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1. 发明申请

US20110171269A1 METHOD FOR MANUFACTURING UNIFORM SIZE POLYMERIC NANOPARTICLES CONTAINING POORLY SOLUBLE DRUGS 有权
标题翻译：制造含有不溶性药物的均匀聚合物纳米颗粒的方法
公开(公告)号：US20110171269A1
公开(公告)日：2011-07-14
申请号：US12990540
申请日：2009-04-30
申请人： Bong Hyun Chung , Yong Taik Lim , Jung Hyun Han
发明人： Bong Hyun Chung , Yong Taik Lim , Jung Hyun Han
IPC分类号： A61K9/00 , A61K31/235 , A61P1/16 , B82Y40/00 , B82Y5/00
CPC分类号： A61K9/1652 , A61K9/5153 , A61K31/235 , A61K31/343 , A61K31/513 , A61K31/519 , A61K31/5415 , A61K31/573 , A61K31/585 , A61K31/704 , A61K31/7048 , B01D65/00 , C08J3/03 , Y10S516/929
摘要： The present invention relates to a method for manufacturing uniform size polymeric nanoparticles containing poorly soluble drugs, and more particularly, to a method for manufacturing uniform size polymeric nanoparticles containing poorly soluble drugs, including a first step of dissolving a biodegradable polymer in a non-volatile polar organic solvent, a second step of adding poorly soluble drugs to water and the biodegradable polymer solution to produce a dispersion, and a third step of adding the dispersion to emulsifier solutions in a batch under the condition of low mechanical energy level stirring. The polymeric nanoparticles of the present invention is capable of manufacturing nano-sized small and uniform polymeric nanoparticles through a simple method of employing a non-volatile polar solvent, especially a solvent having a polarity similar to that of water, as a solvent for a mixture solution of biodegradable polymer and poorly soluble materials, and using a low mechanical energy condition and batch-adding of dispersion in an emulsifying process. The polymeric nanoparticles of the present invention are advantageous in that the dissolution rate of the poorly soluble drugs contained in polymeric particles is dramatically improved, and the poorly soluble drugs are gradually and steadily released and maintained at a constant density over a long period of time.
摘要翻译：本发明涉及一种制备均匀尺寸的含有难溶性药物的聚合物纳米颗粒的方法，更具体地说，涉及一种制备均匀尺寸的含有难溶性药物的聚合物纳米颗粒的方法，包括将可生物降解聚合物溶解在非挥发性物质中的第一步骤极性有机溶剂，向水中添加难溶性药物和生物降解性聚合物溶液以产生分散体的第二步骤，以及在低机械能级搅拌的条件下将分散体分批加入到乳化剂溶液中的第三步骤。本发明的聚合物纳米颗粒能够通过使用非挥发性极性溶剂，特别是极性类似于水的溶剂的简单方法作为混合物的溶剂来制造纳米尺寸的小而均匀的聚合物纳米颗粒可生物降解聚合物和难溶性物质的溶液，并且使用低机械能条件和在乳化过程中分批添加分散体。本发明的聚合物纳米颗粒的优点在于，包含在聚合物颗粒中的难溶性药物的溶解速度显着提高，并且难溶性药物在长时间内逐渐且稳定地释放并保持在恒定的密度。

2. 发明申请

US20110020225A1 POROUS POLYMER PARTICLES IMMOBILIZED WITH CHARGED MOLECULES AND METHOD FOR PREPARING THE SAME 审中-公开
标题翻译：用充电分子固定的多孔聚合物颗粒及其制备方法
公开(公告)号：US20110020225A1
公开(公告)日：2011-01-27
申请号：US12672517
申请日：2008-08-05
申请人： Bong Hyun Chung , Yong Taik Lim , Jung Hyun Han
发明人： Bong Hyun Chung , Yong Taik Lim , Jung Hyun Han
IPC分类号： A61K49/00 , A61K9/14 , A61P31/00
CPC分类号： A61K9/5031 , A61K49/0034 , A61K49/0054 , A61K49/0056 , A61K49/0089 , C08J3/12 , C08J2367/04
摘要： The present invention relates to porous polymer particles containing a charged molecule immobilized therein and a method for preparing the same. According to the disclosed invention, porous particles can be prepared using a biocompatible polymer and, at the same time, a charged molecule can be immobilized in the pores of the porous particles, such that various charged molecules can be loaded in the porous particles. In addition, various kinds of drugs or functional materials can be loaded into the porous particles of the present invention by electrostatic attraction and absorption or adsorption by a capillary phenomenon occurring due to porous properties.
摘要翻译：本发明涉及含有固定在其中的带电分子的多孔聚合物颗粒及其制备方法。根据所公开的发明，可以使用生物相容性聚合物制备多孔颗粒，并且同时可以将带电分子固定在多孔颗粒的孔中，使得各种带电分子可以负载在多孔颗粒中。此外，通过由于多孔性质而发生的毛细管现象的静电吸引和吸收，可以将各种药物或功能材料装载到本发明的多孔颗粒中。

