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1. 发明授权

US5202254A Process for improving mass transfer in a membrane bioreactor and providing a more homogeneous culture environment 失效
标题翻译：改善膜生物反应器中大量转移并提供更多均质文化环境的方法
公开(公告)号：US5202254A
公开(公告)日：1993-04-13
申请号：US595939
申请日：1990-10-11
申请人： Bruce P. Amiot , Martin H. Banas , Allen S. Reichler , Scott T. Waniger
发明人： Bruce P. Amiot , Martin H. Banas , Allen S. Reichler , Scott T. Waniger
IPC分类号： C12M3/06
CPC分类号： C12M29/16 , C12M23/58 , C12M25/10 , C12M29/10 , C12M41/00
摘要： A process for improving mass transfer in a bioreactor having at least one semi-permeable membrane defining first and second chambers on opposite sides of the membrane provides for circulating a first media including nutrients and the like through the first chamber and for circulating a second media for cell culture through the second chamber of the bioreactor. The first and second media may be circulated through a plurality of bioreactors connected in parallel while balancing the flow in each reactor. The flow in the second circuit can be periodically reversed to provide increased cell culture.

2. 发明授权

US5725831A Nucleic acid amplification apparatus 失效
标题翻译：核酸扩增装置
公开(公告)号：US5725831A
公开(公告)日：1998-03-10
申请号：US409805
申请日：1995-03-24
申请人： Allen S. Reichler , Peter A. Bourdelle , Raymond F. Cracauer
发明人： Allen S. Reichler , Peter A. Bourdelle , Raymond F. Cracauer
IPC分类号： C12N15/09 , B01L3/00 , B01L7/00 , C07H21/04 , C12M1/00 , C12M1/20 , C12M1/26 , C12Q1/68 , G01N33/543 , G01N21/03
CPC分类号： B01L3/502 , B01L3/50273 , B01L7/52 , C12Q1/6848 , G01N33/54366 , B01L2200/027 , B01L2200/16 , B01L2300/0825 , B01L2300/087 , B01L2400/0406 , B01L2400/0487 , B01L3/5027 , Y10T436/143333 , Y10T436/2575
摘要： An apparatus for containing a liquid biological sample and for performing a biological process thereon comprises a sample area for receiving the sample, at least one reaction area in fluid communication with the sample area, a pneumatic area in pneumatic communication with the reaction area and the sample area, and a pneumatic port in the pneumatic area for connection of the apparatus to a pneumatic aspiration/dispensing pipette. The pneumatic aspiration/dispensing pipette provides for controlled flow of the liquid biological sample between the sample area and the reaction area. To reduce evaporative loss of the sample from the apparatus, a sample tower is provided in fluid communication with the sample area. A similar tower may be provided at the pneumatic port to reduce evaporative loss through the pneumatic area. A restricted orifice between the sample tower and the sample area holds the liquid sample in place during removal of the sample from the apparatus, counteracting the tendency of the liquid bolus to flow back toward the reaction area due to capillary forces. Also disclosed is a novel sealing arrangement which provides an effective pneumatic seal between the pneumatic port and a pneumatic aspiration/dispensing pipette without requiring the apparatus to include a separate "O" ring or other type of discrete sealing device.
摘要翻译：用于容纳液体生物样品并用于进行生物过程的装置包括用于接收样品的样品区域，与样品区域流体连通的至少一个反应区域，与反应区域和样品气动连通的气动区域区域和气动区域中的气动端口，用于将设备连接到气动吸入/分配移液管。气动抽吸/分液移液管提供液体生物样品在样品区域和反应区域之间的受控流动。为了减少来自设备的样品的蒸发损失，提供与样品区域流体连通的样品塔。可以在气动端口处设置类似的塔架，以减少通过气动区域的蒸发损失。在样品塔和样品区域之间的限制孔口将样品从装置中取出期间将液体样本保持在适当的位置，抵消了液体弹丸由于毛细作用力朝向反应区域流动的趋势。还公开了一种新颖的密封装置，其在气动端口和气动吸入/分配移液管之间提供有效的气动密封，而不需要该装置包括单独的“O”形环或其他类型的离散密封装置。

3. 外观设计

USD257394S Ampule cuvette 失效
公开(公告)号：USD257394S
公开(公告)日：1980-10-14
申请号：US924254
申请日：1978-07-13
申请人： Allen S. Reichler
设计人： Allen S. Reichler

4. 发明授权

US5707860A Vehicle for delivery of particles to a sample 失效
标题翻译：用于将颗粒递送到样品的载体
公开(公告)号：US5707860A
公开(公告)日：1998-01-13
申请号：US614230
申请日：1996-03-12
申请人： Matthew P. Collis , Allen S. Reichler
发明人： Matthew P. Collis , Allen S. Reichler
IPC分类号： C12M1/00 , A61K9/48 , A61K48/00 , B01L3/14 , C07H21/00 , C12M1/33 , C12N1/04 , C12Q1/00 , C12Q1/24 , C12Q1/68 , G01N35/00 , C12M3/00
CPC分类号： C12Q1/24 , B01L3/50825 , C12M47/06 , C12M47/20 , C12N1/04 , C12Q1/00 , B01L2400/0677 , G01N2035/00267 , G01N2333/35 , Y10T436/25375
摘要： The present invention relates to a vehicle for delivery of particles to a sample of cells. The vehicle includes a barrier to retain the particles, which barrier in one embodiment is a frangible, dissolvable or meltable material. Once released into the sample, the particles are useful in methods to lyse or disrupt cells or in methods to separate cellular components from one another if the cells in the sample are already lysed or disrupted.
摘要翻译：本发明涉及用于将颗粒递送到细胞样品的载体。车辆包括保持颗粒的阻挡物，在一个实施方案中该阻挡物是易碎的，可溶解的或可熔化的材料。一旦释放到样品中，颗粒可用于裂解或破坏细胞的方法，或者如果样品中的细胞已经裂解或破坏，则将细胞组分彼此分离的方法是有用的。

