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1. 发明授权

US5858457A Process to form mesostructured films 失效
标题翻译：形成介孔结构膜的方法
公开(公告)号：US5858457A
公开(公告)日：1999-01-12
申请号：US937407
申请日：1997-09-25
申请人： C. Jeffrey Brinker , Mark T. Anderson , Rahul Ganguli , Yunfeng Lu
发明人： C. Jeffrey Brinker , Mark T. Anderson , Rahul Ganguli , Yunfeng Lu
IPC分类号： B01J29/04 , B01D71/02 , B01J29/03 , C01B37/00 , C01B37/02 , C01B39/02 , C04B38/00 , C04B41/45 , C09C1/30 , C23C18/12 , B05D5/06
CPC分类号： C09C1/3063 , B01D67/0048 , B01D67/0083 , B01D71/024 , B01D71/025 , B01J29/0308 , C01B37/00 , C01B37/02 , C04B38/0054 , C04B41/009 , C04B41/4582 , C09C1/3045 , C23C18/1216 , C23C18/1254 , B01D2323/08 , B01D2323/14 , B01D2323/50 , B01D2325/023 , B01D2325/26 , C01P2002/72 , C04B2111/00801 , C04B2111/0081
摘要： This invention comprises a method to form a family of supported films film with pore size in the approximate range 0.8-20 nm exhibiting highly ordered microstructures and porosity derived from an ordered micellar or liquid-crystalline organic-inorganic precursor structure that forms during film deposition. Optically transparent, 100-500-nm thick films exhibiting a unique range of microstructures and uni-modal pore sizes are formed in seconds in a continuous coating operation. Applications of these films include sensors, membranes, low dielectric constant interlayers, anti-reflective coatings, and optical hosts.
摘要翻译：本发明包括一种形成孔径在大约0.8-20nm范围内的负载膜薄膜族的方法，其表现出高度有序的微结构和孔隙率，其衍生自在膜沉积期间形成的有序胶束或液晶有机 - 无机前体结构。在连续涂布操作中，在几秒钟内形成光学透明的100-500nm厚的薄膜，其具有独特的微结构范围和单一孔径。这些膜的应用包括传感器，膜，低介电常数中间层，抗反射涂层和光学主机。

2. 再颁专利

USRE41612E1 Method for making surfactant-templated thin films 有权
标题翻译：制备表面活性剂模板薄膜的方法
公开(公告)号：USRE41612E1
公开(公告)日：2010-08-31
申请号：US10670187
申请日：2003-09-23
申请人： C. Jeffrey Brinker , Yunfeng Lu , Hong You Fan
发明人： C. Jeffrey Brinker , Yunfeng Lu , Hong You Fan
IPC分类号： B05D3/02 , B05D1/02 , B05D1/18 , B05D3/10 , B05D3/12
CPC分类号： B82Y30/00
摘要： An evaporation-induced self-assembly method to prepare a porous, surfactant-templated, thin film by mixing a silica sol, a solvent, a surfactant, and an interstitial compound, evaporating a portion of the solvent to form a liquid, crystalline thin film mesophase material, and then removal of the surfactant template. Coating onto a substrate produces a thin film with the interstitial compound either covalently bonded to the internal surfaces of the ordered or disordered mesostructure framework or physically entrapped within the ordered or disordered mesostructured framework. Particles can be formed by aerosol processing or spray drying rather than coating onto a substrate. The selection of the interstitial compound provides a means for developing thin films for applications including membranes, sensors, low dielectric constant films, photonic materials and optical hosts.
摘要翻译：通过混合硅溶胶，溶剂，表面活性剂和间隙化合物制备多孔表面活性剂模板化薄膜的蒸发诱导自组装方法，蒸发溶剂的一部分以形成液体，晶体薄膜中间相材料，然后除去表面活性剂模板。涂覆在基材上产生薄膜，其中间隙化合物共价键合到有序或无序的介观结构框架的内表面或物理地截留在有序或无序的介观结构框架内。颗粒可以通过气溶胶处理或喷雾干燥形成，而不是涂覆在基材上。间隙化合物的选择提供了一种用于开发用于包括膜，传感器，低介电常数膜，光子材料和光学主体的薄膜的薄膜的方法。

