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1. 发明申请

US20080154112A1 Hair-grasping EEG electrode, applicator, and method for application 审中-公开
标题翻译：护发EEG电极，敷贴器和应用方法
公开(公告)号：US20080154112A1
公开(公告)日：2008-06-26
申请号：US11977182
申请日：2007-10-23
申请人： Brian Murphy , Ben Lane , Austin Cox , Alexander Flamm , Andy Rogers , Justin Muratore , Brian Bean , Andrea Leigh McCracken Pringle
发明人： Brian Murphy , Ben Lane , Austin Cox , Alexander Flamm , Andy Rogers , Justin Muratore , Brian Bean , Andrea Leigh McCracken Pringle
IPC分类号： A61B5/0408
CPC分类号： A61B5/0478 , A61B5/68 , A61B5/6814 , A61B2562/0217
摘要： Disclosed herein is a hair-grasping EEG electrode and an insertion tool for placement of the electrode on the scalp. The electrode has a novel two-piece clamping design formed of cooperating halves that capture and tension the hair, pulling the electrode snuggly against the scalp before locking together to anchor the electrode in place. The insertion tool allows easy manipulation and fast and consistent installation without need for lengthy user training and practice. Moreover, the insertion tool assumes some of the functionality so that the electrode can be simplified, allowing a smaller footprint and part count, as well as allowing the non-conductive portions of the electrode to be disposable. Dispensing of electrolytic gel is a convenient option to improve the interface, and this may be readily dispensed from the tool, or from reservoirs integral to the electrode. The combination greatly reduces EEG study setup time and technician labor costs.
摘要翻译：本文公开了一种护发型EEG电极和用于将电极放置在头皮上的插入工具。电极具有新颖的两片式夹持设计，由配合的一半形成，捕获和张紧头发，将电极紧贴头皮拉动，然后锁定在一起以将电极锚定在适当位置。插入工具允许轻松操作和快速一致的安装，无需长时间的用户培训和练习。此外，插入工具具有一些功能，使得电极可以被简化，允许更小的占地面积和部件数量，以及允许电极的非导电部分是一次性的。电解凝胶的分配是改善界面的方便的选择，并且这可以容易地从工具分配，或者从与电极成一体的储存器中分配。该组合大大降低了EEG研究设置时间和技术人员的劳动力成本。

2. 发明授权

US08158062B2 Disposable fluid sample collection device 有权
标题翻译：一次性液体样品收集装置
公开(公告)号：US08158062B2
公开(公告)日：2012-04-17
申请号：US10578453
申请日：2004-11-05
申请人： Chris Dykes , Ben Lane , Mike Abbott , Brian Murphy , Eva Dixon , Brian Bean , Brian Lipford , Samuel Reed
发明人： Chris Dykes , Ben Lane , Mike Abbott , Brian Murphy , Eva Dixon , Brian Bean , Brian Lipford , Samuel Reed
IPC分类号： B01J19/00
CPC分类号： B01L3/50273 , A61B5/14532 , A61B5/14546 , A61B5/150022 , A61B5/150229 , A61B5/150259 , A61B5/150343 , A61B5/157 , B01L2300/0825 , B01L2400/0406 , B01L2400/0481
摘要： A fluid sampling device (100) that operates by a combination of capillary action to collect a small fluid sample, and by pressure differential when inserted into an analyzer (200) to expose the fluid sample for testing by the analyzer (200). The device is especially suited for use as a disposable blood sampling unit designed to interface with a blood analyzer, albeit the concept of the invention may be employed for sampling and testing virtually any fluids.
摘要翻译：一种流体采样装置（100），其通过毛细管作用的组合来收集小的流体样品，以及当插入到分析器（200）中时通过压差来暴露流体样本以供分析器（200）测试。该装置特别适合用作设计成与血液分析仪相接口的一次性血液采样单元，尽管可以采用本发明的概念来对实际上任何流体进行取样和测试。