5. 发明授权

US5578270A System for nucleic acid based diagnostic assay 失效
标题翻译：基于核酸的诊断测定系统
公开(公告)号：US5578270A
公开(公告)日：1996-11-26
申请号：US409821
申请日：1995-03-24
申请人： Allen S. Reichler , David J. Antol , Michael L. Lamos , Peter A. Bourdelle , Scott D. Hildebrand
发明人： Allen S. Reichler , David J. Antol , Michael L. Lamos , Peter A. Bourdelle , Scott D. Hildebrand
IPC分类号： G01N33/58 , B01L3/00 , C07H21/04 , C12M1/00 , C12N15/09 , C12Q1/68 , G01N35/00 , G01N35/02 , G01N35/10 , G01N21/05
CPC分类号： B01L3/502 , G01N35/028 , G01N35/0099 , G01N35/109 , Y10T436/114998 , Y10T436/119163
摘要： An automated system is provided for carrying out nucleic acid based assays on a plurality of liquid samples with little or no intervention by a human operator. The system includes at least one reaction station adapted to hold and apply controlled amounts of heat to a plurality of reaction devices in which the liquid samples are receivable. Each of the reaction devices includes a sample area for receiving a liquid sample, a reaction area into which the liquid sample is movable to carry out a nucleic acid decontamination or amplification reaction on the sample, and a pneumatic port for allowing air to be aspirated from and dispensed into the reaction device to move the sample between the sample area and the reaction area. A robotically controlled aspiration and dispensing head is adapted to move into contact with the pneumatic ports of the reaction devices, and to aspirate air from and dispense air into the pneumatic ports of the reaction devices in order to move the liquid samples between the sample and reaction areas of the reaction devices. A programmable control system is provided for causing the robotically controlled aspiration and dispensing head to move into contact with the pneumatic ports of the reaction devices, and to aspirate air from and dispense air into the reaction devices in order to cause the desired movement of the liquid samples within the reaction devices. The robotically controlled aspiration and dispensing head is also adapted to transfer the liquid samples to and from the reaction devices using disposable pipettes, and to introduce liquid reagents into the reacted samples after the samples have been transferred from the reaction devices to separate assay devices. A robotically controlled wash head is also provided to aspirate and dispense wash fluids and reagent fluids from the assay devices.
摘要翻译：提供了一种自动化系统，用于在很少或由人类操作者干预的情况下对多个液体样品进行基于核酸的测定。该系统包括至少一个反应站，其适于将受控量的热量保持并施加到液体样品可接收的多个反应装置中。每个反应装置包括用于接收液体样品的样品区域，液体样品可移动到其中以对样品进行核酸去污或扩增反应的反应区域，以及用于允许从空气中吸出空气的气动端口并分配到反应装置中以在样品区域和反应区域之间移动样品。机器人控制的抽吸和分配头适于移动与反应装置的气动端口接触，并且将空气吸入空气并将空气分配到反应装置的气动端口中，以便在样品和反应之间移动液体样品反应装置的区域。提供了一种可编程控制系统，用于使机器人控制的抽吸和分配头移动到与反应装置的气动端口接触，并且将空气吸入空气并将其分配到反应装置中，以引起液体的所需运动反应装置内的样品。机器人控制的抽吸和分配头还适于使用一次性移液管将液体样品转移到反应装置和从反应装置转移，并且在样品已经从反应装置转移到分离的测定装置之后将液体试剂引入反应的样品中。还提供机器人控制的洗头以从测定装置吸取和分配洗涤液和试剂流体。

6. 发明授权

US4198484A Cuvette ampule for use with automatic analyzer apparatus 失效
标题翻译：比色杯安瓿用于自动分析仪
公开(公告)号：US4198484A
公开(公告)日：1980-04-15
申请号：US928114
申请日：1978-07-26
申请人： Allen S. Reichler , Larry E. Swaton
发明人： Allen S. Reichler , Larry E. Swaton
IPC分类号： G01N21/03 , C12M1/24 , C12Q1/04 , G01N21/24
CPC分类号： G01N21/03 , B01L9/06 , B01L2300/043 , B01L2300/069 , B01L3/50853
摘要： A cuvette ampule for use with automated chemical and microbiological analysis apparatuses. The nutrient containing ampule features an upper detachable stem and lower body portion which includes a pair of flat, uniformly spaced sides having the desired optical characteristics. One or more of the cuvette ampules is to be seated and maintained in a fixed position within a cartridge to facilitate insertion into analytical apparatuses. Breaking and removing the ampule stem provides an opening for receipt of the chemical or biological fluid to be evaluated. A compressible member covers each opening to seal the opened ampule and maintain the position of the ampule in the cartridge.
摘要翻译：用于自动化学和微生物分析仪器的比色皿安瓿。含有营养的安瓿具有上部可拆卸的杆和下部主体部分，其包括一对具有所需光学特性的平坦均匀间隔的侧面。将一个或多个比色皿安瓿座置于并保持在盒内的固定位置以便于插入分析装置中。打破和移除安瓿杆为接收待评估的化学或生物流体提供了一个开口。可压缩构件覆盖每个开口以密封打开的安瓿并将安瓿的位置保持在盒中。

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