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1. 发明授权

US07685485B2 Functional failure analysis techniques for programmable integrated circuits 失效
标题翻译：用于可编程集成电路的功能故障分析技术
公开(公告)号：US07685485B2
公开(公告)日：2010-03-23
申请号：US10698739
申请日：2003-10-30
申请人： Binh Vo , Wan-Pin Hung , David Huang , Peter Boyle , Qi Richard Chen , Kaiyu Ren , Adam J. Wright , John DiCosola , Laiq Chughtai , Seng Yew Lim
发明人： Binh Vo , Wan-Pin Hung , David Huang , Peter Boyle , Qi Richard Chen , Kaiyu Ren , Adam J. Wright , John DiCosola , Laiq Chughtai , Seng Yew Lim
IPC分类号： G01R31/28
CPC分类号： G01R31/31935 , G01R31/31705 , G01R31/318516
摘要： Techniques are provided for isolating failed routing resources on a programmable circuit. Failing test patterns and the test logs are fed to a Statistical Failure Isolation (SFI) tool. The SFI tool extracts failing paths from the test patterns. A statistical analysis is performed on interconnect resources related to failing paths. The resources on the paths are then tallied to create a histogram of resources. These resources are then be fed into an Adaptive Failure Isolation (AFI) tool to auto-generate verification patterns. A tester uses the verification patterns to isolate failed interconnect resources.
摘要翻译：提供了用于隔离可编程电路上的故障路由资源的技术。失败的测试模式和测试日志被馈送到统计失效隔离（SFI）工具。 SFI工具提取测试模式的失败路径。对与故障路径相关的互连资源进行统计分析。然后对路径上的资源进行计算，以创建资源直方图。然后将这些资源馈送到自适应故障隔离（AFI）工具中，以自动生成验证模式。测试人员使用验证模式来隔离故障的互连资源。

2. 发明申请

US20050022085A1 Functional failure analysis techniques for programmable integrated circuits 失效
标题翻译：用于可编程集成电路的功能故障分析技术
公开(公告)号：US20050022085A1
公开(公告)日：2005-01-27
申请号：US10698739
申请日：2003-10-30
申请人： Binh Vo , Wan-Pin Hung , David Huang , Peter Boyle , Qi Chen , Kaiyu Ren , Adam Wright , John DiCosola , Laiq Chughtai , Seng Lim
发明人： Binh Vo , Wan-Pin Hung , David Huang , Peter Boyle , Qi Chen , Kaiyu Ren , Adam Wright , John DiCosola , Laiq Chughtai , Seng Lim
IPC分类号： G01R31/317 , G01R31/3185 , G01R31/3193 , G01R31/28 , G06F11/00
CPC分类号： G01R31/31935 , G01R31/31705 , G01R31/318516
摘要： Techniques are provided for isolating failed routing resources on a programmable circuit. Failing test patterns and the test logs are fed to a Statistical Failure Isolation (SFI) tool. The SFI tool extracts failing paths from the test patterns. A statistical analysis is performed on interconnect resources related to failing paths. The resources on the paths are then tallied to create a histogram of resources. These resources are then be fed into an Adaptive Failure Isolation (AFI) tool to auto-generate verification patterns. A tester uses the verification patterns to isolate failed interconnect resources.
摘要翻译：提供了用于隔离可编程电路上的故障路由资源的技术。失败的测试模式和测试日志被馈送到统计失效隔离（SFI）工具。 SFI工具提取测试模式的失败路径。对与故障路径相关的互连资源进行统计分析。然后对路径上的资源进行计算，以创建资源直方图。然后将这些资源馈送到自适应故障隔离（AFI）工具中，以自动生成验证模式。测试人员使用验证模式来隔离故障的互连资源。