3. 发明授权

US09114399B2 System and method for serial processing of multiple nucleic acid assays 有权
标题翻译：用于多重核酸测定的连续加工的系统和方法
公开(公告)号：US09114399B2
公开(公告)日：2015-08-25
申请号：US13223290
申请日：2011-08-31
申请人： Ivor T. Knight , Kenton C. Hasson , Johnathan S. Coursey , Hongye Liang , Sami Kanderian , Gregory H. Owen , Weidong Cao , Ying-Xin Wang , Scott Corey , Ben Lane , Conrad Laskowski , Alex Flamm , Brian Murphy , Eric Schneider , Takayoshi Hanagata , Hiroshi Inoue , Shulin Zeng , Brian Bean , Franklin Regan
发明人： Ivor T. Knight , Kenton C. Hasson , Johnathan S. Coursey , Hongye Liang , Sami Kanderian , Gregory H. Owen , Weidong Cao , Ying-Xin Wang , Scott Corey , Ben Lane , Conrad Laskowski , Alex Flamm , Brian Murphy , Eric Schneider , Takayoshi Hanagata , Hiroshi Inoue , Shulin Zeng , Brian Bean , Franklin Regan
IPC分类号： B01L7/00 , C12Q1/68 , G01N35/08 , B01L3/00 , G01N35/10
CPC分类号： B01L3/502746 , B01L3/502784 , B01L7/52 , B01L7/525 , B01L2200/025 , B01L2200/027 , B01L2200/028 , B01L2200/10 , B01L2300/0663 , B01L2300/0816 , B01L2300/1822 , B01L2300/1827 , B01L2300/1844 , B01L2400/0487 , C12Q1/686 , G01N21/77 , G01N35/08 , G01N35/1095 , G01N2021/7786 , C12Q2561/113 , C12Q2565/629
摘要： The present invention relates to systems and methods for the real time processing of nucleic acid during polymerase chain reaction (PCR) and thermal melt applications. According to an aspect of the invention, a system for the rapid serial processing of multiple nucleic acid assays is provided. In one embodiment, the system includes, but is not limited to: a microfluidic cartridge having microfluidic (flow-through) channels, a fluorescence imaging system, a temperature measurement and control system; a pressure measurement and control system for applying variable pneumatic pressures to the microfluidic cartridge; a storage device for holding multiple reagents (e.g., a well-plate); a liquid handling system comprising at least one robotic pipettor for aspirating, mixing, and dispensing reagent mixtures to the microfluidic cartridge; systems for data storage, processing, and output; and a system controller to coordinate the various devices and functions.
摘要翻译：本发明涉及用于在聚合酶链反应（PCR）和热熔体应用中实时处理核酸的系统和方法。根据本发明的一个方面，提供了用于多重核酸测定的快速连续处理的系统。在一个实施例中，该系统包括但不限于：具有微流体（流通）通道的微流控筒，荧光成像系统，温度测量和控制系统; 压力测量和控制系统，用于将可变气动压力施加到微流控筒; 用于容纳多个试剂（例如，孔板）的储存装置; 液体处理系统，包括至少一个用于将试剂混合物抽吸，混合和分配到微流控盒的机器人移液器; 用于数据存储，处理和输出的系统; 和一个系统控制器来协调各种设备和功能。

