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    • 5. 发明授权
    • Continuous, non-invasive technique for measuring blood pressure using impedance plethysmography
    • 使用阻抗体积描记法测量血压的连续,非侵入性技术
    • US06648828B2
    • 2003-11-18
    • US09683916
    • 2002-03-01
    • Bruce A. FriedmanRichard MederoLawrence T. HershSai Kolluri
    • Bruce A. FriedmanRichard MederoLawrence T. HershSai Kolluri
    • A61B502
    • A61B5/0285A61B5/021A61B5/02125A61B5/0295
    • Blood pressure is measured using the pulse transit time required for the blood volume pulse to propagate between two locations in an animal. Impedance plethysmography is employed to detect when the blood volume pulse occurs at one location. The plethysmograph may detect thoracic impedance to determine when the aortic heart valve opens or it may detect impedance at one location on a limb of the animal. Occurrence of the blood volume pulse at another location can be determined by impedance plethysmography or another technique, such as pulse oximetry. The calculation of cardiac stroke volume can be employed to compensate the derivation of the blood pressure for effects due to blood vessel compliance. A nonblood pressure monitor may periodically provide a reference blood pressure measurement that is used calibrate derivation of the blood pressure based on the pulse transit time.
    • 使用血液体积脉冲在动物的两个位置之间传播所需的脉搏传播时间来测量血压。 采用阻抗体积描记法检测血液体积脉搏何时出现在一个位置。 体积描记器可以检测胸部阻抗以确定主动脉瓣心脏瓣膜何时打开,或者可以在动物肢体的一个位置处检测阻抗。 可以通过阻抗体积描记法或其他技术(例如脉搏血氧测定法)来确定另一位置处的血容量脉冲的发生。 心脏搏动量的计算可用于补偿由于血管依从性引起的血压的推导。 非血压监视器可以周期性地提供参考血压测量,其用于基于脉冲传播时间来校准血压的推导。
    • 8. 发明授权
    • Method and apparatus for automated vascular function testing
    • 自动血管功能检测方法和装置
    • US08043223B2
    • 2011-10-25
    • US11562489
    • 2006-11-22
    • Bruce A. FriedmanKai E. ThomeniusAaron M. Dentinger
    • Bruce A. FriedmanKai E. ThomeniusAaron M. Dentinger
    • A61B5/02
    • A61B5/02416A61B5/02007A61B5/02125A61B5/022A61B5/14551A61B8/06A61B8/4227
    • A method and system for use in measuring the endothelial dysfunction utilizing flow mediated dilation and determining arterial health of a patient. The system includes a non-invasive blood pressure monitor, an ultrasound system and a pulse oximeter monitor that all communicate with each other to perform the flow mediated dilation. Initially, the ultrasound transducer, blood pressure cuff and pulse oximeter sensor are positioned on an arm of the patient. The blood pressure cuff is inflated to occlude an artery for an occlusion period. Following the occlusion period, the ultrasound system is automatically signaled to begin determining a parameter of the artery, such as diameter, and the flow rate of blood through the artery without any operator intervention. At the same time, the pulse wave velocity PWV is calculated between the ultrasound transducer and the finger probe of the pulse oximeter following the occlusion period. Based upon the detected characteristics of the artery before and after occlusion, as well as the PWV, the system can determine the endothelial dysfunction and arterial health of the patient.
    • 用于利用流介导的扩张和确定患者的动脉健康来测量内皮功能障碍的方法和系统。 该系统包括无创血压监测器,超声波系统和脉搏血氧计监测器,它们彼此通信以进行流量介导的扩张。 最初,超声波换能器,血压袖带和脉搏血氧饱和度传感器位于患者的手臂上。 血压袖带充气以闭塞动脉以阻塞期。 在闭塞期之后,自动发信号通知超声系统以开始确定动脉的参数,例如直径,以及血液通过动脉的流速,无需任何操作者干预。 同时,在闭塞期之后,在超声换能器和脉搏血氧计的手指探针之间计算出脉搏波速度PWV。 根据检测到的阻塞前后动脉的特征以及PWV,系统可以确定患者的内皮功能障碍和动脉健康。