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1. 发明授权

US5868938A Chiral stationary phases for chromatographic separation of optical isomers 失效
标题翻译：用于光学异构体色谱分离的手性固定相
公开(公告)号：US5868938A
公开(公告)日：1999-02-09
申请号：US753971
申请日：1996-12-04
申请人： Bruno Bomer, deceased , by Guido Martin Bomer , Rolf Grosser , Walter Lange , Uwe Zweering , Burkhard Kohler , Wolfram Sirges , Michael Grosse-Bley
发明人： Bruno Bomer, deceased , by Guido Martin Bomer , Rolf Grosser , Walter Lange , Uwe Zweering , Burkhard Kohler , Wolfram Sirges , Michael Grosse-Bley
IPC分类号： B01D15/08 , B01D15/38 , B01J20/32 , C07B57/00 , C08F2/44 , C08F292/00 , C08K3/00 , C08L57/00 , C09C3/10 , G01N30/02 , C08F20/54
CPC分类号： B01J20/327 , B01D15/3833 , B01J20/103 , B01J20/286 , B01J20/289 , B01J20/29 , B01J20/3204 , B01J20/3219 , B01J20/3257 , B01J20/3259 , B01J20/328 , C07B57/00 , C08F292/00 , B01J2220/54 , B01J2220/58
摘要： The invention relates to chiral polymers which are bonded to a support and have improved properties, a process for the preparation of these materials and their use as chiral stationary phases in the chromatograhic separation of optical isomers, in particular of racemates into their enantiomers.
摘要翻译：本发明涉及结合到载体上并具有改进性能的手性聚合物，这些材料的制备方法以及它们在光学异构体，特别是外消旋体到其对映异构体的色谱分离中作为手性固定相的用途。

2. 发明授权

US5739360A Intermediates for the synthesis of bisphosphine compounds 失效
标题翻译：用于合成双膦化合物的中间体
公开(公告)号：US5739360A
公开(公告)日：1998-04-14
申请号：US714747
申请日：1996-09-16
申请人： Wolfram Sirges , Christian Laue , Dieter Arlt , Rolf Grosser
发明人： Wolfram Sirges , Christian Laue , Dieter Arlt , Rolf Grosser
IPC分类号： B01J31/16 , C07B53/00 , C07B57/00 , C07B61/00 , C07F9/655 , C07D307/91
CPC分类号： C07F9/65517
摘要： The invention relates to novel bisphosphonates and to processes for their preparation and for their resolution into the enantiomers. The bisphosphonates according to the invention are valuable intermediates for the preparation of bisphosphine compounds, especially chiral bisphosphine ligands. These in turn are constituents of transition metal complexes which are used as catalysts inter alia in asymmetric hydrogenation. The novel bisphosphonates have the general formula (I) ##STR1## in which R.sup.1 is linear or branched alkyl having up to 6 carbon atoms, aryl or aralkyl, each of which can optionally be substituted, or two radicals R.sup.1 together are a bridging hydrocarbon radical having up to 6 carbon atoms, and can exist in the form of their racemates or as enantiomers.
摘要翻译：本发明涉及新的双膦酸盐及其制备方法及其分解成对映体。根据本发明的双膦酸盐是制备双膦化合物，特别是手性双膦配体的有价值的中间体。这些又是作为催化剂的过渡金属络合物的成分，特别是用于不对称氢化。新型二膦酸盐具有通式（I）其中R 1为具有至多6个碳原子的直链或支链烷基，芳基或芳烷基，其中每一个可任选被取代，或两个基团R 1一起为具有至多6个碳原子的桥连烃基，并且可以以其外消旋体的形式存在或作为对映异构体存在。

3. 发明授权

US07026307B2 Method for producing 1,3-disubstituted 2-nitroguanidines 有权
标题翻译： 1,3-二取代的2-硝基胍的制备方法
公开(公告)号：US07026307B2
公开(公告)日：2006-04-11
申请号：US10476599
申请日：2002-04-24
申请人： Jörn Stölting , Kai van Laak , Wolfram Sirges , Armin Heyn , Torsten Taschner
发明人： Jörn Stölting , Kai van Laak , Wolfram Sirges , Armin Heyn , Torsten Taschner
IPC分类号： A01N43/00 , A61K31/33
CPC分类号： C07D277/32 , C07D213/61 , C07D307/14
摘要： The present invention relates to a process for the preparation of compounds of the formula (I) by reacting compounds of the formula (II) in which R1, R2, R4 and Het are as defined in the description, with anhydrous hydrogen halide in the presence of a nitrile.
摘要翻译：本发明涉及一种制备式（I）化合物的方法，其中R 1，R 2，R 2，R 2，R 2， Het如说明书中所定义，与无水卤化氢在腈存在下反应。

