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1. 发明授权

US06566298B2 Diphosphines 有权
公开(公告)号：US06566298B2
公开(公告)日：2003-05-20
申请号：US10219750
申请日：2002-08-15
申请人： Birgit Driessen-Hölscher , Joachim Kralik , Inga Ritzkopf , Christian Steffens , Guido Giffels , Claus Dreisbach , Thomas Prinz , Walter Lange
发明人： Birgit Driessen-Hölscher , Joachim Kralik , Inga Ritzkopf , Christian Steffens , Guido Giffels , Claus Dreisbach , Thomas Prinz , Walter Lange
IPC分类号： B01J3124
CPC分类号： B01J31/2409 , B01J2231/641 , B01J2231/645 , B01J2531/0266 , B01J2531/80 , B01J2531/821 , B01J2531/822 , B01J2531/827 , C07C303/28 , C07D321/10 , C07F9/5027 , C07F9/5072 , C07F9/572 , C07F9/65515 , C07F15/0013 , C07F15/004 , C07F15/0053 , C07F15/008 , C07C309/65
摘要： The invention relates to the preparation and use as catalysts of diphosphines of the formula (I) in which R is C6-C14-aryl or C4-C13-heteroaryl containing 1 to 3 heteroatoms selected from the group consisting of nitrogen, oxygen, and sulfur, wherein the aryl and heteroaryl radicals may optionally be substituted by halogen, C1-C6-alkyl, C1-C6-alkoxy, and/or trimethylsilyl, and R1 to R4, independently of one another, are each hydrogen, C1-C10-alkyl, C1-C10-alkoxy, F, Cl, or Br.

2. 发明授权

US06462200B2 Diphosphines 失效
标题翻译：二膦
公开(公告)号：US06462200B2
公开(公告)日：2002-10-08
申请号：US09948826
申请日：2001-09-07
申请人： Birgit Driessen-Hölscher , Joachim Kralik , Inga Ritzkopf , Christian Steffens , Guido Giffels , Claus Dreisbach , Thomas Prinz , Walter Lange
发明人： Birgit Driessen-Hölscher , Joachim Kralik , Inga Ritzkopf , Christian Steffens , Guido Giffels , Claus Dreisbach , Thomas Prinz , Walter Lange
IPC分类号： C07F9572
CPC分类号： B01J31/2409 , B01J2231/641 , B01J2231/645 , B01J2531/0266 , B01J2531/80 , B01J2531/821 , B01J2531/822 , B01J2531/827 , C07C303/28 , C07D321/10 , C07F9/5027 , C07F9/5072 , C07F9/572 , C07F9/65515 , C07F15/0013 , C07F15/004 , C07F15/0053 , C07F15/008 , C07C309/65
摘要： The invention relates to the preparation and use as catalysts of diphosphines of the formula (I) in which R is C6-C14-aryl or C4-C13-heteroaryl containing 1 to 3 heteroatoms selected from the group consisting of nitrogen, oxygen, and sulfur, wherein the aryl and heteroaryl radicals may optionally be substituted by halogen, C1-C6-alkyl, C1-C6-alkoxy, and/or trimethylsilyl, and R1 to R4, independently of one another, are each hydrogen, C1-C10-alkyl, C1-C10-alkoxy, F, Cl, or Br.
摘要翻译：本发明涉及制备和用作式（I）的二膦的催化剂，其中R是含有1至3个选自氮，氧和硫的杂原子的C 6 -C 14 - 芳基或C 4 -C 13 - 杂芳基，其中芳基和杂芳基可以任选被卤素，C 1 -C 6 - 烷基，C 1 -C 6 - 烷氧基和/或三甲基甲硅烷基取代，R 1 -R 4各自独立地为氢，C 1 -C 10 - 烷基，C 1 -C 10 - 烷氧基，F，Cl或Br。

3. 发明授权

US06689889B2 Chromatographic separation of enantiomers of lactones 失效
标题翻译：内酯对映异构体的色谱分离
公开(公告)号：US06689889B2
公开(公告)日：2004-02-10
申请号：US09757919
申请日：2001-01-10
申请人： Walter Lange , Rolf Grosser , Burkhard Köhler , Stefan Michel , Bruno Bömer , Uwe Zweering
发明人： Walter Lange , Rolf Grosser , Burkhard Köhler , Stefan Michel , Bruno Bömer , Uwe Zweering
IPC分类号： C07D40506
CPC分类号： C07D405/06 , C07B2200/07 , C07D309/30 , G01N30/02 , G01N30/48 , B01D15/3833
摘要： The present invention relates to the use of optically active polymers of N-acryloyl-phenylalanine neomenthylamide as such, in crosslinked form and/or in carrier-bonded form as stationary phases for the chromatographic separation of enantiomers of lactones.
摘要翻译：本发明涉及N-丙烯酰基 - 苯丙氨酸新戊酰胺的光学活性聚合物作为固定相的交联形式和/或载体键合形式用于内酯对映异构体的色谱分离。