3. 发明授权

US06270846B1 Method for making surfactant-templated, high-porosity thin films 有权
标题翻译：制备表面活性剂模板，高孔隙率薄膜的方法
公开(公告)号：US06270846B1
公开(公告)日：2001-08-07
申请号：US09517689
申请日：2000-03-02
申请人： C. Jeffrey Brinker , Yunfeng Lu , Hongyou Fan
发明人： C. Jeffrey Brinker , Yunfeng Lu , Hongyou Fan
IPC分类号： B05B500
CPC分类号： B01F17/0028 , B01F17/0021 , B01F17/0042 , B01F17/0057 , B01F17/0064 , C03C17/007 , C03C17/009 , C03C2217/425 , Y10T428/21 , Y10T428/24331
摘要： An evaporation-induced self-assembly method to prepare a surfactant-templated thin film by mixing a silica sol, a surfactant, and a hydrophobic polymer and then evaporating a portion of the solvent during coating onto a substrate and then heating to form a liquid-phase, thin film material with a porosity greater than approximately 50 percent. The high porosity thin films can have dielectric constants less than 2 to be suitable for applications requiring low-dielectric constants. An interstitial compound can be added to the mixture, with the interstitial compound either covalently bonded to the pores or physically entrapped within the porous structure. The selection of the interstitial compound provides a means for developing thin films for applications including membranes, sensors, low dielectric constant films, photonic materials and optical hosts.
摘要翻译：蒸发诱导的自组装方法，通过混合二氧化硅溶胶，表面活性剂和疏水聚合物制备表面活性剂模板化薄膜，然后在涂布过程中将一部分溶剂蒸发到基底上，然后加热形成液体 - 孔隙率大于约50％的薄膜材料。高孔隙率薄膜可以具有小于2的介电常数，以适用于需要低介电常数的应用。间隙化合物可以加入到混合物中，间隙化合物共价键合到孔或物理地截留在多孔结构内。间隙化合物的选择提供了一种用于开发用于包括膜，传感器，低介电常数膜，光子材料和光学主体的薄膜的薄膜的方法。

4. 发明授权

US06264741B1 Self-assembly of nanocomposite materials 有权
标题翻译：纳米复合材料的自组装
公开(公告)号：US06264741B1
公开(公告)日：2001-07-24
申请号：US09449036
申请日：1999-11-24
申请人： C. Jeffrey Brinker , Alan Sellinger , Yunfeng Lu
发明人： C. Jeffrey Brinker , Alan Sellinger , Yunfeng Lu
IPC分类号： C30B1110
CPC分类号： B82Y30/00 , C09K19/00
摘要： A method of making a nanocomposite self-assembly is provided where at least one hydrophilic compound, at least one hydrophobic compound, and at least one amphiphilic surfactant are mixed in an aqueous solvent with the solvent subsequently evaporated to form a self-assembled liquid crystalline mesophase material. Upon polymerization of the hydrophilic and hydrophobic compounds, a robust nanocomposite self-assembled material is formed. Importantly, in the reaction mixture, the amphiphilic surfactant has an initial concentration below the critical micelle concentration to allow formation of the liquid-phase micellar mesophase material. A variety of nanocomposite structures can be formed, depending upon the solvent evaporazation process, including layered mesophases, tubular mesophases, and a hierarchical composite coating composed of an isotropic worm-like micellar overlayer bonded to an oriented, nanolaminated underlayer.
摘要翻译：提供制备纳米复合自组装的方法，其中至少一种亲水性化合物，至少一种疏水性化合物和至少一种两亲表面活性剂在水性溶剂中与溶剂混合，随后蒸发形成自组装液晶中间相材料。在聚合亲水和疏水化合物时，形成了坚固的纳米复合材料自组装材料。重要的是，在反应混合物中，两亲表面活性剂的初始浓度低于临界胶束浓度以允许形成液相胶束中间相材料。可以形成各种纳米复合结构，这取决于溶剂蒸发过程，包括层状中间相，管状中间相，和由定向的纳米层压底层粘合的各向同性的蠕虫状胶束覆盖层组成的分级复合涂层。

