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1. 发明申请

US20120149994A1 METHOD AND SYSTEM FOR CONTROLLING NON-INVASIVE BLOOD PRESSURE DETERMINATION BASED ON OTHER PHYSIOLOGICAL PARAMETERS 审中-公开
标题翻译：基于其他生理参数控制非侵入性血压测定的方法和系统
公开(公告)号：US20120149994A1
公开(公告)日：2012-06-14
申请号：US12967256
申请日：2010-12-14
申请人： William J. Luczyk , Lawrence T. Hersh , Robert F. Donehoo , Bruce A. Friedman
发明人： William J. Luczyk , Lawrence T. Hersh , Robert F. Donehoo , Bruce A. Friedman
IPC分类号： A61B5/02 , A61B5/022
CPC分类号： A61B5/02255 , A61B5/02225 , A61B5/0452 , A61B5/14542 , A61B5/7203 , A61B5/721 , A61B5/7221
摘要： A system and method for processing a cuff pressure waveform to determine the blood pressure of a patient. The processing unit of the NIBP monitoring system receives status signals from one or more physiological parameter monitors. The physiological parameter monitors each include an operating algorithm that causes the physiological parameter monitor to generate a status signal indicating whether artifacts are present that prevent the determination of the physiological parameter. When the processing unit receives the monitoring signal from the physiological parameter monitor indicating the presence of artifacts, the processing unit adjusts the operation of the NIBP monitor. The adjustment of the NIBP monitor may be to delay the beginning of the NIBP determination cycle until artifacts are no longer present from the physiological parameter monitor or to control the cuff pressure in such a manner as to keep the patient safe and comfortable until the artifacts are no longer present.
摘要翻译：一种用于处理袖带压波形以确定患者的血压的系统和方法。 NIBP监控系统的处理单元从一个或多个生理参数监视器接收状态信号。生理参数监视器每个都包括使生理参数监视器产生指示是否存在妨碍生理参数的确定的伪影的状态信号的操作算法。当处理单元从生理参数监视器接收到指示伪像的存在的监视信号时，处理单元调整NIBP监视器的操作。 NIBP监视器的调整可能是延迟NIBP确定周期的开始，直到生理参数监视器中不再存在伪影，或者以保持患者的安全和舒适的方式来控制袖带压力，直到假象是不再存在

2. 发明申请

US20100249616A1 NIBP TARGET INFLATION PRESSURE AUTOMATION USING DERIVED SPO2 SIGNALS 有权
标题翻译： NIBP目标充气压力自动化使用衍生的SPO2信号
公开(公告)号：US20100249616A1
公开(公告)日：2010-09-30
申请号：US12412057
申请日：2009-03-26
申请人： Robert F. Donehoo , Lawrence T. Hersh , Sai Kolluri
发明人： Robert F. Donehoo , Lawrence T. Hersh , Sai Kolluri
IPC分类号： A61B5/02
CPC分类号： A61B5/022 , A61B5/02225 , A61B5/7239
摘要： A method and system for operating a non-invasive blood pressure monitor that utilizes an SpO2 plethysmograph waveform to determine the initial inflation pressure for the NIBP monitor. A pulse sensor is placed on the patient's limb distal to the blood pressure cuff and provides a pulse waveform to the NIBP monitor. The NIBP monitor calculates a second derivative of the pulse waveform, which includes a series of acceleration peaks corresponding to pulse signals within the pulse waveform. When the blood pressure cuff reaches systolic pressure, the acceleration peaks contained within the acceleration waveform are eliminated, thus providing an indication that the cuff pressure has reached systolic pressure for the patient. Use of the SPO2 plethysmograph signal to determine the initial inflation pressure reduces both the over-inflation of the blood pressure cuff and the under-inflation of the blood pressure cuff, which increases the rate at which the blood pressure measurement can be made while increasing patient comfort.
摘要翻译：一种用于操作非侵入性血压监测器的方法和系统，其利用SpO2体积描记器波形来确定NIBP监测器的初始充气压力。将脉搏传感器放置在远离血压袖带的患者肢体上，并向NIBP监护仪提供脉搏波形。 NIBP监视器计算脉搏波形的二阶导数，其包括与脉冲波形内的脉冲信号相对应的一系列加速度峰值。当血压袖带达到收缩压时，加速波形中包含的加速度峰值被消除，从而提供袖带压力已达到患者收缩压的指示。使用SPO2体积描记器信号来确定初始充气压力会降低血压袖带的过度充气和血压袖带的欠充气，从而增加患者血压测量的速度，同时增加患者安慰。

