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    • 6. 发明授权
    • Process for treating hard tissues
    • 硬组织治疗方法
    • US6159012A
    • 2000-12-12
    • US387449
    • 1999-09-01
    • Joel D. OxmanHoa T. BuiDwight W. Jacobs
    • Joel D. OxmanHoa T. BuiDwight W. Jacobs
    • A61K6/00A61K6/083A61K6/087A61B17/06A61C5/00A61K6/08C08L63/00
    • A61K6/0023Y10S522/908
    • In a first aspect, a method for treating hard tissue that includes: (a) applying to hard tissue a composition that includes a cationically active functional group, a free radically active functional group, and a polymerization initiator capable of initiating free radical polymerization, where the number of moles of cationically active functional groups per gram of composition is no greater than about 0.0075; and (b) exposing the composition to polymerization conditions to form an adhesive bonded to the hard tissue.In a second aspect, a method for treating hard tissue that includes: (a) applying to hard tissue a first polymerizable composition that includes a free radically active functional group and a polymerization initiator capable of initiating free radical polymerization, but is essentially free of polymerizable components having cationically active functional groups and is capable of forming an adhesive bonded to the hard tissue upon exposure to polymerization conditions; (b) applying a second polymerizable composition; and (c) exposing the second composition to polymerization conditions to form a hardened composition adhered to the hard tissue. The second composition includes (i) a cationically active functional group and (ii) an polymerization initiator capable of initiating cationic polymerization.
    • 第一方面,一种硬组织处理方法,包括:(a)向硬组织施加包含阳离子活性官能团,自由基活性官能团和能引发自由基聚合的聚合引发剂的组合物,其中 每克组合物中阳离子活性官能团的摩尔数不大于约0.0075; 和(b)将组合物暴露于聚合条件以形成粘合到硬组织的粘合剂。 在第二方面,一种硬组织处理方法,包括:(a)向硬组织施加包含自由基活性官能团的第一可聚合组合物和能引发自由基聚合的聚合引发剂,但基本上不含可聚合的 具有阳离子活性官能团的组分并且能够在暴露于聚合条件时形成粘合到硬组织的粘合剂; (b)施加第二可聚合组合物; 和(c)将第二组合物暴露于聚合条件以形成粘附到硬组织的硬化组合物。 第二组合物包括(i)阳离子活性官能团和(ii)能够引发阳离子聚合的聚合引发剂。