3. 发明授权

US08758822B2 Method for manufacturing uniform size polymeric nanoparticles containing poorly soluble drugs 有权
标题翻译：制备均匀尺寸的含有难溶性药物的聚合物纳米颗粒的方法
公开(公告)号：US08758822B2
公开(公告)日：2014-06-24
申请号：US12990540
申请日：2009-04-30
申请人： Bong Hyun Chung , Yong Taik Lim , Jung Hyun Han
发明人： Bong Hyun Chung , Yong Taik Lim , Jung Hyun Han
IPC分类号： A61K9/14 , A61K38/00 , A61K38/36 , A61K38/13 , A01N45/00 , A61K31/56 , A61K31/585 , A61K31/54 , A61K31/505 , A61K31/095 , A61K31/045 , B01D61/00 , A61K9/16 , C08J3/03 , B01D65/00
CPC分类号： A61K9/1652 , A61K9/5153 , A61K31/235 , A61K31/343 , A61K31/513 , A61K31/519 , A61K31/5415 , A61K31/573 , A61K31/585 , A61K31/704 , A61K31/7048 , B01D65/00 , C08J3/03 , Y10S516/929
摘要： The present invention relates to a method for manufacturing uniform size polymeric nanoparticles containing poorly soluble drugs, and more particularly, to a method for manufacturing uniform size polymeric nanoparticles containing poorly soluble drugs, including a first step of dissolving a biodegradable polymer in a non-volatile polar organic solvent, a second step of adding poorly soluble drugs to water and the biodegradable polymer solution to produce a dispersion, and a third step of adding the dispersion to emulsifier solutions in a batch under the condition of low mechanical energy level stirring. The polymeric nanoparticles of the present invention is capable of manufacturing nano-sized small and uniform polymeric nanoparticles through a simple method of employing a non-volatile polar solvent, especially a solvent having a polarity similar to that of water, as a solvent for a mixture solution of biodegradable polymer and poorly soluble materials, and using a low mechanical energy condition and batch-adding of dispersion in an emulsifying process. The polymeric nanoparticles of the present invention are advantageous in that the dissolution rate of the poorly soluble drugs contained in polymeric particles is dramatically improved, and the poorly soluble drugs are gradually and steadily released and maintained at a constant density over a long period of time.
摘要翻译：本发明涉及一种制备均匀尺寸的含有难溶性药物的聚合物纳米颗粒的方法，更具体地说，涉及一种制备均匀尺寸的含有难溶性药物的聚合物纳米颗粒的方法，包括将可生物降解聚合物溶解在非挥发性物质中的第一步骤极性有机溶剂，向水中添加难溶性药物和生物降解性聚合物溶液以产生分散体的第二步骤，以及在低机械能级搅拌的条件下将分散体分批加入到乳化剂溶液中的第三步骤。本发明的聚合物纳米颗粒能够通过使用非挥发性极性溶剂，特别是极性类似于水的溶剂的简单方法作为混合物的溶剂来制造纳米尺寸的小而均匀的聚合物纳米颗粒可生物降解聚合物和难溶性物质的溶液，并且使用低机械能条件和在乳化过程中分批添加分散体。本发明的聚合物纳米颗粒的优点在于，包含在聚合物颗粒中的难溶性药物的溶解速度显着提高，并且难溶性药物在长时间内逐渐稳定地释放并保持在恒定的密度。

4. 发明授权

US08734762B2 Perfluorocarbon nano-emulsion containing quantum dot nanoparticles and method for preparing the same 有权
标题翻译：含有量子点纳米粒子的全氟化碳纳米乳液及其制备方法
公开(公告)号：US08734762B2
公开(公告)日：2014-05-27
申请号：US12738394
申请日：2008-08-20
申请人： Bong Hyun Chung , Yong Taik Lim , Bang Sil Choi , Jung Hyun Han
发明人： Bong Hyun Chung , Yong Taik Lim , Bang Sil Choi , Jung Hyun Han
IPC分类号： A61B5/00 , A61B8/00 , A61K9/66
CPC分类号： C09K11/565 , C09K11/02 , C09K11/883
摘要： The present invention relates to a perfluorocarbon nanoemulsion containing quantum dot nanoparticles and a method for preparing the same, more specifically, relates to a method for preparing a multifunctional perfluorocarbon nanoemulsion which simultaneously shows the fluorine-based magnetic resonance properties of perfluorocarbon and the optical properties of quantum dot nanoparticles, the method comprising dispersing quantum dot nanoparticles, modified with a fluorine end group, in perfluorocarbon, and then adding an aqueous emulsifier solution containing lipid to the dispersion. The disclosed perfluorocarbon nanoemulsion containing quantum dot nanoparticles has excellent biocompatibility and simultaneously shows optical properties and magnetic resonance properties, and thus can be used as a contrast agent for multi-mode molecular imaging. Accordingly, the nanoemulsion can be used to study cell and small-animal molecular imaging in various fields, including biological and medical fields.
摘要翻译：本发明涉及含有量子点纳米粒子的全氟碳纳米乳液及其制备方法，更具体地涉及制备多功能全氟碳纳米乳液的方法，该方法同时显示全氟化碳的氟基磁共振性能和光学性能量子点纳米粒子，该方法包括将用氟端基改性的量子点纳米粒子分散在全氟化碳中，然后向分散体中加入含有脂质的水性乳化剂溶液。所公开的含有量子点纳米粒子的全氟化碳纳米乳液具有优异的生物相容性，并同时显示光学性质和磁共振性质，因此可用作多模式分子成像的造影剂。因此，纳米乳液可用于研究包括生物和医学领域在内的各个领域的细胞和小动物分子成像。

