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1. 发明申请

US20090297605A1 Composition And Device For In Vivo Cartilage Repair 审中-公开
标题翻译：用于体内软骨修复的组合物和装置
公开(公告)号：US20090297605A1
公开(公告)日：2009-12-03
申请号：US12463108
申请日：2009-05-08
申请人： Brent L. Atkinson , Pedro Bittman , James J. Benedict , John Ranieri , Marsha L. Whitney , Donald Chickering
发明人： Brent L. Atkinson , Pedro Bittman , James J. Benedict , John Ranieri , Marsha L. Whitney , Donald Chickering
IPC分类号： A61K9/10 , A61K9/14 , A61K38/02
CPC分类号： A61K9/5153 , A61B17/06166 , A61F2/30756 , A61F2002/2817 , A61F2002/30036 , A61F2002/30062 , A61F2002/30677 , A61F2210/0004 , A61F2250/0035 , A61F2310/00365 , A61L27/227 , A61L27/24 , A61L27/26 , A61L27/48 , A61L27/50 , A61L27/54 , A61L2300/252 , A61L2300/30 , A61L2300/624 , A61L2400/12 , A61L2430/06 , B82Y5/00 , Y10S977/91 , Y10S977/914 , C08L89/06 , C08L5/08
摘要： The composition as described serves for in vivo cartilage repair. It basically consists of a naturally derived osteoinductive and/or chondroinductive mixture of factors (e.g. derived from bone) or of a synthetic mimic of such a mixture combined with a nanosphere delivery system. A preferred mixture of factors is the combination of factors isolated from bone, known as BP and described by Poser and Benedict (WO 95/13767). The nanosphere delivery system consists of nanospheres defined as polymer particles of less than 1000 nm in diameter (whereby the majority of particles preferably ranges between 200-400 nm) in which nanospheres the combination of factors is encapsulated. The nanospheres are loaded with the mixture of factors in a weight ratio of 0.001 to 17% (w/w), preferably of 1 to 4% (w/w) and have a release profile with an initial burst of 10 to 20% of the total load over the first 24 hours and a long time release of at least 0.1 per day during at least seven following days. The nanospheres are composed of e.g. ((D,L)lactic acid/glycolic acid)-copolymer (PLGA). The loaded nanospheres are e.g. made by phase inversion. The composition is advantageously utilized as a device comprising any biodegradable matrix in which the nanospheres loaded with the factor combination is contained.
摘要翻译：所述的组合物用于体内软骨修复。其基本上由天然衍生的成骨诱导和/或软骨诱导的因子（例如衍生自骨）的混合物或与纳米球递送系统组合的这种混合物的合成模拟物组成。因素的优选混合物是从骨分离的因子（称为BP）并由Poser和Benedict（WO 95/13767）描述的组合。纳米球传递系统由纳米球定义为直径小于1000nm的聚合物颗粒（其中大多数颗粒的范围优选在200-400nm之间），其中纳米球包封因子的组合。纳米球以重量比为0.001至17％（w / w），优选1至4％（w / w）的因子混合物加载，并具有释放曲线，初始爆发为10至20％至少在接下来的七天内，前24小时的总负荷和每天至少0.1次的长时间释放。纳米球由例如，（（D，L）乳酸/乙醇酸） - 共聚物（PLGA）。负载的纳米球是例如。通过相位反演。组合物有利地用作包含其中包含加载因子组合的纳米球的任何可生物降解的基质的装置。