3. 发明授权

US08556821B2 Adaptive frequency domain filtering for improved non-invasive blood pressure estimation 有权
标题翻译：自适应频域滤波改善非侵入性血压估计
公开(公告)号：US08556821B2
公开(公告)日：2013-10-15
申请号：US12034143
申请日：2008-02-20
申请人： Lawrence T. Hersh , Sai Kolluri , Robert F. Donehoo
发明人： Lawrence T. Hersh , Sai Kolluri , Robert F. Donehoo
IPC分类号： A61B5/22
CPC分类号： A61B5/0225 , A61B5/02225 , A61B5/024 , A61B5/7257
摘要： A system for processing oscillometric data from a plurality of pressure steps to determine the blood pressure of a patient as disclosed herein. A heart rate monitor connected to the patient acquires the patient's heart rate. A time to frequency domain converter receives oscillometric data and converts the oscillometric data into the frequency domain. A harmonic frequency calculator is connected to the heart rate monitor and derives at least the heart rate fundamental frequency. A filter connected to the time to frequency domain converter and the harmonic frequency calculator that produces a filter frequency domain oscillometric signal. A reconstruction calculator receives the filtered frequency domain oscillometric signal and reconstructs a time domain oscillometric signal. A method of computing an oscillometric envelope for use in determining the blood pressure of a patient is also disclosed herein.
摘要翻译：一种用于从多个压力步骤处理示波数据以确定如本文所公开的患者的血压的系统。连接到患者的心率监测器获取患者的心率。一段时间到频域转换器接收示波数据并将示波数据转换成频域。谐波频率计算器连接到心率监测器，并至少得出心率基频。连接到时域转换器的滤波器和产生滤波器频域示波信号的谐波频率计算器。重建计算器接收滤波后的频域示波信号并重构时域示波信号。本文还公开了计算用于确定患者的血压的示波包络的方法。

4. 发明授权

US08211030B2 NIBP target inflation pressure automation using derived SPO2 signals 有权
标题翻译： NIBP目标通气压力自动化使用衍生的SPO2信号
公开(公告)号：US08211030B2
公开(公告)日：2012-07-03
申请号：US12412057
申请日：2009-03-26
申请人： Robert F. Donehoo , Lawrence T. Hersh , Sai Kolluri
发明人： Robert F. Donehoo , Lawrence T. Hersh , Sai Kolluri
IPC分类号： A61B5/02
CPC分类号： A61B5/022 , A61B5/02225 , A61B5/7239
摘要： A method and system for operating a non-invasive blood pressure monitor that utilizes an SpO2 plethysmograph waveform to determine the initial inflation pressure for the NIBP monitor. A pulse sensor is placed on the patient's limb distal to the blood pressure cuff and provides a pulse waveform to the NIBP monitor. The NIBP monitor calculates a second derivative of the pulse waveform, which includes a series of acceleration peaks corresponding to pulse signals within the pulse waveform. When the blood pressure cuff reaches systolic pressure, the acceleration peaks contained within the acceleration waveform are eliminated, thus providing an indication that the cuff pressure has reached systolic pressure for the patient. Use of the SPO2 plethysmograph signal to determine the initial inflation pressure reduces both the over-inflation of the blood pressure cuff and the under-inflation of the blood pressure cuff, which increases the rate at which the blood pressure measurement can be made while increasing patient comfort.
摘要翻译：一种用于操作非侵入性血压监测器的方法和系统，其利用SpO2体积描记器波形来确定NIBP监测器的初始充气压力。将脉搏传感器放置在远离血压袖带的患者肢体上，并向NIBP监护仪提供脉搏波形。 NIBP监视器计算脉搏波形的二阶导数，其包括与脉冲波形内的脉冲信号相对应的一系列加速度峰值。当血压袖带达到收缩压时，加速波形中包含的加速度峰值被消除，从而提供袖带压力已达到患者收缩压的指示。使用SPO2体积描记器信号来确定初始充气压力会降低血压袖带的过度充气和血压袖带的欠充气，从而增加患者血压测量的速度，同时增加患者安慰。