4. 发明授权

US5274167A Polymeriable optically active (meth) acrylic acid derivatives 失效
标题翻译：可聚合光学活性（甲基）丙烯酸衍生物
公开(公告)号：US5274167A
公开(公告)日：1993-12-28
申请号：US835169
申请日：1992-02-13
申请人： Walter Lange , Bruno Bomer , Rolf Grosser , Dieter Arlt
发明人： Walter Lange , Bruno Bomer , Rolf Grosser , Dieter Arlt
IPC分类号： B01J20/26 , B01J20/32 , C07C233/49 , C07C237/22 , C07C271/22 , C07D207/16 , C07D295/185 , C08F20/54 , C07C229/00
CPC分类号： B01J20/286 , B01J20/26 , B01J20/261 , B01J20/265 , B01J20/267 , B01J20/285 , B01J20/29 , B01J20/3204 , B01J20/3217 , B01J20/327 , B01J20/328 , C07C233/49 , C07C237/22 , C07C271/22 , C07D207/16 , C07D295/185 , C08F20/54 , B01J2220/54 , C07C2101/14 , C07C2102/28 , C07C2102/42
摘要： An optically active N-(meth)acryloyl amino acid amide of the formula ##STR1## in which R is hydrogen or methyl,R.sub.1 represents an optionally substituted alkyl, cycloalkyl, aralkyl, aryl or heteroaryl radical,R.sub.3 represents hydrogen or denotes together with R.sub.1 a tri- or tetramethylene group;X denotes oxygen or a NR.sub.4 -group wherein R.sub.4 represents hydrogen or alkyl or denotes together with R.sub.2 and the nitrogen atom a 5- to 7-membered ring which ring is optionally substituted by the group COO-alkyl (1-6 carbon atoms) or by one or two alkyl radicals (1-4 carbon atoms) andR.sub.2 denotes a strongly space-filling hydrocarbon radical.The amide is polymerized and optionally bound to a support such as silica, and can then be used for the chromatographic separation of racemic mixtures of pharmacologically active compounds.
摘要翻译：式（I）的光学活性N-（甲基）丙烯酰氨基酸酰胺，其中R是氢或甲基，R 1表示任选取代的烷基，环烷基，芳烷基，芳基或杂芳基，R 3表示氢或表示与R1一起是三亚甲基或四亚甲基; X表示氧或NR4-基团，其中R4表示氢或烷基或与R2和氮原子一起表示5-7元环，该环任选被COO-烷基（1-6个碳原子）或通过一个或两个烷基（1-4个碳原子），R 2表示强空间填充烃基。酰胺聚合并任选地结合到载体如二氧化硅上，然后可用于色谱分离药理活性化合物的外消旋混合物。

5. 发明授权

US4782961A Crane 失效
标题翻译：起重机
公开(公告)号：US4782961A
公开(公告)日：1988-11-08
申请号：US16411
申请日：1987-02-19
申请人： Walter Lange
发明人： Walter Lange
IPC分类号： B66D1/52 , B66C23/53
CPC分类号： B66D1/52 , Y10S254/90
摘要： A crane is provided which comprises a hoisting mechanism, which comprises a hoisting rope and a hoisting rope winch. A winch drive for the hoisting rope or a torque-limiting coupling connected between said winch drive and said winch is so controlled that in a period of time which preferably exceeds one second to the rope-pulling force exerted on the hoisting rope is increased in steps or continuously to a value which corresponds to the weight of the load or is sufficient to hoist the load, and that the winch is adapted to be rotated in a payout sense by opposing forces which tend to pull the hoisting rope from the winch and which exceed the instantaneous rope-pulling force.
摘要翻译：提供了一种起重机，其包括提升机构，其包括提升绳索和提升绳索绞车。用于提升绳索的绞盘驱动器或连接在所述绞盘驱动器和所述绞盘之间的扭矩限制联接器被控制，使得在优选地超过一秒的时间段内，施加在提升绳索上的拉绳力逐步增加或连续地达到对应于负载的重量或足以提升负载的值，并且绞盘适于以倾斜的方式旋转，该相对的力倾向于从绞盘拉动提升绳索并且超过瞬间拉绳力。

