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1. 发明授权

US4880789A 2'-Substituted-4-deoxy-thiazolo(5,4-c)-rifamycin SV derivatives 失效
标题翻译： 2'-取代-4-脱氧 - 噻唑（5,4-c） - 三环霉素SV衍生物
公开(公告)号：US4880789A
公开(公告)日：1989-11-14
申请号：US238985
申请日：1988-08-24
申请人： Bruno Cavalleri , Marco Turconi , Giovanni Tamborini
发明人： Bruno Cavalleri , Marco Turconi , Giovanni Tamborini
IPC分类号： A61K31/425 , A61P31/04 , C07D513/18
CPC分类号： C07D513/18
摘要： The present invention concerns new 2'-substituted-4-deoxy-thiazolo[5,4-c]rifamycin SV derivatives having antibacterial activity.These compounds are compounds obtained by chemical modification of thiazolo[5,4-c]rifamycin SV.
摘要翻译：本发明涉及具有抗菌活性的新的2'-取代-4-脱氧 - 噻唑并[5,4-c]利福霉素SV衍生物。这些化合物是通过化学修饰噻唑并[5,4-c]利福霉素SV获得的化合物。

2. 发明授权

US5306715A Rifapentine hydrohalides 失效
标题翻译：利福喷丁氢卤化物
公开(公告)号：US5306715A
公开(公告)日：1994-04-26
申请号：US635172
申请日：1991-01-08
申请人： Emilio Occelli , Marino Nebuloni , Bruno Cavalleri
发明人： Emilio Occelli , Marino Nebuloni , Bruno Cavalleri
IPC分类号： A61K31/395 , A61K31/495 , A61P31/04 , C07D498/08
CPC分类号： C07D498/08
摘要： A solid rifapentine hydrohalide useful for anti-bacterial purposes.
摘要翻译： PCT No.PCT / EP89 / 00694 Sec。 371日期1991年1月8日 102（e）日期1991年8月1日PCT提交1989年6月21日PCT公布。公开号WO90 / 00553 日期1990年1月25日。用于抗菌目的的固体利福喷丁氢卤酸盐。

3. 发明授权

US4661470A Ester derivatives of antibiotic L 17046 失效
公开(公告)号：US4661470A
公开(公告)日：1987-04-28
申请号：US797295
申请日：1985-11-12
申请人： Adriano Malabarba , Ambrogio Magni , Paolo Strazzolini , Bruno Cavalleri , Aldo Trani
发明人： Adriano Malabarba , Ambrogio Magni , Paolo Strazzolini , Bruno Cavalleri , Aldo Trani
IPC分类号： A61K38/00 , A61P31/04 , C07K1/113 , C07K9/00 , C07K14/195 , C07K14/41 , A61K37/02 , C07K5/12
CPC分类号： C07K9/008 , Y10S930/19
摘要： The present invention is directed to ester derivatives at the carboxylic function of the glycopeptidic antibiotic substance called antibiotic L 17046 with antimicrobial activity mainly against gram-positive bacteria.

4. 发明授权

US4427656A Antibiotic A/16686 factor A.sub.2, the process for the preparation thereof and the co-produced antibiotic A/16686 factors A.sub.1 and A.sub.3 失效
标题翻译：抗生素A / 16686因子A2，其制备方法和共同生产的抗生素A / 16686因子A1和A3
公开(公告)号：US4427656A
公开(公告)日：1984-01-24
申请号：US288718
申请日：1981-07-31
申请人： Bruno Cavalleri , Enrico Selva
发明人： Bruno Cavalleri , Enrico Selva
IPC分类号： C07G11/00 , A61K35/74 , A61P31/04 , C12N1/20 , C12P1/06 , C12R1/045 , A61K35/00 , C12R1/45
CPC分类号： C12R1/045 , C12P1/06 , Y10S435/827
摘要： The present invention refers to a chlorine containing antibiotic substance, named antibiotic A/16686 factor A.sub.2, in an essentially pure form. The invention also relates to the process for the production of antibiotic A/16686 factors A.sub.2 by cultivation of an Actinoplanes strain and to the co-produced antibiotic A/16686 factos A.sub.1 and A.sub.3. Antibiotic A/16686 factors A.sub.1, A.sub.2 and A.sub.3 as well as the corresponding non-toxic physiologically acceptable acid addition salts are antimicrobial agents particularly active against gram-positive bacteria.
摘要翻译：本发明涉及一种基本上纯的形式的含氯抗生素物质，称为抗生素A / 16686因子A2。本发明还涉及通过培养Actinoplanes菌株和共同生产的抗生素A / 16686事实A1和A3生产抗生素A / 16686因子A2的方法。抗生素A / 16686因子A1，A2和A3以及相应的无毒生理学上可接受的酸加成盐是对革兰氏阳性细菌特别有活性的抗微生物剂。

