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1. 发明申请

US20050227938A1 Antisense modulation of TFAP2C expression 审中-公开
标题翻译： TFAP2C表达的反义调制
公开(公告)号：US20050227938A1
公开(公告)日：2005-10-13
申请号：US11015193
申请日：2004-12-17
申请人： C. Bennett , Brenda Baker , Nicholas Dean , Brett Monia , Susan Freier , James Karras , Hong Zhang , Susan Murray , Madeline Butler , Erich Koller , Thomas Condon , William Gaarde , Andrew Watt , Mark Graham , Jacqueline Wyatt , Lex Cowsert , Kenneth Dobie , Mark Roach
发明人： C. Bennett , Brenda Baker , Nicholas Dean , Brett Monia , Susan Freier , James Karras , Hong Zhang , Susan Murray , Madeline Butler , Erich Koller , Thomas Condon , William Gaarde , Andrew Watt , Mark Graham , Jacqueline Wyatt , Lex Cowsert , Kenneth Dobie , Mark Roach
IPC分类号： A61K38/00 , A61K48/00 , C07H21/02 , C12N15/113
CPC分类号： C12N15/1138 , A61K38/00 , C12N2310/315 , C12N2310/321 , C12N2310/322 , C12N2310/335 , C12N2310/341 , C12N2310/346 , Y02P20/582 , C12N2310/3521 , C12N2310/3525
摘要： Antisense compounds, compositions and methods are provided for modulating the expression of TFAP2C. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding TFAP2C. Methods of using these compounds for modulation of TFAP2C expression and for treatment of diseases associated with expression of TFAP2C are provided.
摘要翻译：提供反义化合物，组合物和方法用于调节TFAP2C的表达。组合物包含靶向编码TFAP2C的核酸的反义化合物，特别是反义寡核苷酸。提供了使用这些化合物调节TFAP2C表达和治疗与TFAP2C表达相关的疾病的方法。

2. 发明申请

US20050153924A1 Antisense modulation of interferon gamma receptor 2 审中-公开
标题翻译：干扰素γ受体2的反义调制
公开(公告)号：US20050153924A1
公开(公告)日：2005-07-14
申请号：US11013543
申请日：2004-12-15
申请人： C. Bennett , Brett Monia , Susan Murray , Madeline Butler , Nicholas Dean , Rosanne Crooke , Mark Graham , Hong Zhang , Susan Freier , Brenda Baker , Eric Marcusson , Jacqueline Wyatt , Lex Cowsert , Kenneth Dobie , Andrew Watt
发明人： C. Bennett , Brett Monia , Susan Murray , Madeline Butler , Nicholas Dean , Rosanne Crooke , Mark Graham , Hong Zhang , Susan Freier , Brenda Baker , Eric Marcusson , Jacqueline Wyatt , Lex Cowsert , Kenneth Dobie , Andrew Watt
IPC分类号： A61K38/00 , A61K48/00 , C07H21/02 , C12N15/113 , C12Q1/68
CPC分类号： C12N15/1138 , A61K38/00 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , Y02P20/582 , C12N2310/3525
摘要： Antisense compounds, compositions and methods are provided for modulating the expression of Interferon gamma receptor 2. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding Interferon gamma receptor 2. Methods of using these compounds for modulation of Interferon gamma receptor 2 expression and for treatment of diseases associated with expression of Interferon gamma receptor 2 are provided.
摘要翻译：提供反义化合物，组合物和方法用于调节干扰素γ受体2的表达。组合物包含靶向编码干扰素γ受体2的核酸的反义化合物，特别是反义寡核苷酸。使用这些化合物调节干扰素γ受体2的方法提供了与干扰素γ受体2表达相关的疾病的表达和治疗。

