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1. 发明授权

US07554090B2 Apparatus and process for dose-guided radiotherapy 有权
标题翻译：剂量引导放疗的装置和方法
公开(公告)号：US07554090B2
公开(公告)日：2009-06-30
申请号：US10548391
申请日：2005-03-04
申请人： C. Norman Coleman , Robert Miller , Rosemary Altemus , Holly Ning , Alan Lee Huston , Brian L. Justus , Paul Falkenstein
发明人： C. Norman Coleman , Robert Miller , Rosemary Altemus , Holly Ning , Alan Lee Huston , Brian L. Justus , Paul Falkenstein
IPC分类号： G01T1/16
CPC分类号： A61N5/1048 , A61N5/1064 , A61N5/1071 , A61N2005/1072
摘要： A method and an apparatus for dose-guided radiotherapy for a patient (P) having an identified radiotherapy target utilizes a radiation detecting array (R) of radiation-sensitive dosimeters for the real-time remote measurement of radiotherapy at the radiation detecting array (R). The radiation detecting array is positioned within the patient's (P) body along the treatment path before or after the identified radiotherapy target or the device may be positioned beyond the patient (P) to measure transit dose. A radiation source (A) for emitting radiation for radiotherapy along a treatment path through the patient (P) to the identified radiotherapy target is utilized. The method includes generating a predicted dose pattern of radiation at the placed radiation detecting array (R). The predicted dose pattern assumes an on-target radiation source (A) emitting the radiotherapy beam along the treatment path through the patient (P) to the identified radiotherapy target. Gating of the radiation source (A) can occur responsive to the comparing of the predicted dose pattern of radiation to the real-time dose pattern at the radiation detecting array (R). Radiation intensity can vary between low levels to a treatment level responsive to coincidence of the predicted dose pattern of radiation to the real-time dose pattern at the radiation detecting array (R).
摘要翻译：用于具有识别的放射治疗靶标的患者（P）的剂量引导放射治疗的方法和装置利用辐射敏感剂量计的放射线检测阵列（R）用于放射线检测阵列（R）处的放射治疗的实时远程测量）。放射线检测阵列沿着治疗路径位于患者的（P）体内，在识别的放射治疗靶标之前或之后，或者该装置可以位于患者（P）之外，以测量转运剂量。利用用于沿着通过患者（P）的治疗路径发射放射线的辐射源（A）到所识别的放射治疗靶标。该方法包括在放置的放射线检测阵列（R）处产生辐射的预测剂量图案。预测的剂量模式假设沿着经由患者（P）的治疗路径发射放射治疗束到被识别的放射治疗靶标的靶标辐射源（A）。辐射源（A）的门控可以响应于放射线检测阵列（R）的预测辐射剂量模式与实时剂量模式的比较而发生。辐射强度可以根据预测的辐射剂量模式与放射线检测阵列（R）处的实时剂量图案的一致性，在低水平与治疗水平之间变化。