5. 发明申请

US20090209868A1 Adaptive Frequency Domain Filtering for Improved Non-Invasive Blood Pressure Estimation 有权
标题翻译：用于改善非侵入性血压估计的自适应频域滤波
公开(公告)号：US20090209868A1
公开(公告)日：2009-08-20
申请号：US12034143
申请日：2008-02-20
申请人： Lawrence T. Hersh , Sai Kolluri , Robert F. Donehoo
发明人： Lawrence T. Hersh , Sai Kolluri , Robert F. Donehoo
IPC分类号： A61B5/02
CPC分类号： A61B5/0225 , A61B5/02225 , A61B5/024 , A61B5/7257
摘要： A system for processing oscillometric data from a plurality of pressure steps to determine the blood pressure of a patient as disclosed herein. A heart rate monitor connected to the patient acquires the patient's heart rate. A time to frequency domain converter receives oscillometric data and converts the oscillometric data into the frequency domain. A harmonic frequency calculator is connected to the heart rate monitor and derives at least the heart rate fundamental frequency. A filter connected to the time to frequency domain converter and the harmonic frequency calculator that produces a filter frequency domain oscillometric signal. A reconstruction calculator receives the filtered frequency domain oscillometric signal and reconstructs a time domain oscillometric signal. A method of computing an oscillometric envelope for use in determining the blood pressure of a patient is also disclosed herein.
摘要翻译：一种用于从多个压力步骤处理示波数据以确定如本文所公开的患者的血压的系统。连接到患者的心率监测器获取患者的心率。一段时间到频域转换器接收示波数据并将示波数据转换成频域。谐波频率计算器连接到心率监测器，并至少得出心率基频。连接到时域到频域转换器的滤波器和产生滤波器频域示波信号的谐波频率计算器。重建计算器接收滤波后的频域示波信号并重构时域示波信号。本文还公开了计算用于确定患者的血压的示波包络的方法。

6. 发明申请

US20100174202A1 METHOD AND SYSTEM FOR COMBINING OSCILLOMETRIC BLOOD PRESSURE ENVELOPE DATA OBTAINED FROM DIFFERENT SIGNAL PROCESSING PATHS 审中-公开
标题翻译：用于组合来自不同信号处理程序的OSCILOMETRIC BLOOD压力包数据的方法和系统
公开(公告)号：US20100174202A1
公开(公告)日：2010-07-08
申请号：US12350412
申请日：2009-01-08
申请人： Lawrence T. Hersh , Sai Kolluri , Bruce A. Friedman , Richard Medero
发明人： Lawrence T. Hersh , Sai Kolluri , Bruce A. Friedman , Richard Medero
IPC分类号： A61B5/0225
CPC分类号： A61B5/0225 , A61B5/02225 , A61B5/0402 , A61B5/1455
摘要： A blood pressure measurement system that utilizes a non-invasive blood pressure (NIBP) monitor having a blood pressure cuff and pressure transducer. The measurement system provides a plurality of separate processing techniques that each receive a plurality of oscillometric waveform sample values generated using the pressure transducer. Each of the processing techniques separately generates a set of envelope points based upon the oscillometric data values. The sets of envelope points are appropriately scaled such that the sets of scaled envelope points are combined with each other to create a set of combined, scaled envelope points. Various different methods can be used to scale the sets of envelope points prior to the combination of the scaled envelope points. Based upon the combination of scaled envelope points, the blood pressure is calculated and displayed by the NIBP monitor.
摘要翻译：一种血压测量系统，其利用具有血压袖带和压力换能器的非侵入性血压（NIBP）监测器。测量系统提供多个单独的处理技术，每个处理技术接收使用压力传感器产生的多个示波波形采样值。每个处理技术基于示波器数据值分别产生一组包络点。适当地缩放包络点集合，使得缩放包络点的集合彼此组合以创建一组组合的，缩放的包络点。可以使用各种不同的方法在缩放的包络点的组合之前缩放包络点集合。根据缩放的包络点的组合，由NIBP监视器计算和显示血压。

