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1. 发明授权

US09044738B2 Methods and compositions for extraction and storage of nucleic acids 有权
标题翻译：用于提取和储存核酸的方法和组合物
公开(公告)号：US09044738B2
公开(公告)日：2015-06-02
申请号：US13460076
申请日：2012-04-30
申请人： Bing Li , David Roger Moore , Erik Leeming Kvam
发明人： Bing Li , David Roger Moore , Erik Leeming Kvam
IPC分类号： C12N15/10 , B01J20/24 , G01N1/40
CPC分类号： B01J20/24 , C12N15/1006 , G01N1/40
摘要： The present disclosure generally relates to solid matrices for the extraction, stabilization, and storage of nucleic acids, particularly RNA, in a dry format under ambient conditions for a prolonged period of time. Methods for extracting, collecting, and recovering nucleic acids from the solid compositions are also described.
摘要翻译：本公开内容通常涉及用于在环境条件下长时间提取，稳定和储存核酸，特别是RNA的干燥形式的固体基质。还描述了从固体组合物中提取，收集和回收核酸的方法。

2. 发明申请

US20130171669A1 POROUS MEMBRANES HAVING A HYDROPHILIC COATING AND METHODS FOR THEIR PREPARATION AND USE 审中-公开
标题翻译：具有水解涂层的多孔膜及其制备和使用方法
公开(公告)号：US20130171669A1
公开(公告)日：2013-07-04
申请号：US13340793
申请日：2011-12-30
申请人： Bing Li , David Roger Moore
发明人： Bing Li , David Roger Moore
IPC分类号： G01N33/566 , C07K16/00 , B32B23/00 , B32B3/26 , B32B23/08 , B32B27/06 , B01J19/12 , C08B15/06 , C07K14/00
CPC分类号： C08B15/06 , B01D71/20 , B01D71/78 , B01D71/82 , B01D2323/02 , B01D2323/385 , G01N33/54393 , Y10T428/249979 , Y10T428/31779 , Y10T428/31884 , Y10T428/31971
摘要： A modified porous membrane comprising a polymeric hydrophilic coating bonded to a porous membrane is described. The polymeric hydrophilic coatings grafted to the porous membranes comprise, for example, a PEG moiety such as a PEGMA, a PEGDA, or a TMPET, wherein the polymeric hydrophilic coating on the porous membrane decreases non-specific binding of unwanted material to the porous membrane and increases the signal to noise ratio in immunoassays, in vitro diagnostic tests, and point of care tests. Methods of making these modified porous membranes are also disclosed.
摘要翻译：描述了包含与多孔膜结合的聚合亲水涂层的改性多孔膜。接枝到多孔膜上的聚合亲水性涂层包括例如PEG部分，例如PEGMA，PEGDA或TMPET，其中多孔膜上的聚合亲水性涂层降低了不需要的材料与多孔膜的非特异性结合并增加免疫测定中的信噪比，体外诊断测试和护理测试点。还公开了制备这些改性多孔膜的方法。

3. 发明申请

US20130171618A1 POROUS MEMBRANES HAVING A POLYMERIC COATING AND METHODS FOR THEIR PREPARATION AND USE 审中-公开
标题翻译：具有聚合物涂层的多孔膜及其制备和使用方法
公开(公告)号：US20130171618A1
公开(公告)日：2013-07-04
申请号：US13340052
申请日：2011-12-29
申请人： Bing Li , Cathryn Ellen Olsen , David Roger Moore
发明人： Bing Li , Cathryn Ellen Olsen , David Roger Moore
IPC分类号： G01N33/53
CPC分类号： G01N33/5306 , G01N33/54353 , G01N33/54393 , G01N33/545 , G01N33/548
摘要： A modified porous membrane comprising a polymer coating grafted to a porous membrane is described. The polymer coatings grafted to the porous membranes generally comprise a polymer of variable length of an electron beam (e-beam) reactive moiety, designated “poly-(A)x,” a linkage group that forms a bond between the between the poly-(A)x, and a functional B group available to react with a chemical group on a biomolecule, wherein the polymer coating on the porous membrane facilitates the immobilization of a biomolecule, such as DNA, RNA, a protein, and an antibody, on the porous membrane. The compositions find use in immunoassays, in vitro diagnostic tests, point of care tests, techniques for the isolation of a biomolecule from a biological sample, and other methods that require the immobilization of a biomolecule on a porous membrane. Methods of making these modified porous membranes are also disclosed.
摘要翻译：描述了包含接枝到多孔膜上的聚合物涂层的改性多孔膜。接枝到多孔膜上的聚合物涂层通常包含可变长度的电子束（电子束）反应性部分的聚合物，称为“聚（A）x”，其是在聚 - （A）x和可用于与生物分子上的化学基团反应的官能B基团，其中多孔膜上的聚合物涂层有助于将生物分子如DNA，RNA，蛋白质和抗体固定在多孔膜。该组合物用于免疫测定，体外诊断测试，护理点测试，用于从生物样品中分离生物分子的技术以及需要在多孔膜上固定生物分子的其它方法。还公开了制备这些改性多孔膜的方法。