2. 发明授权

US06582471B1 Composition and device for in vivo cartilage repair 失效
标题翻译：用于体内软骨修复的组合物和装置
公开(公告)号：US06582471B1
公开(公告)日：2003-06-24
申请号：US09485594
申请日：2000-09-13
申请人： Pedro Bittmann , Brent Atkinson , James J. Benedict , John Ranieri , Marsha L. Whitney , Donald Chickering
发明人： Pedro Bittmann , Brent Atkinson , James J. Benedict , John Ranieri , Marsha L. Whitney , Donald Chickering
IPC分类号： A61F236
CPC分类号： A61K9/5153 , A61B17/06166 , A61F2/30756 , A61F2002/2817 , A61F2002/30036 , A61F2002/30062 , A61F2002/30677 , A61F2210/0004 , A61F2250/0035 , A61F2310/00365 , A61L27/227 , A61L27/24 , A61L27/26 , A61L27/48 , A61L27/50 , A61L27/54 , A61L2300/252 , A61L2300/30 , A61L2300/624 , A61L2400/12 , A61L2430/06 , B82Y5/00 , Y10S977/91 , Y10S977/914 , C08L89/06 , C08L5/08
摘要： The composition as described serves for in vivo cartilage repair. It basically consists of a naturally derived osteoinductive and/or chondroinductive mixture of factors (e.g. derived from bone) or of a synthetic mimic of such a mixture combined with a nanosphere delivery system. A preferred mixture of factors is the combination of factors isolated from bone, known as BP and described by Poser and Benedict (WO 95/13767). The nanosphere delivery system consists of nanospheres defined as polymer particles of less than 1000 nm in diameter (whereby the majority of particles preferably ranges between 200-400 nm) in which nanospheres the combination of factors is encapsulated. The nanospheres are loaded with the mixture of factors in a weight ratio of 0.001 to 17% (w/w), preferably of 1 to 4% (w/w) and have a release profile with an initial burst of 10 to 20% of the total load over the first 24 hours and a long time release of at least 0.1 per day during at least seven following days. The nanospheres are composed of e.g. ((D,L)-lactic acid/glycolic acid)-copolymer (PLGA). The loaded nanospheres are e.g. made by phase inversion. The composition is advantageously utilized as a device comprising any biodegradable matrix in which the nanospheres loaded with the factor combination is contained.
摘要翻译：所述的组合物用于体内软骨修复。其基本上由天然衍生的成骨诱导和/或软骨诱导的因子（例如衍生自骨）的混合物或与纳米球递送系统组合的这种混合物的合成模拟物组成。因素的优选混合物是从骨分离的因子（称为BP）并由Poser和Benedict（WO 95/13767）描述的组合。纳米球传递系统由纳米球定义为直径小于1000nm的聚合物颗粒（其中大多数颗粒的范围优选在200-400nm之间），其中纳米球包封因子的组合。纳米球以重量比为0.001至17％（w / w），优选1至4％（w / w）的因子混合物加载，并具有释放曲线，初始爆发为10至20％至少在接下来的七天内，前24小时的总负荷和每天至少0.1次的长时间释放。纳米球由例如，（（D，L） - 乳酸/乙醇酸） - 共聚物（PLGA）。负载的纳米球是例如。通过相位反演。组合物有利地用作包含其中包含加载因子组合的纳米球的任何可生物降解的基质的装置。