5. 发明申请

US20110212032A1 POLYMER PARTICLES FOR NIR/MR BIMODAL MOLECULAR IMAGING AND METHOD FOR PREPARING THE SAME 审中-公开
标题翻译：用于NIR / MR双模分子成像的聚合物颗粒及其制备方法
公开(公告)号：US20110212032A1
公开(公告)日：2011-09-01
申请号：US12672185
申请日：2008-08-20
申请人： Bong Hyun Chung , Yong Taik LIm , Jung Hyun Han
发明人： Bong Hyun Chung , Yong Taik LIm , Jung Hyun Han
IPC分类号： A61K49/12 , C12Q1/02
CPC分类号： C08J5/005 , A61K49/0002 , A61K49/0034 , A61K49/0067 , A61K49/0093 , A61K49/1824 , B82Y30/00 , C08J3/12 , C08J3/2053 , C08J3/215 , C08J2367/02 , G01R33/0213 , G01R33/1269 , G01R33/281 , G01R33/4808 , G01R33/5601
摘要： The present invention relates to polymer particles showing magnetic properties and fluorescent properties simultaneously and a preparation method thereof More specifically, relates to polymer particles for near infrared (NIR)/magnetic resonance (MR) bimodal molecular imaging, contain a magnetic nanomaterial and an NIR fluorescent material, and a preparation method thereof The disclosed polymer particles show magnetic properties and fluorescent properties simultaneously, and thus are useful as contrast agents for NIR/MR bimodal molecular imaging.
摘要翻译：本发明涉及同时显示磁特性和荧光特性的聚合物颗粒及其制备方法更具体地，涉及用于近红外（NIR）/磁共振（MR）双峰分子成像的聚合物颗粒，其含有磁性纳米材料和NIR荧光材料及其制备方法所公开的聚合物颗粒同时显示磁性和荧光特性，因此可用作NIR / MR双峰分子成像的造影剂。

6. 发明申请

US20100233094A1 PERFLUOROCARBON NANO-EMULSION CONTAINING QUANTUM DOT NANOPARTICLES AND METHOD FOR PREPARING THE SAME 有权
标题翻译：含有量子纳米粒子的全氟烷纳米乳液及其制备方法
公开(公告)号：US20100233094A1
公开(公告)日：2010-09-16
申请号：US12738394
申请日：2008-08-20
申请人： Bong Hyun Chung , Yong Taik Lim , Bang Sil Choi , Jung Hyun Han
发明人： Bong Hyun Chung , Yong Taik Lim , Bang Sil Choi , Jung Hyun Han
IPC分类号： A61B5/055
CPC分类号： C09K11/565 , C09K11/02 , C09K11/883
摘要： The present invention relates to a perfluorocarbon nanoemulsion containing quantum dot nanoparticles and a method for preparing the same, more specifically, relates to a method for preparing a multifunctional perfluorocarbon nanoemulsion which simultaneously shows the fluorine-based magnetic resonance properties of perfluorocarbon and the optical properties of quantum dot nanoparticles, the method comprising dispersing quantum dot nanoparticles, modified with a fluorine end group, in perfluorocarbon, and then adding an aqueous emulsifier solution containing lipid to the dispersion. The disclosed perfluorocarbon nanoemulsion containing quantum dot nanoparticles has excellent biocompatibility and simultaneously shows optical properties and magnetic resonance properties, and thus can be used as a contrast agent for multi-mode molecular imaging. Accordingly, the nanoemulsion can be used to study cell and small-animal molecular imaging in various fields, including biological and medical fields.
摘要翻译：本发明涉及含有量子点纳米粒子的全氟碳纳米乳液及其制备方法，更具体地涉及制备多功能全氟碳纳米乳液的方法，该方法同时显示全氟化碳的氟基磁共振性能和光学性能量子点纳米粒子，该方法包括将用氟端基改性的量子点纳米粒子分散在全氟化碳中，然后向分散体中加入含有脂质的水性乳化剂溶液。所公开的含有量子点纳米粒子的全氟化碳纳米乳液具有优异的生物相容性，并同时显示光学性质和磁共振性质，因此可用作多模式分子成像的造影剂。因此，纳米乳液可用于研究包括生物和医学领域在内的各个领域的细胞和小动物分子成像。