3. 发明申请

US20060019920A1 Antisense modulation of MEKK4 expression 审中-公开
公开(公告)号：US20060019920A1
公开(公告)日：2006-01-26
申请号：US11179128
申请日：2005-07-11
申请人： C. Bennett , Susan Freier , Brett Monia , Nicholas Dean , Hong Zhang , Robert McKay , Donna Ward , William Gaarde , Jacqueline Wyatt , Andrew Watt , Rosanne Crooke , Mark Graham , Pamela Nero , Kenneth Dobie , Alexander Borchers , Eric Marcusson , Mark Roach
发明人： C. Bennett , Susan Freier , Brett Monia , Nicholas Dean , Hong Zhang , Robert McKay , Donna Ward , William Gaarde , Jacqueline Wyatt , Andrew Watt , Rosanne Crooke , Mark Graham , Pamela Nero , Kenneth Dobie , Alexander Borchers , Eric Marcusson , Mark Roach
IPC分类号： A61K48/00 , C07H21/02
CPC分类号： C12N9/1205 , Y02P20/582
摘要： Antisense compounds, compositions and methods are provided for modulating the expression of MEKK4. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding MEKK4. Methods of using these compounds for modulation of MEKK4 expression and for treatment of diseases associated with expression of MEKK4 are provided.

4. 发明申请

US20050222073A1 Antisense modulation of thyroid hormone receptor interactor 6 expression 审中-公开
标题翻译：反义调制甲状腺激素受体相互作用6表达
公开(公告)号：US20050222073A1
公开(公告)日：2005-10-06
申请号：US11071724
申请日：2005-03-02
申请人： C. Bennett , Brett Monia , Rosanne Crooke , Mark Graham , Susan Freier , Pamela Nero , Edward Wancewicz , Nicholas Dean , Lex Cowsert , Kenneth Dobie
发明人： C. Bennett , Brett Monia , Rosanne Crooke , Mark Graham , Susan Freier , Pamela Nero , Edward Wancewicz , Nicholas Dean , Lex Cowsert , Kenneth Dobie
IPC分类号： A61K38/00 , A61K48/00 , C07H21/02 , C12N15/113
CPC分类号： C12N15/113 , A61K38/00 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , Y02P20/582 , C12N2310/3525
摘要： Antisense compounds, compositions and methods are provided for modulating the expression of thyroid hormone receptor interactor 6. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding thyroid hormone receptor interactor 6. Methods of using these compounds for modulation of thyroid hormone receptor interactor 6 expression and for treatment of diseases associated with expression of thyroid hormone receptor interactor 6 are provided.
摘要翻译：提供反义化合物，组合物和方法用于调节甲状腺激素受体相互作用体6的表达。该组合物包含靶向编码甲状腺激素受体相互作用核酸的反义化合物，特别是反义寡核苷酸。6.使用这些化合物调节甲状腺激素的方法受体相互作用6表达和用于治疗与甲状腺激素受体相互作用者6的表达相关的疾病。

5. 发明申请

US20060264395A1 Modulation of apolipoprotein c-III expression 有权
标题翻译：载脂蛋白c-III表达的调节
公开(公告)号：US20060264395A1
公开(公告)日：2006-11-23
申请号：US10553722
申请日：2004-04-15
申请人： Rosanne Crooke , Mark Graham , Kristina Tarbet , Kenneth Dobie
发明人： Rosanne Crooke , Mark Graham , Kristina Tarbet , Kenneth Dobie
IPC分类号： A61K48/00 , C07H21/02
CPC分类号： C12N15/113 , A61K38/00 , C12N2310/11 , C12N2310/314 , C12N2310/315 , C12N2310/321 , C12N2310/322 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12N2310/351 , C12N2320/30 , C12N2330/31 , C12N2310/3521
摘要： Compounds, compositions and methods are provided for modulating the expression of apolipoprotein C-III. The compositions comprise oligonucleotides, targeted to nucleic acid encoding apolipoprotein C-III. Methods of using these compounds for modulation of apolipoprotein C-III expression and for diagnosis and treatment of disease associated with expression of apolipoprotein C-III are provided.
摘要翻译：提供化合物，组合物和方法用于调节载脂蛋白C-III的表达。组合物包含靶向编码载脂蛋白C-III的核酸的寡核苷酸。提供了使用这些化合物调节载脂蛋白C-III表达和用于诊断和治疗与载脂蛋白C-III表达相关的疾病的方法。

