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1. 发明授权

US08541005B2 Cysteine-tagged streptococcal protein G variant 有权
标题翻译：半胱氨酸标记的链球菌蛋白G变体
公开(公告)号：US08541005B2
公开(公告)日：2013-09-24
申请号：US12306903
申请日：2007-06-20
申请人： Bong Hyun Chung , Jeong Min Lee , Sun-Ok Jung , Yongwon Jung
发明人： Bong Hyun Chung , Jeong Min Lee , Sun-Ok Jung , Yongwon Jung
IPC分类号： A61K39/09 , A61K39/085 , C12Q1/00
CPC分类号： C07K14/31 , C07K17/00 , C07K2319/00 , C07K2319/20 , G01N33/54366 , G01N33/54393 , G01N33/56938 , G01N33/6854 , G01N2333/31 , G01N2333/315
摘要： The present invention relates to an N-terminal cysteine-tagged Streptococcal protein G variant. Since the variant binds in a directional manner to a surface of a biochip or a biosensor, the variant provides a biochip and a biosensor having an improved antibody-immobilizing capability, compared with an untagged protein G variant.
摘要翻译：本发明涉及N-末端半胱氨酸标记的链球菌蛋白G变体。由于变体以定向方式结合生物芯片或生物传感器的表面，与未标记的蛋白G变体相比，该变体提供具有改进的抗体固定能力的生物芯片和生物传感器。

2. 发明申请

US20100173430A1 CYSTEINE-TAGGED STAPHYLOCOCCAL PROTEIN G VARIANT 有权
公开(公告)号：US20100173430A1
公开(公告)日：2010-07-08
申请号：US12306903
申请日：2007-06-20
申请人： Bong Hyun Chung , Jeong Min Lee , Sun-Ok Jung , Yongwon Jung
发明人： Bong Hyun Chung , Jeong Min Lee , Sun-Ok Jung , Yongwon Jung
IPC分类号： G01N33/543 , C07K14/315 , C12N15/31 , C12N15/63 , C12N1/00 , C12P21/00 , G01N33/00
CPC分类号： C07K14/31 , C07K17/00 , C07K2319/00 , C07K2319/20 , G01N33/54366 , G01N33/54393 , G01N33/56938 , G01N33/6854 , G01N2333/31 , G01N2333/315
摘要： The present invention relates to an N-terminal cysteine-tagged Streptococcal protein G variant. Since the variant binds in a directional manner to a surface of a biochip or a biosensor, the variant provides a biochip and a biosensor having an improved antibody-immobilizing capability, compared with an untagged protein G variant.
摘要翻译：本发明涉及N-末端半胱氨酸标记的链球菌蛋白G变体。由于变体以定向方式结合生物芯片或生物传感器的表面，与未标记的蛋白G变体相比，该变体提供具有改进的抗体固定能力的生物芯片和生物传感器。

3. 发明申请

US20100209945A1 METHOD FOR PREPARING ANTIBODY MONOLAYERS WHICH HAVE CONTROLLED ORIENTATION USING PEPTIDE HYBRID 有权
标题翻译：使用肽混合物制备具有控制方向的抗体单体的方法
公开(公告)号：US20100209945A1
公开(公告)日：2010-08-19
申请号：US12679982
申请日：2007-10-18
申请人： Sang Jeon Chung , Bong Hyun Chung , Yongwon Jung , Hyo Jin Kang , Jeong Min Lee
发明人： Sang Jeon Chung , Bong Hyun Chung , Yongwon Jung , Hyo Jin Kang , Jeong Min Lee
IPC分类号： G01N33/53 , C07K7/08 , C07K7/06 , G01N1/31
CPC分类号： C07K17/00 , C07K7/02 , C07K7/08 , G01N33/54353 , G01N33/54393
摘要： The present invention relates to a method for preparing an protein monolayer using a peptide hybrid for protein immobilization, more precisely a peptide hybrid for protein immobilization which has improved solubility by introducing a PEG linker and a proper reaction group to the oligopeptide having specific affinity to selected types of proteins and is designed to provide enough space between solid substrates and proteins immobilized, whereby various solid substrates treated by the hybrid catch specific proteins effectively on. The peptide hybrid for protein immobilization of the present invention facilitates the control of orientation of an antibody on various solid surfaces and immobilization of various antibodies of different origins or having different isotypes with different affinity. Therefore, the surface treatment technique using the peptide hybrid of the invention can be effectively used for the production of various immunosensors and immune chips.
摘要翻译：本发明涉及一种使用肽杂交体制备蛋白质单层的方法，更准确地说是用于蛋白质固定的肽杂合物，其通过将PEG接头和适当的反应基团引入具有对所选择的特异性亲和力的寡肽而具有改善的溶解性蛋白质类型被设计为在固体底物和固定的蛋白质之间提供足够的空间，由此通过混合物处理的各种固体底物有效捕获特异性蛋白质。用于本发明的蛋白质固定的肽杂合物有助于控制抗体在各种固体表面上的取向，并且固定不同来源的各种抗体或具有不同亲和力的不同同种型。因此，使用本发明的肽杂交体的表面处理技术可以有效地用于生产各种免疫传感器和免疫芯片。

4. 发明授权

US08236509B2 Method for preparing antibody monolayers which have controlled orientation using peptide hybrid 有权
标题翻译：使用肽杂交制备具有受控取向的抗体单层的方法
公开(公告)号：US08236509B2
公开(公告)日：2012-08-07
申请号：US12679982
申请日：2007-10-18
申请人： Sang Jeon Chung , Bong Hyun Chung , Yongwon Jung , Hyo Jin Kang , Jeong Min Lee
发明人： Sang Jeon Chung , Bong Hyun Chung , Yongwon Jung , Hyo Jin Kang , Jeong Min Lee
IPC分类号： G01N33/53
CPC分类号： C07K17/00 , C07K7/02 , C07K7/08 , G01N33/54353 , G01N33/54393
摘要： The present invention relates to a method for preparing an protein monolayer using a peptide hybrid for protein immobilization, more precisely a peptide hybrid for protein immobilization which has improved solubility by introducing a PEG linker and a proper reaction group to the oligopeptide having specific affinity to selected types of proteins and is designed to provide enough space between solid substrates and proteins immobilized, whereby various solid substrates treated by the hybrid catch specific proteins effectively on. The peptide hybrid for protein immobilization of the present invention facilitates the control of orientation of an antibody on various solid surfaces and immobilization of various antibodies of different origins or having different isotypes with different affinity. Therefore, the surface treatment technique using the peptide hybrid of the invention can be effectively used for the production of various immunosensors and immune chips.
摘要翻译：本发明涉及一种使用肽杂交体制备蛋白质单层的方法，更准确地说，用于蛋白质固定的肽杂交体，其通过将PEG接头和适当的反应基团引入具有对所选择的特异性亲和力的寡肽而具有改善的溶解性蛋白质类型被设计为在固体底物和固定的蛋白质之间提供足够的空间，由此通过混合物处理的各种固体底物有效捕获特异性蛋白质。用于本发明的蛋白质固定化的肽杂合物有助于控制抗体在各种固体表面上的取向并且固定不同来源的各种抗体或具有不同亲和力的不同同种型。因此，使用本发明的肽杂交体的表面处理技术可以有效地用于生产各种免疫传感器和免疫芯片。

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