7. 发明授权

US06648828B2 Continuous, non-invasive technique for measuring blood pressure using impedance plethysmography 有权
标题翻译：使用阻抗体积描记法测量血压的连续，非侵入性技术
公开(公告)号：US06648828B2
公开(公告)日：2003-11-18
申请号：US09683916
申请日：2002-03-01
申请人： Bruce A. Friedman , Richard Medero , Lawrence T. Hersh , Sai Kolluri
发明人： Bruce A. Friedman , Richard Medero , Lawrence T. Hersh , Sai Kolluri
IPC分类号： A61B502
CPC分类号： A61B5/0285 , A61B5/021 , A61B5/02125 , A61B5/0295
摘要： Blood pressure is measured using the pulse transit time required for the blood volume pulse to propagate between two locations in an animal. Impedance plethysmography is employed to detect when the blood volume pulse occurs at one location. The plethysmograph may detect thoracic impedance to determine when the aortic heart valve opens or it may detect impedance at one location on a limb of the animal. Occurrence of the blood volume pulse at another location can be determined by impedance plethysmography or another technique, such as pulse oximetry. The calculation of cardiac stroke volume can be employed to compensate the derivation of the blood pressure for effects due to blood vessel compliance. A nonblood pressure monitor may periodically provide a reference blood pressure measurement that is used calibrate derivation of the blood pressure based on the pulse transit time.
摘要翻译：使用血液体积脉冲在动物的两个位置之间传播所需的脉搏传播时间来测量血压。采用阻抗体积描记法检测血液体积脉搏何时出现在一个位置。体积描记器可以检测胸部阻抗以确定主动脉瓣心脏瓣膜何时打开，或者可以在动物肢体的一个位置处检测阻抗。可以通过阻抗体积描记法或其他技术（例如脉搏血氧测定法）来确定另一位置处的血容量脉冲的发生。心脏搏动量的计算可用于补偿由于血管依从性引起的血压的推导。非血压监视器可以周期性地提供参考血压测量，其用于基于脉冲传播时间来校准血压的推导。

8. 发明授权

US07186218B2 Method and system for cuff pressure reversions 有权
标题翻译：袖带压力逆转的方法和系统
公开(公告)号：US07186218B2
公开(公告)日：2007-03-06
申请号：US10375409
申请日：2003-02-27
申请人： Lawrence T. Hersh , Richard Medero , Bruce A. Friedman , Sai Kolluri
发明人： Lawrence T. Hersh , Richard Medero , Bruce A. Friedman , Sai Kolluri
IPC分类号： A61B5/02
CPC分类号： A61B5/02225 , A61B5/0225 , A61B5/7207 , G06F19/00
摘要： A method and system for determining when to make a reversion to smaller cuff pressure steps during an oscillometric blood pressure measurement is disclosed. The method and system comprise comparing conformance of oscillometric envelope blood pressure data with previous blood pressure data, including measuring a shift between the oscillometric envelope blood pressure data and an oscillometric envelope derived from the previous blood pressure data. In addition, the method and system include making a reversion decision based on whether the shift exceeds an allowable threshold. Once a reversion decision is made a subsequent decision may be made as to the need for increasing the cuff pressure level.
摘要翻译：公开了一种用于在示波器血压测量期间确定何时进行更小的袖带压力步骤的方法和系统。所述方法和系统包括比较示波包络血压数据与先前血压数据的一致性，包括测量示波包络血压数据与从先前血压数据得出的示波包络之间的偏移。此外，所述方法和系统包括基于所述偏移是否超过允许阈值来进行回归决定。一旦进行回归决定，可以随后作出关于增加袖带压力水平的需要的决定。