4. 发明申请

US20120052560A1 SYSTEM AND METHOD FOR SERIAL PROCESSING OF MULTIPLE NUCLEIC ACID ASSAYS 有权
标题翻译：多种核酸分析系统和方法的串行处理
公开(公告)号：US20120052560A1
公开(公告)日：2012-03-01
申请号：US13223290
申请日：2011-08-31
申请人： Ivor T. Knight , Kenton C. Hasson , Johnathan S. Coursey , Hongye Liang , Sami Kanderian , Gregory H. Owen , Weidong Cao , Ying-Xin Wang , Scott Corey , Ben Lane , Conrad Laskowski , Alex Flamm , Brian Murphy , Eric Schneider , Takayoshi Hanagata , Hiroshi Inoue , Shulin Zeng , Brian Bean , Franklin Regan
发明人： Ivor T. Knight , Kenton C. Hasson , Johnathan S. Coursey , Hongye Liang , Sami Kanderian , Gregory H. Owen , Weidong Cao , Ying-Xin Wang , Scott Corey , Ben Lane , Conrad Laskowski , Alex Flamm , Brian Murphy , Eric Schneider , Takayoshi Hanagata , Hiroshi Inoue , Shulin Zeng , Brian Bean , Franklin Regan
IPC分类号： C12M1/40
CPC分类号： B01L3/502746 , B01L3/502784 , B01L7/52 , B01L7/525 , B01L2200/025 , B01L2200/027 , B01L2200/028 , B01L2200/10 , B01L2300/0663 , B01L2300/0816 , B01L2300/1822 , B01L2300/1827 , B01L2300/1844 , B01L2400/0487 , C12Q1/686 , G01N21/77 , G01N35/08 , G01N35/1095 , G01N2021/7786 , C12Q2561/113 , C12Q2565/629
摘要： The present invention relates generally to systems and methods for the rapid serial processing of multiple nucleic acid assays. More particularly, the present invention provides for the real time processing of nucleic acid during polymerase chain reaction (PCR) and thermal melt applications. According to an aspect of the invention, a system for the rapid serial processing of multiple nucleic acid assays is provided. In one embodiment, the system includes, but is not limited to: a microfluidic cartridge having microfluidic (flow-through) channels, a fluorescence imaging system, a temperature measurement and control system; a pressure measurement and control system for applying variable pneumatic pressures to the microfluidic cartridge; a storage device for holding multiple reagents (e.g., a well-plate); a liquid handling system comprising at least one robotic pipettor for aspirating, mixing, and dispensing reagent mixtures to the microfluidic cartridge; systems for data storage, processing, and output; and a system controller to coordinate the various devices and functions.
摘要翻译：本发明一般涉及用于多重核酸测定的快速连续加工的系统和方法。更具体地说，本发明提供了在聚合酶链反应（PCR）和热熔体应用中核酸的实时处理。根据本发明的一个方面，提供了用于多重核酸测定的快速连续处理的系统。在一个实施例中，该系统包括但不限于：具有微流体（流通）通道的微流控筒，荧光成像系统，温度测量和控制系统; 压力测量和控制系统，用于将可变气动压力施加到微流控筒; 用于容纳多个试剂（例如，孔板）的储存装置; 液体处理系统，包括至少一个用于将试剂混合物抽吸，混合和分配到微流控盒的机器人移液器; 用于数据存储，处理和输出的系统; 和一个系统控制器来协调各种设备和功能。

5. 外观设计

USD522657S1 Ultrasonic determination of red blood cell indices device 失效
标题翻译：超声波测定红细胞指数装置
公开(公告)号：USD522657S1
公开(公告)日：2006-06-06
申请号：US29192185
申请日：2003-10-20
申请人： Brian Murphy , Chris Dykes , Eva Dixon , Brian Lipford , Samuel Reed , Ben Lane , Mike Abbott , Brian Bean
设计人： Brian Murphy , Chris Dykes , Eva Dixon , Brian Lipford , Samuel Reed , Ben Lane , Mike Abbott , Brian Bean

