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1. 发明授权

US4102878A Process for the preparation of the cholecystokinin-pancreozymin octapeptide amide sulfate ester 失效
标题翻译：制备胆囊收缩素 - 胰蛋白酶八肽酰胺硫酸酯的方法
公开(公告)号：US4102878A
公开(公告)日：1978-07-25
申请号：US792043
申请日：1977-04-28
申请人： Botond Penke , Lajos Balaspiri , Peter Pallai , Kalman Kovacs , Vince Varro , Janos Lonovics , Laszlo Varga , Gyorgy Dobo , Geza Ivanyi , Lajos Kovacs , Miklos Low , Judit Low, nee Kaloczy
发明人： Botond Penke , Lajos Balaspiri , Peter Pallai , Kalman Kovacs , Vince Varro , Janos Lonovics , Laszlo Varga , Gyorgy Dobo , Geza Ivanyi , Lajos Kovacs , Miklos Low , Judit Low, nee Kaloczy
IPC分类号： C07K1/113 , A61K38/00 , A61K38/08 , C07K1/00 , C07K7/06 , C07K14/595 , C07C103/52
CPC分类号： C07K14/595 , Y02P20/55
摘要： A process for the preparation of L-aspartyl-(O-sulfato-L-tyrosyl)-L-methionyl-glycyl-L-tryptophyl-L-methionyl-L-aspartyl-L-phenylalanine amide, which comprises treating the protected octapeptide amide of the general formula (II) ##STR1## wherein X is BOC, Cbz or Ddz,Y is O.sup.t Bu, OBzl or OH andW is O.sup.t Bu, OBzl or OH,in the presence of an ether with an excess of the complex compound of sulfur trioxide and a tertiary amine containing at least one alkyl group, converting the obtained sulfate ester of the protected octapeptide amide into an alkali metal salt and simultaneously removing the formyl group from the tryptophan unit by reacting the sulfate ester with an alkali metal hydroxide, and then splitting off the remaining protective groups by acidolysis.
摘要翻译：一种制备L-天冬氨酰 - （O-硫酸盐-L-酪氨酰）-L-甲硫氨酰 - 甘氨酰-L-色氨酰-L-甲硫氨酰-L-天冬氨酰-L-苯丙氨酸酰胺的方法，其包括处理受保护的八肽通式（II）的酰胺其中X是BOC，Cbz或Ddz，Y是OtBu，OBz1或OH，W是OtBu，OBz1或OH，在醚存在下与过量的络合物三氧化硫和含有至少一个烷基的叔胺，将得到的保护的八肽酰胺的硫酸酯转化为碱金属盐，同时通过使硫酸酯与碱金属氢氧化物反应从色氨酸单元除去甲酰基，以及然后通过酸解分解剩余的保护基团。