4. 发明授权

US06489513B2 Process for the preparation of enantiomerically pure (5, 5′-dichloro-6,6′-dimethoxy-biphenyl-2,2′-diyl)- bis(diphenylphosphine oxides) 有权
标题翻译：制备对映体纯（5，5'-二氯-6,6'-二甲氧基 - 联苯-2,2'-二基） - 双（二苯基膦氧化物）的方法
公开(公告)号：US06489513B2
公开(公告)日：2002-12-03
申请号：US10010176
申请日：2001-11-13
申请人： Torsten Pohl , Thomas Prinz , Guido Giffels , Wolfram Sirges
发明人： Torsten Pohl , Thomas Prinz , Guido Giffels , Wolfram Sirges
IPC分类号： C07F953
CPC分类号： C07F9/5329
摘要： The invention relates to the preparation of enantiomerically pure bis-diphenylphosphine oxides in a particularly advantageous manner by (1) reacting an aromatic bromine compound with a diphenylphosphinic chloride in a mixture of tetrahydrofuran and an aromatic hydrocarbon to give a diphenylphosphine oxide, which is isolated from a solution in an aromatic hydrocarbon by adding a saturated aliphatic hydrocarbon; (2) metalating the resulting diphenylphosphine oxide in the 6-position and reacting the metalated diphenylphosphine oxide with iodine at temperatures not less than −25° C. in such a way that a small amount of iodine is always present in excess, giving a 2-iodo-diphenylphosphine oxide; (3) preparing a racemic bis-diphenylphosphine oxide from the resulting 2-iodo-diphenylphosphine oxide using copper and an aromatic hydrocarbon solvent and crystallizing the racemic bis-diphenylphosphine oxide from a solution in an aromatic hydrocarbon; and (4) separating isomers using an enantiomerically pure mono- or dicarboxylic acid to obtain a first enantiomer by crystallization from a solution in an aromatic hydrocarbon and obtaining a second enantiomer by hydrolysis and subsequent crystallization from a solution in an aromatic hydrocarbon.
摘要翻译：本发明涉及通过（1）使芳族溴化合物与二苯基次膦酰氯在四氢呋喃和芳族烃的混合物中反应得到二苯基氧化膦，特别有利的方法制备对映体纯双的二苯基膦氧化物，得到二苯基氧化膦通过加入饱和脂肪烃在芳族烃中的溶液; （2）将得到的二苯基氧化膦金属化在6位上，并使金属化二苯基氧化膦与碘在不低于-25℃的温度下反应，使得少量的碘总是存在于过量的中，得到2 碘代二苯基氧化膦; （3）使用铜和芳烃溶剂从所得的2-碘 - 二苯基氧化膦制备外消旋二苯基二氧化膦氧化物，并从外来物质中溶解外消旋双 - 二苯基膦氧化物; 和（4）使用对映异构体纯的单羧酸或二羧酸分离异构体，以通过从芳族烃溶液中结晶获得第一对映异构体，并通过水解并随后从芳族烃溶液中结晶得到第二对映异构体。

5. 发明授权

US06720451B2 Method for producing N-methyl-N′-nitroguanidine 有权
标题翻译：制备N-甲基-N'-硝基胍的方法
公开(公告)号：US06720451B2
公开(公告)日：2004-04-13
申请号：US10169842
申请日：2002-07-09
申请人： Kai van Laak , Wolfram Sirges
发明人： Kai van Laak , Wolfram Sirges
IPC分类号： C07C29100
CPC分类号： C07C277/08 , C07C279/36
摘要： The present invention relates to a novel process for the preparation of N-methyl-N′-nitroguanidine by reacting nitroguanidine with aqueous methylamine solution buffered by the addition of inorganic or organic acids.
摘要翻译：本发明涉及通过硝基胍与加入无机或有机酸缓冲的甲胺溶液反应制备N-甲基-N'-硝基胍的新方法。

