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1. 发明申请

US20120218001A1 Techniques for Phase Detection 审中-公开
标题翻译：相位检测技术
公开(公告)号：US20120218001A1
公开(公告)日：2012-08-30
申请号：US13505714
申请日：2010-10-31
申请人： Brian Leibowitz , Hae-Chang Lee , Farshid Aryanfar , Kun-Yung Chang , Jie Shen
发明人： Brian Leibowitz , Hae-Chang Lee , Farshid Aryanfar , Kun-Yung Chang , Jie Shen
IPC分类号： H03D13/00
CPC分类号： H03D13/00 , H03L7/08 , H03L7/0814 , H03L7/0816 , H03L7/085
摘要： A phase detection circuit can include two phase detectors that each generate a non-zero output in response to input signals being aligned in phase. The input signals are based on two periodic signals. The phase detection circuit subtracts the output signal of one phase detector from the output signal of the other phase detector to generate a signal having a zero value when the periodic signals are in phase. Alternatively, a phase detector generates a phase comparison signal indicative of a phase difference between periodic signals. The phase comparison signal has a non-zero value in response to input signals to the phase detector being aligned in phase. The input signals are based on the periodic signals. An output circuit receives the phase comparison signal and generates an output having a zero value in response to the periodic signals being aligned in phase.
摘要翻译：相位检测电路可以包括两个相位检测器，每个相位检测器响应于同相对准的输入信号而产生非零输出。输入信号基于两个周期信号。相位检测电路从另一相位检测器的输出信号中减去一相位检测器的输出信号，当周期信号同相时产生具有零值的信号。或者，相位检测器产生指示周期信号之间的相位差的相位比较信号。相位比较信号响应于相位检测器的相位输入信号具有非零值。输入信号基于周期信号。输出电路接收相位比较信号，并响应于同相对齐的周期信号产生具有零值的输出。

2. 发明申请

US20100281289A1 Bidirectional Memory Interface with Glitch Tolerant Bit Slice Circuits 审中-公开
标题翻译：具有毛刺允许位片电路的双向存储器接口
公开(公告)号：US20100281289A1
公开(公告)日：2010-11-04
申请号：US12743075
申请日：2008-11-14
申请人： Kun-Yung Chang , Jie Shen , Hae-Chang Lee , Fariborz Assaderaghi , Richard E. Perego , Jung-Hoon Chun
发明人： Kun-Yung Chang , Jie Shen , Hae-Chang Lee , Fariborz Assaderaghi , Richard E. Perego , Jung-Hoon Chun
IPC分类号： G06F1/12 , G06F1/04 , H03L7/06 , H03H7/01 , G06G7/12
CPC分类号： G06F13/1689
摘要： A bit slice circuit having transmit and receive modes of operation is described. The bit slice circuit comprises: first transmit circuitry and first receive circuitry operating in a first clock domain, wherein the first circuitry receives a first clock signal; second transmit circuitry and second receive circuitry operating in a second clock domain, wherein the second circuitry receives a second clock signal; transmit transition circuitry and receive transition circuitry, the transmit transition circuitry coupling the first transmit circuitry to the second transmit circuitry, the receive transition circuitry coupling the first receive circuitry to the second receive circuitry, wherein the transition circuitry receives the first and second clock signals; and a single phase mixer that generates the second clock signal, wherein the second clock signal has a first phase in the transmit mode of operation and second phase in the receive mode of operation.
摘要翻译：描述了具有发送和接收操作模式的位分片电路。所述位片电路包括：第一发射电路和在第一时钟域中操作的第一接收电路，其中所述第一电路接收第一时钟信号; 第二发送电路和在第二时钟域中操作的第二接收电路，其中所述第二电路接收第二时钟信号; 发射转换电路和接收转换电路，所述发射转换电路将所述第一发射电路耦合到所述第二发射电路，所述接收转换电路将所述第一接收电路耦合到所述第二接收电路，其中所述转换电路接收所述第一和第二时钟信号; 以及产生所述第二时钟信号的单相混频器，其中所述第二时钟信号具有所述发送操作模式中的第一相位和所述接收操作模式中的第二相位。

