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1. 发明授权

US08133714B2 Process for the fermentative preparation of organic chemical compounds using coryneform bacteria in which the SugR gene is present in attenuated form 有权
标题翻译：使用其中SugR基因以减毒形式存在的棒状细菌发酵制备有机化合物的方法
公开(公告)号：US08133714B2
公开(公告)日：2012-03-13
申请号：US12232610
申请日：2008-09-19
申请人： Brigitte Bathe , Bastian Blombach , Bernhard Eikmanns , Verena Engels , Georg Thierbach , Volker Wendisch
发明人： Brigitte Bathe , Bastian Blombach , Bernhard Eikmanns , Verena Engels , Georg Thierbach , Volker Wendisch
IPC分类号： C12N1/21 , C12P13/04 , C12P13/08 , C12P13/06 , C12N15/00 , C07K14/00 , C07H21/00
CPC分类号： C12P13/08 , C12P13/06 , C12P13/10
摘要： The invention relates to a recombinant coryneform bacterium which secretes an organic chemical compound and in which the sugR gene which codes for a polypeptide having the activity of an SugR regulator has been attenuated. The invention further relates to a processes for using this bacterium for the fermentative preparation of organic chemical compounds.
摘要翻译：本发明涉及分泌有机化合物的重组棒状细菌，其中编码具有SugR调节剂活性的多肽的sugR基因已被减弱。本发明还涉及使用该细菌用于有机化合物的发酵制剂的方法。

2. 发明授权

US08592177B2 Process for the fermentative preparation of organic chemical compounds using Coryneform bacteria in which the sugR gene is present in attenuated form 有权
标题翻译：使用棒状细菌发酵制备有机化合物的方法，其中sugR基因以减毒形式存在
公开(公告)号：US08592177B2
公开(公告)日：2013-11-26
申请号：US13355531
申请日：2012-01-21
申请人： Brigitte Bathe , Georg Thierbach , Volker Wendisch , Verena Engels , Bernhard Eikmanns , Bastian Blombach
发明人： Brigitte Bathe , Georg Thierbach , Volker Wendisch , Verena Engels , Bernhard Eikmanns , Bastian Blombach
IPC分类号： C12P13/04 , C12P13/08 , C12P13/06 , C12P1/00 , C12N1/21
CPC分类号： C12P13/08 , C12P13/06 , C12P13/10
摘要： The invention relates to a recombinant coryneform bacterium which secretes an organic chemical compound and in which the sugR gene which codes for a polypeptide having the activity of an SugR regulator has been attenuated. The invention further relates to a processes for using this bacterium for the fermentative preparation of organic chemical compounds.
摘要翻译：本发明涉及分泌有机化合物的重组棒状细菌，其中编码具有SugR调节剂活性的多肽的sugR基因已被减弱。本发明还涉及使用该细菌用于有机化合物的发酵制剂的方法。

3. 发明申请

US20120214211A1 Process for the Fermentative Preparation of Organic Chemical Compounds Using Coryneform Bacteria in which the SugR Gene is Present in Attenuated Form 有权
标题翻译：使用其中SugR基因以减弱形式存在的棒状细菌的有机化合物的发酵制备方法
公开(公告)号：US20120214211A1
公开(公告)日：2012-08-23
申请号：US13355531
申请日：2012-01-21
申请人： Brigitte Bathe , Bastian Blombach , Bernhard Eikmanns , Verena Engels , Georg Thierbach , Volker Wendisch
发明人： Brigitte Bathe , Bastian Blombach , Bernhard Eikmanns , Verena Engels , Georg Thierbach , Volker Wendisch
IPC分类号： C12P13/08 , C12P7/40 , C12P7/42 , C12P13/06 , C12P13/04
CPC分类号： C12P13/08 , C12P13/06 , C12P13/10
摘要： The invention relates to a recombinant coryneform bacterium which secretes an organic chemical compound and in which the sugR gene which codes for a polypeptide having the activity of an SugR regulator has been attenuated. The invention further relates to a processes for using this bacterium for the fermentative preparation of organic chemical compounds.
摘要翻译：本发明涉及分泌有机化合物的重组棒状细菌，其中编码具有SugR调节剂活性的多肽的sugR基因已被减弱。本发明还涉及使用该细菌用于有机化合物的发酵制剂的方法。

