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1. 发明授权

US06169079A Oligonucleotide inhibition of cell adhesion 失效
标题翻译：寡核苷酸抑制细胞粘附
公开(公告)号：US06169079A
公开(公告)日：2001-01-02
申请号：US09128496
申请日：1998-08-03
申请人： C. Frank Bennett , Christopher K. Mirabelli
发明人： C. Frank Bennett , Christopher K. Mirabelli
IPC分类号： A01N4304
CPC分类号： C07H21/04 , A61K38/00 , A61K48/00 , C07K14/70525 , C07K14/70542 , C07K14/70564 , C12N15/1138 , C12N2310/315 , C12N2310/322 , C12N2310/352 , C12N2310/3533
摘要： Compositions and methods are provided for the treatment and diagnosis of diseases amenable to treatment through modulation of the synthesis or metabolism of intercellular adhesion molecules. In accordance with preferred embodiments, oligonucleotides are provided which are specifically hybridizable with nucleic acids encoding intercellular adhesion molecule-1, vascular cell adhesion molecule-1, and endothelial leukocyte adhesion molecule-1. The oligonucleotide comprises nucleotide units sufficient in identity and number to effect said specific hybridization. In other preferred embodiments, the oligonucleotides are specifically hybridizable with a transcription initiation site, a translation initiation site, 5′-untranslated sequences, 3′-untranslated sequences, and intervening sequences. Methods of treating animals suffering from disease amenable to therapeutic intervention by modulating cell adhesion proteins with an oligonucleotide specifically hybridizable with RNA or DNA corresponding to one of the foregoing proteins are disclosed. Methods for treatment of diseases responding to inhibition of cell adhesion molecules are disclosed.
摘要翻译：提供组合物和方法，用于治疗和诊断适于通过调节细胞间粘附分子的合成或代谢来治疗的疾病。根据优选实施方案，提供了与编码细胞间粘附分子-1，血管细胞粘附分子-1和内皮细胞粘附分子-1的核酸特异性杂交的寡核苷酸。所述寡核苷酸包含足以实现所述特异性杂交的同一性和数目的核苷酸单元。在其它优选实施方案中，寡核苷酸与转录起始位点，翻译起始位点，5'-非翻译序列，3'非翻译序列和插入序列特异性杂交。公开了通过用与上述蛋白质之一相对应的RNA或DNA特异性杂交的寡核苷酸调节细胞粘附蛋白来治疗患有治疗性干预的疾病的方法。公开了治疗响应于细胞粘附分子抑制的疾病的方法。

2. 发明授权

US06300491B1 Oligonucleotide inhibition of cell adhesion 失效
标题翻译：寡核苷酸抑制细胞粘附
公开(公告)号：US06300491B1
公开(公告)日：2001-10-09
申请号：US09009490
申请日：1998-01-20
申请人： C. Frank Bennett , Christopher K. Mirabelli
发明人： C. Frank Bennett , Christopher K. Mirabelli
IPC分类号： C07H2102
CPC分类号： C07H21/04 , A61K38/00 , A61K48/00 , C07K14/70525 , C07K14/70542 , C07K14/70564 , C12N15/1138 , C12N2310/315 , C12N2310/322 , C12N2310/352 , C12N2310/3533
摘要： Compositions and methods are provided for the treatment and diagnosis of diseases amenable to treatment through modulation of the synthesis or metabolism of intercellular adhesion molecules. In accordance with preferred embodiments, oligonucleotides are provided which are specifically hybridizable with nucleic acids encoding intercellular adhesion molecule-1, vascular cell adhesion molecule-1, and endothelial leukocyte adhesion molecule-1. The oligonucleotide comprises nucleotide units sufficient in identity and number to effect said specific hybridization. In other preferred embodiments, the oligonucleotides are specifically hybridizable with a transcription initiation site, a translation initiation site, 5′-untranslated sequences, 3′-untranslated sequences, and intervening sequences. Methods of treating animals suffering from disease amenable to therapeutic intervention by modulating cell adhesion proteins with an oligonucleotide specifically hybridizable with RNA or DNA corresponding to one of the foregoing proteins are disclosed. Methods for treatment of diseases responding to modulation cell adhesion molecules are disclosed.
摘要翻译：提供组合物和方法，用于治疗和诊断适于通过调节细胞间粘附分子的合成或代谢来治疗的疾病。根据优选实施方案，提供了与编码细胞间粘附分子-1，血管细胞粘附分子-1和内皮细胞粘附分子-1的核酸特异性杂交的寡核苷酸。所述寡核苷酸包含足以实现所述特异性杂交的同一性和数目的核苷酸单元。在其它优选实施方案中，寡核苷酸与转录起始位点，翻译起始位点，5'-非翻译序列，3'非翻译序列和插入序列特异性杂交。公开了通过用与上述蛋白质之一相对应的RNA或DNA特异性杂交的寡核苷酸调节细胞粘附蛋白来治疗患有治疗性干预的疾病的方法。公开了治疗响应于调节细胞粘附分子的疾病的方法。

