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1. 发明授权

US09017667B2 Dosage forms that facilitate rapid activation of barley protease zymogen 有权
标题翻译：促进大麦蛋白酶酶原快速活化的剂型
公开(公告)号：US09017667B2
公开(公告)日：2015-04-28
申请号：US13123219
申请日：2009-10-09
申请人： Bret Berner
发明人： Bret Berner
IPC分类号： A61K38/48 , A61K9/20 , A61K9/48 , A61K9/50 , C12N9/50 , A61K9/16
CPC分类号： A61K38/4873 , A61K9/1623 , A61K9/2013 , A61K9/2077 , A61K9/2095 , A61K9/4858 , A61K9/5042 , A61K9/5084 , C12N9/50
摘要： The therapeutic efficacy of zymogen proteins for oral administration is improved by including in the formulation one or more excipients that optimize pH and other reaction conditions for rapid activation of the zymogen shortly after ingestion.
摘要翻译：通过在制剂中包含一种或多种优化pH和其他反应条件以在摄入后不久快速激活酶原的赋形剂来改善酶原蛋白质用于口服给药的治疗功效。

2. 发明授权

US09000046B2 Gastric retentive dosage forms for extended release of acamprosate into the upper gastrointestinal tract 有权
标题翻译：胃酸滞留剂用于将阿坎酸延长释放到上消化道
公开(公告)号：US09000046B2
公开(公告)日：2015-04-07
申请号：US13247956
申请日：2011-09-28
申请人： Bret Berner , Cuiping Chen
发明人： Bret Berner , Cuiping Chen
IPC分类号： A61K31/16 , A61K9/22 , A61K9/26 , A61K31/185 , A61K9/00 , A61K9/20
CPC分类号： A61K9/0065 , A61K9/2027 , A61K9/2031 , A61K9/2054 , A61K31/185 , A61K47/10
摘要： Gastric retentive dosage forms for sustained release of acamprosate are described which may allow once- or twice-daily dosing for both acute and long-term treatment of a disorder including alcohol dependence, tinnitus, sleep apnea, Parkinson's disease, levodopa-induced dyskinesias in Parkinson's disease, Alzheimer's disease, Huntington's disease, Amyotrophic lateral sclerosis, Cortical spreading depression, migraine, schizophrenia, anxiety, tardive dyskinesia, spasticity, multiple sclerosis, various types pain, or binge eating. Methods of treatment using the dosage forms and methods of making the dosage forms are also described.
摘要翻译：描述了用于持续释放阿坎酸的胃滞留剂型，其可以允许急性和长期治疗包括酒精依赖性，耳鸣，睡眠呼吸暂停，帕金森病，左旋多巴诱导的帕金森氏症运动障碍的疾病的每日一次或两次疾病，阿尔茨海默病，亨廷顿舞蹈病，肌萎缩性侧索硬化，皮质扩张抑郁症，偏头痛，精神分裂症，焦虑症，迟发性运动障碍，痉挛性，多发性硬化，各种类型的疼痛或暴饮暴食。还描述了使用剂型和制备剂型的方法的治疗方法。

3. 发明申请

US20120077878A1 GASTRIC RETENTIVE DOSAGE FORMS FOR EXTENDED RELEASE OF ACAMPROSATE INTO THE UPPER GASTROINTESTINAL TRACT 有权
标题翻译：胃肠增强剂用于延长胃肠激素释放的胃肠道剂量
公开(公告)号：US20120077878A1
公开(公告)日：2012-03-29
申请号：US13247956
申请日：2011-09-28
申请人： Bret Berner , Cuiping Chen
发明人： Bret Berner , Cuiping Chen
IPC分类号： A61K31/185 , A61P25/32
CPC分类号： A61K9/0065 , A61K9/2027 , A61K9/2031 , A61K9/2054 , A61K31/185 , A61K47/10
摘要： Gastric retentive dosage forms for sustained release of acamprosate are described which may allow once- or twice-daily dosing for both acute and long-term treatment of a disorder including alcohol dependence, tinnitus, sleep apnea, Parkinson's disease, levodopa-induced dyskinesias in Parkinson's disease, Alzheimer's disease, Huntington's disease, Amyotrophic lateral sclerosis, Cortical spreading depression, migraine, schizophrenia, anxiety, tardive dyskinesia, spasticity, multiple sclerosis, various types pain, or binge eating. Methods of treatment using the dosage forms and methods of making the dosage forms are also described.
摘要翻译：描述了用于持续释放阿坎酸的胃滞留剂型，其可以允许急性和长期治疗包括酒精依赖性，耳鸣，睡眠呼吸暂停，帕金森病，左旋多巴诱导的帕金森氏症运动障碍的疾病的每日一次或两次疾病，阿尔茨海默病，亨廷顿舞蹈病，肌萎缩性侧索硬化，皮质扩张抑郁症，偏头痛，精神分裂症，焦虑症，迟发性运动障碍，痉挛性，多发性硬化，各种类型的疼痛或暴饮暴食。还描述了使用剂型和制备剂型的方法的治疗方法。