3. 发明授权

US08604822B2 Methods and apparatus for testing electric power devices 有权
标题翻译：电力设备测试方法和装置
公开(公告)号：US08604822B2
公开(公告)日：2013-12-10
申请号：US12956785
申请日：2010-11-30
申请人： Stefan Schroeder , Cyrus David Harbourt , Jie Shen
发明人： Stefan Schroeder , Cyrus David Harbourt , Jie Shen
IPC分类号： G01R31/40
CPC分类号： G01R31/42
摘要： A method of assembling a testing apparatus for a full-power converter assembly includes coupling an electric power supply apparatus to an electric power grid. The method also includes coupling a direct current (DC) generation apparatus to the electric power supply apparatus. The method further includes coupling an electric power grid simulation device to the DC generation apparatus. The method also includes coupling a full-power converter assembly test connection to the electric power grid simulation device.
摘要翻译：一种组装全功率转换器组件的测试装置的方法包括将电力供应装置耦合到电力网。该方法还包括将直流（DC）产生装置耦合到电力供应装置。该方法还包括将电网模拟装置耦合到DC发生装置。该方法还包括将全功率转换器组件测试连接耦合到电力网模拟设备。

4. 发明授权

US08144490B2 Operation of a three level converter 有权
标题翻译：三电平转换器的运行
公开(公告)号：US08144490B2
公开(公告)日：2012-03-27
申请号：US12615566
申请日：2009-11-10
申请人： Said Farouk Said El-Barbari , Robert Roesner , Jie Shen
发明人： Said Farouk Said El-Barbari , Robert Roesner , Jie Shen
IPC分类号： H02M7/487
CPC分类号： H02M7/487 , H02M7/5395 , Y10S323/906
摘要： A method of operating a three level converter includes controlling the output voltage of the converter when a DC link voltage of the three level converter is lower than one-half of a rated DC link voltage of the converter by, for each leg of the converter, alternately connecting an output terminal of the leg to the positive terminal or the negative terminal of the DC link. When the DC link voltage is at least one-half of the rated DC link voltage, the method includes controlling the output voltage of the converter by, for each leg, selectively connecting the output terminal of the converter to the positive terminal, the negative terminal, or a mid-point of the DC link.
摘要翻译：一种操作三电平转换器的方法包括：当三电平转换器的直流母线电压低于转换器的额定直流母线电压的一半时，通过转换器的每个支路来控制转换器的输出电压，交替地将脚的输出端连接到DC链路的正极或负极。当直流母线电压至少为额定直流母线电压的一半时，该方法包括通过对每个支路选择性地将转换器的输出端连接到正极端子来控制转换器的输出电压，负极端子，或DC链路的中点。

5. 发明申请

US20100298205A1 METHODS AND COMPOSITIONS FOR THE TREATMENT OF CONDITIONS RELATED TO GASTRIC ACID SECRETION 审中-公开
标题翻译：用于治疗与胃酸分泌相关的条件的方法和组合物
公开(公告)号：US20100298205A1
公开(公告)日：2010-11-25
申请号：US12639627
申请日：2009-12-16
申请人： Jie Shen , Devin F. Welty , Diane D. Tang-Liu
发明人： Jie Shen , Devin F. Welty , Diane D. Tang-Liu
IPC分类号： A61K38/06 , A61K31/4439 , A61K31/47 , A61P1/00
CPC分类号： A61K31/4704 , A61K31/4439 , A61K38/06 , A61K45/06 , A61K2300/00
摘要： A method comprising orally administering to a mammal a proton pump inhibitor, or a pharmaceutically acceptable prodrug thereof, and a compound which modulates the activity of the MRP2 or other transporter proteins involved in efflux of a proton pump inhibitor or a prodrug, is disclosed herein, said method being effective for the prevention or treatment of a disease or condition related to gastric acid secretion. This method applied to compounds which both inhibit and stimulate MRP2 activity or activity of other transporter proteins involved in efflux of a proton pump inhibitor or a prodrug.Compositions, medicaments, and experimental results related thereto are also disclosed.
摘要翻译：本文公开了一种方法，其包括向哺乳动物施用质子泵抑制剂或其药学上可接受的前药，以及调节参与质子泵抑制剂或前药流出的MRP2或其它转运蛋白的活性的化合物，所述方法对于预防或治疗与胃酸分泌有关的疾病或病症是有效的。该方法适用于抑制和刺激涉及质子泵抑制剂或前体药物流出的其他转运蛋白的MRP2活性或活性的化合物。还公开了与其相关的组合物，药物和实验结果。