6. 发明授权

US07381832B2 Polyhalogen-substituted cinnamic acids and cinnamic acid derivatives and a process for the preparation of polyhalogen-substituted cinnamic acids and cinnamic acid derivatives 失效
标题翻译：多卤代替肉桂酸和肉桂酸衍生物以及制备多卤代替肉桂酸和肉桂酸衍生物的方法
公开(公告)号：US07381832B2
公开(公告)日：2008-06-03
申请号：US11150721
申请日：2005-06-10
申请人： Walter Lange , Joachim Komoschinski , Markus Eckert , Michael Dockner
发明人： Walter Lange , Joachim Komoschinski , Markus Eckert , Michael Dockner
IPC分类号： C07C69/76 , C07C63/64 , C07C233/00
CPC分类号： C07C57/60 , C07C45/46 , C07C45/62 , C07C49/697 , C07C51/363
摘要： Polyhalogenated cinnamic acids and cinnamic acid derivatives are prepared by reacting diazonium salts accessible from polyhalogenated anilines with acrylic acid or acrylic acid derivatives in the presence of a homogeneous, palladium-containing catalyst at about −5 to about +100° C. Some of the cinnamic acids and cinnamic acid derivatives obtainable in this way are new. Cinnamic acids and cinnamic acid derivatives which can be prepared according to the invention can be used for the preparation of indanones which are precursors for agro- and pharmaceutical chemicals and for substances having liquid-crystalline properties.
摘要翻译：多卤代肉桂酸和肉桂酸衍生物通过在大约-5至大约+ 100℃的均相的含钯催化剂存在下，将可从多卤代苯胺获得的重氮盐与丙烯酸或丙烯酸衍生物反应来制备。一些肉桂酸以这种方式获得的酸和肉桂酸衍生物是新的。可以根据本发明制备的肉桂酸和肉桂酸衍生物可用于制备作为农药和药物化学品的前体的茚满酮和具有液晶性质的物质。

7. 发明申请

US20070213536A1 Process for the enantiomeric enrichment of cis-8-benzyl-7,9-dioxo-2,8-diazabicyclo[4.3.0]nonane 失效
标题翻译：顺式-8-苄基-7,9-二氧代-2,8-二氮杂双环[4.3.0]壬烷对映异构体富集方法
公开(公告)号：US20070213536A1
公开(公告)日：2007-09-13
申请号：US11651309
申请日：2007-01-09
申请人： Herbert Diehl , Andreas Krebs , Elvira Krebs , Walter Lange , Hanns-Ingolf Paul , Dietrich Seidel , Rolf Grosser , Tobias Reichelt
发明人： Herbert Diehl , Andreas Krebs , Elvira Krebs , Walter Lange , Hanns-Ingolf Paul , Dietrich Seidel , Rolf Grosser , Tobias Reichelt
IPC分类号： C07D471/02
CPC分类号： C07D471/04 , C07B2200/07
摘要： The present invention relates to a process for the enantiomeric enrichment of cis-8-benzyl-7,9-dioxo-2,8-diazabicyclo[4.3.0]nonane with the aid of continuous countercurrent chromatography, which is also described as SMB chromatography (SMB=simulated moving bed). In a further aspect, the invention relates to a process for the preparation of (1S,6R)-8-benzyl-7,9-dioxo-2,8-diazabicyclo[4.3.0]nonane using the aforementioned process, which furthermore includes a racemization step.
摘要翻译：本发明涉及顺式-8-苄基-7,9-二氧代-2,8-二氮杂双环[4.3.0]壬烷对映体富集的方法，借助于连续逆流色谱法，其也被描述为SMB色谱法（SMB =模拟移动床）。另一方面，本发明涉及使用上述方法制备（1S，6R）-8-苄基-7,9-二氧代-2,8-二氮杂双环[4.3.0]壬烷的方法，该方法还包括外消旋化步骤

