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1. 发明申请

US20050240267A1 Allograft implant 有权
标题翻译：同种异体植入物
公开(公告)号：US20050240267A1
公开(公告)日：2005-10-27
申请号：US11093111
申请日：2005-03-28
申请人： Brandon Randall , Roger Goodwin , Dominique Messerli , Jacqueline Myer , Robert Delurio , Michael Boyer , Christopher Angelucci
发明人： Brandon Randall , Roger Goodwin , Dominique Messerli , Jacqueline Myer , Robert Delurio , Michael Boyer , Christopher Angelucci
IPC分类号： A61B17/88 , A61B17/92 , A61F2/00 , A61F2/28 , A61F2/30 , A61F2/44 , A61F2/46
CPC分类号： A61F2/44 , A61F2/28 , A61F2/3094 , A61F2/4455 , A61F2/4611 , A61F2002/2835 , A61F2002/30057 , A61F2002/30266 , A61F2002/30383 , A61F2002/30387 , A61F2002/30492 , A61F2002/30507 , A61F2002/30571 , A61F2002/30604 , A61F2002/30617 , A61F2002/30782 , A61F2002/30795 , A61F2002/3082 , A61F2002/30843 , A61F2002/30904 , A61F2002/4622 , A61F2002/4628 , A61F2002/4629 , A61F2220/0025 , A61F2230/0082 , A61F2250/0097 , A61F2310/00359
摘要： An allogenic implant for use in intervertebral fusion is formed from one or more two pieces. The pieces are made from bone, and are joined together to form an implant having sufficient strength and stability to maintain a desired distance between first and second vertebrae in a spinal fusion procedure. The implant pieces may be formed of cortical bone and connected by dovetail joints, and at least one cortical bone pin may be provided to lock the pieces together and to add strength to the implant. Teeth are formed on the vertebra engaging surfaces of the implant prevent short-term slippage of the implant.
摘要翻译：用于椎间融合的同种异体植入物由一个或多个两片形成。这些片由骨制成，并且连接在一起以形成具有足够强度和稳定性的植入物，以在脊柱融合程序中保持第一和第二椎骨之间的期望距离。植入物片可以由皮质骨形成并且通过燕尾接头连接，并且可以提供至少一个皮质骨针将锁定在一起并增加植入物的强度。牙齿形成在植入物的椎骨接合表面上，防止植入物的短期滑动。

2. 发明申请

US20110045087A1 POROUS BIOCOMPATIBLE POLYMER MATERIAL AND METHODS 有权
标题翻译：多孔生物聚合物材料和方法
公开(公告)号：US20110045087A1
公开(公告)日：2011-02-24
申请号：US12666216
申请日：2009-01-30
申请人： Sean Hamilton Kerr , Ali Recber , Thomas Pepe , Dominique Messerli , Lawton Laurence , Ryan Walsh , Thomas Kueenzi , Brandon Randall
发明人： Sean Hamilton Kerr , Ali Recber , Thomas Pepe , Dominique Messerli , Lawton Laurence , Ryan Walsh , Thomas Kueenzi , Brandon Randall
IPC分类号： A61K9/16 , A61K33/42 , A61K33/00 , A61K47/30 , A61K33/04 , A61P19/08 , A61F2/44
CPC分类号： A61L27/56 , A61B17/86 , A61F2/4455 , A61F2002/2817 , A61F2002/30062 , A61F2002/30064 , A61F2002/3008 , A61F2002/30387 , A61F2002/30426 , A61F2002/30578 , A61F2002/30604 , A61F2002/30841 , A61F2002/3092 , A61F2002/3097 , A61F2210/0004 , A61F2220/0025 , A61F2250/0098 , A61F2310/00796 , A61F2310/00976 , A61L27/18 , A61L27/26 , A61L27/50 , A61L2430/02 , A61N1/3622 , C08G65/00 , C08J9/24 , C08J9/26
摘要： Embodiments described include devices and methods for forming a porous polymer material. Devices disclosed and formed using the methods described include a spacer for spinal fusion, craniomaxillofacial (CMF) structures, and other structures for tissue implants.
摘要翻译：所描述的实施例包括用于形成多孔聚合物材料的装置和方法。使用所述方法公开和形成的装置包括用于脊柱融合的间隔物，颅颌面（CMF）结构以及组织植入物的其它结构。

