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1. 发明授权

US07682329B2 Methods and apparatus for leukoreduction of red blood cells 有权
标题翻译：红细胞白细胞减少的方法和装置
公开(公告)号：US07682329B2
公开(公告)日：2010-03-23
申请号：US11278884
申请日：2006-04-06
申请人： Bruce W. Gibbs , Jon Herskovits
发明人： Bruce W. Gibbs , Jon Herskovits
IPC分类号： A61M37/00
CPC分类号： A61M1/3633 , A61M1/0209 , A61M1/0218 , A61M1/0231 , A61M1/30 , A61M1/303 , A61M1/308 , A61M1/3693 , A61M1/3696 , A61M1/38 , A61M2202/0439 , A61M2205/12 , A61M2205/123
摘要： A method and apparatus for red blood collection and filtration is provided wherein a red blood cell collection assembly provides for leukoreduction filtration concurrent with or soon after the red blood cell separation and collection procedure. Such procedures involve filtering the separated red blood cells in a diluted state after and/or prior to flushing the filter with storage solution. Storage solution may thus be passed through the leukoreduction filter before, with and/or after the RBCs have been filtered therethrough. The red blood cell collection, filtration and storage assembly is preferably preconnected to a blood component separation disposable assembly, including, for example, a centrifuge vessel and a blood removal/return assembly for removing blood from a donor, passing the blood to the centrifuge vessel for separation of the blood into components for collection and providing for filtration of the separated red blood cell component.
摘要翻译：提供了一种用于红血液收集和过滤的方法和装置，其中红细胞收集组件与红血细胞分离和收集程序同时或之后提供白细胞减少过滤。这种方法包括在用储存溶液冲洗过滤器之后和/或之前以稀释状态过滤分离的红细胞。因此，在RBC已经过滤之前，之后和/或之后，储存溶液可以通过白细胞减少滤过器。红细胞收集，过滤和储存组件优选地预先连接到血液成分分离一次性组件，包括例如离心机容器和用于从供体去除血液的除血/返回组件，使血液通过离心机容器用于将血液分离成用于收集的组分并提供用于分离的红细胞组分的过滤。

2. 发明授权

US07789847B2 Methods and apparatus for leukoreduction of red blood cells 有权
公开(公告)号：US07789847B2
公开(公告)日：2010-09-07
申请号：US11842479
申请日：2007-08-21
申请人： Bruce W. Gibbs , Jon Herskovits
发明人： Bruce W. Gibbs , Jon Herskovits
IPC分类号： A61M37/00
CPC分类号： A61M1/3633 , A61M1/0209 , A61M1/0218 , A61M1/0231 , A61M1/30 , A61M1/303 , A61M1/308 , A61M1/3693 , A61M1/3696 , A61M1/38 , A61M2202/0439 , A61M2205/12 , A61M2205/123
摘要： A method and apparatus for red blood collection and filtration is provided wherein a red blood cell collection assembly provides for leukoreduction filtration concurrent with or soon after the red blood cell separation and collection procedure. Such procedures involve filtering the separated red blood cells in a diluted state after and/or prior to flushing the filter with storage solution. Storage solution may thus be passed through the leukoreduction filter before, with and/or after the RBCs have been filtered therethrough. The red blood cell collection, filtration and storage assembly is preferably preconnected to a blood component separation disposable assembly, including, for example, a centrifuge vessel and a blood removal/return assembly for removing blood from a donor, passing the blood to the centrifuge vessel for separation of the blood into components for collection and providing for filtration of the separated red blood cell component.