9. 发明授权

US07621876B2 Continuous, non-invasive technique for determining blood pressure using a transmission line model and transcutaneous ultrasound measurements 有权
标题翻译：使用传输线模型和经皮超声测量来确定血压的连续，非侵入性技术
公开(公告)号：US07621876B2
公开(公告)日：2009-11-24
申请号：US11083259
申请日：2005-03-17
申请人： Ralph T. Hoctor , Lawrence T. Hersh , Bruce A. Friedman
发明人： Ralph T. Hoctor , Lawrence T. Hersh , Bruce A. Friedman
IPC分类号： A61B5/02 , A61B5/103 , A61B5/117 , A61B8/00 , A61B8/14
CPC分类号： A61B5/022 , A61B5/02125 , A61B8/04 , A61B8/06 , A61B8/13 , A61B8/4236 , A61B8/4472
摘要： A method and technique for the continuous, non-invasive measurement of blood pressure. The blood pressure measurement technique of the present invention utilizes ultrasound measurements to determine the diameter of the blood vessel in which the blood pressure is being measured as well as the flow rate of blood at both an input point and an output point along the blood vessel. The system utilizes a transmission line model to relate various blood vessel measurements with electrical components. The transmission line model, in combination with data management techniques including state variable representations and Kalman filtering, is used to develop a blood pressure measurement in real time.
摘要翻译：一种连续，无创血压测量的方法和技术。本发明的血压测量技术利用超声波测量来确定其中测量血压的血管的直径以及沿着血管的输入点和输出点处的血液的流速。该系统利用传输线模型将各种血管测量与电气部件联系起来。传输线模型结合包括状态变量表示和卡尔曼滤波在内的数据管理技术，用于实时开发血压测量。

10. 发明申请

US20090209874A1 EXTRAPOLATING ICA KNOWLEDGE FROM ONE EPOCH TO ANOTHER FOR IMPROVED FETAL ECG SEPARATION 有权
标题翻译：将一个EPOCH的ICA知识扩展到另一个改进的FET心电图分离
公开(公告)号：US20090209874A1
公开(公告)日：2009-08-20
申请号：US12034129
申请日：2008-02-20
申请人： Sai Kolluri , Bruce A. Friedman , Lawrence T. Hersh , Rush Winslow Hood, JR.
发明人： Sai Kolluri , Bruce A. Friedman , Lawrence T. Hersh , Rush Winslow Hood, JR.
IPC分类号： A61B5/0448
CPC分类号： A61B5/0444 , A61B5/4362
摘要： A method of utilizing a maternal-fetal monitoring system to monitor the physiological properties of both a maternal patient and a fetus. A series of ECG electrodes are placed across the maternal patient's abdomen and receives ECG input waveforms across sixteen separate channels. The sixteen channels of information are processed using an ICA algorithm to generate a series of ICA output waveforms and a transfer matrix. Following the current epoch, the transfer matrix is applied to the input waveforms on a continuous basis. The conditioned input waveforms are displayed immediately following the first epoch and prior to the expiration of a subsequent epoch. The transfer matrix for the second epoch is combined with the transfer matrix for the first epoch to generate an updated transfer matrix. Various filtering operations on the transfer matrix coefficients may be used to find the updated transfer matrix before the end of the current epoch.
摘要翻译：一种利用母胎监测系统来监测母亲患者和胎儿的生理特性的方法。一系列ECG电极放置在母亲患者的腹部，并接收跨16个独立通道的ECG输入波形。使用ICA算法处理16个信道的信道，以生成一系列ICA输出波形和传送矩阵。在当前时代之后，传输矩阵连续地应用于输入波形。条件输入波形显示在第一纪元之后，并在随后的时期到期之前。将第二纪元的传递矩阵与第一纪元的传输矩阵组合以生成更新的传送矩阵。可以使用传递矩阵系数上的各种滤波操作来在当前时期结束之前找到更新的传输矩阵。

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