3. 发明申请

US20060241760A1 Spinal implant 审中-公开
标题翻译：脊柱植入
公开(公告)号：US20060241760A1
公开(公告)日：2006-10-26
申请号：US11114556
申请日：2005-04-26
申请人： Brandon Randall , Kenneth Kobayashi , Dominique Messerli
发明人： Brandon Randall , Kenneth Kobayashi , Dominique Messerli
IPC分类号： A61F2/44
CPC分类号： A61F2/447 , A61F2/4611 , A61F2002/2835 , A61F2002/30062 , A61F2002/3008 , A61F2002/30133 , A61F2002/30617 , A61F2002/3071 , A61F2002/30828 , A61F2002/30841 , A61F2002/30843 , A61F2002/4475 , A61F2002/4629 , A61F2210/0004 , A61F2230/0015 , A61F2250/0085 , A61F2250/0097 , A61F2250/0098 , A61F2310/00017 , A61F2310/00023
摘要： The present invention is directed to a spinal implant, preferably a bioresorbable spinal implant, for insertion between vertebrae bodies. The implant preferably includes an anterior surface, a posterior surface, first and second lateral surfaces extending therebetween, a superior surface for engaging one of the vertebrae bodies, an inferior surface for engaging the other vertebrae body, and a central bore which extends from the superior surface to the inferior surface. The central bore preferably has a generally lobe-shaped footprint. The anterior surface of the implant preferably includes a pair of vertical channels sized and configured to engage an insertion instrument and the superior surface preferably has a convexly curved surface extending substantially from the anterior surface to the posterior surface while the inferior surface preferably has a substantially constant taper extending from the anterior surface to the posterior surface.
摘要翻译：本发明涉及用于在椎骨体之间插入的脊柱植入物，优选为生物可再吸收的脊柱植入物。植入物优选地包括前表面，后表面，在其间延伸的第一和第二侧表面，用于接合椎骨体之一的上表面，用于接合另一个椎骨体的下表面和从上部延伸的中心孔表面到下表面。中心孔优选地具有通常为凸起的足迹。植入物的前表面优选地包括一对垂直通道，其大小和构造成与插入器具接合，并且上表面优选地具有基本上从前表面延伸到后表面延伸的凸形曲面，而下表面优选具有基本上恒定的锥形从前表面延伸到后表面。

4. 发明授权

US08530560B2 Porous biocompatible polymer material and methods 有权
标题翻译：多孔生物相容性聚合物材料及方法
公开(公告)号：US08530560B2
公开(公告)日：2013-09-10
申请号：US12666216
申请日：2009-01-30
申请人： Sean Hamilton Kerr , Ali Recber , Thomas Pepe , Dominique Messerli , Lawton Laurence , Ryan Walsh , Thomas Kueenzi , Brandon Randall
发明人： Sean Hamilton Kerr , Ali Recber , Thomas Pepe , Dominique Messerli , Lawton Laurence , Ryan Walsh , Thomas Kueenzi , Brandon Randall
IPC分类号： C04B28/14
CPC分类号： A61L27/56 , A61B17/86 , A61F2/4455 , A61F2002/2817 , A61F2002/30062 , A61F2002/30064 , A61F2002/3008 , A61F2002/30387 , A61F2002/30426 , A61F2002/30578 , A61F2002/30604 , A61F2002/30841 , A61F2002/3092 , A61F2002/3097 , A61F2210/0004 , A61F2220/0025 , A61F2250/0098 , A61F2310/00796 , A61F2310/00976 , A61L27/18 , A61L27/26 , A61L27/50 , A61L2430/02 , A61N1/3622 , C08G65/00 , C08J9/24 , C08J9/26
摘要： Embodiments described include devices and methods for forming a porous polymer material. Devices disclosed and formed using the methods described include a spacer for spinal fusion, craniomaxillofacial (CMF) structures, and other structures for tissue implants.
摘要翻译：所描述的实施例包括用于形成多孔聚合物材料的装置和方法。使用所述方法公开和形成的装置包括用于脊柱融合的间隔物，颅颌面（CMF）结构以及组织植入物的其它结构。