3. 发明授权

US5936714A Red blood cell spillover detection technique 失效
标题翻译：红细胞溢出检测技术
公开(公告)号：US5936714A
公开(公告)日：1999-08-10
申请号：US52277
申请日：1998-03-30
申请人： Bruce W. Gibbs
发明人： Bruce W. Gibbs
IPC分类号： G01N33/49 , A61M1/36 , G01N15/00 , G01N21/27 , G01N21/31 , G01N21/35 , G01N21/53 , G01N33/487 , G01N33/48
CPC分类号： G01N21/532 , A61M1/367 , G01N21/3151 , G01N33/491 , A61M2205/331 , A61M2205/3313
摘要： An apparatus and a method are provided to monitor a generally transparent blood tube at a location that is downstream from a blood separator in order to detect the presence of red blood cells in a tube that is intended to carry a different blood component, for example platelets. A red light source and a green light source are located in relation to the tube so that red light emission and green light emission are directed toward the tube and toward the flowing blood component(s) that is carried within the tube. The red light source produces a red reflection intensity from red blood cells whose magnitude increases as a function of an increase in the concentration of red blood cells. The green light source produces a green reflection intensity from the red blood cells whose magnitude decreases as a function of an increase in the concentration of the red blood cells. These two light reflections are sensed by means of one broadband photodetector, or by two band-specific photodetectors, that are located on the same side of the tube, so as to be responsive only to reflected light. An output is provided by detecting the ratio of the magnitude of the red reflection intensity to the magnitude of the green reflection intensity.
摘要翻译：提供了一种装置和方法，用于在位于血液分离器下游的位置处监测通常透明的血管，以便检测用于携带不同血液成分的管中红细胞的存在，例如血小板。红色光源和绿色光源相对于管设置，使得红色发光和绿色光发射指向管并朝向在管内承载的流动的血液成分。红色光源产生红细胞的红色反射强度，红细胞的大小随着红细胞浓度的增加而增加。绿色光源产生红细胞的绿色反射强度，红细胞的大小作为红细胞浓度增加的函数而减小。这两个光反射通过一个宽带光电探测器或两个带特定的光电检测器来检测，这两个光电探测器位于管的同一侧，以便只响应于反射光。通过检测红色反射强度的大小与绿色反射强度的大小的比例来提供输出。

4. 发明授权

US07651474B2 Method and apparatus for leukoreduction of red blood cells 有权
标题翻译：红细胞白细胞减少的方法和装置
公开(公告)号：US07651474B2
公开(公告)日：2010-01-26
申请号：US10861199
申请日：2004-06-03
申请人： Geert Van Waeg , Bruce W. Gibbs , Marc Antoon , Laura Goodrich
发明人： Geert Van Waeg , Bruce W. Gibbs , Marc Antoon , Laura Goodrich
IPC分类号： A61M37/00 , C02F1/44
CPC分类号： A61M1/3693 , A61M1/0209 , A61M1/0218 , A61M1/0231 , A61M1/30 , A61M1/303 , A61M1/308 , A61M1/3633 , A61M1/3692 , A61M1/3696 , A61M1/3698 , A61M2202/0429 , A61M2202/0439 , A61M2205/123 , A61M2202/0071
摘要： A method and apparatus for red blood collection and filtration is provided wherein a red blood cell collection assembly provides for leukoreduction filtration concurrent with or soon after the red blood cell collection procedure. The procedure preferably involves filtering the separated red blood cells in a high hematocrit (high-crit) state prior to addition of storage solution thereto. Preferably, a storage solution is passed through the leukoreduction filter after the RBCs have been filtered therethrough. The red blood cell collection filtration and storage assembly is preferably preconnected to a blood component separation disposable assembly, including, for example, a centrifuge vessel and a blood removal/return assembly for removing blood from a donor, passing the blood to the centrifuge vessel for separation of the blood into components for collection and providing for filtration of the separated red blood cell component, as described.
摘要翻译：提供一种用于红血采集和过滤的方法和装置，其中红细胞收集组件与红细胞收集程序同时或之后提供白细胞减少过滤。该方法优选包括在加入其中的储存溶液之前以高血细胞比容（高暴击）状态过滤分离的红细胞。优选地，在通过其过滤RBC之后，使储存溶液通过白细胞减少过滤器。红细胞收集过滤和储存组件优选地预先连接到血液成分分离一次性组件，包括例如离心机容器和用于从供体去除血液的除血/返回组件，将血液通过离心机容器将血液分离成用于收集的组分并提供分离的红细胞组分的过滤，如所述。