2. 发明授权

US4183909A Phenylglycine-containing new peptides with gastrine effects and a process for the preparation thereof 失效
标题翻译：含有苯基甘氨酸的新肽具有胃泌素作用及其制备方法
公开(公告)号：US4183909A
公开(公告)日：1980-01-15
申请号：US859931
申请日：1977-12-12
申请人： Istvan Schon , Lajos Kisfaludy , Vince Varro , Laszlo Varga , Jozsef Nafradi
发明人： Istvan Schon , Lajos Kisfaludy , Vince Varro , Laszlo Varga , Jozsef Nafradi
IPC分类号： C07K5/10 , A61K38/00 , A61K38/07 , A61K38/22 , A61P1/00 , A61P1/04 , C07K1/113 , C07K5/117 , C07K7/06 , C07K14/575 , A61K29/00 , A61K37/00 , C07C103/52
CPC分类号： C07K5/1024 , A61K38/00
摘要： The invention relates to novel peptides of formula (I),A-Try-B-Asp-Phg-NH.sub. 2 (I)whereinA is tert.-butoxycarbonyl-aminooxy-acyl, benzyloxycarbonyl-aminooxy-acyl, (aminooxy)-acyl or E-aminooxy-acyl, wherein E is benzoyl or straight-chained or branched C.sub.1-5 aliphatic acyl, andB represents methionyl, leucyl, norleucyl, norvalyl or 2-amino-decanoyl,or acid addition salts or complexes thereof. The novel compounds according to the invention exert gastrin effects and can be applied to advantage in the diagnostics and therapy. The novel compounds of formula (I) are prepared according to the invention by reacting a tetrapeptideamide of formula (II),H-Try-B-Asp-Phg-NH.sub. 2 (II)wherein B is as defined above, with an (aminooxy)-acyl containing compound of the general formula A.sub.1 -X, whereinA.sub.1 has the same meanings as A with the exception of the (aminooxy)-acyl, andX is hydroxy group, halogen, pivaloyloxy, a group of the formula R--O--CO.sub.2 -- (wherein R is lower alkyl, phenoxy which can have a nitro substituent or one or more halogen or N-succinimidoxy.
摘要翻译：本发明涉及式（I）的新型肽A-Try-B-Asp-Phg-NH 2（I），其中A为叔丁氧基羰基 - 氨基氧基 - 酰基，苄氧基羰基 - 氨氧基 - 酰基，（氨氧基） - 酰基或E-氨基氧基 - 酰基，其中E是苯甲酰基或直链或支链C 1-5脂肪族酰基，B代表甲硫氨酰基，亮氨酰基，正亮氨酰基，缬氨酰基或2-氨基 - 癸酰基，或其酸加成盐或配合物。根据本发明的新型化合物发挥促胃泌素作用，并且可以在诊断和治疗中有利地应用。通过使式（II）的四肽酰胺，其中B如上所定义的H-Try-B-Asp-Phg-NH 2（II）与（氨基氧基）） - 酰基的通式为Al-X的化合物，其中除了（氨基氧基） - 酰基以外，与A相同，A为氧基，X为羟基，卤素，新戊酰氧基，式RO-CO2 - （其中R是低级烷基，可具有硝基取代基的苯氧基或一个或多个卤素或N-琥珀酰亚胺氧基）。

3. 发明授权

US4172130A .alpha.-AMINOACYL CONTAINING NEW PEPTIDES WITH GASTRIN EFFECTS AND A PROCESS FOR THE PREPARATION THEREOF 失效
标题翻译：含有GASTRIN效应的新型肽的60-氨基酸及其制备方法
公开(公告)号：US4172130A
公开(公告)日：1979-10-23
申请号：US865503
申请日：1977-12-29
申请人： Lajos Kisfaludy , Istvan Schon , Vince Varro , Laszlo Varga , Jozsef Nafradi
发明人： Lajos Kisfaludy , Istvan Schon , Vince Varro , Laszlo Varga , Jozsef Nafradi
IPC分类号： C07K5/10 , A61K38/00 , A61K38/08 , A61K38/22 , A61P1/00 , C07C53/15 , C07C291/04 , C07D207/40 , C07D207/404 , C07K1/08 , C07K1/107 , C07K1/113 , C07K5/117 , C07K7/02 , C07K7/06 , C07K14/575 , A61K37/00 , C07C103/52
CPC分类号： C07D207/404 , C07C291/04 , C07C53/15 , C07K5/1024 , A61K38/00
摘要： Peptides of the formula:A--Trp--B--Asp--Phe--NH--Ywherein A is tert.-butoxycarbonyl-aminooxy-acyl, benzyloxycarbonyl-aminooxy-acyl, (aminooxy)-acyl, or E-aminooxy-acyl, wherein E is benzoyl or straight-chain or branched C.sub.1-5 aliphatic acyl, B is methionyl, leucyl, norleucyl, norvalyl or 2-amino-decanoyl, and Y is hydrogen or carboxymethoxy, and pharmaceutically acceptable acid-addition salts or complexes thereof have gastric-acid secretion increasing effects.
摘要翻译：下式的肽：