3. 发明授权

US6096722A Antisense modulation of cell adhesion molecule expression and treatment of cell adhesion molecule-associated diseases 失效
标题翻译：细胞粘附分子表达的反义调控和细胞粘附分子相关疾病的治疗
公开(公告)号：US6096722A
公开(公告)日：2000-08-01
申请号：US85759
申请日：1998-05-27
申请人： C. Frank Bennett , Christopher K. Mirabelli , Brenda Baker
发明人： C. Frank Bennett , Christopher K. Mirabelli , Brenda Baker
IPC分类号： A01N43/04 , A61K31/70 , A61K38/00 , A61K48/00 , C07H21/00 , C07H21/02 , C07H21/04 , C12N15/113 , C12P19/34 , C12Q1/68
CPC分类号： C12N15/1138 , A61K38/00 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346
摘要： Compositions and methods are provided for the modulation of expression of cellular adhesion molecules. In accordance with preferred embodiments, oligonucleotides are provided which are specifically hybridizable with nucleic acids encoding intercellular adhesion molecule-1, vascular cell adhesion molecule-1, and endothelial leukocyte adhesion molecule-1. Methods of modulating expression of cellular adhesion molecules are provided, as are methods of treating conditions associated with cellular adhesion molecules. In a preferred embodiment, the cellular adhesion molecule is ICAM-1, and a preferred antisense sequence targeted to human ICAM-1 is demonstrated to have clinical utility in several disease indications.
摘要翻译：提供组合物和方法用于调节细胞粘附分子的表达。根据优选实施方案，提供了与编码细胞间粘附分子-1，血管细胞粘附分子-1和内皮细胞粘附分子-1的核酸特异性杂交的寡核苷酸。提供调节细胞粘附分子表达的方法，以及治疗与细胞粘附分子相关的病症的方法。在优选的实施方案中，细胞粘附分子是ICAM-1，并且针对人ICAM-1的优选反义序列证明在几种疾病适应症中具有临床效用。

4. 发明授权

US6015894A Oligonucleotide modulation of cell adhesion 失效
标题翻译：细胞粘附的寡核苷酸调节
公开(公告)号：US6015894A
公开(公告)日：2000-01-18
申请号：US982845
申请日：1997-12-02
申请人： C. Frank Bennett , Christopher K. Mirabelli
发明人： C. Frank Bennett , Christopher K. Mirabelli
IPC分类号： A01N43/04 , A61K31/70 , A61K48/00 , C07H21/00 , C07H21/02 , C07H21/04 , C12N15/00 , C12P19/34 , C12Q1/68
CPC分类号： C07H21/04 , A61K48/00 , C07K14/70525 , C07K14/70542 , C07K14/70564 , C12N15/1138 , A61K38/00 , C12N2310/315 , C12N2310/322 , C12N2310/352 , C12N2310/3533
摘要： Compositions and methods are provided for the treatment and diagnosis of diseases amenable to treatment through modulation of the synthesis or metabolism of intercellular adhesion molecules. In accordance with preferred embodiments, oligonucleotides are provided which are specifically hybridizable with nucleic acids encoding intercellular adhesion molecule-1, vascular cell adhesion molecule-1, and endothelial leukocyte adhesion molecule-1. The oligonucleotide comprises nucleotide units sufficient in identity and number to effect said specific hybridization. In other preferred embodiments, the oligonucleotides are specifically hybridizable with a transcription initiation site, a translation initiation site, 5'-untranslated sequences, 3'-untranslated sequences, and intervening sequences. Methods of treating animals suffering from disease amenable to therapeutic intervention by modulating cell adhesion proteins with an oligonucleotide specifically hybridizable with RNA or DNA corresponding to one of the foregoing proteins are disclosed. Methods for treatment of diseases responding to modulation cell adhesion molecules are disclosed.
摘要翻译：提供组合物和方法，用于治疗和诊断适于通过调节细胞间粘附分子的合成或代谢来治疗的疾病。根据优选实施方案，提供了与编码细胞间粘附分子-1，血管细胞粘附分子-1和内皮细胞粘附分子-1的核酸特异性杂交的寡核苷酸。所述寡核苷酸包含足以实现所述特异性杂交的同一性和数目的核苷酸单元。在其它优选实施方案中，寡核苷酸与转录起始位点，翻译起始位点，5'-非翻译序列，3'非翻译序列和插入序列特异性杂交。公开了通过用与上述蛋白质之一相对应的RNA或DNA特异性杂交的寡核苷酸调节细胞粘附蛋白来治疗患有治疗性干预的疾病的方法。公开了治疗响应于调节细胞粘附分子的疾病的方法。