5. 发明授权

US08114003B2 Methods for hemolysis detection in centrifugal blood separator 有权
标题翻译：离心血液分离器溶血检测方法
公开(公告)号：US08114003B2
公开(公告)日：2012-02-14
申请号：US12423883
申请日：2009-04-15
申请人： Todd Curtis Green , Bruce W. Gibbs
发明人： Todd Curtis Green , Bruce W. Gibbs
IPC分类号： B04B15/00
CPC分类号： A61M1/3693 , A61M1/30 , A61M1/303 , A61M1/308 , A61M1/3643 , A61M1/3644 , A61M1/3646 , A61M1/3696 , A61M1/38 , A61M2205/18
摘要： A centrifugal blood processing apparatus comprising a centrifuge rotor, a separation chamber, a tubing set for conducting blood components and fluids and having an inlet line, and an outlet line. Apparatus tests flow conditions using a red light-green light sensor to detect non-recoverable hemolysis during priming by identifying a high R/G ratio, preferably a ratio of greater than or equal to fifty (50), prior to the beginning of the first return of blood components to a donor followed by identifying a R/G ratio at least as great as one and one tenth (1.1) together with a green signal less than a predetermined value, preferably less than or equal to one thousand (1000) reflectance units. If these conditions are detected, an alarm is given and the apheresis procedure is discontinued.
摘要翻译：一种离心血液处理设备，包括离心机转子，分离室，用于传导血液成分和流体的管道组件，并具有入口管线和出口管线。装置使用红色浅绿色光传感器测试流动条件，以通过在第一次开始之前识别高R / G比率，优选大于或等于五十（50）的比率来检测引发期间的不可恢复的溶血将血液成分返回到供体，然后将至少高达十分之一（1.1）的R / G比与绿色信号一起小于预定值，优选小于或等于一千（1000）反射率单位。如果检测到这些情况，则会发出警报，并停止血液分离程序。

6. 发明授权

US07686779B1 Extracorporeal blood processing methods and apparatus 有权
标题翻译：体外血液处理方法和装置
公开(公告)号：US07686779B1
公开(公告)日：2010-03-30
申请号：US09672519
申请日：2000-09-27
申请人： Bruce W. Gibbs
发明人： Bruce W. Gibbs
IPC分类号： A61M37/00 , A61M35/00
CPC分类号： A61M1/0209 , A61M1/0218 , A61M1/0231 , A61M1/30 , A61M1/303 , A61M1/308 , A61M1/3692 , A61M1/3693 , A61M1/3696 , A61M1/3698
摘要： A preconnected disposable and method for red blood collection is provided wherein the preconnected disposable includes a red blood cell collection assembly comprising a leukoreduction filter and a red blood cell storage bag. Such a red blood cell collection assembly is preferably preconnected to a blood component separation vessel, cassette assembly and a blood removal/return assembly for removing blood from a donor, separating the blood into components for collection and providing for filtration of the separated red blood cell component.
摘要翻译：提供了一种用于红血采集的预先连接的一次性和方法，其中所述预连接的一次性物品包括红细胞收集组件，其包含白细胞减少过滤器和红血球储存袋。这种红细胞收集组件优选地预先连接到血液成分分离容器，盒组件和用于从供体去除血液的除血/返回组件，将血液分离成用于收集的组分并提供用于分离的红细胞的过滤零件。

7. 发明授权

US5734464A Red blood cell spillover detection technique 失效
公开(公告)号：US5734464A
公开(公告)日：1998-03-31
申请号：US746109
申请日：1996-11-06
申请人： Bruce W. Gibbs
发明人： Bruce W. Gibbs
IPC分类号： G01N33/49 , A61M1/36 , G01N15/00 , G01N21/27 , G01N21/31 , G01N21/35 , G01N21/53 , G01N33/487 , G01N33/48
CPC分类号： G01N21/532 , A61M1/367 , G01N21/3151 , G01N33/491 , A61M2205/331 , A61M2205/3313
摘要： An apparatus and a method are provided to monitor a generally transparent blood tube at a location that is downstream from a blood separator in order to detect the presence of red blood cells in a tube that is intended to carry a different blood component, for example platelets. A red light source and a green light source are located in relation to the tube so that red light emission and green light emission are directed toward the tube and toward the flowing blood component(s) that is carried within the tube. The red light source produces a red reflection intensity from red blood cells whose magnitude increases as a function of an increase in the concentration of red blood cells. The green light source produces a green reflection intensity from the red blood cells whose magnitude decreases as a function of an increase in the concentration of the red blood cells. These two light reflections are sensed by means of one broadband photodetector, or by two band-specific photodetectors, that are located on the same side of the tube, so as to be responsive only to reflected light. An output is provided by detecting the ratio of the magnitude of the red reflection intensity to the magnitude of the green reflection intensity.

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