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1. 发明授权

US06320072B1 Method for isolation of n-protected s-phenylcysteine 失效
标题翻译：用于分离正保护的S-苯基半胱氨酸的方法
公开(公告)号：US06320072B1
公开(公告)日：2001-11-20
申请号：US09646702
申请日：2000-12-14
申请人： Yasuyoshi Ueda , Hiroshi Murao , Koki Yamashita , Koichi Kinoshita
发明人： Yasuyoshi Ueda , Hiroshi Murao , Koki Yamashita , Koichi Kinoshita
IPC分类号： C07C32100
CPC分类号： C07C319/28 , Y02P20/55 , C07C323/59
摘要： This invention provides a method of isolating N-protected-S-phenylcysteine (1) of high purity, expediently, efficiently and in good yield, which comprises causing said N-protected-S-phenylcysteine to be salted out in the form of a base salt in the presence of water. wherein R1 represents an amino-protecting group; R2 represents a hydrogen atom or, either independently of R1 or taken together with R1, represents an amino-protecting group.
摘要翻译：本发明提供了一种方法，有效和高效分离高纯度N-保护的S-苯基半胱氨酸（1）的方法，其包括使所述N-保护的S-苯基半胱氨酸以碱的形式盐析盐，其中R 1表示氨基保护基; R 2表示氢原子，或独立地为R 1或与R 1一起表示氨基保护基。

2. 发明授权

US06300514B1 Aryl (sulfide, sulfoxide and sulfone) derivatives and drugs containing the same as the active ingredient 失效
标题翻译：芳基（硫醚，亚砜和砜）衍生物和含有与活性成分相同的药物
公开(公告)号：US06300514B1
公开(公告)日：2001-10-09
申请号：US09214116
申请日：1999-01-15
申请人： Kanji Takahashi , Tsuneyuki Sugiura
发明人： Kanji Takahashi , Tsuneyuki Sugiura
IPC分类号： C07C32100
CPC分类号： C07K5/0812 , C07C317/44 , C07C317/46 , C07C317/50 , C07C323/52 , C07C323/59 , C07C323/60 , C07K5/06078
摘要： Pharmaceutical composition containing aryl (sulfide, sulfoxide, sulfone) derivatives of the formula (1) and the salts thereof as active ingredient (wherein R1 is H, alkyl; R2 is COOR7, CONHOR8; E is —CONR9—, —NR9CO—, —OCO—,—COO—, —CH2—O—, —(CH2)2—, vinylene, ethynylene; J is bond, alkylene; A is H, alkyl, Ar, alkyl-OH ; R3, R4 is H, alkyl, COOR19, hydroxy, —NR20R21, Ar1 etc.); R5, R6 is H, methyl) and the novel aryl (sulfide, sulfoxide, sulfone) derivatives of the formula (I). The compounds of the formula (I) have inhibitory activity against matrix metalloproteinases, therefore, the compounds of the formula (I) are useful for prevention and/or treatment of rheumatoid diseases, arthrosteitis, unusual bone resorption, osteoporosis, periodontitis, interstitial nephritis, arteriosclerosis, pulmonary emphysema, cirrhosis, cornea injury, autoimmune diseases, diseases caused by vascular emigration or infiltration of leukocytes, arterialization etc.
摘要翻译：含有式（1）的芳基（硫醚，亚砜，砜）衍生物及其盐作为活性成分（其中R 1为H，烷基; R 2为COOR 7，CONHOR 8; E为-CONR 9 - ， - NR 9 CO-， - OCO - ， - COO-， - CH 2 -O - ， - （CH 2）2 - ，亚乙烯基，亚乙炔基; J是键，亚烷基; A是H，烷基，Ar，烷基-OH; R 3，R 4是H，烷基， COOR 19，羟基，-NR 20 R 21，Ar 1等）; R5，R6是H，甲基）和式（Ⅰ）的新型芳基（硫醚，亚砜，砜）衍生物。式（I）化合物对基质金属蛋白酶具有抑制活性，因此式 I）可用于预防和/或治疗类风湿病，关节炎，异常骨吸收，骨质疏松症，牙周炎，间质性肾炎，动脉硬化，肺气肿，肝硬化，角膜损伤，自身免疫性疾病，血管迁移或白细胞浸润引起的疾病，动脉化等