5. 发明授权

US5843738A Oligonucleotide modulation of cell adhesion 失效
公开(公告)号：US5843738A
公开(公告)日：1998-12-01
申请号：US440740
申请日：1995-05-12
申请人： C. Frank Bennett , Christopher K. Mirabelli
发明人： C. Frank Bennett , Christopher K. Mirabelli
IPC分类号： A01N43/04 , A61K31/70 , A61K48/00 , C07H21/00 , C07H21/02 , C07H21/04 , C12N15/00 , C12P19/34 , C12Q1/68
CPC分类号： C07H21/04 , A61K48/00 , C07K14/70525 , C07K14/70542 , C07K14/70564 , C12N15/1138 , A61K38/00 , C12N2310/315 , C12N2310/322 , C12N2310/352 , C12N2310/3533
摘要： Compositions and methods are provided for the treatment and diagnosis of diseases amenable to treatment through modulation of the synthesis or metabolism of intercellular adhesion molecules. In accordance with preferred embodiments, oligonucleotides are provided which are specifically hybridizable with nucleic acids encoding intercellular adhesion molecule-1, vascular cell adhesion molecule-1, and endothelial leukocyte adhesion molecule-1. The oligonucleotide comprises nucleotide units sufficient in identity and number to effect said specific hybridization. In other preferred embodiments, the oligonucleotides are specifically hybridizable with a transcription initiation site, a translation initiation site, 5'-untranslated sequences, 3'-untranslated sequences, and intervening sequences. Methods of treating animals suffering from disease amenable to therapeutic intervention by modulating cell adhesion proteins with an oligonucleotide specifically hybridizable with RNA or DNA corresponding to one of the foregoing proteins are disclosed. Methods for treatment of diseases responding to modulation cell adhesion molecules are disclosed.