6. 发明申请

US20050009088A1 Antisense modulation of apolipoprotein B-expression 有权
标题翻译：载脂蛋白B表达的反义调节
公开(公告)号：US20050009088A1
公开(公告)日：2005-01-13
申请号：US10920612
申请日：2004-08-17
申请人： Rosanne Crooke , Mark Graham , Kristina Tarbet , Kenneth Dobie
发明人： Rosanne Crooke , Mark Graham , Kristina Tarbet , Kenneth Dobie
IPC分类号： A61K38/00 , C12N15/113 , C12Q1/68 , A61K48/00 , C07H21/04
CPC分类号： C12N15/113 , A61K38/00 , C12N2310/13 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , Y02P20/582 , C12N2310/3525
摘要： Antisense compounds, compositions and methods are provided for modulating the expression of apolipoprotein B. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding apolipoprotein B. Methods of using these compounds for modulation of apolipoprotein B expression and for treatment of diseases associated with expression of apolipoprotein B are provided.
摘要翻译：提供反义化合物，组合物和方法用于调节载脂蛋白B的表达。组合物包含靶向编码载脂蛋白B的核酸的反义化合物，特别是反义寡核苷酸。使用这些化合物调节载脂蛋白B表达和治疗疾病的方法与载脂蛋白B的表达相关。

7. 发明授权

US08944590B2 Electronic spectacle frames 有权
标题翻译：电子眼镜架
公开(公告)号：US08944590B2
公开(公告)日：2015-02-03
申请号：US13298997
申请日：2011-11-17
申请人： Ronald D. Blum , Joshua N. Haddock , Claudio Dalla Longa , Mark Graham , Yongping Wang
发明人： Ronald D. Blum , Joshua N. Haddock , Claudio Dalla Longa , Mark Graham , Yongping Wang
IPC分类号： G02C5/16 , G02C7/10 , G02C7/08
CPC分类号： G02C7/101 , G02C7/083
摘要： Embodiments may provide a first device that comprises eyeglasses, where the eyeglasses may further include a lens housing, a first temple and a second temple coupled to the lens housing, and a first and a second lens supported by the lens housing. The first device may further include a façade that covers the lens housing. The first device may further comprise an electronic component and at least one conductive path may be provided from the electronic component to the first lens having a portion that runs through the lens housing.
摘要翻译：实施例可以提供包括眼镜的第一装置，其中眼镜还可以包括透镜壳体，耦合到透镜壳体的第一镜腿和第二镜腿以及由透镜壳体支撑的第一和第二透镜。第一装置还可以包括覆盖透镜壳体的外墙。第一装置还可以包括电子部件，并且可以从电子部件到具有穿过透镜壳体的部分的第一透镜提供至少一个导电路径。

8. 发明申请

US20130070198A1 MOISTURE-RESISTANT ELECTRONIC SPECTACLE FRAMES 审中-公开
标题翻译：防水电子框架
公开(公告)号：US20130070198A1
公开(公告)日：2013-03-21
申请号：US13587645
申请日：2012-08-16
申请人： Charles Willey , Joshua Haddock , Mark Graham , Claudio Dalla Longa , Ronald Blum , William Kokonaski
发明人： Charles Willey , Joshua Haddock , Mark Graham , Claudio Dalla Longa , Ronald Blum , William Kokonaski
IPC分类号： G02C11/00 , G02C13/00
CPC分类号： G02C11/10 , G02B27/017 , G02B2027/0178 , G02C7/083 , G02C7/101 , G02C13/001 , H01R13/2414 , H01R35/04
摘要： Eyewear including an optical functional member, control electronics, and a sealed electrical connective element connecting the electronics to the optical functional member. The connective element can directly connect the electronics to the optical functional member, or can connect through an intermediate contact, e.g., a plug-and-receptacle. The connective element can be routed from the electronics, around a rimlock of the eyewear to the optical functional member. The connective element can be a conductive compressible member, such as conductive rubber. In some embodiments, the connective element can be a multiconductor cable.
摘要翻译：眼镜包括光学功能元件，控制电子元件以及将电子元件连接到光学功能元件的密封电连接元件。连接元件可以将电子器件直接连接到光学功能元件，或者可以通过诸如插头和插座的中间触点连接。连接元件可以从电子设备，眼镜框架周围路由到光学功能部件。连接元件可以是导电可压缩构件，例如导电橡胶。在一些实施例中，连接元件可以是多导体电缆。

