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1. 发明授权

US08352035B2 Connector assemblies for implantable stimulators 有权
公开(公告)号：US08352035B2
公开(公告)日：2013-01-08
申请号：US12262789
申请日：2008-10-31
申请人： Brett Schleicher , Rafael Carbunaru , Todd K. Whitehurst , Kristen N. Jaax , Greg Baldwin , Andrew DiGiore
发明人： Brett Schleicher , Rafael Carbunaru , Todd K. Whitehurst , Kristen N. Jaax , Greg Baldwin , Andrew DiGiore
IPC分类号： A61N1/00
CPC分类号： A61N1/3754 , A61N1/37205 , A61N1/37235 , A61N1/375 , A61N1/3752 , A61N1/3787
摘要： Exemplary systems include a stimulator configured to be implanted within a patient, the stimulator having a body defined by at least one side surface disposed in between distal and proximal end surfaces, and a connector assembly configured to be coupled to the stimulator and extend parallel to the at least one side surface of the stimulator. The connector assembly is further configured to facilitate removable coupling of a lead having one or more electrodes disposed thereon to the stimulator.

2. 发明申请

US20110295330A1 ANCHORING UNITS FOR LEADS OF IMPLANTABLE ELECTRIC STIMULATION SYSTEMS AND METHODS OF MAKING AND USING 有权
标题翻译：可植入电刺激系统引导锚固单元及其制造和使用方法
公开(公告)号：US20110295330A1
公开(公告)日：2011-12-01
申请号：US13207876
申请日：2011-08-11
申请人： Brett Schleicher , Andrew DiGiore , Rafael Carbunaru , Courtney Lane , Kristen N. Jaax
发明人： Brett Schleicher , Andrew DiGiore , Rafael Carbunaru , Courtney Lane , Kristen N. Jaax
IPC分类号： A61N1/36 , A61N1/05
CPC分类号： A61N1/0558
摘要： A nerve stimulation lead has a distal end, a proximal end, and a longitudinal length. The nerve stimulation lead includes a plurality of electrodes disposed at the distal end, a plurality of terminals disposed at the proximal end, and a plurality of conductive wires electrically coupling the plurality of electrodes electrically to the plurality of terminals. The nerve stimulation lead also includes at least one anchoring unit disposed on the nerve stimulation lead. The at least one anchoring unit is configured and arranged for anchoring the nerve stimulation lead against a bony structure.
摘要翻译：神经刺激引线具有远端，近端和纵向长度。神经刺激引线包括设置在远端的多个电极，设置在近端的多个端子，以及将多个电极电连接到多个端子的多个导线。神经刺激引线还包括设置在神经刺激引线上的至少一个锚定单元。所述至少一个锚定单元被配置和布置成用于将神经刺激引线抵靠骨结构锚定。

3. 发明申请

US20090248095A1 ANCHORING UNITS FOR LEADS OF IMPLANTABLE ELECTRIC STIMULATION SYSTEMS AND METHODS OF MAKING AND USING 有权
标题翻译：可植入电刺激系统引导锚固单元及其制造和使用方法
公开(公告)号：US20090248095A1
公开(公告)日：2009-10-01
申请号：US12413081
申请日：2009-03-27
申请人： Brett Schleicher , Andrew DiGiore , Rafael Carbunaru , Courtney Lane , Kristen N. Jaax
发明人： Brett Schleicher , Andrew DiGiore , Rafael Carbunaru , Courtney Lane , Kristen N. Jaax
IPC分类号： A61N1/00 , A61N1/04
CPC分类号： A61N1/0558
摘要： A nerve stimulation lead has a distal end, a proximal end, and a longitudinal length. The nerve stimulation lead includes a plurality of electrodes disposed at the distal end, a plurality of terminals disposed at the proximal end, and a plurality of conductive wires electrically coupling the plurality of electrodes electrically to the plurality of terminals. The nerve stimulation lead also includes at least one anchoring unit disposed on the nerve stimulation lead. The at least one anchoring unit is configured and arranged for anchoring the nerve stimulation lead against a bony structure.
摘要翻译：神经刺激引线具有远端，近端和纵向长度。神经刺激引线包括设置在远端的多个电极，设置在近端的多个端子，以及将多个电极电连接到多个端子的多个导线。神经刺激引线还包括设置在神经刺激引线上的至少一个锚定单元。所述至少一个锚定单元被配置和布置成用于将神经刺激引线抵靠骨结构锚定。