2. 发明申请

US20070058778A1 Apparatus and process for dose-guided radiotherapy 有权
标题翻译：剂量引导放疗的装置和方法
公开(公告)号：US20070058778A1
公开(公告)日：2007-03-15
申请号：US10548391
申请日：2004-03-04
申请人： C. Coleman , Robert Miller , Rosemary Altemus , Holly Ning , Alan Huston , Brian Justus , Paul Falkenstein
发明人： C. Coleman , Robert Miller , Rosemary Altemus , Holly Ning , Alan Huston , Brian Justus , Paul Falkenstein
IPC分类号： A61N5/10
CPC分类号： A61N5/1048 , A61N5/1064 , A61N5/1071 , A61N2005/1072
摘要： A method and an apparatus for dose-guided radiotherapy for a patient (P) having an identified radiotherapy target utilizes a radiation detecting array (R) of radiation-sensitive dosimeters for the real-time remote measurement of radiotherapy at the radiation detecting array (R). The radiation detecting array is positioned within the patient's (P) body along the treatment path before or after the identified radiotherapy target or the device may be positioned beyond the patient (P) to measure transit dose. A radiation source (A) for emitting radiation for radiotherapy along a treatment path through the patient (P) to the identified radiotherapy target is utilized. The method includes generating a predicted dose pattern of radiationa at the placed radiation detecting array (R). The predicted dose pattern assumes an on-target radiation source (A) emitting the radiotherapy beam along the treatment path through the patient (P) to the identified radiotherapy target. Gating of the radiation source (A) can occur responsive to the comparing of the predicted dose pattern of radiation to the real-time dose pattern at the radiation detecting array (R). Radiation intensity can vary between low levels to a treatment level responsive to coincidence of the predicted dose pattern of radiation to the real-time dose pattern at the radiation detecting array (R).
摘要翻译：用于具有识别的放射治疗靶标的患者（P）的剂量引导放射治疗的方法和装置利用辐射敏感剂量计的放射线检测阵列（R）用于放射线检测阵列（R）处的放射治疗的实时远程测量）。放射线检测阵列沿着治疗路径位于患者的（P）体内，在识别的放射治疗靶标之前或之后，或者该装置可以位于患者（P）之外，以测量转运剂量。利用用于沿着通过患者（P）的治疗路径发射放射线的辐射源（A）到所识别的放射治疗靶标。该方法包括在放置的放射线检测阵列（R）处产生辐射的预测剂量图案。预测的剂量模式假设沿着经由患者（P）的治疗路径发射放射治疗束到被识别的放射治疗靶标的靶标辐射源（A）。辐射源（A）的门控可以响应于放射线检测阵列（R）的预测辐射剂量模式与实时剂量模式的比较而发生。辐射强度可以根据预测的辐射剂量模式与放射线检测阵列（R）处的实时剂量图案的一致性，在低水平与治疗水平之间变化。

3. 发明授权

US08433167B2 Fused array preform fabrication of holey optical fibers 有权
标题翻译：多孔光纤的熔融阵列预制件制造
公开(公告)号：US08433167B2
公开(公告)日：2013-04-30
申请号：US11689584
申请日：2007-03-22
申请人： Paul Falkenstein , Brian L Justus
发明人： Paul Falkenstein , Brian L Justus
IPC分类号： G02B6/032
CPC分类号： G02B6/02347 , C03B37/0122 , C03B37/02781 , C03B2203/14 , C03B2203/16 , C03B2203/22 , C03B2203/24 , C03B2203/42 , G02B6/02328
摘要： This invention pertains to a holey fiber and to a fabrication method for making the fiber. The holey fiber can transmit light by total internal reflection or by Bragg diffraction, can be single mode or multimode and can have solid core or a hollow core. The holey fiber has outside diameter typically of 20 microns to 5 mm, a hollow core of a diameter typically of 0.2 micron to 150 microns and longitudinal channels therethrough of a diameter typically of 0.1 micron to 150 microns. The channels are disposed in a desired arrangement with center-to-center distance variation of less than about 2% along the length of the fiber and the cross-section thereof is round that varies less than about 2%.
摘要翻译：本发明涉及多孔纤维及其制造方法。有孔光纤可以通过全内反射或布拉格衍射传输光，可以是单模或多模，并且可以具有实芯或中空芯。多孔纤维具有通常为20微米至5mm的外径，直径通常为0.2微米至150微米的中空芯，通过其的纵向通道，其直径通常为0.1微米至150微米。通道以所需的布置方式布置，沿着纤维长度的中心到中心距离变化小于约2％，并且其横截面是圆形的，其变化小于约2％。