5. 发明授权

US06387453B1 Method for making surfactant-templated thin films 有权
标题翻译：制备表面活性剂模板薄膜的方法
公开(公告)号：US06387453B1
公开(公告)日：2002-05-14
申请号：US09517873
申请日：2000-03-02
申请人： C. Jeffrey Brinker , Yunfeng Lu , Hongyou Fan
发明人： C. Jeffrey Brinker , Yunfeng Lu , Hongyou Fan
IPC分类号： B05D302
CPC分类号： B82Y30/00
摘要： An evaporation-induced self-assembly method to prepare a porous, surfactant-templated, thin film by mixing a silica sol, a solvent, a surfactant, and an interstitial compound, evaporating a portion of the solvent to form a liquid, crystalline thin film mesophase material, and then removal of the surfactant template. Coating onto a substrate produces a thin film with the interstitial compound either covalently bonded to the internal surfaces of the ordered or disordered mesostructure framework or physically entrapped within the ordered or disordered mesostructured framework. Particles can be formed by aerosol processing or spray drying rather than coating onto a substrate. The selection of the interstitial compound provides a means for developing thin films for applications including membranes, sensors, low dielectric constant films, photonic materials and optical hosts.
摘要翻译：通过混合硅溶胶，溶剂，表面活性剂和间隙化合物制备多孔表面活性剂模板化薄膜的蒸发诱导自组装方法，蒸发溶剂的一部分以形成液体，晶体薄膜中间相材料，然后除去表面活性剂模板。涂覆在基材上产生薄膜，其中间隙化合物共价键合到有序或无序的介观结构框架的内表面或物理地截留在有序或无序的介观结构框架内。颗粒可以通过气溶胶处理或喷雾干燥形成，而不是涂覆在基材上。间隙化合物的选择提供了一种用于开发用于包括膜，传感器，低介电常数膜，光子材料和光学主体的薄膜的薄膜的方法。

6. 发明授权

US08864045B1 Aerosol fabrication methods for monodisperse nanoparticles 有权
标题翻译：单分散纳米粒子的气溶胶制备方法
公开(公告)号：US08864045B1
公开(公告)日：2014-10-21
申请号：US13300069
申请日：2011-11-18
申请人： Xingmao Jiang , C. Jeffrey Brinker
发明人： Xingmao Jiang , C. Jeffrey Brinker
IPC分类号： B05B1/24
CPC分类号： B05B1/24 , B22F1/0018 , B22F1/02 , B22F9/06 , B22F2001/0092 , C01B13/34 , C01B21/06 , C01P2004/32 , C01P2004/34 , C01P2004/64 , C22C2202/02 , C23C18/08 , C23C18/1204 , C23C18/1241 , C23C18/1245 , C23C18/127 , C23C18/1295
摘要： Exemplary embodiments provide materials and methods for forming monodisperse particles. In one embodiment, the monodisperse particles can be formed by first spraying a nanoparticle-containing dispersion into aerosol droplets and then heating the aerosol droplets in the presence of a shell precursor to form core-shell particles. By removing either the shell layer or the nanoparticle core of the core-shell particles, monodisperse nanoparticles can be formed.
摘要翻译：示例性实施方案提供了用于形成单分散颗粒的材料和方法。在一个实施方案中，单分散颗粒可以通过首先将含纳米颗粒的分散体喷雾到气溶胶液滴中，然后在壳前体的存在下加热气溶胶液滴形成核 - 壳颗粒来形成。通过去除核 - 壳颗粒的壳层或纳米颗粒芯，可以形成单分散纳米颗粒。