4. 发明申请

US20100034895A1 METHODS OF TREATMENT USING A GASTRIC RETAINED GABAPENTIN DOSAGE 有权
标题翻译：使用GASTRIC保留的加巴酚丁剂量治疗方法
公开(公告)号：US20100034895A1
公开(公告)日：2010-02-11
申请号：US12563781
申请日：2009-09-21
申请人： Bret Berner , Sui Yuen Eddie Hou , Gloria M. Gusler
发明人： Bret Berner , Sui Yuen Eddie Hou , Gloria M. Gusler
IPC分类号： A61K9/14 , A61K31/195 , A61P25/00
CPC分类号： A61K9/2866 , A61K9/0004 , A61K9/0065 , A61K9/2031 , A61K9/2054 , A61K9/284 , A61K9/48 , A61K31/195 , A61K45/06 , A61M31/002
摘要： A method of treatment for epilepsy and other disease stasis described, which comprises delivery of gabapentin in a gastric retained dosage form.
摘要翻译：描述了治疗癫痫和其他疾病的方法，其包括在胃保留剂型中递送加巴喷丁。

5. 发明申请

US20050215872A1 Monitoring of physiological analytes 有权
公开(公告)号：US20050215872A1
公开(公告)日：2005-09-29
申请号：US10982166
申请日：2004-11-05
申请人： Bret Berner , Chia-Ming Chiang , Michael Garrison , Janan Jona , Russell Potts , Janet Tamada , Michael Tierney
发明人： Bret Berner , Chia-Ming Chiang , Michael Garrison , Janan Jona , Russell Potts , Janet Tamada , Michael Tierney
IPC分类号： G01N27/28 , A61B5/00 , A61B5/145 , A61B5/1477 , A61N1/30 , G01N27/327 , A61B5/05
CPC分类号： A61B5/1486 , A61B5/14532 , A61B5/150022 , A61B5/150091 , A61B5/157 , A61N1/30 , C12Q1/006
摘要： Methods and devices are provided for measuring the concentration of target chemical analytes present in a biological system. Device configuration and/or measurement techniques are employed in order to reduce the effect of interfering species on sensor sensitivity. One important application of the invention involves a method and device for monitoring blood glucose values.

6. 发明授权

US06488962B1 Tablet shapes to enhance gastric retention of swellable controlled-release oral dosage forms 有权
标题翻译：片剂形状以增强可膨胀控释口服剂型的胃滞留
公开(公告)号：US06488962B1
公开(公告)日：2002-12-03
申请号：US09598061
申请日：2000-06-20
申请人： Bret Berner , Jenny Louie-Helm
发明人： Bret Berner , Jenny Louie-Helm
IPC分类号： A61K914
CPC分类号： A61K9/0065 , A61K9/2031 , A61K9/2072
摘要： The retention of oral drug dosage forms in the stomach is improved by using swellable dosage forms that are shaped in a manner that will prevent them from inadvertently passing through the pylorus as a result of being in a particular orientation. The planar projection of the shape is one that has two orthogonal axes of different lengths, the longer being short enough to permit easy swallowing prior to swelling while the shorter is long enough within one-half hour of swelling to prevent passage through the pylorus.
摘要翻译：口服药物剂型在胃中的保留通过使用可膨胀的剂型来改善，其可以以防止它们因特定方向而无意地穿过幽门的方式成型。形状的平面突起是具有不同长度的两个正交轴的平面突起，其长度足够短以允许在肿胀之前容易吞咽，而较短的时间足以在半小时内膨胀以防止通过幽门。