3. 发明授权

US06777575B2 Process for the preparation of 2-alkylthio benzoic acid derivatives 失效
标题翻译： 2-烷硫基苯甲酸衍生物的制备方法
公开(公告)号：US06777575B2
公开(公告)日：2004-08-17
申请号：US09462181
申请日：2000-03-28
申请人： Didier Bernard , Agnès Viauvy
发明人： Didier Bernard , Agnès Viauvy
IPC分类号： C07C32100
CPC分类号： C07C319/14 , C07C323/62
摘要： A process for preparing a compound of the formula comprising reacting a compound of the formula wherein R3 is nitro or halo, or a salt thereof, with a compound of the formula R1SX (III) wherein X is hydrogen or alkali metal.
摘要翻译：制备式肟化合物R3的化合物的方法是硝基或卤素或其盐与式R 1 X X（III）的化合物，其中X是氢或碱金属。

4. 发明授权

US06613937B2 S-nitroso- and S-nitro-N-acyl-L-cysteine ester derivatives as pharmalogically active agents and pharmaceutical compositions containing said compounds 失效
公开(公告)号：US06613937B2
公开(公告)日：2003-09-02
申请号：US10016453
申请日：2001-10-30
申请人： Dimitrios Tsikas
发明人： Dimitrios Tsikas
IPC分类号： C07C32100
CPC分类号： C07C381/00
摘要： SNACE derivatives as pharmacological active agents and pharmacological compositions containing these compounds, in particular for transdermal, oral, rectal and inhalational application, are described.

5. 发明授权

US06555712B2 Process for the preparation of diorganotrisulfide 有权
公开(公告)号：US06555712B2
公开(公告)日：2003-04-29
申请号：US09820202
申请日：2001-03-28
申请人： Pradipta Sinha , Sujit Roy
发明人： Pradipta Sinha , Sujit Roy
IPC分类号： C07C32100
CPC分类号： C07C319/22 , C07C321/18 , C07C321/14 , C07C321/20 , C07C323/07
摘要： The present invention discloses a process for the preparation of a diorganotrisulfide said process by reacting an organic halide and elemental sulfur (&agr;-rhombic) using catalytic copper (II) halide and tin (II) halide in a mixture of organic solvents at 30-70° C.

6. 发明授权

US06518459B2 Process and apparatus for producing organic polysulfides 失效
标题翻译：生产有机多硫化物的方法和设备
公开(公告)号：US06518459B2
公开(公告)日：2003-02-11
申请号：US09915924
申请日：2001-07-26
申请人： Brooks D. Bennett
发明人： Brooks D. Bennett
IPC分类号： C07C32100
CPC分类号： C07C321/14 , C07C319/24
摘要： A filtering means containing gelatinous and solid materials is cleaned without dismantling the filtering means by contacting the gelatinous material inside the filtering means with a solvent, thereby physically degrading the gelatinous material such that the degraded gelatinous material can pass through the filtering means.
摘要翻译：通过使过滤装置内的凝胶状物质与溶剂接触来清洁含有凝胶状固体物质的过滤装置，而不需要使过滤装置拆卸，从而物理降解凝胶状材料，使得降解的凝胶状材料可以通过过滤装置。

7. 发明授权

US06362374B1 Composition of and method for polysulfides having a reduced odor level 有权
标题翻译：具有降低的气味水平的多硫化物的组成和方法
公开(公告)号：US06362374B1
公开(公告)日：2002-03-26
申请号：US09563040
申请日：2000-05-01
申请人： David R. Forester , Roger L. Sowerby , Bharat B. Malik , Victor A. Gober
发明人： David R. Forester , Roger L. Sowerby , Bharat B. Malik , Victor A. Gober
IPC分类号： C07C32100
CPC分类号： C07C319/26 , C07C321/14
摘要： The present invention is directed to a composition that contains polysulfides and that has a reduced odor level and to a method for reducing the odor of polysulfides. The composition contains a polysulfide and an inhibitor that reduces the odor level. The polysulfides include sulfurized olefins prepared by reacting the olefin with sulfur and H2S in the presence of a catalyst. The inhibitors are selected from the group consisting of hydrocarbyl acrylates and hydrocarbyl methacrylates. The method for reducing the odor level of polysulfides involves contacting the polysulfide with an inhibitor selected from the group consisting of hydrocarbyl acrylates and hydrocarbyl methacrylates under conditions that reduce the odor level.
摘要翻译：本发明涉及含有多硫化物并且具有降低的气味水平的组合物和降低多硫化物气味的方法。该组合物含有降低气味水平的多硫化物和抑制剂。多硫化物包括在催化剂存在下使烯烃与硫和H 2 S反应制备的硫化烯烃。抑制剂选自丙烯酸烃基酯和甲基丙烯酸烃基酯。用于降低多硫化物气味水平的方法包括在降低气味水平的条件下使多硫化物与选自丙烯酸烃基酯和甲基丙烯酸烷基酯的抑制剂接触。