4. 发明申请

US20090192568A1 METHODS AND SYSTEMS FOR TREATING SEIZURES CAUSED BY BRAIN STIMULATION 失效
标题翻译：用于治疗由脑刺激引起的疾病的方法和系统
公开(公告)号：US20090192568A1
公开(公告)日：2009-07-30
申请号：US12339639
申请日：2008-12-19
申请人： Todd K. Whitehurst , Rafael Carbunaru , Kristen N. Jaax , Andrew DiGiore , Brett Schleicher , Greg Baldwin
发明人： Todd K. Whitehurst , Rafael Carbunaru , Kristen N. Jaax , Andrew DiGiore , Brett Schleicher , Greg Baldwin
IPC分类号： A61N1/36 , A61M37/00
CPC分类号： A61N1/36064 , A61N1/0529 , A61N1/0534 , A61N1/36082 , A61N1/37205 , A61N1/3756
摘要： Methods for treating seizures caused by brain stimulation include providing a stimulator, programming the stimulator with one or more stimulation parameters configured to treat a medical condition, applying at least one stimulus with the stimulator to a stimulation site within the brain of a patient in accordance with the one or more stimulation parameters, and monitoring the patient for a seizure caused by the at least one stimulus.
摘要翻译：用于治疗由脑刺激引起的癫痫发作的方法包括提供刺激器，用刺激器编程配置成治疗医疗状况的一个或多个刺激参数，使用刺激器施加至少一个刺激到患者脑内的刺激部位，一个或多个刺激参数，以及监测由至少一个刺激引起的癫痫发作的患者。

5. 发明授权

US08709030B1 Explanting implantable devices 失效
标题翻译：外植体装置
公开(公告)号：US08709030B1
公开(公告)日：2014-04-29
申请号：US12322137
申请日：2009-01-28
申请人： Brett Schleicher
发明人： Brett Schleicher
IPC分类号： A61B17/32
CPC分类号： A61B17/3415 , A61B17/32053 , A61B17/3209 , A61B17/3468 , A61N1/37205
摘要： Systems and techniques for explanting implantable devices are described. In one aspect, a device includes an explant tool configured to explant an implantable device from a body. The explant tool includes an elongate shank comprising a forward portion defining a longitudinal passage and a front tip attached to the forward portion and defining an opening to the longitudinal passage defined by the forward portion. The front tip comprises a slanted surface that slopes in a direction so as to spread tissue during forward penetration of the front tip into the body.
摘要翻译：描述了用于移植植入式装置的系统和技术。在一个方面，一种装置包括外植体工具，其被配置为从身体移除可植入装置。外植体包括细长的柄部，其包括限定纵向通道的前部部分和附接到前部部分并限定由前部限定的纵向通道的开口的前部尖端。前端包括倾斜的表面，该倾斜表面沿着前方尖端前进穿入体内的方向倾斜以便传播组织。

6. 发明授权

US08670833B2 Methods and apparatus for using sensors with a deep brain stimulation system 有权
标题翻译：使用具有深脑刺激系统的传感器的方法和装置
公开(公告)号：US08670833B2
公开(公告)日：2014-03-11
申请号：US12959890
申请日：2010-12-03
申请人： James Makous , Brett Schleicher , Rafael Carbunaru , Kristen Jaax , Andrew DiGiore
发明人： James Makous , Brett Schleicher , Rafael Carbunaru , Kristen Jaax , Andrew DiGiore
IPC分类号： A61N1/00
CPC分类号： A61N1/36139 , A61N1/0534
摘要： A system and method for applying stimulation to a target stimulation site within a patient, while avoiding undesirable eye movement side effects of the stimulation, are provided. The method includes determining whether eye movement, sensed by internal or external electrodes, is a side effect of a conveyed electrical stimulus. If the eye movement is a side effect, the electrical current distribution of the stimulus is modified in order to steer a locus of the electrical stimulus from one tissue region of the patient to another different tissue region of the patient, thereby mitigating the eye movement side effects. For example, the locus of the electrical stimulus may be steered away from the oculomotor nerve. Eye movement side effects of DBS treatment may include apraxia of lid opening, downward movement and adduction of only one eyeball, and/or continuous deviation of both eyeballs.
摘要翻译：提供了一种用于将刺激应用于患者内的目标刺激部位同时避免刺激的不期望的眼睛运动副作用的系统和方法。该方法包括确定由内部或外部电极感测的眼睛运动是否是所传送的电刺激的副作用。如果眼睛运动是副作用，则刺激的电流分布被修改以便将电刺激的轨迹从患者的一个组织区域引导到患者的另一不同组织区域，从而减轻眼睛运动侧效果。例如，电刺激的轨迹可以被转向离开眼动神经。 DBS治疗的眼睛运动副作用可能包括盖开口的不适，仅有一只眼球的向下运动和内收，和/或两只眼球的连续偏差。