4. 发明申请

US20090117624A1 Process for the fermentative preparation of organic chemical compounds using coryneform bacteria in which the SugR gene is present in attenuated form 有权
标题翻译：使用其中SugR基因以减毒形式存在的棒状细菌发酵制备有机化合物的方法
公开(公告)号：US20090117624A1
公开(公告)日：2009-05-07
申请号：US12232610
申请日：2008-09-19
申请人： Brigitte Bathe , Bastian Blombach , Bernhard Eikmanns , Verena Engels , Georg Thierbach , Volker Wendisch
发明人： Brigitte Bathe , Bastian Blombach , Bernhard Eikmanns , Verena Engels , Georg Thierbach , Volker Wendisch
IPC分类号： C12P13/08 , C12N1/21 , C12P13/06 , C12P13/04
CPC分类号： C12P13/08 , C12P13/06 , C12P13/10
摘要： The invention relates to a recombinant coryneform bacterium which secretes an organic chemical compound and in which the sugR gene which codes for a polypeptide having the activity of an SugR regulator has been attenuated. The invention further relates to a processes for using this bacterium for the fermentative preparation of organic chemical compounds.
摘要翻译：本发明涉及分泌有机化合物的重组棒状细菌，其中编码具有SugR调节剂活性的多肽的sugR基因已被减弱。本发明还涉及使用该细菌用于有机化合物的发酵制剂的方法。

5. 发明授权

US08343734B2 Mutant of the proB gene from coryneform bacteria 有权
标题翻译：来自棒状细菌的proB基因的突变体
公开(公告)号：US08343734B2
公开(公告)日：2013-01-01
申请号：US13118645
申请日：2011-05-31
申请人： Stephan Hans , Brigitte Bathe , Georg Thierbach
发明人： Stephan Hans , Brigitte Bathe , Georg Thierbach
IPC分类号： C12P1/00
CPC分类号： C12N9/12
摘要： The invention relates to processes for fermentative production of L-proline using bacteria which contain mutated variants of the proB gene.
摘要翻译：本发明涉及使用含有proB基因突变变体的细菌发酵生产L-脯氨酸的方法。

6. 发明授权

US07910715B2 Alleles of the oxyR gene from coryneform bacteria 有权
标题翻译：来自棒状细菌的oxyR基因的等位基因
公开(公告)号：US07910715B2
公开(公告)日：2011-03-22
申请号：US11937888
申请日：2007-11-09
申请人： Brigitte Bathe , Wilfried Claes , Silke Jerrentrup , Caroline Kreutzer , Georg Thierbach
发明人： Brigitte Bathe , Wilfried Claes , Silke Jerrentrup , Caroline Kreutzer , Georg Thierbach
IPC分类号： C07H21/04 , C12N1/00 , C12N1/20
CPC分类号： C12N15/77 , A23K10/12 , A23K20/147 , C07K14/34 , C12P13/04 , C12P13/08 , C12P13/227
摘要： The invention relates to mutants and alleles of the oxyR gene of coryneform bacteria coding for variants of the OxyR transcription regulator and processes for producing amino acids using bacteria which comprise these alleles.
摘要翻译：本发明涉及编码OxyR转录调节子变体的棒状细菌的oxyR基因的突变体和等位基因，以及使用包含这些等位基因的细菌产生氨基酸的方法。

7. 发明授权

US07754446B2 Alleles of the rel gene from coryneform bacteria 有权
标题翻译：来自棒状细菌的rel基因的等位基因
公开(公告)号：US07754446B2
公开(公告)日：2010-07-13
申请号：US11873073
申请日：2007-10-16
申请人： Brigitte Bathe , Caroline Kreutzer , Georg Thierbach
发明人： Brigitte Bathe , Caroline Kreutzer , Georg Thierbach
IPC分类号： C12P1/00
CPC分类号： C12P13/08 , A23L33/135 , A23L33/175 , C12N9/1235 , C12P13/04
摘要： An isolated mutant of a coryneform bacterium comprising a gene coding for a polypeptide having GTP-pyrophosphate kinase activity, wherein said polypeptide comprises an amino acid sequence in which one of the proteinogenic amino acids other than L-proline is present in position 38 or a corresponding or comparable position. In addition, an isolated polynucleotide encoding a polypeptide having GTP-pyrophosphate kinase enzyme activity, a vector comprising the isolated polynucleotide, a recombinant microorganism comprising the vector, and a process for preparing the recombinant coryneform bacterium is described. A method for over-expressing a GTP-pyrophosphate kinase, a method of preparing an L-amino acid, an L-lysine comprising and L-tryptophan comprising feed is also described.
摘要翻译：棒状细菌的分离突变体，其包含编码具有GTP-焦磷酸激酶活性的多肽的基因，其中所述多肽包含氨基酸序列，其中除了L-脯氨酸以外的蛋白原氨基酸之一存在于位置38或相应的或相当的地位。此外，描述了编码具有GTP焦磷酸激酶酶活性的多肽的分离的多核苷酸，包含分离的多核苷酸的载体，包含载体的重组微生物和制备重组棒状杆菌型细菌的方法。还描述了过表达GTP焦磷酸激酶的方法，制备L-氨基酸的方法，包含L-赖氨酸的L-赖氨酸和包含L-色氨酸的饲料。