3. 发明申请

US20060216325A1 Composition and device for in vivo cartilagerepair 审中-公开
标题翻译：用于体内软骨修复的组合物和装置
公开(公告)号：US20060216325A1
公开(公告)日：2006-09-28
申请号：US11433968
申请日：2006-05-15
申请人： Brent Atkinson , Pedro Bittman , James Benedict , John Ranieri , Marsha Whitney , Donald Chickering
发明人： Brent Atkinson , Pedro Bittman , James Benedict , John Ranieri , Marsha Whitney , Donald Chickering
IPC分类号： A61F2/28
CPC分类号： A61K9/5153 , A61B17/06166 , A61F2/30756 , A61F2002/2817 , A61F2002/30036 , A61F2002/30062 , A61F2002/30677 , A61F2210/0004 , A61F2250/0035 , A61F2310/00365 , A61L27/227 , A61L27/24 , A61L27/26 , A61L27/48 , A61L27/50 , A61L27/54 , A61L2300/252 , A61L2300/30 , A61L2300/624 , A61L2400/12 , A61L2430/06 , B82Y5/00 , Y10S977/91 , Y10S977/914 , C08L89/06 , C08L5/08
摘要： The composition as described serves for in vivo cartilage repair. It basically consists of a naturally derived osteoinductive and/or chondroinductive mixture of factors (e.g. derived from bone) or of a synthetic mimic of such a mixture combined with a nanosphere delivery system. A preferred mixture of factors is the combination of factors isolated from bone, known as BP and described by Poser and Benedict (WO 95/13767). The nanosphere delivery system consists of nanospheres defined as polymer particles of less than 1000 nm in diameter (whereby the majority of particles preferably ranges between 200-400 nm) in which nanospheres the combination of factors is encapsulated. The nanospheres are loaded with the mixture of factors in a weight ratio of 0.001 to 17% (w/w), preferably of 1 to 4% (w/w) and have a release profile with an initial burst of 10 to 20% of the total load over the first 24 hours and a long time release of at least 0.1 per day during at least seven following days. The nanospheres are composed of e.g. ((D,L)-lactic acid/glycolic acid)-copolymer (PLGA). The loaded nanospheres are e.g. made by phase inversion. The composition is advantageously utilized as a device comprising any biodegradable matrix in which the nanospheres loaded with the factor combination is contained.
摘要翻译：所述的组合物用于体内软骨修复。其基本上由天然衍生的成骨诱导和/或软骨诱导的因子（例如衍生自骨）的混合物或与纳米球递送系统组合的这种混合物的合成模拟物组成。因素的优选混合物是从骨分离的因子（称为BP）并由Poser和Benedict（WO 95/13767）描述的组合。纳米球传递系统由纳米球定义为直径小于1000nm的聚合物颗粒（其中大多数颗粒的范围优选在200-400nm之间），其中纳米球包封因子的组合。纳米球以重量比为0.001至17％（w / w），优选1至4％（w / w）的因子混合物加载，并具有释放曲线，初始爆发为10至20％至少在接下来的七天内，前24小时的总负荷和每天至少0.1次的长时间释放。纳米球由例如，（（D，L） - 乳酸/乙醇酸） - 共聚物（PLGA）。负载的纳米球是例如。通过相位反演。组合物有利地用作包含其中包含加载因子组合的纳米球的任何可生物降解的基质的装置。

4. 发明申请

US20080021892A1 Process and system for matching product and markets 有权
标题翻译：产品和市场匹配的流程和系统
公开(公告)号：US20080021892A1
公开(公告)日：2008-01-24
申请号：US11891947
申请日：2007-08-13
申请人： Steven Kimbrough , Ian MacMillan , John Ranieri
发明人： Steven Kimbrough , Ian MacMillan , John Ranieri
IPC分类号： G06F17/30
CPC分类号： G06Q30/06 , G06Q30/08 , Y10S707/931 , Y10S707/944 , Y10S707/99931 , Y10S707/99933
摘要： The present invention provides a search method and system for matching a commodity to one or more applications for using the commodity. A plurality of properties associated with the commodity are identified. A collection of documents for searching for a plurality of combinations of said properties is then defined, wherein the combination includes a single property or multiple properties. The defined collection of documents is searched for all occurrences of the combination of properties, and the hits retrieved for those documents that include the properties. The hits are then associated with one or more subclasses of a classification scheme, and reviewed for those hits that include the properties of the commodity but not the commodity, wherein subclasses not including hits that include the commodity are matched as applications for the commodity.
摘要翻译：本发明提供了一种搜索方法和系统，用于将商品与一种或多种应用商品进行匹配。识别与商品相关联的多个属性。然后定义用于搜索所述属性的多个组合的文档的集合，其中所述组合包括单个属性或多个属性。搜索定义的文档集合，搜索属性组合的所有事件，并搜索包含属性的那些文档的匹配。然后，命中与分类方案的一个或多个子类相关联，并对包括商品的属性但不包括商品的那些匹配进行审查，其中不包括商品的命中的子类被匹配作为商品的应用。