6. 发明申请

US20100152749A1 Table-mounted surgical instrument stabilizers with single-handed or voice activated maneuverability 审中-公开
标题翻译：台式手术器械稳定器具有单手或声控激活的机动性
公开(公告)号：US20100152749A1
公开(公告)日：2010-06-17
申请号：US12584366
申请日：2009-09-03
申请人： Walter von Pechmann , Samuel C. Yoon , Ben Lane , Keith Lipford , Austin Cox
发明人： Walter von Pechmann , Samuel C. Yoon , Ben Lane , Keith Lipford , Austin Cox
IPC分类号： A61B19/00
CPC分类号： A61B90/50 , A61B2090/508 , A61B2090/571
摘要： A surgical instrument stabilizer system for securely holding virtually any instrument during any procedure, delivering vacuum when applicable, and yet allowing easy single-handed or voice activated repositioning by a user. The system utilizes opposing horizontal side-rails mounted to opposing sides of a surgical table, and opposing arms each slidably mounted on a side rail for global lengthwise positioning along the side rails. The arms carry a transverse beam at the foot of the operating table, and a flexible arm is movably mounted on the beam for global lengthwise positioning along the beam. Alternately, the flexible arm may be affixed directly to one of the existing horizontal side rails. The flexible arm leads to an instrument-supporting hand piece pivotally mounted for angular orientation of an instrument supported thereby. The flexible arm can be freely articulated to any position and locked in place. Thus, a supported instrument can be repositioned quickly and easily by single-handed or voice activated manipulation by a surgeon or surgical assistant, and locked in any position up and down along a vertical axis, forward and back, i.e, toward or away from the patient, and rotationally.
摘要翻译：一种手术器械稳定器系统，用于在任何程序中可靠地夹持任何仪器，在适用时提供真空，并允许用户轻松进行单手或声音激活的重新定位。该系统利用安装在手术台的相对侧的相对的水平侧轨，以及相对的臂，每个臂可滑动地安装在侧轨上，用于沿侧轨整体纵向定位。手臂在手术台的脚部处携带横梁，并且柔性臂可移动地安装在梁上，用于沿着梁的全局纵向定位。或者，柔性臂可以直接固定在现有的水平侧轨之一上。柔性臂通向枢轴安装的仪器支撑手柄，用于由其支撑的仪器的角度定向。柔性臂可以自由铰接到任何位置并锁定到位。因此，可以通过外科医生或外科助手的单手或声音激活的操纵来快速且容易地重新定位被支撑的器械，并且沿着垂直轴线向前和向后，即朝向或远离耐心等候。

7. 发明授权

US08709356B2 Systems and methods for minimization or elimination of diffusion effects in a microfluidic system 有权
标题翻译：用于在微流体系统中最小化或消除扩散效应的系统和方法
公开(公告)号：US08709356B2
公开(公告)日：2014-04-29
申请号：US12758395
申请日：2010-04-12
申请人： Brian Murphy , Scott Corey , Alex Flamm , Ben Lane , Conrad Laskowski , Chad Schneider
发明人： Brian Murphy , Scott Corey , Alex Flamm , Ben Lane , Conrad Laskowski , Chad Schneider
IPC分类号： B01L3/00
CPC分类号： C12Q1/6806 , B01L3/502715 , B01L3/502784 , B01L7/525 , B01L2200/0684 , B01L2200/10 , B01L2200/141 , B01L2200/147 , B01L2300/0816 , B01L2300/0861 , B01L2300/0867 , B01L2300/18 , C12Q2565/629 , F04B49/065 , F04B49/106 , G01N21/66 , G01N33/50 , G01N2035/00544 , H05B1/025 , Y10S435/808 , Y10S436/805 , Y10S436/809 , Y10T436/25
摘要： The present invention relates to systems and methods for minimizing or eliminating diffusion effects. Diffused regions of a segmented flow of multiple, miscible fluid species may be vented off to a waste channel, and non-diffused regions of fluid may be preferentially pulled off the channel that contains the segmented flow. Multiple fluid samples that are not contaminated via diffusion may be collected for analysis and measurement in a single channel. The systems and methods for minimizing or eliminating diffusion effects may be used to minimize or eliminate diffusion effects in a microfluidic system for monitoring the amplification of DNA molecules and the dissociation behavior of the DNA molecules.
摘要翻译：本发明涉及用于最小化或消除扩散效应的系统和方法。多个可混溶流体物质的分段流的扩散区域可以排出到废物通道，并且流体的非扩散区域可以优先地从包含分段流动的通道中拉出。可以收集未经扩散污染的多个流体样品，以便在单个通道中进行分析和测量。可以使用用于最小化或消除扩散效应的系统和方法来最小化或消除用于监测DNA分子的扩增和DNA分子的解离行为的微流体系统中的扩散效应。