7. 发明申请

US20140079774A1 POROUS NANOPARTICLE-SUPPORTED LIPID BILAYERS (PROTOCELLS) FOR TARGETED DELIVERY AND METHODS OF USING SAME 有权
标题翻译：用于定向输送的多孔纳米脂质载体（PROTOCELLS）及其使用方法
公开(公告)号：US20140079774A1
公开(公告)日：2014-03-20
申请号：US14113371
申请日：2012-04-27
申请人： C. Jeffrey Brinker , Eric C. Carnes , Carleen Erin Ashley
发明人： C. Jeffrey Brinker , Eric C. Carnes , Carleen Erin Ashley
IPC分类号： A61K9/127 , A61K45/06 , A61K31/704 , A61K31/711
CPC分类号： A61K9/1271 , A61K31/704 , A61K31/711 , A61K33/24 , A61K38/00 , A61K39/05 , A61K45/06 , A61K47/62 , A61K47/6901 , A61K48/0016 , C07K14/47 , C12N15/1135 , C12N15/88 , C12N2310/14 , C12N2320/32 , C12N2810/40
摘要： The present invention is directed to protocells for specific targeting of hepatocellular and other cancer cells which comprise a nanoporous silica core with a supported lipid bilayer; at least one agent which facilitates cancer cell death (such as a traditional small molecule, a macromolecular cargo (e.g. siRNA or a protein toxin such as ricin toxin A-chain or diphtheria toxin A-chain) and/or a histone-packaged plasmid DNA disposed within the nanoporous silica core (preferably supercoiled in order to more efficiently package the DNA into protocells) which is optionally modified with a nuclear localization sequence to assist in localizing protocells within the nucleus of the cancer cell and the ability to express peptides involved in therapy (apoptosis/cell death) of the cancer cell or as a reporter, a targeting peptide which targets cancer cells in tissue to be treated such that binding of the protocell to the targeted cells is specific and enhanced and a fusogenic peptide that promotes endosomal escape of protocells and encapsulated DNA. Protocells according to the present invention may be used to treat cancer, especially including hepatocellular (liver) cancer using novel binding peptides (c-MET peptides) which selectively bind to hepatocellular tissue or to function in diagnosis of cancer, including cancer treatment and drug discovery.
摘要翻译：本发明涉及用于特异性靶向肝细胞和其它癌细胞的原细胞，其包含具有支持的脂质双层的纳米多孔二氧化硅核心; 促进癌细胞死亡的至少一种试剂（例如传统的小分子，大分子货物（例如siRNA或蛋白质毒素如蓖麻毒素A链或白喉毒素A链）和/或组蛋白包装的质粒DNA 设置在纳米多孔硅芯内（优选超螺旋以更有效地将DNA包装到原细胞中），其任选地用核定位序列修饰以帮助定位癌细胞核内的原细胞，以及表达参与治疗的肽的能力（凋亡/细胞死亡）或作为报告物，靶向肽靶向待治疗的组织中的癌细胞，使得原细胞与靶细胞的结合是特异性和增强的，并且促进内体逃逸的融合肽原细胞和包封的DNA。根据本发明的原细胞可用于治疗癌症，特别是包括肝细胞（肝）癌症选择性结合肝细胞组织或在癌症诊断中起作用的新型结合肽（c-MET肽），包括癌症治疗和药物发现。