6. 发明授权

US06583312B2 Process for preparing optically active trimethyllactic acid and its esters 失效
标题翻译：光学活性三甲基乳酸及其酯的制备方法
公开(公告)号：US06583312B2
公开(公告)日：2003-06-24
申请号：US09864906
申请日：2001-05-24
申请人： Wolfram Sirges , Claus Dreisbach
发明人： Wolfram Sirges , Claus Dreisbach
IPC分类号： C07C69675
CPC分类号： C07C51/367 , C07C67/31 , C07C59/01 , C07C69/675
摘要： The invention relates to a novel process for preparing optically active trimethyllactic acid and/or its esters by catalytic hydrogenation of trimethylpyruvic acid and/or its esters in the presence of noble metal complex catalysts containing phosphorus ligands.
摘要翻译：本发明涉及在含有磷配体的贵金属络合物催化剂存在下，通过三甲基丙酮酸和/或其酯的催化氢化来制备光学活性的三甲基乳酸和/或其酯的新方法。

7. 发明授权

US06528651B1 Method for production of 1,3-disubtituted 2-nitroguanidines 有权
标题翻译：生产1,3-二取代的2-硝基胍的方法
公开(公告)号：US06528651B1
公开(公告)日：2003-03-04
申请号：US10149891
申请日：2002-06-14
申请人： Kai van Laak , Wolfram Sirges , Detlef Wollweber
发明人： Kai van Laak , Wolfram Sirges , Detlef Wollweber
IPC分类号： C07D21302
CPC分类号： C07D277/32 , C07D213/61 , C07D307/14
摘要： The present invention relates to a process for the preparation of compounds of the formula (I) by reacting compounds of the formula (II) in which Het, R1, R2 and R4 are as defined in the description, with anhydrous hydrogen chloride or compounds which generate hydrogen chloride.
摘要翻译：本发明涉及通过使式（II）化合物（其中Het，R 1，R 2和R 4如说明书中所定义）与无水氯化氢反应制备式（I）化合物的方法或产生氯化氢。

8. 发明授权

US07211697B2 Method for producing specific crystalline modifications of polmorphous substances 有权
标题翻译：制备无定形物质的特定结晶修饰物的方法
公开(公告)号：US07211697B2
公开(公告)日：2007-05-01
申请号：US10515431
申请日：2003-05-23
申请人： Axel Eble , Wolfram Sirges , Ulrich Schwiedop , Armin Heyn
发明人： Axel Eble , Wolfram Sirges , Ulrich Schwiedop , Armin Heyn
IPC分类号： C07C315/99
CPC分类号： C07C317/24 , A01N41/10 , B01D9/0036 , C07C2601/14
摘要： The present invention pertains to a process for the production of a specific crystal modification of a polymorphic, organic substance by precipitation of the specific crystal modification from the aqueous solution of the salt of the polymorphic substances using ordinary water-soluble organic solvents as additives as well as an acid or base.
摘要翻译：本发明涉及通过使用普通水溶性有机溶剂作为添加剂从多晶型物质的盐的水溶液中析出特定的结晶改性来制备多晶型有机物的特定结晶改性的方法作为酸或碱。

9. 发明申请

US20060036115A1 Method For Producing Specific Crystalline Modifications Of Polmorphous Substances 有权
标题翻译：生产特定结晶修饰的方法
公开(公告)号：US20060036115A1
公开(公告)日：2006-02-16
申请号：US10515431
申请日：2003-05-23
申请人： Axel Eble , Wolfram Sirges , Ulrich Schwiedop , Armin Heyn
发明人： Axel Eble , Wolfram Sirges , Ulrich Schwiedop , Armin Heyn
IPC分类号： C07C315/00
CPC分类号： C07C317/24 , A01N41/10 , B01D9/0036 , C07C2601/14
摘要： The present invention pertains to a process for the production of a specific crystal modification of a polymorphic, organic substance by precipitation of the specific crystal modification from the aqueous solution of the salt of the polymorphic substances using ordinary water-soluble organic solvents as additives as well as an acid or base.
摘要翻译：本发明涉及通过使用普通水溶性有机溶剂作为添加剂从多晶型物质的盐的水溶液中析出特定的结晶改性来制备多晶型有机物的特定结晶改性的方法作为酸或碱。

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