8. 外观设计

USD686334S1 Chip station assembly 有权
标题翻译：芯片组装
公开(公告)号：USD686334S1
公开(公告)日：2013-07-16
申请号：US29385967
申请日：2011-02-23
申请人： Eric Schneider , Alex Flamm , Brian Murphy , Chad Schneider , Charly Mar , Ben Lane , Jeremy Savage , Conrad Laskowski
设计人： Eric Schneider , Alex Flamm , Brian Murphy , Chad Schneider , Charly Mar , Ben Lane , Jeremy Savage , Conrad Laskowski

9. 发明授权

US07523649B2 Method and apparatus for ultrasonic determination of hematocrit and hemoglobin concentrations 有权
标题翻译：用于超声波测定血细胞比容和血红蛋白浓度的方法和装置
公开(公告)号：US07523649B2
公开(公告)日：2009-04-28
申请号：US10580697
申请日：2004-11-26
申请人： Francis Scott Corey , Ben Lane , Brian Murphy , Brian Lipford , Samuel Reed
发明人： Francis Scott Corey , Ben Lane , Brian Murphy , Brian Lipford , Samuel Reed
IPC分类号： G01N15/06 , G01N29/00
CPC分类号： A61B5/14546 , A61B5/14535 , A61B5/150022 , A61B5/150229 , A61B5/150259 , A61B5/150343 , A61B5/15087 , A61B5/150969 , A61B5/15142 , A61B5/157 , A61B8/00 , G01N29/024 , G01N29/032 , G01N33/49 , G01N2291/02466 , G01N2291/02881 , G01N2291/044
摘要： An ultrasonic field-portable system for accurately measuring hematocrit (HCT) and hemoglobin concentration (HGB) in small food samples. The system includes an analyzer (10) that allows extremely accurate measurements of blood hematocrit from only one or two drops of +>>d collected in a disposable sampling device (12) that is then inserted into the analyzer (10). The system is compact enough to package into a point of care device, making it a point of care device with accuracy comparable to larger CBC lab equipment.
摘要翻译：一种用于在小食品样品中精确测量血细胞比容（HCT）和血红蛋白浓度（HGB）的超声波现场便携式系统。该系统包括分析器（10），其允许在一次性采样装置（12）中收集的仅一个或两滴+ >> d的血液血细胞比容的非常精确的测量，然后将其插入分析器（10）。该系统足够紧凑，可以将其包装到护理设备中，使其成为与较大CBC实验室设备相当的精确点。

10. 发明申请

US20070266778A1 Method and Apparatus for Ultrasonic Determination of Hematocrit and Hemoglobin Concentrations 有权
标题翻译：超声波测定血细胞比容和血红蛋白浓度的方法和装置
公开(公告)号：US20070266778A1
公开(公告)日：2007-11-22
申请号：US10580697
申请日：2004-11-26
申请人： Francis Corey , Ben Lane , Brian Murphy , Brian Lipford , Samuel Reed
发明人： Francis Corey , Ben Lane , Brian Murphy , Brian Lipford , Samuel Reed
IPC分类号： G01N29/00
CPC分类号： A61B5/14546 , A61B5/14535 , A61B5/150022 , A61B5/150229 , A61B5/150259 , A61B5/150343 , A61B5/15087 , A61B5/150969 , A61B5/15142 , A61B5/157 , A61B8/00 , G01N29/024 , G01N29/032 , G01N33/49 , G01N2291/02466 , G01N2291/02881 , G01N2291/044
摘要： An ultrasonic field-portable system for accurately measuring hematocrit (HCT) and hemoglobin concentration (HGB) in small food samples. The system includes an analyzer (10) that allows extremely accurate measurements of blood hematocrit from only one or two drops of +>>d collected in a disposable sampling device (12) that is then inserted into the analyzer (10). The system is compact enough to package into a point of care device, making it a point of care device with accuracy comparable to larger CBC lab equipment.
摘要翻译：一种用于在小食品样品中精确测量血细胞比容（HCT）和血红蛋白浓度（HGB）的超声波现场便携式系统。该系统包括分析器（10），其允许在一次性采样装置（12）中收集的仅一个或两滴+ >> d的血液血细胞比容的非常精确的测量，然后将其插入分析器（10）。该系统足够紧凑，可以将其包装到护理设备中，使其成为与较大CBC实验室设备相当的精确点。

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