5. 发明授权

US5041534A Process for preparing antibiotic L 17054 失效
标题翻译：制备抗生素L 17054的方法
公开(公告)号：US5041534A
公开(公告)日：1991-08-20
申请号：US929040
申请日：1986-11-10
申请人： Adriano Malabarba , Paolo Strazzolini , angelo Borghi , Bruno Cavalleri , Carolina Coronelli
发明人： Adriano Malabarba , Paolo Strazzolini , angelo Borghi , Bruno Cavalleri , Carolina Coronelli
IPC分类号： A61K38/00 , C07K9/00
CPC分类号： C07K9/008 , A61K38/00
摘要： The present invention is directed to the essentially pure preparation of an antibiotic substance arbitrarily designated antibiotic L 17054. This antibiotic substance is obtained from the known antibiotic substance named teicoplanin (formerly teichomycin) by chemical treatment. The new compound and the pharmaceutically acceptable salts possess antimicrobial activity.
摘要翻译：本发明涉及任意指定的抗生素L 17054的抗生素物质的基本上纯的制剂。该抗生素物质通过化学处理从已知的名称为替考拉宁（以下称为teichomycin）的抗生素物质获得。新化合物和药学上可接受的盐具有抗微生物活性。

6. 发明授权

US4954483A Carboxylic acid ester derivatives or deglucoteicoplanin 失效
标题翻译：羧酸酯衍生物或脱葡萄糖精蛋白
公开(公告)号：US4954483A
公开(公告)日：1990-09-04
申请号：US243168
申请日：1988-09-08
申请人： Adriano Malabarba , Paolo Strazzolini , Aldo Trani , Ambrogio Magni , Bruno Cavalleri
发明人： Adriano Malabarba , Paolo Strazzolini , Aldo Trani , Ambrogio Magni , Bruno Cavalleri
IPC分类号： C07K7/64 , A61K38/00 , C07K1/02 , C07K1/113 , C07K9/00
CPC分类号： C07K9/008 , A61K38/00
摘要： The present invention is directed to carboxylic acid esters of deglucoteicoplanin, i.e. of the aglycon moiety of the antibiotic teicoplanin. The compounds of the invention are conveniently prepared either by deglucoteicoplanin or by any of the glycopeptides of the teicoplanin group, such as teicoplanin itself, one of its components, antibiotic L 17054 and antibiotic L 17046.
摘要翻译： PCT No.PCT / EP85 / 00262 Sec。 371日期1986年2月6日 102（e）日期1986年2月6日PCT归档1985年6月2日PCT公布。出版物WO86 / 日本1986年1月3日。本发明涉及脱葡萄糖可乐碱的羧酸酯，即抗生素替考拉宁的糖苷配基部分。本发明的化合物可以方便地通过脱葡萄糖精蛋白或替考拉宁组的任何糖肽制备，例如替考拉宁本身，其组分之一，抗生素L 17054和抗生素L 17046。

7. 发明授权

US4684644A Basic monocarboxyamide derivatives of actagardine having antibiotic activity and compositions thereof 失效
标题翻译：具有抗生素活性的卡那定的基本单羧酰胺衍生物及其组合物
公开(公告)号：US4684644A
公开(公告)日：1987-08-04
申请号：US842523
申请日：1986-03-21
申请人： Adriano Malabarba , Bruno Cavalleri
发明人： Adriano Malabarba , Bruno Cavalleri
IPC分类号： C07G11/00 , A61K35/74 , A61P31/04 , C12P1/06 , A61K35/00 , C07D295/14
CPC分类号： C12P1/06
摘要： The present invention is directed to a class of basic monocarboxyamide derivatives of actagardine. Actagardine (INN) is an antibiotic substance produced by actinoplanes strains such as Actinoplanes Sp. ATCC 31048 and Actinoplanes Sp. ATCC 31049 which are described in U.S. Pat. No. 4,022,884. Actagardine shows antimicrobial in vitro and in vivo activity against gram-positive organisms. Its complete chemical structure is not yet known but there is only information on its chemical functions and main fragments. In particular, it has been found that actagardine has two carboxylic functions and a primary amino function and can therefore be represented as follows: ##STR1## The compounds of the invention are monoamide derivatives at one of the carboxy functions of actagardine. More particularly, they are basic monoamide derivatives of actagardine which may be schematically represented by the following formula I: ##STR2## The compound of the invention possess improved antimicrobial activity in particular against gram positive bacteria.
摘要翻译：本发明涉及一类基本的单加酰胺酰胺衍生物。放线菌肽（INN）是一种抗生素，由Actinoplanes Sp。 ATCC 31048和Actinoplanes Sp。 ATCC 31049，其描述于美国专利No. 第4,022,884号。阿卡加丁显示抗革兰氏阳性生物的体外和体内活性。其完整的化学结构尚不清楚，但只有其化学功能和主要碎片的信息。特别地，已经发现，阿格达加胺具有两个羧基官能团和伯氨基官能团，因此可以表示如下：本发明的化合物是在加马丁的羧基官能团之一的单酰胺衍生物。更具体地说，它们是阿加豆苷的碱性单酰胺衍生物，其可以由下式I示意性地表示：式I本发明的化合物具有改善的抗菌活性，特别是抗革兰氏阳性细菌。