6. 发明授权

US07528612B2 System and method for monitoring a motor control center 有权
标题翻译：用于监控电机控制中心的系统和方法
公开(公告)号：US07528612B2
公开(公告)日：2009-05-05
申请号：US11541137
申请日：2006-09-29
申请人： Neil Gollhardt , David L. Jensen , Fahed Awad , Jie Shen , David D. Brandt , David T. Rollay
发明人： Neil Gollhardt , David L. Jensen , Fahed Awad , Jie Shen , David D. Brandt , David T. Rollay
IPC分类号： G01R31/08 , H01R27/02
CPC分类号： H02B13/025 , H02B1/36 , H02B11/02 , H02H3/04 , H02H7/0822
摘要： A system, in one embodiment, includes a power distribution center having an enclosure with an access door configured to move between a closed position and an open position. The power distribution center includes a non-contact sensor disposed inside the enclosure, wherein the non-contact sensor includes a non-contact voltage sensor, or a non-contact temperature sensor, or a combination thereof. The power distribution center also includes an indicator viewable outside of the enclosure while the door is in the closed position, wherein the indicator is coupled to the non-contact sensor.
摘要翻译：在一个实施例中，系统包括配电中心，配电中心具有外壳，其具有被配置为在关闭位置和打开位置之间移动的通道门。配电中心包括设置在外壳内的非接触传感器，其中非接触式传感器包括非接触式电压传感器或非接触式温度传感器，或其组合。在门处于关闭位置时，配电中心还包括可在外壳外部观察的指示器，其中指示器联接到非接触式传感器。

7. 发明申请

US20090090623A1 Biosensor having integrated heating element and electrode with metallic catalyst 审中-公开
标题翻译：具有集成加热元件和电极与金属催化剂的生物传感器
公开(公告)号：US20090090623A1
公开(公告)日：2009-04-09
申请号：US12153272
申请日：2008-05-15
申请人： Min-Chieh Chuang , Yun-Chu Ho , Tai-Kang Shing , Chung-Chiun Liu , Jie Shen
发明人： Min-Chieh Chuang , Yun-Chu Ho , Tai-Kang Shing , Chung-Chiun Liu , Jie Shen
IPC分类号： G01N33/50 , H01B1/22
CPC分类号： H01B1/22 , H01B1/24
摘要： The invention discloses a biosensor includes a strip having an integrated heating element and an electrode with metallized graphite including metal in the range of 0.1-5% in weight; graphite in the range of below 55% in weight; and polymer. The biosensor further includes an electric measuring device having a slot enabling the strip to insert therein.
摘要翻译：本发明公开了一种生物传感器，其包括具有集成加热元件的条带和包含0.1-5重量％范围内金属的金属化石墨的电极; 石墨的重量在55％以下; 和聚合物。生物传感器还包括具有能够将条插入其中的槽的电测量装置。