7. 发明申请

US20120041178A1 Coenzyme Q10 Nanoparticles, Preparation Method Thereof and Composition Containing Said Nanoparticles 失效
标题翻译：辅酶Q10纳米颗粒，其制备方法和含有所述纳米颗粒的组合物
公开(公告)号：US20120041178A1
公开(公告)日：2012-02-16
申请号：US13263296
申请日：2010-04-06
申请人： Bong Hyun Chung , Jung Hyun Han
发明人： Bong Hyun Chung , Jung Hyun Han
IPC分类号： C07K14/00 , C07C323/58 , C07C229/22 , C07C279/14 , C07D207/16 , C07K14/47 , C07K14/76 , C07K14/765 , C07C227/14 , C07C229/00 , C07C229/26 , B82Y40/00 , B82Y5/00
CPC分类号： A61K31/122 , A23L33/15 , A23V2002/00 , A61K9/0014 , A61K9/127 , A61K9/145 , A61K9/146 , A61K47/10 , A23V2250/314
摘要： Provided are a coenzyme Q10 nanoparticle, a method of preparing the same and a composition having the nanoparticle. According to the present invention, Coenzyme Q10 may be dissolved in only a water-miscible organic solvent, and easily made into a nano-sized particle and solubilized under a low energy condition, for example, by simple stirring. The coenzyme Q10 may be dispersion-stabilized by an amino acid or protein. The coenzyme Q10 is formed in a nano-sized particle and solubilized, an absorption rate may be increased and simultaneously deliver the amino acid and protein with the nanoparticle. Thus, the coenzyme Q10 nanoparticle can be effectively used in food, cosmetics and medicine.
摘要翻译：提供了辅酶Q10纳米颗粒，其制备方法和具有纳米颗粒的组合物。根据本发明，辅酶Q10可以仅溶解在水混溶性有机溶剂中，并且容易地制成纳米尺寸的颗粒并在低能量条件下溶解，例如通过简单搅拌。辅酶Q10可以通过氨基酸或蛋白质进行分散稳定化。辅酶Q10在纳米尺寸的颗粒中形成并溶解，可以增加吸收速率并同时与纳米颗粒递送氨基酸和蛋白质。因此，辅酶Q10纳米颗粒可以有效地用于食品，化妆品和医药。

8. 发明授权

US08785598B2 Coenzyme Q10 nanoparticles, preparation method thereof and composition containing said nanoparticles 失效
标题翻译：辅酶Q10纳米颗粒，其制备方法和含有所述纳米颗粒的组合物
公开(公告)号：US08785598B2
公开(公告)日：2014-07-22
申请号：US13263296
申请日：2010-04-06
申请人： Bong Hyun Chung , Jung Hyun Han
发明人： Bong Hyun Chung , Jung Hyun Han
IPC分类号： C07K14/00
CPC分类号： A61K31/122 , A23L33/15 , A23V2002/00 , A61K9/0014 , A61K9/127 , A61K9/145 , A61K9/146 , A61K47/10 , A23V2250/314
摘要： Provided are a coenzyme Q10 nanoparticle, a method of preparing the same and a composition having the nanoparticle. According to the present invention, Coenzyme Q10 may be dissolved in only a water-miscible organic solvent, and easily made into a nano-sized particle and solubilized under a low energy condition, for example, by simple stirring. The coenzyme Q10 may be dispersion-stabilized by an amino acid or protein. The coenzyme Q10 is formed in a nano-sized particle and solubilized, an absorption rate may be increased and simultaneously deliver the amino acid and protein with the nanoparticle. Thus, the coenzyme Q10 nanoparticle can be effectively used in food, cosmetics and medicine.
摘要翻译：提供了辅酶Q10纳米颗粒，其制备方法和具有纳米颗粒的组合物。根据本发明，辅酶Q10可以仅溶解在水混溶性有机溶剂中，并且容易地制成纳米尺寸的颗粒并在低能量条件下溶解，例如通过简单搅拌。辅酶Q10可以通过氨基酸或蛋白质进行分散稳定化。辅酶Q10在纳米尺寸的颗粒中形成并溶解，可以增加吸收速率并同时与纳米颗粒递送氨基酸和蛋白质。因此，辅酶Q10纳米颗粒可以有效地用于食品，化妆品和医药。

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