4. 发明授权

US5288718A Method for decorporating radioactive isotope from living organism 失效
标题翻译：从活生物体中放射性同位素脱核的方法
公开(公告)号：US5288718A
公开(公告)日：1994-02-22
申请号：US80985
申请日：1993-06-21
申请人： Laszlo Varga , Mihaly Torocsik , Laszlo B. Sztanyik , Erno Brucher , Jozsef Emri , Bela Gyori
发明人： Laszlo Varga , Mihaly Torocsik , Laszlo B. Sztanyik , Erno Brucher , Jozsef Emri , Bela Gyori
IPC分类号： C07D273/00 , A61K31/33 , A61K49/02
CPC分类号： C07D273/00
摘要： Pharmaceutical composition for decorporating radioactive isotopes from living organisms comprising as active agent a product prepared by reacting 1,4,10,17-tetraoxa-7,16-diazacyclooctadecane with 2-bromomalonic acid disodium salt.
摘要翻译：用于从活生物体中放出放射性同位素的药物组合物，其包含通过使1,4,10,17-四氧杂-7,16-二氮杂环十八烷与2-溴马来酸二钠盐反应制备的产物作为活性剂。

5. 发明申请

US20120138606A1 FUEL CONTAINER FOR MOTOR VEHICLES WITH A TIE ROD 有权
标题翻译：汽油车用燃油容器
公开(公告)号：US20120138606A1
公开(公告)日：2012-06-07
申请号：US13389463
申请日：2010-08-05
申请人： Laszlo Varga
发明人： Laszlo Varga
IPC分类号： B65D6/00
CPC分类号： B60K15/03177 , B60K2015/03467
摘要： A fuel container operating under overpressure and consisting of two shells is to be reinforced by means of an inner column so that, when the two shells are conjoined, a tension resistant connection is created. For this purpose, the column consists of a first and a second part connected to the respective shell, one part having catches, the other part having latching hooks, which catches and latching hooks for a tension resistant snap-in connection when joined together. For this purpose, both parts have latching surfaces and deflecting surfaces and the latching hook is resiliently displaceable.
摘要翻译：在超压下操作并由两个壳组成的燃料容器将通过内柱加强，使得当两个壳结合时，产生抗张力连接。为此，柱由连接到相应壳体的第一部分和第二部分组成，一个部分具有卡爪，另一部分具有闩锁钩，当连接在一起时，卡扣钩和卡扣钩用于抗张力咬合连接。为此，两个部件都具有锁定表面和偏转表面，并且闩锁钩可弹性移位。

6. 发明申请

US20080171189A1 System for Detecting the Defects of a Wall Coating, and Procedure for Manufacturing Such a System 审中-公开
标题翻译：用于检测墙涂的缺陷的系统以及制造这种系统的程序
公开(公告)号：US20080171189A1
公开(公告)日：2008-07-17
申请号：US11792023
申请日：2005-11-29
申请人： Laszlo Varga , Laszlo Kalafszky , Imre Toth
发明人： Laszlo Varga , Laszlo Kalafszky , Imre Toth
IPC分类号： B32B3/06 , B05D5/12 , B32B37/12 , B32B37/14
CPC分类号： G01M3/045 , Y10T156/10 , Y10T428/249955
摘要： The invention relates to a system for detecting the defects of a wall used for enclosing a space where—generally liquid—materials are stored, with a coating on its internal side, especially a container wall, or/and the defects in the coating. In numerous fields of life all types of different materials, such as chemicals, solvents, petroleum oil and petroleum fractions, etc. need to be stored in a way excluding the possibility of these materials getting into the environment or other materials from the environment intermixing with the stored materials. In most cases such materials are stored in containers made of different materials, mostly metal, the walls of which holes may appear either as a result of corrosion or other damage, and through the appearing holes materials can flow either from outside into the container or from inside the container into the environment, and so the stored material may become unsuitable for use or serious environmental pollution may occur. In the interest of damage prevention different monitoring systems are used to detect holes appearing in container walls as soon as possible.
摘要翻译：本发明涉及一种用于检测用于封闭空间的壁的系统，其中通常是液体材料被储存，其内部具有涂层，特别是容器壁，或/和涂层中的缺陷。在许多生命领域，需要以不同于这些材料进入环境的可能性或与环境混合的其他材料的方式存储所有类型的不同材料，如化学品，溶剂，石油和石油馏分等。存储的材料。在大多数情况下，这种材料储存在由不同材料制成的容器中，大部分是金属的，其壁孔由于腐蚀或其他损坏而出现，通过出现的孔，材料可以从外部流入容器或从在容器内进入环境，因此储存的材料可能不适合使用或可能发生严重的环境污染。为了防止损害，使用不同的监控系统尽快检测出容器壁上的孔。