8. 发明授权

US06667413B2 Uracil compounds and use thereof 有权
标题翻译：尿嘧啶化合物及其用途
公开(公告)号：US06667413B2
公开(公告)日：2003-12-23
申请号：US10193287
申请日：2002-07-12
申请人： Yoshitomo Tohyama , Yuzuru Sanemitsu , Tomohiko Gotou
发明人： Yoshitomo Tohyama , Yuzuru Sanemitsu , Tomohiko Gotou
IPC分类号： C07C32100
CPC分类号： C07D239/54 , A01N43/54 , C07C217/90 , C07C265/12 , C07C271/28 , C07C271/58
摘要： The present invention relates to an uracil compound of the formula [I]: wherein W represents oxygen, sulfur, imino or C1 to C3 alkylimino; Y represents oxygen, sulfur, imino or C1 to C3 alkylimino; R1 represents C1 to C3 alkyl or C1 to C3 haloalkyl; R2 represents C1 to C3 alkyl; R4 represents hydrogen or methyl; R5 represents C1 to C6 alkyl, C1 to C6 haloalkyl, or the like; X1 represents halogen, cyano or nitro; X2 represents hydrogen or halogen; and each of X3 and X4 independently represents hydrogen, halogen, C1 to C6 alkyl, or the like. The present compound has an excellent herbicidal activity.
摘要翻译：本发明涉及式[I]的尿嘧啶化合物：其中W表示氧，硫，亚氨基或C 1至C 3烷基亚氨基; Y表示氧，硫，亚氨基或C 1至C 3烷基亚氨基; R 1表示C 1至C 3烷基或C 1至C 3卤代烷基; R 2表示C 1至C 3烷基; R 4表示氢或甲基; R 5表示C 1〜C 6烷基，C 1〜C 6卤代烷基等; X 1表示卤素，氰基或硝基; X 2表示氢或卤素; X 3和X 4各自独立地表示氢，卤素，C 1〜C 6烷基等。本发明化合物具有优异的除草活性。

9. 发明授权

US06482978B2 Production method of aromatic carboxylic acid derivative 失效
公开(公告)号：US06482978B2
公开(公告)日：2002-11-19
申请号：US09820009
申请日：2001-03-29
申请人： Daisuke Takahashi , Masakazu Nakazawa , Kunisuke Izawa
发明人： Daisuke Takahashi , Masakazu Nakazawa , Kunisuke Izawa
IPC分类号： C07C32100
CPC分类号： C07C327/32 , C07C51/363 , C07C57/58
摘要： The present invention provides methods for producing a highly pure aromatic bromocarboxylic acid derivative and an aromatic acylthiocarboxylic acid derivative in high yields. The methods of the present invention include reacting an aromatic amino acid in an aqueous solvent in the presence of sodium nitrite, hydrogen bromide and at least one member selected from the group consisting of an aliphatic carboxylic acid and an alcohol, to give an aromatic bromocarboxylic acid derivative, and reacting the aromatic bromocarboxylic acid derivative and an organic thio acid in the presence of an amine to give an aromatic acylthiocarboxylic acid derivative.

10. 发明授权

US06399832B1 Process for producing organic trisulfides 失效
标题翻译：生产有机三硫化物的方法
公开(公告)号：US06399832B1
公开(公告)日：2002-06-04
申请号：US09607559
申请日：2000-06-29
申请人： Brooks D. Bennett
发明人： Brooks D. Bennett
IPC分类号： C07C32100
CPC分类号： C07C319/24 , C07C321/14
摘要： Selectively producing organic trisulfides by contacting a mercaptan, a sulfur compound, and a catalyst under conditions sufficient to produce a reaction product comprising organic polysulfides, and subjecting the reaction product to trisulfide enhancing conditions which are effective to inhibit the formation of organic disulfides and promote the conversion of organic tetrasulfides to organic trisulfides.
摘要翻译：通过在足以产生包含有机多硫化物的反应产物的条件下使硫醇，硫化合物和催化剂接触选择性地生产有机三硫化物，并使反应产物进行有效抑制有机二硫化物形成的三硫化物增强条件并促进有机四硫化物转化为有机三硫化物。

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