7. 发明授权

US06068853A Temporally controlled drug delivery systems 失效
标题翻译：临时控制药物输送系统
公开(公告)号：US06068853A
公开(公告)日：2000-05-30
申请号：US542580
申请日：1995-10-13
申请人： Steven Andrew Giannos , Steven Minh Dinh , Bret Berner
发明人： Steven Andrew Giannos , Steven Minh Dinh , Bret Berner
IPC分类号： A61K9/00 , A61K9/70
CPC分类号： A61K9/7084 , A61K9/0002
摘要： A delivery mechanism and device for the passive periodic release of a drug or an active ingredient which avoids the need for external power sources and/or electronic controllers. By taking advantage of oscillating chemical systems, one can change the state, i.e. the pH, of a solution, a drug, enhancer or solubilizer resulting in oscillating the ability of an active ingredient to be delivered transdermally. The pH of a solution can be oscillated over a range of pH values from 2 to 10 by the reduction and oxidation (redox) reactions of salts, such as permanganates, iodates, sulfates, chlorates, or bromates. Upon activation, the delivery system conditions begin to oscillate and with it, the delivery of the active agent oscillates.
摘要翻译：用于药物或活性成分的被动定期释放的递送机制和装置，其避免需要外部电源和/或电子控制器。通过利用振荡化学体系，可以改变溶液，药物，增强剂或增溶剂的状态，即pH，导致活性成分经皮递送的能力的振荡。通过盐，如高锰酸盐，碘酸盐，硫酸盐，氯酸盐或溴酸盐的还原和氧化（氧化还原）反应，溶液的pH可以在2至10的pH范围内振荡。在激活时，递送系统条件开始振荡并且随之而起，活性剂的递送振荡。

8. 发明授权

US5468501A Article useful for administration of pharmacologically-active substances transdermally, orally or by means of implant 失效
标题翻译：用于透皮，口服或通过植入物施用药理活性物质的物品
公开(公告)号：US5468501A
公开(公告)日：1995-11-21
申请号：US385205
申请日：1995-02-08
申请人： Agis Kydonieus , Kishore R. Shah , Bret Berner
发明人： Agis Kydonieus , Kishore R. Shah , Bret Berner
IPC分类号： A61K9/70 , A61K31/21 , A61M31/00 , A61F13/00
CPC分类号： A61K9/7084 , A61K31/21 , A61M31/002
摘要： A device useful for administration of pharmacologically-active substances transdermally, orally, or by means of subdermal implant includes an impermeable backing layer, a plasticized polyvinyl chloride layer, and an adhesive layer, wherein the plasticized polyvinyl chloride layer includes from about 20 up to about 70% by weight of a polyvinyl chloride resin, from about 20 up to about 70% by weight of a plasticizer, and from about 0.5 up to about 35% by weight of a pharmacologically-active substance such as isosorbide dinitrate, nicotine, clonidine, guanfacine, indomethacin, nitroglycerin, and prostaglandin and optionally excipients.
摘要翻译：用于通过皮下，口服或通过皮下植入来施用药理活性物质的装置包括不渗透背衬层，塑化聚氯乙烯层和粘合剂层，其中增塑聚氯乙烯层包括约20至约约 70重量％的聚氯乙烯树脂，约20至约70重量％的增塑剂和约0.5至约35重量％的药理活性物质如硝酸异山梨酯，尼古丁，可乐定，胍法辛，吲哚美辛，硝酸甘油和前列腺素以及任选的赋形剂。

9. 发明授权

US08980254B2 Formulation for oral administration of proteins 有权
标题翻译：口服蛋白质的配方
公开(公告)号：US08980254B2
公开(公告)日：2015-03-17
申请号：US13058830
申请日：2009-08-21
申请人： Matthew John Siegel , Bret Berner
发明人： Matthew John Siegel , Bret Berner
IPC分类号： A61K38/48 , A61K9/20
CPC分类号： A61K38/4873 , A61K9/0053 , A61K9/2009 , A61K9/2013 , A61K38/48 , C12N9/50 , C12N9/96 , C12Y304/22
摘要： Pharmaceutical formulations of orally administered proteins can be stabilized from oxidative degradation and inactivation in the stomach and GI tract by the addition of an antioxidant.
摘要翻译：通过添加抗氧化剂，可以通过胃和胃肠道的氧化降解和灭活来稳定口服给药的蛋白质的药物制剂。

10. 发明授权

US08440232B2 Methods of treatment using a gastric retained gabapentin dosage 有权
标题翻译：使用胃保留加巴喷丁剂量的治疗方法
公开(公告)号：US08440232B2
公开(公告)日：2013-05-14
申请号：US13270126
申请日：2011-10-10
申请人： Bret Berner , Sui Yuen Eddie Hou , Gloria M. Gusler
发明人： Bret Berner , Sui Yuen Eddie Hou , Gloria M. Gusler
IPC分类号： A61K9/00 , A61K9/14 , A61K31/195 , A61P25/00 , A61P25/08
CPC分类号： A61K9/2866 , A61K9/0004 , A61K9/0065 , A61K9/2031 , A61K9/2054 , A61K9/284 , A61K9/48 , A61K31/195 , A61K45/06 , A61M31/002
摘要： A method of treatment for epilepsy and other disease states is described, which comprises delivery of gabapentin in a gastric retained dosage form.
摘要翻译：描述了治疗癫痫和其他疾病状态的方法，其包括在胃保留剂型中递送加巴喷丁。

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