6. 发明授权

US5591623A Oligonucleotide modulation of cell adhesion 失效
标题翻译：细胞粘附的寡核苷酸调节
公开(公告)号：US5591623A
公开(公告)日：1997-01-07
申请号：US7997
申请日：1993-01-21
申请人： C. Frank Bennett , Christopher K. Mirabelli
发明人： C. Frank Bennett , Christopher K. Mirabelli
IPC分类号： A61K38/00 , A61K48/00 , C07K14/705 , C12N5/22 , C12N15/113 , A61K31/70 , C07H21/04 , C12Q1/68
CPC分类号： C12N15/1138 , A61K48/00 , C07K14/705 , C07K14/70525 , C07K14/70542 , C07K14/70564 , A61K38/00 , C12N2310/315 , C12N2310/322 , C12N2310/352 , C12N2310/3521 , C12N2310/3531 , C12N2310/3533
摘要： Compositions and methods are provided for the treatment and diagnosis of diseases amenable to treatment through modulation of the synthesis or metabolism of intercellular adhesion molecules. In accordance with preferred embodiments, oligonucleotides are provided which are specifically hybridizable with nucleic acids encoding intercellular adhesion molecule-1, vascular cell adhesion molecule-1, and endothelial leukocyte adhesion molecule-1. The oligonucleotide comprises nucleotide units sufficient in identity and number to effect said specific hybridization. In other preferred embodiments, the oligonucleotides are specifically hybridizable with a transcription initiation site, a translation initiation site, 5'-untranslated sequences, 3'-untranslated sequences, and intervening sequences. Methods of treating animals suffering from disease amenable to therapeutic intervention by modulating cell adhesion proteins with an oligonucleotide specifically hybridizable with RNA or DNA corresponding to one of the foregoing proteins are disclosed. Methods for treatment of diseases responding to modulation cell adhesion molecules are disclosed.
摘要翻译：提供组合物和方法，用于治疗和诊断适于通过调节细胞间粘附分子的合成或代谢来治疗的疾病。根据优选实施方案，提供了与编码细胞间粘附分子-1，血管细胞粘附分子-1和内皮细胞粘附分子-1的核酸特异性杂交的寡核苷酸。所述寡核苷酸包含足以实现所述特异性杂交的同一性和数目的核苷酸单元。在其它优选实施方案中，寡核苷酸与转录起始位点，翻译起始位点，5'-非翻译序列，3'非翻译序列和插入序列特异性杂交。公开了通过用与上述蛋白质之一相对应的RNA或DNA特异性杂交的寡核苷酸调节细胞粘附蛋白来治疗患有治疗性干预的疾病的方法。公开了治疗响应于调节细胞粘附分子的疾病的方法。

7. 发明授权

US6093811A Oligonucleotide modulation of cell adhesion 失效
公开(公告)号：US6093811A
公开(公告)日：2000-07-25
申请号：US991525
申请日：1997-12-16
申请人： C. Frank Bennett , Christopher K. Mirabelli
发明人： C. Frank Bennett , Christopher K. Mirabelli
IPC分类号： A01N43/04 , A61K31/70 , A61K48/00 , C07H21/00 , C07H21/02 , C07H21/04 , C12N15/00 , C12P19/34 , C12Q1/68
CPC分类号： C07H21/04 , A61K48/00 , C07K14/70525 , C07K14/70542 , C07K14/70564 , C12N15/1138 , A61K38/00 , C12N2310/315 , C12N2310/322 , C12N2310/352 , C12N2310/3533
摘要： Compositions and methods are provided for the treatment and diagnosis of diseases amenable to treatment through modulation of the synthesis or metabolism of intercellular adhesion molecules. In accordance with preferred embodiments, oligonucleotides are provided which are specifically hybridizable with nucleic acids encoding intercellular adhesion molecule-1, vascular cell adhesion molecule-1, and endothelial leukocyte adhesion molecule-1. The oligonucleotide comprises nucleotide units sufficient in identity and number to effect said specific hybridization. In other preferred embodiments, the oligonucleotides are specifically hybridizable with a transcription initiation site, a translation initiation site, 5'-untranslated sequences, 3'-untranslated sequences, and intervening sequences. Methods of treating animals suffering from disease amenable to therapeutic intervention by modulating cell adhesion proteins with an oligonucleotide specifically hybridizable with RNA or DNA corresponding to one of the foregoing proteins are disclosed. Methods for treatment of diseases responding to modulation cell adhesion molecules are disclosed.

8. 发明授权

US5514788A Oligonucleotide modulation of cell adhesion 失效
公开(公告)号：US5514788A
公开(公告)日：1996-05-07
申请号：US63167
申请日：1993-05-17
申请人： C. Frank Bennett , Christopher K. Mirabelli
发明人： C. Frank Bennett , Christopher K. Mirabelli
IPC分类号： A61K38/00 , A61K48/00 , C07K14/705 , C12N15/113 , C12N15/00 , C07H21/04
CPC分类号： C12N15/1138 , A61K48/00 , C07K14/70525 , C07K14/70542 , C07K14/70564 , A61K38/00 , C12N2310/315 , C12N2310/322 , C12N2310/352 , C12N2310/3533
摘要： Compositions and methods are provided for the treatment and diagnosis of diseases amenable to treatment through modulation of the synthesis or metabolism of intercellular adhesion molecules. In accordance with preferred embodiments, oligonucleotides are provided which are specifically hybridizable with nucleic acids encoding intercellular adhesion molecule-1, vascular cell adhesion molecule-1, and endothelial leukocyte adhesion molecule-1. The oligonucleotide comprises nucleotide units sufficient in identity and number to effect said specific hybridization. In other preferred embodiments, the oligonucleotides are specifically hybridizable with a transcription initiation site, a translation initiation site, 5'-untranslated sequences, 3'-untranslated sequences, and intervening sequences. Methods of treating animals suffering from disease amenable to therapeutic intervention by modulating cell adhesion proteins with an oligonucleotide specifically hybridizable with RNA or DNA corresponding to one of the foregoing proteins are disclosed. Methods for treatment of diseases responding to modulation cell adhesion molecules are disclosed.

