/00
CPC分类号： A61M27/00 , A61F9/00781 , A61L29/041 , A61L29/145 , A61M25/0009 , A61L29/14 , C08L33/26 , C08L33/20
摘要： The invention relates to a capillary drain consisting of a flat bundle of capillaries made from hydrogels and suitable particularly for treating glaucoma in opthalmology. The drain is manufactured so that a system of parallel fibers or filaments is laid between parallel plates separated from each other by flat thin distance inserts or gaskets, an initiated monomer mixture suitable for producing water-swellable cross-linked hydrogels is filled into the mold thus obtained, the monomer mixture is allowed to polymerize under cross-linking conditions, the mold is removed and the fibers or filaments removed e.g., by dissolving or melting or pulling them out.
摘要翻译：本发明涉及由水凝胶制成的平坦毛细管束组成的毛细管排泄液，特别适用于治疗眼科学中的青光眼。排水管被制造成使得平行纤维或细丝系统被放置在通过平坦的薄距离插入件或垫圈彼此分离的平行板之间，将适合于生产水溶胀性交联水凝胶的起始单体混合物填充到模具中得到的单体混合物在交联条件下聚合，除去模具，除去纤维或细丝，例如通过溶解或熔化或将其拉出。

10. 发明授权

US3895169A Method for producing a hydrophilic layer on the surface of non-hydrophilic acrylic resins 失效
标题翻译：在非水解丙烯酸树脂表面生产疏水层的方法
公开(公告)号：US3895169A
公开(公告)日：1975-07-15
申请号：US29484672
申请日：1972-10-04
申请人： CESKOSLOVENSKA AKADEMIE VED
发明人： WICHTERLE OTTO
IPC分类号： C08J7/04 , C08J7/12 , B44D1/092
CPC分类号： C08J7/12 , C08J2333/00 , Y10T428/31536 , Y10T428/31935
摘要： A method of forming a hydrophilic layer on the surface of nonhydrophilic acrylic resins which have been shaped or molded into a desired configuration or structure. In carrying out the method, the resin structure is hydrolysed and reesterified with a strong acid and a polyhydroxy organic compound, such as sulfuric acid and ethylene glycol, respectively, and generally at temperatures above at least about 50*C.
摘要翻译：在非亲水性丙烯酸树脂的表面上形成亲水层的方法，所述非亲水性丙烯酸树脂已被成形或模制成所需的构型或结构。在进行该方法时，树脂结构分别用强酸和多羟基有机化合物如硫酸和乙二醇水解并重新酯化，通常在高于至少约50℃的温度下进行。

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