4. 发明申请

US20130289265A1 METHODS AND COMPOSITIONS FOR EXTRACTION AND STORAGE OF NUCLEIC ACIDS 有权
标题翻译：提取和储存核酸的方法和组合物
公开(公告)号：US20130289265A1
公开(公告)日：2013-10-31
申请号：US13460076
申请日：2012-04-30
申请人： Bing Li , David Roger Moore , Erik Leeming Kvam
发明人： Bing Li , David Roger Moore , Erik Leeming Kvam
IPC分类号： B01J20/24 , C12N15/10
CPC分类号： B01J20/24 , C12N15/1006 , G01N1/40
摘要： The present disclosure generally relates to solid matrices for the extraction, stabilization, and storage of nucleic acids, particularly RNA, in a dry format under ambient conditions for a prolonged period of time. Methods for extracting, collecting, and recovering nucleic acids from the solid compositions are also described.
摘要翻译：本公开内容通常涉及用于在环境条件下长时间提取，稳定和储存核酸，特别是RNA的干燥形式的固体基质。还描述了从固体组合物中提取，收集和回收核酸的方法。

5. 发明申请

US20130171619A1 POROUS MEMBRANES HAVING A HYDROPHILIC COATING AND METHODS FOR THEIR PREPARATION AND USE 审中-公开
标题翻译：具有水解涂层的多孔膜及其制备和使用方法
公开(公告)号：US20130171619A1
公开(公告)日：2013-07-04
申请号：US13362793
申请日：2012-01-31
申请人： Bing Li , David Roger Moore
发明人： Bing Li , David Roger Moore
IPC分类号： G01N33/545 , G01N21/64 , G01N33/569 , G01N33/566 , G01N33/574 , C12Q1/70 , B32B3/26 , G01N21/76
CPC分类号： B32B3/26 , C12Q1/70 , G01N33/54393 , Y10T428/249991
摘要： A modified porous membrane comprising a polymeric hydrophilic coating grafted to a porous membrane is described. The polymeric hydrophilic coatings grafted to the porous membranes comprise, for example, a PEG moiety such as a PEGMA, a PEGDA, or a TMPET, wherein the polymeric hydrophilic coating on the porous membrane decreases non-specific binding of unwanted material to the porous membrane and increases the signal to noise ratio in immunoassays, in vitro diagnostic tests, and point of care tests. Methods of making these modified porous membranes are also disclosed.
摘要翻译：描述了包含接枝到多孔膜上的聚合亲水涂层的改性多孔膜。接枝到多孔膜上的聚合亲水性涂层包括例如PEG部分，例如PEGMA，PEGDA或TMPET，其中多孔膜上的聚合亲水性涂层降低了不需要的材料与多孔膜的非特异性结合并增加免疫测定中的信噪比，体外诊断测试和护理测试点。还公开了制备这些改性多孔膜的方法。