5. 发明授权

US07257568B2 Process and system for matching products and markets 有权
标题翻译：匹配产品和市场的流程和系统
公开(公告)号：US07257568B2
公开(公告)日：2007-08-14
申请号：US10272337
申请日：2002-10-16
申请人： Steven O. Kimbrough , Ian MacMillan , John Ranieri
发明人： Steven O. Kimbrough , Ian MacMillan , John Ranieri
IPC分类号： G06F7/08
CPC分类号： G06Q30/06 , G06Q30/08 , Y10S707/931 , Y10S707/944 , Y10S707/99931 , Y10S707/99933
摘要： The present invention provides a search method and system for matching a commodity to one or more applications for using the commodity. A plurality of properties associated with the commodity are identified. A collection of documents for searching for a plurality of combinations of the identified properties is also defined, wherein the combination includes a single property or multiple properties. The defined collection of documents is searched for all occurrences or indications of the combination of properties, and the hits are retrieved for those documents that include one or more of the identified properties. The hits are then associated with one or more subclasses of a classification scheme, and reviewed for those hits that include the identified properties of the commodity, but that need not otherwise identify the commodity per se.
摘要翻译：本发明提供了一种搜索方法和系统，用于将商品与一种或多种应用商品进行匹配。识别与商品相关联的多个属性。还定义了用于搜索所识别的属性的多个组合的文档的集合，其中所述组合包括单个属性或多个属性。搜索定义的文档集合以查找属性组合的所有事件或指示，并为包含一个或多个所标识属性的文档检索匹配。然后，命中与分类方案的一个或多个子类相关联，并对包括商品的所识别属性的那些匹配进行审查，但是不需要另外标识商品本身。

6. 发明申请

US20060128625A1 Povidone-containing carriers for polypeptide growth factors 失效
公开(公告)号：US20060128625A1
公开(公告)日：2006-06-15
申请号：US11338914
申请日：2006-01-25
申请人： Rama Akella , John Ranieri
发明人： Rama Akella , John Ranieri
IPC分类号： A61K38/18 , A61K9/14
CPC分类号： A61K9/0019 , A61K9/0014 , A61K38/1808 , A61K38/1825 , A61K38/1841 , A61K38/1858 , A61K38/1875 , A61K38/30 , A61K47/32 , A61K47/58 , A61K2300/00
摘要： A liquid carrier medium is provided which is suitable for solubilizing growth factors, such as mixtures of bone morphogenetic proteins, that are found to induce an angiogenic response in ischemic tissues. The liquid medium comprises an aqueous solution of polyvinyl pyrrolidone.

7. 发明申请

US20070106662A1 Categorized document bases 有权
标题翻译：分类文件库
公开(公告)号：US20070106662A1
公开(公告)日：2007-05-10
申请号：US11586306
申请日：2006-10-25
申请人： Steven Kimbrough , Ian MacMillan , John Ranieri , James Thompson
发明人： Steven Kimbrough , Ian MacMillan , John Ranieri , James Thompson
IPC分类号： G06F17/30
CPC分类号： G06F17/30707
摘要： A method of managing information comprises generating a categorized document base. Generating the document base comprises providing a pre-existing classification of things other than documents, providing a source collection of documents, and automatically assessing the documents using Information Retrieval techniques to assign at least some of the documents to one or more taxa of the classification. For each taxon in the classification one or more numerical scores are assigned, based at least in part on a composition, makeup or constitution of the documents assigned to the taxon of the categorized document base.
摘要翻译：管理信息的方法包括生成分类文档库。生成文档基础包括提供除文档之外的事物的预先分类，提供文档的源集合，以及使用信息检索技术自动评估文档，以将至少一些文档分配给分类的一个或多个分类。对于分类中的每个分类，至少部分地基于分配给分类文档基础的分类单的文档的构成，组成或构成来分配一个或多个数值分数。