8. 发明申请

US20050234264A1 Polyhalogen-substituted cinnamic acids and cinnamic acid derivatives and a process for the preparation of polyhalogen-substituted cinnamic acids and cinnamic acid derivatives 失效
公开(公告)号：US20050234264A1
公开(公告)日：2005-10-20
申请号：US11150721
申请日：2005-06-10
申请人： Walter Lange , Joachim Komoschinski , Markus Eckert , Michael Dockner
发明人： Walter Lange , Joachim Komoschinski , Markus Eckert , Michael Dockner
IPC分类号： C07C45/46 , C07C45/62 , C07C49/697 , C07C51/363 , C07C57/60 , C07C233/81 , C07C63/04 , C07C65/36
CPC分类号： C07C57/60 , C07C45/46 , C07C45/62 , C07C49/697 , C07C51/363
摘要： Polyhalogenated cinnamic acids and cinnamic acid derivatives are prepared by reacting diazonium salts accessible from polyhalogenated anilines with acrylic acid or acrylic acid derivatives in the presence of a homogeneous, palladium-containing catalyst at about −5 to about +100° C. Some of the cinnamic acids and cinnamic acid derivatives obtainable in this way are new. Cinnamic acids and cinnamic acid derivatives which can be prepared according to the invention can be used for the preparation of indanones which are precursors for agro- and pharmaceutical chemicals and for substances having liquid-crystalline properties.

9. 发明授权

US06559334B1 Polymers chromatographic separation of enantiomers 失效
标题翻译：聚合物色谱分离对映异构体
公开(公告)号：US06559334B1
公开(公告)日：2003-05-06
申请号：US08290047
申请日：1994-08-12
申请人： Walter Lange , Michael Grosse-Bley , Bruno Bömer , Rolf Grosser , Franz-Peter Hoever
发明人： Walter Lange , Michael Grosse-Bley , Bruno Bömer , Rolf Grosser , Franz-Peter Hoever
IPC分类号： C07C32100
CPC分类号： C08F20/60 , B01D15/3833 , B01J20/261 , B01J20/265 , B01J20/285 , C07B57/00 , C07K5/06026 , C07K5/06052 , C07K5/0606 , C07K5/06078
摘要： The invention relates to novel optically active polymerizable dipeptides, to the process for the preparation thereof, to the polymerization thereof and to the use of the polymers as adsorbents for the chromatographic separation of enantiomers.
摘要翻译：本发明涉及新颖的光学活性可聚合二肽，其制备方法，其聚合反应以及聚合物作为吸附剂用于色谱分离对映异构体的用途。

10. 发明授权

US5357001A Optically active amino acid sulphoxide and amino acid sulphone derivatives, their preparation, their polymerisation and use as adsorbents for chromatographic resolution of racemates 失效
标题翻译：光活性氨基酸亚砜和氨基酸砜衍生物，它们的制备，它们的聚合和用作吸附剂用于外消旋体的色谱拆分
公开(公告)号：US5357001A
公开(公告)日：1994-10-18
申请号：US81537
申请日：1993-06-23
申请人： Michael Grosse-Bley , Bruno Bomer , Rolf Grosser , Walter Lange , Franz-Peter Hoever , Dieter Arlt
发明人： Michael Grosse-Bley , Bruno Bomer , Rolf Grosser , Walter Lange , Franz-Peter Hoever , Dieter Arlt
IPC分类号： B01D15/08 , C07B53/00 , C07B57/00 , C07C317/50 , C07C323/59 , C07D277/06 , C08F2/00 , C08F2/44 , C08F20/52 , C08F20/54 , C08F8/34 , C08F20/58 , C08F20/60 , C08F28/00
CPC分类号： C07B57/00 , C07C317/50 , C07D277/06 , C08F20/54 , C07C2101/14 , C07C2102/42 , Y10T436/10 , Y10T436/17 , Y10T436/18
摘要： The invention relates to new optically active amino acid derivatives of the general formula (I) ##STR1## in which n, R, R.sub.1, R.sub.2, R.sub.3, X and A have the meaning given in the description, which amino acid derivatives contain sulphoxide or sulphone groups, to two basic synthetic routes for the preparation from sulphur-containing amino acids, to the polymerization of these monomers and to the use of the polymers as optically active adsorbents for chromatographic resolution of racemates to give the enantiomers.
摘要翻译：本发明涉及通式（I）的新的光学活性氨基酸衍生物，其中n，R，R1，R2，R3，X和A具有说明书中给出的含义，哪些氨基酸衍生物含有亚砜或砜基团，用于从含硫氨基酸制备的两种基本合成路线，到这些单体的聚合，以及使用聚合物作为光学活性吸附剂用于外消旋体的色谱拆分以得到对映异构体。

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