7. 发明授权

US08636693B2 Propellant pillow 失效
标题翻译：推进剂枕头
公开(公告)号：US08636693B2
公开(公告)日：2014-01-28
申请号：US13095258
申请日：2011-04-27
申请人： Brett Schleicher
发明人： Brett Schleicher
IPC分类号： A61M1/00
CPC分类号： A61M5/14276 , A61M5/14593
摘要： A propellant pillow for use in an implantable pump is described herein. The propellant pillow generally includes a propellant bag having a septum attached thereto. In one embodiment, the pillow may further include a rigid member associated with the propellant bag to prevent piercing of the bag by an injection device inserted through the septum during a filling process. In another embodiment, the propellant pillow includes a propellant bag having a surrounding layer of resealable material encompassing the bag. The surrounding layer also serves to prevent piercing of the bag during filling of the pillow with a propellant. Methods of filling such propellant pillows with propellant as well as utilizing such pillows in connection with implantable pumps are also described herein.
摘要翻译：这里描述了用于可植入泵的推进剂枕头。推进剂枕头通常包括具有附着于其上的隔膜的推进剂袋。在一个实施例中，枕头可以进一步包括与推进剂袋相关联的刚性构件，以防止在填充过程中插入穿过隔膜的注射装置刺穿袋。在另一个实施方案中，推进剂枕头包括具有围绕该袋的可再密封材料的周围层的推进剂袋。周围层还用于在用推进剂填充枕头期间防止袋刺穿。这里还描述了用推进剂填充这种推进剂枕头以及利用与可植入泵结合的这种枕头的方法。

8. 发明授权

US08600512B2 Methods and systems for treating seizures caused by brain stimulation 失效
公开(公告)号：US08600512B2
公开(公告)日：2013-12-03
申请号：US12339639
申请日：2008-12-19
申请人： Todd K. Whitehurst , Rafael Carbunaru , Kristen N. Jaax , Andrew DiGiore , Brett Schleicher , Greg Baldwin
发明人： Todd K. Whitehurst , Rafael Carbunaru , Kristen N. Jaax , Andrew DiGiore , Brett Schleicher , Greg Baldwin
IPC分类号： A61N1/00
CPC分类号： A61N1/36064 , A61N1/0529 , A61N1/0534 , A61N1/36082 , A61N1/37205 , A61N1/3756
摘要： Methods for treating seizures caused by brain stimulation include providing a stimulator, programming the stimulator with one or more stimulation parameters configured to treat a medical condition, applying at least one stimulus with the stimulator to a stimulation site within the brain of a patient in accordance with the one or more stimulation parameters, and monitoring the patient for a seizure caused by the at least one stimulus.

9. 发明申请

US20130103006A1 MESH PROTECTION SYSTEM 审中-公开
标题翻译： MESH保护系统
公开(公告)号：US20130103006A1
公开(公告)日：2013-04-25
申请号：US13276469
申请日：2011-10-19
申请人： Brett Schleicher
发明人： Brett Schleicher
IPC分类号： A61M5/142
CPC分类号： A61M5/14276 , A61M39/0208 , A61M2039/0081 , A61M2039/009 , A61M2039/0238 , A61M2209/045
摘要： An improved safety feature for preventing overdosage to a patient is disclosed. In one embodiment, the feature includes an improved screen member that prevents the inadvertent entry of a needle having too large a diameter. The screen member includes a plurality of holes that are configured so as to rid unwanted dead spaces that can damage an injection device during injection. Another embodiment of the safety feature includes a plurality of pins situated so as to similarly create a plurality of openings for reception of certain sized injection devices. Methods of providing a bolus dose to a patient are also disclosed.
摘要翻译：公开了用于防止患者过量的改进的安全特征。在一个实施例中，该特征包括改进的屏幕构件，其防止无意地进入具有太大直径的针。屏幕构件包括多个孔，其被构造成消除在注射期间可能损坏注射装置的不必要的死空间。安全特征的另一个实施例包括多个销，这些销定位成类似地产生用于接收某些尺寸的注射装置的多个开口。还公开了向患者提供推注剂量的方法。

10. 发明申请

US20120277676A1 PROPELLANT PILLOW 失效
公开(公告)号：US20120277676A1
公开(公告)日：2012-11-01
申请号：US13095258
申请日：2011-04-27
申请人： Brett Schleicher
发明人： Brett Schleicher
IPC分类号： A61M5/142 , B65B1/04
CPC分类号： A61M5/14276 , A61M5/14593
摘要： A propellant pillow for use in an implantable pump is described herein. The propellant pillow generally includes a propellant bag having a septum attached thereto. In one embodiment, the pillow may further include a rigid member associated with the propellant bag to prevent piercing of the bag by an injection device inserted through the septum during a filling process. In another embodiment, the propellant pillow includes a propellant bag having a surrounding layer of resealable material encompassing the bag. The surrounding layer also serves to prevent piercing of the bag during filling of the pillow with a propellant. Methods of filling such propellant pillows with propellant as well as utilizing such pillows in connection with implantable pumps are also described herein.
摘要翻译：这里描述了用于可植入泵的推进剂枕头。推进剂枕头通常包括具有附着于其上的隔膜的推进剂袋。在一个实施例中，枕头可以进一步包括与推进剂袋相关联的刚性构件，以防止在填充过程中插入穿过隔膜的注射装置刺穿袋。在另一个实施方案中，推进剂枕头包括具有围绕该袋的可再密封材料的周围层的推进剂袋。周围层还用于在用推进剂填充枕头期间防止袋刺穿。这里还描述了用推进剂填充这种推进剂枕头以及利用与可植入泵结合的这种枕头的方法。

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