8. 发明授权

US07271313B2 Presenilin-deficient mouse model of age-dependent neurodegeneration and cognitive loss 失效
标题翻译：早老素缺陷小鼠模型的年龄依赖性神经变性和认知损失
公开(公告)号：US07271313B2
公开(公告)日：2007-09-18
申请号：US10409672
申请日：2003-04-09
申请人： Jie Shen
发明人： Jie Shen
IPC分类号： A01K67/027 , C12N15/00
CPC分类号： A01K67/0276 , A01K2217/075 , A01K2227/105 , A01K2267/0312 , C07K14/4711 , C12N15/8509 , C12N2800/30
摘要： The present invention is directed to recombinantly engineered mice that are deficient in the expression of both presenilin-1 and presenilin-2. The mice exhibit characteristics of age-dependent cognitive impairments and neurodegeneration similar to those seen in Alzheimer's disease patients. This presenilin-deficient mouse model can be used to screen compounds capable of slowing, preventing or reversing the progression of cognitive impairments and neurodegeneration. The invention is also directed to the development of treatments for Alzheimer's disease based on augmentation or restoration of presenilin function in the brain. On the basis of the findings described herein, the invention is further directed to the development of assays to detect functional presenilin deficiency in human individuals, preferably through analysis of presenilin substrates, which may provide biomarkers useful in the diagnosis of Alzheimer's disease.
摘要翻译：本发明涉及缺乏早老素-1和早老蛋白-2的表达的重组工程小鼠。老鼠显示与老年痴呆症患者相似的年龄依赖性认知障碍和神经变性的特征。这种早老素缺乏型小鼠模型可用于筛选能够减缓，预防或逆转认知障碍和神经退行性进展的化合物。本发明还涉及基于大脑中早老素功能的增强或恢复的阿尔茨海默病治疗的发展。基于本文所述的发现，本发明进一步涉及开发用于检测人类个体中功能性早老素缺乏症的测定法，优选通过分析早老素底物，其可以提供可用于诊断阿尔茨海默氏病的生物标志物。

9. 发明申请

US20210244851A1 COMPOSITIONS AND METHODS FOR TARGETING ANGIOGENESIS FOR FRACTURE NONUNION TREATMENT UNDER INFLAMMATORY DISEASES 有权
公开(公告)号：US20210244851A1
公开(公告)日：2021-08-12
申请号：US17170310
申请日：2021-02-08
申请人： Jie Shen , Jianjun Guan
发明人： Jie Shen , Jianjun Guan
IPC分类号： A61L27/22 , A61L27/58 , A61L27/18
摘要： Methods and formulations for promoting the healing of fracture nonunion sites under inflammatory conditions. The formulation includes a flexible biodegradable scaffold loaded with therapeutically effective amounts of CXCL12 and SPPI encapsulated in biodegradable microspheres. The method includes applying the formulation directly to a region of a fracture nonunion to effect sustained local release of the therapeutically effective amounts of CXCL12 and SPPI to the fracture nonunion region.

10. 发明申请

US20130194881A1 AREA-EFFICIENT MULTI-MODAL SIGNALING INTERFACE 审中-公开
标题翻译：区域多模式信号接口
公开(公告)号：US20130194881A1
公开(公告)日：2013-08-01
申请号：US13878419
申请日：2011-11-07
申请人： Steven C. Woo , Amir Amirkhany , Catherine Chen , David Secker , Jie Shen
发明人： Steven C. Woo , Amir Amirkhany , Catherine Chen , David Secker , Jie Shen
IPC分类号： G11C7/00
CPC分类号： G11C7/00 , G06F13/1694
摘要： One or more pins may be modally assigned to either the command/address (C/A) or data (DQ) blocks of a uniform-package, multi-modal PHY (physical signaling interface) of a memory controller, thus enabling those pins to be used as C/A pins when the PHY is connected to some memory types, and as DQ pins when the PHY is connected to other memory types.
摘要翻译：一个或多个引脚可以被模式地分配给存储器控制器的均匀封装，多模态PHY（物理信令接口）的命令/地址（C / A）或数据（DQ）块，从而使得这些引脚当PHY连接到某些存储器类型时，用作C / A引脚，当PHY连接到其他存储器类型时用作引脚。

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