4. 发明申请

US20070154154A1 Fused Array Preform Fabrication Of Holey Optical Fibers 有权
标题翻译：多孔光纤熔融阵列预制
公开(公告)号：US20070154154A1
公开(公告)日：2007-07-05
申请号：US11689584
申请日：2007-03-22
申请人： Paul Falkenstein , Brian Justus
发明人： Paul Falkenstein , Brian Justus
IPC分类号： G02B6/032 , G02B6/02
CPC分类号： G02B6/02347 , C03B37/0122 , C03B37/02781 , C03B2203/14 , C03B2203/16 , C03B2203/22 , C03B2203/24 , C03B2203/42 , G02B6/02328
摘要： This invention pertains to a holey fiber and to a fabrication method for making the fiber. The holey fiber can transmit light by total internal reflection or by Bragg diffraction, can be single mode or multimode and can have solid core or a hollow core. The holey fiber has outside diameter typically of 20 microns to 5 mm, a hollow core of a diameter typically of 0.2 micron to 150 microns and longitudinal channels therethrough of a diameter typically of 0.1 micron to 150 microns. The channels are disposed in a desired arrangement with center-to-center distance variation of less than about 2% along the length of the fiber and the cross-section thereof is round that varies less than about 2%.
摘要翻译：本发明涉及多孔纤维及其制造方法。有孔光纤可以通过全内反射或布拉格衍射传输光，可以是单模或多模，并且可以具有实芯或中空芯。多孔纤维具有通常为20微米至5mm的外径，直径通常为0.2微米至150微米的中空芯，通过其的纵向通道，其直径通常为0.1微米至150微米。通道以所需的布置方式布置，沿着纤维长度的中心到中心距离变化小于约2％，并且其横截面是圆形的，其变化小于约2％。

5. 发明申请

US20060153512A1 Fused array preform fabrication of holey optical fibers 审中-公开
标题翻译：多孔光纤的熔融阵列预制件制造
公开(公告)号：US20060153512A1
公开(公告)日：2006-07-13
申请号：US10829614
申请日：2004-04-22
申请人： Paul Falkenstein , Brian Justus
发明人： Paul Falkenstein , Brian Justus
IPC分类号： G02B6/032 , C03B37/027
CPC分类号： G02B6/02347 , C03B37/0122 , C03B37/02781 , C03B2203/14 , C03B2203/16 , C03B2203/22 , C03B2203/24 , C03B2203/42 , G02B6/02328
摘要： This invention pertains to a holey fiber and to a fabrication method for making the fiber. The holey fiber can transmit light by total internal reflection or by Bragg diffraction, can be single mode or multimode and can have solid core or a hollow core. The holey fiber has outside diameter typically of 20 microns to 5 mm, a hollow core of a diameter typically of 0.2 micron to 150 microns and longitudinal channels therethrough of a diameter typically of 0.1 micron to 150 microns. The channels are disposed in a desired arrangement with center-to-center distance variation of less than about 2% along the length of the fiber and the cross-section thereof is round that varies less than about 2%. The method includes the steps of stacking structures of at least two different materials of lower and higher softening points in a desired arrangement to form a bundle containing interstices between the structures; heating the bundle to a fusion temperature which is below the softening point of the higher softening point material to form a fused element whereby the lower softening point material softens and flows around the higher softening point material and closes the interstices; removing the structures of the higher softening point material from the fused element to form a preform, thus forming openings in the fused element; and drawing the preform at a draw temperature which is below the softening point of the lower softening point material to form the holey fiber.
摘要翻译：本发明涉及多孔纤维及其制造方法。有孔光纤可以通过全内反射或布拉格衍射传输光，可以是单模或多模，并且可以具有实芯或中空芯。多孔纤维具有通常为20微米至5mm的外径，直径通常为0.2微米至150微米的中空芯，通过其的纵向通道，其直径通常为0.1微米至150微米。通道以所需的布置方式布置，沿着纤维长度的中心到中心距离变化小于约2％，并且其横截面是圆形的，其变化小于约2％。该方法包括以期望的布置堆叠具有较低和较高软化点的至少两种不同材料的结构的步骤，以形成在结构之间包含间隙的束; 将所述束加热至低于所述较高软化点材料的软化点的熔融温度以形成熔融元素，由此所述较低软化点物质软化并流过所述较高软化点材料并闭合所述间隙; 从熔融元件去除较高软化点材料的结构以形成预制件，从而在熔融元件中形成开口; 并且在低于软化点材料的软化点的拉伸温度下拉伸预制件以形成多孔纤维。

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