3. 发明申请

US20190150729A1 SYSTEMS AND METHODS FOR AUTOMATED WIDEFIELD OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY 审中-公开
公开(公告)号：US20190150729A1
公开(公告)日：2019-05-23
申请号：US16308901
申请日：2017-06-15
申请人： David Huang , Gangjun Liu , Yali Jia
发明人： David Huang , Gangjun Liu , Yali Jia
IPC分类号： A61B3/10 , A61B3/00 , A61B3/12 , A61B5/00 , A61B5/11 , A61B5/02
摘要： Disclosed are systems and methods for generating wide-field optical coherence tomography angiography (OCTA) images. In embodiments, multiple OCTA scans of a sample are automatically acquired at overlapping locations. The systems and methods include functionality to adaptively control the scanning procedure such that eye blink and eye motion events are detected in real time and accounted for during 3D scan acquisition. Also disclosed are methods for detecting and correcting motion-related artifacts in OCTA datasets which allow for the longer scan times over larger fields of view required for wide-field imaging. These methods may include division of en face angiogram images into a set of motion-free parallel strips, and application of gross and fine registration methods to align overlapping strips into a motion-corrected composite image. A series of overlapping motion-corrected composite images may be combined into a larger montage to enable wide-field OCTA imaging using multiple OCTA scans.

4. 发明申请

US20160284085A1 SYSTEMS AND METHODS OF CHOROIDAL NEOVASCULARIZATION DETECTION USING OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY 审中-公开
标题翻译：使用光学相干图像摄影的CHOROIDAL NEOVASCULARIZATION检测的系统和方法
公开(公告)号：US20160284085A1
公开(公告)日：2016-09-29
申请号：US15080498
申请日：2016-03-24
申请人： David Huang , Yali Jia , Li Liu
发明人： David Huang , Yali Jia , Li Liu
IPC分类号： G06T7/00 , G06T5/50 , G06T5/00 , G06T5/20 , A61B3/10 , G01B9/02
CPC分类号： G06T7/0016 , A61B3/102 , G01B9/02091 , G06T7/136 , G06T2207/10101 , G06T2207/20036 , G06T2207/20192 , G06T2207/30041
摘要： Disclosed are systems and methods to automatically detect choroidal neovasculatization (CNV) in the outer retina using OCT angiography. Further disclosed are methods of removing projection artifacts from the outer retina and for combining brightness, orientation, and position information in a context-aware saliency model to quantify CNV area in OCT angiograms.
摘要翻译：公开了使用OCT血管造影自动检测外视网膜中的脉络膜新血管化（CNV）的系统和方法。进一步公开的是从外部视网膜去除投影伪影并且用于在上下文感知显着性模型中组合亮度，取向和位置信息以量化OCT血管造影图中的CNV面积的方法。

5. 发明申请

US20160278627A1 OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY METHODS 审中-公开
标题翻译：光学相干摄影方法
公开(公告)号：US20160278627A1
公开(公告)日：2016-09-29
申请号：US15080471
申请日：2016-03-24
申请人： David Huang , Yali Jia
发明人： David Huang , Yali Jia
IPC分类号： A61B3/00 , A61B3/12 , A61B3/14 , A61B3/10
CPC分类号： A61B3/0025 , A61B3/0041 , A61B3/102 , A61B3/1233 , A61B3/1241 , A61B3/14 , G06T2207/30041
摘要： Methods of applying OCT angiography are disclosed. In particular, methods of detecting, visualizing and measuring the extent of retinal neovascularization are disclosed. Further disclosed are methods measuring retinal nonperfusion area and choriocapillaris defect area.
摘要翻译：公开了应用OCT血管造影术的方法。特别地，公开了检测，可视化和测量视网膜新生血管形成程度的方法。还公开了测量视网膜非灌注面积和绒毛膜毛细血管缺损区域的方法。