9. 发明授权

US07603917B2 Full-axis sensor for detecting input force and torque 有权
标题翻译：用于检测输入力和扭矩的全轴传感器
公开(公告)号：US07603917B2
公开(公告)日：2009-10-20
申请号：US11573322
申请日：2005-08-08
申请人： Mark Graham , Chris Lussey
发明人： Mark Graham , Chris Lussey
IPC分类号： G01D7/00
CPC分类号： G01L5/223 , G01L5/16 , G05G9/04737 , G05G2009/04707 , G05G2009/04729 , G05G2009/04762
摘要： A sensor (100) for detecting input force and/or torque with six degrees of freedom for use as a computer input device is provided. The sensor has a technically simple detection mechanism which obviates the need for complex and fragile securing components. A user-manipulable core (106) is enclosed in a casing (109). Electrodes (114) in the casing (109) are separated from the core (106) by a layer of elastically deformable conductive polymer (108). Electric current flows between the core (106) and the electrodes (114). The polymer (108) has variable resistivity depending on the stress it experiences. Manipulation of the core (106) causes deformation of the polymer (108); the type of deformation, and hence the type of force/torque applied to core (106), is determinable from the currents flowing through the electrodes (114).
摘要翻译：提供了用于以六自由度检测用作计算机输入装置的输入力和/或扭矩的传感器（100）。传感器具有技术上简单的检测机制，可以避免对复杂和易碎的固定部件的需要。用户可操纵的芯（106）被封装在壳体（109）中。壳体（109）中的电极（114）通过一层可弹性变形的导电聚合物（108）与芯部（106）分离。电流在芯（106）和电极（114）之间流动。聚合物（108）具有取决于其经历的应力的可变电阻率。芯部（106）的操纵导致聚合物（108）的变形; 变形的类型以及因此施加到芯（106）的力/扭矩的类型可以从流过电极（114）的电流确定。

10. 发明申请

US20080021605A1 VEHICLE EMAIL NOTIFICATION USING DATA FROM DIFFERENT SOURCES 有权
标题翻译：车辆电子邮件通知使用不同来源的数据
公开(公告)号：US20080021605A1
公开(公告)日：2008-01-24
申请号：US11618198
申请日：2006-12-29
申请人： Chester Huber , Anthony DiSalle , Mark Graham , Shane McCutchen , Krishnaraj Inbarajan
发明人： Chester Huber , Anthony DiSalle , Mark Graham , Shane McCutchen , Krishnaraj Inbarajan
IPC分类号： G06F19/00
CPC分类号： G07C5/008 , G06Q10/00 , G06Q10/06 , G06Q10/107 , G06Q30/02 , G06Q30/0278 , G06Q50/30 , G07C5/085 , Y10S370/908
摘要： A vehicle email notification system and method that accesses data from the vehicle as well as from one or more other sources and combines the information into an email that is then sent to the owner or other authorized subscriber. The email notifications are triggered by different events, some of which are independent of the vehicle (e.g., a monthly trigger), and others of which occur at the vehicle, such as a mileage or low oil life trigger. The notification system builds and sends to the subscriber an email message that contains the dynamic vehicle information and identifies any detected vehicle condition for which action is needed.
摘要翻译：车辆电子邮件通知系统和方法，其从车辆以及来自一个或多个其他来源的数据访问并将该信息组合成电子邮件，然后发送给所有者或其他授权用户。电子邮件通知由不同的事件触发，其中一些事件是独立于车辆（例如，每月触发器），其他事件发生在车辆上，例如里程或低油寿命触发。通知系统构建并向用户发送包含动态车辆信息的电子邮件消息，并且识别需要动作的任何检测到的车辆状况。

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