8. 发明授权

US07947579B2 Method of making dense, conformal, ultra-thin cap layers for nanoporous low-k ILD by plasma assisted atomic layer deposition 有权
标题翻译：通过等离子体辅助原子层沉积制备纳米多孔低k ILD的致密，共形，超薄盖层的方法
公开(公告)号：US07947579B2
公开(公告)日：2011-05-24
申请号：US11673190
申请日：2007-02-09
申请人： Ying-Bing Jiang , Joseph L. Cecchi , C. Jeffrey Brinker
发明人： Ying-Bing Jiang , Joseph L. Cecchi , C. Jeffrey Brinker
IPC分类号： H01L21/4763
CPC分类号： A61K45/06 , A61K31/167 , A61K31/7048 , H01L21/76814 , H01L21/76826 , H01L21/76831 , Y10S977/89 , A61K2300/00
摘要： Barrier layers and methods for forming barrier layers on a porous layer are provided. The methods can include chemically adsorbing a plurality of first molecules on a surface of the porous layer in a chamber and forming a first layer of the first molecules on the surface of the porous layer. A plasma can then be used to react a plurality of second molecules with the first layer of first molecules to form a first layer of a barrier layer. The barrier layers can seal the pores of the porous material, function as a diffusion barrier, be conformal, and/or have a negligible impact on the overall ILD k value of the porous material.
摘要翻译：提供了阻挡层和在多孔层上形成阻挡层的方法。所述方法可以包括在多孔层的多孔层的表面上化学吸附多个第一分子并在多孔层的表面上形成第一分子的第一层。然后可以使用等离子体来使多个第二分子与第一分子的第一层反应以形成阻挡层的第一层。阻挡层可以密封多孔材料的孔，用作扩散阻挡层，保形，和/或对多孔材料的整体ILD k值具有可忽略的影响。

9. 发明申请

US20070190777A1 METHOD OF MAKING DENSE, CONFORMAL, ULTRA-THIN CAP LAYERS FOR NANOPOROUS LOW-K ILD BY PLASMA ASSISTED ATOMIC LAYER DEPOSITION 有权
标题翻译：通过等离子体辅助原子层沉积制备纳米级低K薄膜的DENSE，一致，超薄膜层的方法
公开(公告)号：US20070190777A1
公开(公告)日：2007-08-16
申请号：US11673190
申请日：2007-02-09
申请人： Ying Bing Jiang , Joseph L. Cecchi , C. Jeffrey Brinker
发明人： Ying Bing Jiang , Joseph L. Cecchi , C. Jeffrey Brinker
IPC分类号： H01L21/4763
CPC分类号： A61K45/06 , A61K31/167 , A61K31/7048 , H01L21/76814 , H01L21/76826 , H01L21/76831 , Y10S977/89 , A61K2300/00
摘要： Barrier layers and methods for forming barrier layers on a porous layer are provided. The methods can include chemically adsorbing a plurality of first molecules on a surface of the porous layer in a chamber and forming a first layer of the first molecules on the surface of the porous layer. A plasma can then be used to react a plurality of second molecules with the first layer of first molecules to form a first layer of a barrier layer. The barrier layers can seal the pores of the porous material, function as a diffusion barrier, be conformal, and/or have a negligible impact on the overall ILD k value of the porous material.
摘要翻译：提供了阻挡层和在多孔层上形成阻挡层的方法。所述方法可以包括在多孔层的多孔层的表面上化学吸附多个第一分子并在多孔层的表面上形成第一分子的第一层。然后可以使用等离子体来使多个第二分子与第一分子的第一层反应以形成阻挡层的第一层。阻挡层可以密封多孔材料的孔，用作扩散阻挡层，保形，和/或对多孔材料的整体ILD k值具有可忽略的影响。

10. 发明授权

US06983093B2 Fluid light guide having hydrophobic aerogel cladding layer 失效
标题翻译：具有疏水性气凝胶包层的流体导光体
公开(公告)号：US06983093B2
公开(公告)日：2006-01-03
申请号：US09920570
申请日：2001-07-31
申请人： Hanafi R. Fraval , C. Jeffrey Brinker
发明人： Hanafi R. Fraval , C. Jeffrey Brinker
IPC分类号： G02B6/02
CPC分类号： G02B6/032 , G02B1/048
摘要： A light guide is disclosed and includes a flexible elongated tube having an inner surface and first and second ends. A non-supercritically dried hydrophobic aerogel film is affixed to the inner surface of the tube as a cladding layer, and a fluid core is disposed within the tube. The fluid core has a refractive index greater than the refractive index of the aerogel cladding film.
摘要翻译：公开了一种光导，并且包括具有内表面和第一端和第二端的柔性细长管。非超临界干燥的疏水性气凝胶膜作为包层固定在管的内表面上，并且流体芯设置在管内。流体芯的折射率大于气凝胶包覆膜的折射率。

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