8. 发明申请

US20070086989A1 Prosthetic Grafts 审中-公开
标题翻译：假体植入物
公开(公告)号：US20070086989A1
公开(公告)日：2007-04-19
申请号：US11538608
申请日：2006-10-04
申请人： Diane Anderson , John Ranieri , Maurizio Colognesi , Marco Scoccianti , Antonio Facchiano
发明人： Diane Anderson , John Ranieri , Maurizio Colognesi , Marco Scoccianti , Antonio Facchiano
IPC分类号： A01N63/00 , A61K48/00
CPC分类号： A61L27/3804 , A61F2/06 , A61F2/062 , A61K48/00 , A61K48/0075 , A61K2035/126 , A61L27/38 , A61L27/3843 , A61L27/507 , C07K14/52 , C12N5/0656 , C12N2510/02 , C12N2799/022 , C12N2799/04
摘要： An improved prosthetic graft for the bypass, replacement or repair of vessels and organs that are in contact with blood flow is disclosed. The prosthetic graft includes a porous prosthetic implant and adherent cells adhered to the outer surface of the implant. The adherent cells are transfected with at least one recombinant nucleic acid molecule encoding at least one protein that enhances patency of the graft. The prosthetic graft has a long-term patency and success rate that is superior to other previously described prosthetic grafts designed for such use. Also disclosed are methods of making and using such a graft.
摘要翻译：公开了一种用于与血流接触的血管和器官的旁路，置换或修复的改进的假体移植物。假体移植物包括多孔假体植入物和附着于植入物的外表面的贴壁细胞。用至少一种编码至少一种增强移植物通畅的蛋白质的重组核酸分子转染贴壁细胞。假体移植物具有优于其他先前描述的用于这种用途的假体移植物的长期通畅和成功率。还公开了制造和使用这种移植物的方法。

9. 发明授权

US07756891B2 Process and system for matching products and markets 有权
标题翻译：匹配产品和市场的流程和系统
公开(公告)号：US07756891B2
公开(公告)日：2010-07-13
申请号：US11891947
申请日：2007-08-13
申请人： Steven O. Kimbrough , Ian MacMillan , John Ranieri
发明人： Steven O. Kimbrough , Ian MacMillan , John Ranieri
IPC分类号： G06F7/00
CPC分类号： G06Q30/06 , G06Q30/08 , Y10S707/931 , Y10S707/944 , Y10S707/99931 , Y10S707/99933
摘要： The present invention provides a search method and system for matching a commodity to one or more applications for using the commodity. A plurality of properties associated with the commodity are identified. A collection of documents for searching for a plurality of combinations of said properties is then defined, wherein the combination includes a single property or multiple properties. The defined collection of documents is searched for all occurrences of the combination of properties, and the hits retrieved for those documents that include the properties. The hits are then associated with one or more subclasses of a classification scheme, and reviewed for those hits that include the properties of the commodity but not the commodity, wherein subclasses not including hits that include the commodity are matched as applications for the commodity.
摘要翻译：本发明提供了一种搜索方法和系统，用于将商品与一种或多种应用商品进行匹配。识别与商品相关联的多个属性。然后定义用于搜索所述属性的多个组合的文档的集合，其中所述组合包括单个属性或多个属性。搜索定义的文档集合，搜索属性组合的所有事件，并搜索包含属性的那些文档的匹配。然后，命中与分类方案的一个或多个子类相关联，并对包括商品的属性但不包括商品的那些匹配进行审查，其中不包括商品的命中的子类被匹配作为商品的应用。

10. 发明申请

US20080031970A1 Method of Promoting Natural Bypass 审中-公开
标题翻译：促进自然绕道的方法
公开(公告)号：US20080031970A1
公开(公告)日：2008-02-07
申请号：US11843797
申请日：2007-08-23
申请人： James Benedict , John Ranieri , Marsha Whitney , Rama Akella
发明人： James Benedict , John Ranieri , Marsha Whitney , Rama Akella
IPC分类号： A61K35/32 , A61K38/18 , A61K38/30 , A61K47/32 , A61P9/10
CPC分类号： A61K38/1808 , A61K9/0019 , A61K38/1825 , A61K38/1833 , A61K38/1841 , A61K38/1858 , A61K38/1875 , A61K38/30 , A61K47/32 , A61K2300/00
摘要： An angiogenic factor comprising a mixture of proteins derived from bone. The angiogenic protein mixture is produced by a series of steps that allow the proteins to be kept in solution. The angiogenic mixture of bone proteins is produced by a multi-step process that includes at least one ultrafiltration step, an anion exchange chromatography step, a cation exchange chromatography step and a high performance liquid chromatography (HPLC) purification step.
摘要翻译：包含衍生自骨的蛋白质混合物的血管生成因子。血管生成蛋白质混合物通过允许蛋白质保持在溶液中的一系列步骤产生。通过包括至少一个超滤步骤，阴离子交换层析步骤，阳离子交换层析步骤和高效液相色谱（HPLC）纯化步骤的多步法生产骨蛋白的血管生成混合物。

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