5. 发明申请

US20110208226A1 DILATION SYSTEM AND METHOD OF USING THE SAME 有权
标题翻译：放置系统及其使用方法
公开(公告)号：US20110208226A1
公开(公告)日：2011-08-25
申请号：US12681671
申请日：2008-10-06
申请人： Peter Fatone , Brandon Randall
发明人： Peter Fatone , Brandon Randall
IPC分类号： A61M29/00 , A61N1/00
CPC分类号： A61B17/025 , A61B5/0492 , A61B5/4893 , A61B17/0218 , A61B17/1757 , A61B17/3417 , A61B17/3421 , A61B17/3423 , A61B17/3476 , A61B2017/00039 , A61B2017/003 , A61B2017/00331 , A61B2017/0262 , A61B2017/3433 , A61B2090/062
摘要： Directional sequential and blunt stimulating dilation systems (10) and related methods for accessing a patient's spine (2) through the patient's psoas muscle (4) include sequential directional dilators (30, 40) or a blunt stimulating dilator (100, 100′) with at least one channel formed therein. Neural elements or nerves (9) of the psoas muscle are preferably mapped using a stimulating probe (20) thereby defining a safe zone of passage to the patient's spine. The stimulating probe is inserted through the psoas muscle toward the patient's spine. The directional sequential dilators may be inserted to dilate the tissue on any side of the stimulating probe without significantly impacting tissue on the opposite side of the stimulating probe, which may be located, proximate the neural elements. The dilators are rendered directional by having bores (35, 45), by means of which they can be inserted over each other and over the probe, which are offset from their longitudinal axes (31, 41).
摘要翻译：定向顺序和钝性刺激扩张系统（10）以及通过患者腰痛肌肉（4）进入患者脊柱（2）的相关方法包括顺序定向扩张器（30,40）或钝性刺激性扩张器（100,100'），具有形成在其中的至少一个通道。优选使用刺激探针（20）来映射腰肌的神经元件或神经（9），由此限定通向患者脊柱的安全区域。刺激探针通过腰肌肌肉插入患者脊柱。可以插入定向顺序扩张器以在刺激探针的任何一侧扩张组织，而不会在靠近神经元件的刺激探针的相对侧上显着影响组织。扩张器通过具有孔（35,45）而被定向，借助于它们，它们可以彼此插入并且越过探针，它们从它们的纵向轴线（31,41）偏移。