7. 发明授权

US08490807B2 Fuel container for motor vehicles with a tie rod 有权
标题翻译：带有拉杆的机动车用燃油箱
公开(公告)号：US08490807B2
公开(公告)日：2013-07-23
申请号：US13389463
申请日：2010-08-05
申请人： Laszlo Varga
发明人： Laszlo Varga
IPC分类号： B65D6/34 , B65D6/28
CPC分类号： B60K15/03177 , B60K2015/03467
摘要： A fuel container operating under overpressure and consisting of two shells is to be reinforced by means of an inner column so that, when the two shells are conjoined, a tension resistant connection is created. For this purpose, the column consists of a first and a second part connected to the respective shell, one part having catches, the other part having latching hooks, which catches and latching hooks for a tension resistant snap-in connection when joined together. For this purpose, both parts have latching surfaces and deflecting surfaces and the latching hook is resiliently displaceable.
摘要翻译：在超压下操作并由两个壳组成的燃料容器将通过内柱加强，使得当两个壳结合时，产生抗张力连接。为此，柱由连接到相应壳体的第一部分和第二部分组成，一个部分具有卡爪，另一部分具有闩锁钩，当连接在一起时，卡扣钩和卡扣钩用于抗张力咬合连接。为此，两个部件都具有锁定表面和偏转表面，并且闩锁钩可弹性移位。

8. 发明申请

US20050213621A1 Temperature compensation for fiber optic transceivers using optimized convergence algorithms 有权
标题翻译：使用优化的收敛算法对光纤收发器进行温度补偿
公开(公告)号：US20050213621A1
公开(公告)日：2005-09-29
申请号：US10808944
申请日：2004-03-25
申请人： Laszlo Varga , Nelson Diaz , Robert Jones
发明人： Laszlo Varga , Nelson Diaz , Robert Jones
IPC分类号： H01S3/00 , H01S5/06 , H01S5/068 , H01S5/0683
CPC分类号： H01S5/0683 , H01S5/0617 , H01S5/06804 , H01S5/06825
摘要： A temperature compensation system comprises a laser driver having a first potentiometer, the laser driver configured to provide a first signal to a laser based on a value of the first potentiometer and an optical communication analyzer configured to provide a second signal indicative of a first output parameter of the laser. The temperature compensation system comprises a computer system configured to drive the first signal and receive the second signal and determine a first updated value for the first potentiometer to obtain a first desired laser output parameter value based on a first known value of the first potentiometer, the second signal, and the first desired laser output parameter value.
摘要翻译：温度补偿系统包括具有第一电位器的激光驱动器，所述激光驱动器被配置为基于第一电位计的值向激光器提供第一信号;以及光通信分析器，被配置为提供指示第一输出参数的第二信号的激光。温度补偿系统包括计算机系统，被配置为驱动第一信号并接收第二信号，并且确定第一电位器的第一更新值，以基于第一电位器的第一已知值获得第一所需激光输出参数值，第二信号和第一期望的激光输出参数值。