6. 发明申请

US20150324978A1 AQUEOUS CELL DIFFERENTIATION IN ANTERIOR UVEITIS USING OPTICAL COHERENCE TOMOGRAPHY 有权
标题翻译：使用光学相干平面图在前列腺中的质量细胞分化
公开(公告)号：US20150324978A1
公开(公告)日：2015-11-12
申请号：US14704175
申请日：2015-05-05
申请人： David Huang , Yan Li , James T. Rosenbaum , Jennifer Rose-Nussbaumer
发明人： David Huang , Yan Li , James T. Rosenbaum , Jennifer Rose-Nussbaumer
IPC分类号： G06T7/00
CPC分类号： A61B3/102 , A61B3/117 , G06T7/0012 , G06T2207/10101 , G06T2207/30041
摘要： Methods and systems for determining a percentage composition of aqueous cells in an anterior chamber of an eye of a subject based on cell reflectance distributions calculated from OCT image data are disclosed. In one example approach, determining a percentage composition of detected aqueous cells may comprise calculating a percentage of the detected aqueous cells which are polymorphonuclear and calculating a percentage of detected aqueous cells which are mononuclear.
摘要翻译：公开了基于由OCT图像数据计算的细胞反射率分布来确定受试者眼睛前房中的水细胞百分比组成的方法和系统。在一个示例性方法中，确定检测到的水溶性细胞的百分比组成可以包括计算检测到的水合细胞的百分比，其是多形核，并计算检测到的单核水溶液细胞的百分比。

7. 发明授权

US08758707B2 Staining instruments and methods 有权
标题翻译：染色仪器和方法
公开(公告)号：US08758707B2
公开(公告)日：2014-06-24
申请号：US12999259
申请日：2009-06-16
申请人： Andrew Watkins , Nathan Ray , David Huang
发明人： Andrew Watkins , Nathan Ray , David Huang
IPC分类号： B01L3/02 , G01N1/30
CPC分类号： G01N1/312
摘要： An apparatus and method for applying reagents to tissue mounted on slides, in the field of histology is disclosed. The apparatus holds a number of slides, in slide trays, which are loaded onto the apparatus. Each slide tray forms a batch of slides, with all the batched forming a group. The apparatus holds a number of reagents, grouped into a first group comprising bulk type reagents, and a second group comprising antibodies or probes, and detection systems, for identifying elements of the tissue. A group fluid dispenser, in the form of a robot arm, dispense reagents to the group of slides. Each batch of slides has its own batch fluid dispenser to dispense reagents onto the batch of slides. In on embodiment, the group fluid dispenser dispense antibodies, probes, detection reagents to all slides depending on the protocol defined for each slide, and the batch dispensers dispense bulk reagent to each batch, thus freeing the group fluid dispense from dispensing bulk reagents to all slides.
摘要翻译：公开了一种在组织学领域中对安装在载玻片上的组织施加试剂的装置和方法。该装置在装载到装置中的多个幻灯片托盘中保持多个幻灯片。每个滑动托架形成一批幻灯片，所有的批量形成一组。该装置保持多个试剂，分组为包含本体试剂的第一组，以及包含抗体或探针的第二组和用于鉴定组织元件的检测系统。以机器人手臂的形式的组液体分配器将试剂分配到一组载玻片。每批幻灯片都有自己的批量流体分配器，以将试剂分配到批次的载玻片上。在一个实施方案中，组流体分配器根据为每个载片定义的方案向所有载玻片分配抗体，探针，检测试剂，并且批量分配器将批量试剂分配给每个批次，从而释放基团流体分配以将散装试剂分配给所有幻灯片。