6. 发明申请

US20050130294A1 Methods and apparatus for blood separation and analysis using membranes on an optical bio-disc 失效
标题翻译：用于在光学生物盘上使用膜进行血液分离和分析的方法和装置
公开(公告)号：US20050130294A1
公开(公告)日：2005-06-16
申请号：US10891442
申请日：2004-07-13
申请人： Brandon Randall , Raveendra Pottathil , Shuguang Li
发明人： Brandon Randall , Raveendra Pottathil , Shuguang Li
IPC分类号： B01D20060101 , B01D11/04 , C12M1/34 , C12M3/00 , C12N1/00 , C12Q1/00 , G01N15/06 , G01N21/00 , G01N21/29 , G01N21/41 , G01N21/47 , G01N21/75 , G01N31/22 , G01N33/00 , G01N33/558 , G01N35/00
CPC分类号： G01N33/558 , G01N35/00069 , Y10S435/96 , Y10S435/97
摘要： Optical bio-discs for biochemical analysis, bio-disc analysis systems and biochemical analysis methods are described herein. In one embodiment, the bio-disc includes a sample analysis circuit that includes a separation membrane for separating an investigational feature of a sample. The bio-disc also includes a conjugate release pad, and an analysis membrane containing analysis zones that may be analyzed for the presence of analytes. An analysis method includes providing a sample to a separation membrane in a bio-disc, separating an investigational feature from the sample using a separation membrane, mixing reagents that include signal elements for detecting an analyte with the investigational feature so as to form a reagent-investigational feature mixture and capturing an analyte with a signal element bound thereto in an analysis zone on an analysis membrane. The method further includes determining the presence of an analyte by analyzing the signal elements present in the capture zone of the analysis membrane.
摘要翻译：用于生化分析的光学生物盘，生物盘分析系统和生化分析方法在本文中描述。在一个实施例中，生物盘包括样品分析电路，其包括用于分离样品的研究特征的分离膜。生物盘还包括缀合物释放垫，以及含有可分析存在分析物的分析区的分析膜。分析方法包括：将样品提供到生物盘中的分离膜，使用分离膜从样品中分离研究特征，将包括用于检测分析物的信号元件的试剂与研究特征混合，以形成试剂 - 研究特征混合物，并在分析膜上的分析区域中捕获结合有信号元素的分析物。该方法还包括通过分析存在于分析膜的捕获区域中的信号元素来确定分析物的存在。

7. 发明授权

US09387009B2 Dilation system and method of using the same 有权
标题翻译：扩张系统及其使用方法
公开(公告)号：US09387009B2
公开(公告)日：2016-07-12
申请号：US12681671
申请日：2008-10-06
申请人： Peter Fatone , Brandon Randall
发明人： Peter Fatone , Brandon Randall
IPC分类号： A61M29/00 , A61B17/34 , A61B17/17 , A61B5/0492 , A61B17/00
CPC分类号： A61B17/025 , A61B5/0492 , A61B5/4893 , A61B17/0218 , A61B17/1757 , A61B17/3417 , A61B17/3421 , A61B17/3423 , A61B17/3476 , A61B2017/00039 , A61B2017/003 , A61B2017/00331 , A61B2017/0262 , A61B2017/3433 , A61B2090/062
摘要： Directional sequential and blunt stimulating dilation systems (10) and related methods for accessing a patient's spine (2) though the patient's psoas muscle (4) include sequential directional dilators (30, 40) or a blunt stimulating dilator (100, 100′) with at least one channel formed therein. Neural elements or nerves (9) of the psoas muscle are preferably mapped using a stimulating probe (20). The stimulating probe is inserted through the psoas muscle toward the patient's spine. The directional sequential dilators may be inserted to dilate the tissue on any side of the stimulating probe without significantly impacting tissue on the opposite side of the stimulating probe, which may be located, proximate the neural elements. The dilators are rendered directional by having bores (35, 45), by means of which they can be inserted over each other and over the probe, which are offset from their longitudinal axes (31, 41).
摘要翻译：方向性顺序和钝性刺激扩张系统（10）以及通过患者腰痛肌肉（4）进入患者脊柱（2）的相关方法包括顺序定向扩张器（30,40）或钝性刺激性扩张器（100,100'），具有形成在其中的至少一个通道。优选使用刺激探针（20）来映射腰肌的神经元件或神经（9）。刺激探针通过腰肌肌肉插入患者脊柱。可以插入定向顺序扩张器以在刺激探针的任何一侧扩张组织，而不会在靠近神经元件的刺激探针的相对侧上显着影响组织。扩张器通过具有孔（35,45）而被定向，借助于它们，它们可以彼此插入并且越过探针，它们从它们的纵向轴线（31,41）偏移。

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