9. 发明授权

US4652562A Quinoline derivatives and pharmaceutical compositions 失效
标题翻译：喹啉衍生物和药物组合物
公开(公告)号：US4652562A
公开(公告)日：1987-03-24
申请号：US870396
申请日：1986-06-04
申请人： Edit Berenyi nee Poldermann , Laszlo Varga , Laszlo Pallos , Lujza Petocz , Laszlo Ladanyi , Peter Tompe , Eva Hartai nee Zsorzs , Agnes Kovacs nee Palotai
发明人： Edit Berenyi nee Poldermann , Laszlo Varga , Laszlo Pallos , Lujza Petocz , Laszlo Ladanyi , Peter Tompe , Eva Hartai nee Zsorzs , Agnes Kovacs nee Palotai
IPC分类号： A61K31/47 , A61K31/495 , A61K31/535 , A61P35/00 , A61P43/00 , C07D215/42 , C07D215/46 , C07D401/12 , C07D405/12 , C07D413/12
CPC分类号： C07D401/12 , C07D215/46 , C07D405/12
摘要： The invention relates to new quinoline derivatives of the general Formula I ##STR1## (wherein X stands for hydrogen, halogen or lower alkoxy;n is an integer of 1, 2 or 3;R.sup.1 represents hydrogen andR.sup.2 represents hydroxy-lower alkyl or lower alkoxy-lower alkyl or a group of the general formula IV, ##STR2## wherein Z stands for --O--, --S--, --NH-- or --N(lower alkyl)--; the dotted lines represent optional bonds; andm is 0 or 1; orR.sup.1 and R.sup.2 together with the adjacent nitrogen atom, they are attached to, form a 5- or 6-membered heterocyclic group which may optionally contain a further oxygen, nitrogen or sulfur heteroatom and may be optionally substituted),and pharmaceutically acceptable acid addition salts thereof. The new compounds of the present invention exhibit radiosensitizing effect, make hypoxial cells highly sensitive towards radiation and may be used in radiation therapy.
摘要翻译：本发明涉及通式Ⅰ（I）的新喹啉衍生物（其中X代表氢，卤素或低级烷氧基; n是1,2或3的整数; R1代表氢，R2代表羟基低级烷基或低级烷氧基 - 低级烷基或通式Ⅳ的基团，其中Z代表-O - ， - S - ， - NH-或-N（低级烷基） - ;虚线表示任选的键;并且m为0或1;或者R1和R2与相邻的氮原子一起连接，形成可任选地含有另外的氧，氮或硫杂原子的5-或6-元杂环基，并且可以任选取代）及其药学上可接受的酸加成盐。本发明的新化合物显示放射增敏作用，使低氧细胞对辐射高度敏感，并可用于放射治疗。

10. 发明授权

US4514911A Method for removing moisture adhered to surfaces of bodies and for simultaneously adjusting the surface temperature of the bodies 失效
标题翻译：去除附着在物体表面的水分并同时调节物体的表面温度的方法
公开(公告)号：US4514911A
公开(公告)日：1985-05-07
申请号：US397876
申请日：1982-07-13
申请人： Laszlo Varga , Sandor Krekacs , Janos Latorcai , Zoltan Palfi , Istvan Fledrich
发明人： Laszlo Varga , Sandor Krekacs , Janos Latorcai , Zoltan Palfi , Istvan Fledrich
IPC分类号： F26B3/04 , F26B21/12
CPC分类号： F26B21/12 , F26B3/04
摘要： A method for removing the moisture adhered to surfaces of bodies and simultaneously for adjusting the surface temperature of the bodies to a predetermined value, in which air or steam having a temperature within the range of .+-.10 degrees centigrade of the surface temperature to be reached is streamed along the surface of the body, wherein an average velocity of stream of the air or steam is as follows: ##EQU1## wherein v.sub.1 is the average velocity of stream of the air or steam,g is the gravitational acceleration (g=9.81 m/s.sup.2),t.sub.v is the dynamic viscosity of the moisture in the state of its removal,G.sub.1 is the specific weight of the air or steam in the state or removal of the moisture,v.sub.v1 is the velocity of stream of the moisture at radius R.sub.1,R.sub.b is the hydraulic radius of the moistened surface,R.sub.1 is the hydraulic radius of the interface of the moisture and the air or steam,f.sub.1 is the degree of saturation of the air or steam,c is ##EQU2## wherein 0.0015
摘要翻译：一种除去附着在物体表面上的水分并同时用于将物体的表面温度调节到预定值的方法，其中将具有在表面温度的+/- 10摄氏度的温度范围内的空气或蒸汽达到的物体沿着身体的表面流动，其中空气或蒸汽的平均流速如下：其中＆upbar＆v1是空气或蒸汽的平均流速，g是重力加速度（g = 9.81m / s2），tv是去除状态下水分的动态粘度，G1是状态下的空气或蒸汽的比重或水分的去除，vv1是水分流的速度在半径R1处，Rb是润湿表面的液压半径，R1是水分和空气或蒸汽的界面的液压半径，f1是空气或蒸汽的饱和度，c是，其中0.0015

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