8. 发明授权

US3987053A 2-Nitroimidazol derivatives 失效
标题翻译： 2-硝基咪唑衍生物
公开(公告)号：US3987053A
公开(公告)日：1976-10-19
申请号：US582556
申请日：1975-05-29
申请人： Bruno Cavalleri , Giancarlo Lancini
发明人： Bruno Cavalleri , Giancarlo Lancini
IPC分类号： C07D417/04 , C07D233/91
CPC分类号： C07D417/04
摘要： 2-Nitroimidazole derivatives of the general formula ##SPC1##Wherein R is a lower alkyl group and Y is a member of the group consisting of --CH.sub.2 OH, --CHO, CH.sub.3 CO--, vinyl, formylvinyl, styryl, substituted iminomethyl, 2-benzimidazolyl and 5-amino-1,3,4-thiadiazol-2-yl. The term "lower alkyl" designates aliphatic groups of from 1 to 4 carbon atoms; the term "substituted iminomethyl" designates nitrogen-containing functional derivatives of the aldehydic group. The compounds have antimicrobial activity.

9. 发明授权

US4725668A Process for transforming teicoplanin factor A.sub.2 component 1 into teicoplanin factor A.sub.2, component 3 失效
标题翻译：将替考拉宁因子A2组分1转化为替考拉宁因子A2，组分3的方法
公开(公告)号：US4725668A
公开(公告)日：1988-02-16
申请号：US703647
申请日：1985-02-21
申请人： Paolo Strazzolini , Bruno Cavalleri
发明人： Paolo Strazzolini , Bruno Cavalleri
IPC分类号： B01J23/44 , C07B61/00 , C07H15/00 , C07K1/00 , C07K1/113 , C07K9/00 , C07K14/195 , C07K14/41 , C07K5/12 , C07H15/24
CPC分类号： C07K9/008 , Y10S930/19 , Y10S930/27
摘要： The present invention refers to a process for transforming teicoplanin factor A.sub.2 component 1 into teicoplanin factor A.sub.2 component 3 by means of a chemical reaction which includes the catalytical hydrogenation of the substrate.
摘要翻译：本发明涉及通过包括底物的催化氢化的化学反应将替考拉宁因子A2组分1转化为替考拉宁因子A2组分3的方法。

10. 发明授权

US4629781A Chemical process for preparing L 17392 (deglucoteicoplanin) and its salts 失效
标题翻译：制备L 17392（脱葡萄糖可乐素）及其盐的化学方法
公开(公告)号：US4629781A
公开(公告)日：1986-12-16
申请号：US680435
申请日：1984-12-11
申请人： Paolo Strazzolini , Adriano Malabarba , Bruno Cavalleri
发明人： Paolo Strazzolini , Adriano Malabarba , Bruno Cavalleri
IPC分类号： C07D498/22 , C07D245/00 , C07K9/00 , C07K5/12
CPC分类号： C07K9/008 , Y10S930/19 , Y10S930/27
摘要： The present invention is directed to a chemical process for preparing antibiotic L 17392 (deglucoteicoplanin) and its salts with bases and acids by submitting a teicoplanin compound or a teicoplanin-like compound to controlled strong acidic hydrolysis conditions.
摘要翻译：本发明涉及通过将泰可菌素化合物或替考拉宁样化合物递送至受控强酸性水解条件来制备抗生素L 17392（脱葡萄糖可乐宁）及其与碱和酸的盐的化学方法。

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