9. 发明授权

US5811232A Oligonucleotides for Papillomavirus 失效
标题翻译：乳头瘤病毒的寡核苷酸
公开(公告)号：US5811232A
公开(公告)日：1998-09-22
申请号：US692257
申请日：1996-08-05
申请人： Stanley T. Crooke , Christopher K. Mirabelli , David J. Ecker , Lex M. Cowsert
发明人： Stanley T. Crooke , Christopher K. Mirabelli , David J. Ecker , Lex M. Cowsert
IPC分类号： C12Q1/68 , C12Q1/70 , C07H21/04
CPC分类号： C12Q1/70 , C12Q1/6883 , Y10S435/81
摘要： Oligonucleotides and oligonucleotide analogs are provided which are capable of antisense interaction with messenger RNA of papillomavirus. Such oligonucleotides or oligonucleotide analogs can be used for diagnostics and therapeutics as well as for research purposes. In accordance with preferred embodiments of this invention, oligonucleotide or oligonucleotide analog is provided which is hybridizable with a messenger RNA from a papillomavirus. The oligonucleotide or oligonucleotide analog is able to inhibit the function of the RNA, and accordingly is useful for therapy for infections by such papillomavirus. In accordance with a preferred embodiment, portions of the papillomavirus are targeted for antisense attack. Thus oligonucleotides are preferably provided which hybridize with the E2, E1, E7, or E6-7 messenger RNAs.
摘要翻译：提供寡核苷酸和寡核苷酸类似物，其能够与乳头瘤病毒的信使RNA反义相互作用。这样的寡核苷酸或寡核苷酸类似物可用于诊断和治疗以及用于研究目的。根据本发明的优选实施方案，提供可与来自乳头瘤病毒的信使RNA杂交的寡核苷酸或寡核苷酸类似物。寡核苷酸或寡核苷酸类似物能够抑制RNA的功能，因此可用于由这种乳头瘤病毒感染的治疗。根据优选实施方案，乳头瘤病毒的一部分被靶向用于反义攻击。因此优选提供与E2，E1，E7或E6-7信使RNA杂交的寡核苷酸。

10. 发明授权

US5639595A Identification of novel drugs and reagents 失效
标题翻译：鉴定新药和试剂
公开(公告)号：US5639595A
公开(公告)日：1997-06-17
申请号：US161281
申请日：1993-12-02
申请人： Christopher K. Mirabelli , David J. Ecker , Timothy A. Vickers , Debra L. Robertson
发明人： Christopher K. Mirabelli , David J. Ecker , Timothy A. Vickers , Debra L. Robertson
IPC分类号： A61K31/70 , A61P31/12 , A61P31/22 , C12N15/09 , C12N15/113 , C12Q1/02 , C12Q1/68 , C12Q1/70 , G01N33/50 , C07H21/02 , C07H21/04
CPC分类号： C12N15/113 , C12N15/1137 , C12N15/1138 , C12Q1/02 , C12Q1/68 , C12Y302/01023 , G01N33/5014 , C12N2310/111
摘要： Methods for identifying oligonucleotides having a desired activity in vivo are disclosed. In accordance with preferred embodiments, oligonucleotides capable of conferring a desired phenotype are identified. Therapeutic, diagnostic and research methods and compositions employing such oligonucleotides are provided. Prior knowledge of the sequence or structure of a target molecule is generally not required.
摘要翻译：公开了在体内鉴定具有所需活性的寡核苷酸的方法。根据优选实施方案，鉴定出能够赋予所需表型的寡核苷酸。提供了使用这种寡核苷酸的治疗，诊断和研究方法和组合物。通常不需要事先了解靶分子的序列或结构。

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