8. 发明申请

US20090325242A1 Alleles of the zwf gene from coryneform bacteria 有权
标题翻译：来自棒状细菌的zwf基因的等位基因
公开(公告)号：US20090325242A1
公开(公告)日：2009-12-31
申请号：US12458966
申请日：2009-07-28
申请人： Brigitte Bathe , Natalie Schischka , Georg Thierbach
发明人： Brigitte Bathe , Natalie Schischka , Georg Thierbach
IPC分类号： C12P13/24 , C12P13/04 , C12P13/22 , C12P13/20 , C12P13/14 , C12P13/12 , C12P13/10 , C12P13/08 , C12P13/06
CPC分类号： C12P13/08 , C07K14/34 , C12P13/227
摘要： The invention relates to mutants and alleles of the zwf gene of coryneform bacteria, which encode variants of the Zwf subunit of glucose 6-phosphate dehydrogenase (EC: 1.1.1.49), and to processes for preparing amino acids, in particular L-lysine and L-tryptophan, by using bacteria which harbor said alleles.
摘要翻译：本发明涉及编码葡萄糖-6-磷酸脱氢酶（EC：1.1.1.49）的Zwf亚基的变体的棒状细菌的zwf基因的突变体和等位基因，以及制备氨基酸，特别是L-赖氨酸和 L-色氨酸通过使用含有所述等位基因的细菌。

9. 发明申请

US20080261269A1 ALLELES OF THE OXYR GENE FROM CORYNEFORM BACTERIA 有权
标题翻译：来自CORYNEFORM BACTERIA的氧气基因的病毒
公开(公告)号：US20080261269A1
公开(公告)日：2008-10-23
申请号：US11937888
申请日：2007-11-09
申请人： Brigitte Bathe , Wilfried Claes , Silke Jerrentrup , Caroline Kreutzer , Georg Thierbach
发明人： Brigitte Bathe , Wilfried Claes , Silke Jerrentrup , Caroline Kreutzer , Georg Thierbach
IPC分类号： C12P13/04 , C12N1/20 , C12N1/21 , C07H21/04 , C12N1/00 , C12N15/74 , C12N15/00 , C12P21/06
CPC分类号： C12N15/77 , A23K10/12 , A23K20/147 , C07K14/34 , C12P13/04 , C12P13/08 , C12P13/227
摘要： The invention relates to mutants and alleles of the oxyR gene of coryneform bacteria coding for variants of the OxyR transcription regulator and processes for producing amino acids using bacteria which comprise these alleles.
摘要翻译：本发明涉及编码OxyR转录调节子变体的棒状细菌的oxyR基因的突变体和等位基因，以及使用包含这些等位基因的细菌产生氨基酸的方法。

10. 发明授权

US07338790B2 Alleles of the gnd gene from coryneform bacteria 有权
标题翻译：来自棒状细菌的gnd基因的等位基因
公开(公告)号：US07338790B2
公开(公告)日：2008-03-04
申请号：US11227138
申请日：2005-09-16
申请人： Georg Thierbach , Brigitte Bathe , Natalie Schischka
发明人： Georg Thierbach , Brigitte Bathe , Natalie Schischka
IPC分类号： C12P13/22 , C12P13/12 , C12P13/10 , C12N1/21
CPC分类号： C12P13/22 , C12N9/0006 , C12P13/08 , C12P13/227
摘要： The invention relates to mutants and alleles of the gnd gene from coryneform bacteria coding for 6-phosphogluconate dehydrogenases which contain at position 329 or a comparable position of the amino acid sequence any amino acid other than L-valine, and to processes for the production of amino acids, preferably L-lysine and L-tryptophan, by fermentation using bacteria that contain these alleles.
摘要翻译：本发明涉及编码6-磷酸葡萄糖酸脱氢酶的棒状细菌的gnd基因的突变体和等位基因，其含有第329位或氨基酸序列与L-缬氨酸以外的任何氨基酸的可比较位置，以及用于生产氨基酸，优选L-赖氨酸和L-色氨酸，通过使用含有这些等位基因的细菌进行发酵。

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