8. 发明授权

US08486320B2 Spindle motor tray adhesive dispensing method and supplementary apparatus 失效
标题翻译：主轴电机托盘胶粘剂分配方式及补充装置
公开(公告)号：US08486320B2
公开(公告)日：2013-07-16
申请号：US13170457
申请日：2011-06-28
申请人： David Huang
发明人： David Huang
IPC分类号： B32B37/00
CPC分类号： B29C31/048
摘要： A spindle motor tray adhesive dispensing method and supplementary apparatus is disclosed. The apparatus includes a base block and a pressure block. The base block supports the tray to be processed, having a blind hole for receiving one end of the center axle of the tray and three adhesive troughs around the blind hole. The pressure block pressed on the tray above the base block and axially movable relative to the base block, having a guide hole for receiving the other end of the center axle of the tray. An open space is defined above the base block around the pressure block within which an adhesive dispenser is movable to dispense a polymer adhesive to the through holes on the tray and the adhesive troughs of the base block to form rubber pads at the tray when cured.
摘要翻译：公开了一种主轴电机托盘粘合剂分配方法和补充装置。该装置包括基座块和压力块。基座支撑待处理的托盘，具有用于接收托盘的中心轴的一端的盲孔和围绕盲孔的三个粘合槽。压块被压在基座上方的托盘上并相对于基座可轴向移动，具有用于容纳托盘的中心轴的另一端的引导孔。在压块周围的基座上方限定了开放空间，粘合剂分配器可移动到其中，以将聚合物粘合剂分配到托盘上的通孔和基块的粘合剂槽，以在固化时在托盘处形成橡胶垫。

9. 发明授权

US08399484B2 Combination therapy for treating HCV infection 有权
标题翻译：治疗HCV感染的联合疗法
公开(公告)号：US08399484B2
公开(公告)日：2013-03-19
申请号：US12560752
申请日：2009-09-16
申请人： David Huang , Gerhard Gustav Steinmann , Jerry Oscar Stern
发明人： David Huang , Gerhard Gustav Steinmann , Jerry Oscar Stern
IPC分类号： A01N43/42 , A01N43/78 , A01N43/36 , A61K31/47 , A61K31/425 , A61K31/40
CPC分类号： A61K31/7056 , A61K38/06 , A61K38/212 , A61K2300/00
摘要： The present invention relates to therapeutic combinations comprising (a) Compound (1), or a pharmaceutically acceptable salt thereof, as herein described, (b) an interferon alfa and (c) ribavirin. Compound (1) is a selective and potent inhibitor of the HCV NS3 serine protease. The present invention also relates to methods of using such therapeutic combinations for treating HCV infection or alleviating one or more symptoms thereof in a patient.
摘要翻译：本发明涉及治疗性组合，其包含（a）如本文所述的化合物（1）或其药学上可接受的盐，（b）干扰素α和（c）利巴韦林。化合物（1）是HCV NS3丝氨酸蛋白酶的选择性和有效的抑制剂。本发明还涉及使用这种治疗组合来治疗患者的HCV感染或缓解其一种或多种症状的方法。

10. 发明授权

US08244334B2 Methods and systems for blood flow measurement using doppler optical coherence tomography 有权
标题翻译：使用多普勒光学相干断层扫描进行血流测量的方法和系统
公开(公告)号：US08244334B2
公开(公告)日：2012-08-14
申请号：US12101006
申请日：2008-04-10
申请人： David Huang , Yimin Wang
发明人： David Huang , Yimin Wang
IPC分类号： A61B6/00
CPC分类号： A61B3/102
摘要： This invention provides methods for non-invasive, real-time measuring and/or monitoring of local blood flow in a subject. Methods of the invention generally include the steps of obtaining Doppler shift images of at least two planes intersecting blood vessels at the scanned location; determining Doppler angles using the Doppler shift images; and then using the Doppler angles thus determined together with the Doppler shift signals to arrive at a measure of the volumetric blood flow. Also provided are systems and software for performing the methods.
摘要翻译：本发明提供了用于非侵入性，实时测量和/或监测受试者中局部血流的方法。本发明的方法通常包括以下步骤：在扫描位置处获得与血管相交的至少两个平面的多普勒频移图像; 使用多普勒频移图像确定多普勒角度; 然后使用与多普勒频移信号一起确定的多普勒角度来达到体积血流量的量度。还提供了用于执行方法的系统和软件。

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