6. 发明申请

US20130171368A1 POROUS MEMBRANES HAVING A POLYMERIC COATING AND METHODS FOR THEIR PREPARATION AND USE 审中-公开
公开(公告)号：US20130171368A1
公开(公告)日：2013-07-04
申请号：US13339996
申请日：2011-12-29
申请人： Bing Li , Cathryn Ellen Olsen , David Roger Moore
发明人： Bing Li , Cathryn Ellen Olsen , David Roger Moore
IPC分类号： C08J3/28
CPC分类号： C08J3/28 , B01D67/009 , B01D71/12 , B01D71/78 , B01D2323/30 , B01D2323/34 , B01D2323/385 , C08L71/12 , G01N33/54393
摘要： A modified porous membrane comprising a polymer coating grafted to a porous membrane is described. The polymer coatings grafted to the porous membranes generally comprise a polymer of variable length of an electron beam (e-beam) reactive moiety, designated “poly-(A)x,” a linkage group that forms a bond between the between the poly-(A)x, and a functional B group available to react with a chemical group on a biomolecule, wherein the polymer coating on the porous membrane facilitates the immobilization of a biomolecule, such as DNA, RNA, a protein, and an antibody, on the porous membrane. The compositions find use in immunoassays, in vitro diagnostic tests, point of care tests, techniques for the isolation of a biomolecule from a biological sample, and other methods that require the immobilization of a biomolecule on a porous membrane. Methods of making these modified porous membranes are also disclosed.

7. 发明申请

US20130171026A1 POROUS MEMBRANES HAVING A POLYMERIC COATING AND METHODS FOR THEIR PREPARATION AND USE 审中-公开
公开(公告)号：US20130171026A1
公开(公告)日：2013-07-04
申请号：US13339960
申请日：2011-12-29
申请人： Bing Li , Cathryn Ellen Olsen , David Roger Moore
发明人： Bing Li , Cathryn Ellen Olsen , David Roger Moore
IPC分类号： G01N33/53
CPC分类号： G01N33/5306 , G01N33/54353 , G01N33/545 , G01N33/548
摘要： A modified porous membrane comprising a polymer coating grafted to a porous membrane is described. The polymer coatings grafted to the porous membranes generally comprise a polymer of variable length of an electron beam (e-beam) reactive moiety, designated “poly-(A)x,” a linkage group that forms a bond between the between the poly-(A)x, and a functional B group available to react with a chemical group on a biomolecule, wherein the polymer coating on the porous membrane facilitates the immobilization of a biomolecule, such as DNA, RNA, a protein, and an antibody, on the porous membrane. The compositions find use in immunoassays, in vitro diagnostic tests, point of care tests, techniques for the isolation of a biomolecule from a biological sample, and other methods that require the immobilization of a biomolecule on a porous membrane. Methods of making these modified porous membranes are also disclosed.

8. 发明申请

US20180030036A1 Factor IXa Inhibitors 审中-公开
公开(公告)号：US20180030036A1
公开(公告)日：2018-02-01
申请号：US15534029
申请日：2015-12-07
申请人： Ting ZHANG , Yi-Heng CHEN , Liangqin GUO , Alan HARUZA , Tianying JIAN , Bing LI , Dongfang MENG , Dann L. PARKER, JR. , Edward C. SHERER , Harold B. WOOD , Isao SAKURADA , MERCK SHARP & DOHME CORP. , MOCHIDA PHARMACEUTICAL CO., LTD
发明人： Ting Zhang , Yi-Heng Chen , Liangqin Guo , Alan Hruza , Tianying Jian , Bing Li , Dongfang Meng , Dann L. Parker , Edward C. Sherer , Harold B. Wood , Isao Sakurada
IPC分类号： C07D403/12 , C07D401/14 , C07D401/12 , C07D471/04
CPC分类号： C07D403/12 , C07D401/12 , C07D401/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D471/04
摘要： The present invention provides a compound of Formula I, and pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing unstable angina, refractory angina, myocardial infarction, transient ischemic attacks, atrial fibrillation, thrombotic stroke, embolic stroke, deep vein thrombosis, disseminated intravascular coagulation, ocular build up of fibrin, and reocclusion or restenosis of recanalized vessels. The compounds are selective Factor IXa inhibitors.

9. 发明授权

US09806212B2 Ultrathin group II-VI semiconductor layers, group II-VI semiconductor superlattice structures, photovoltaic devices incorporating the same, and related methods 有权
公开(公告)号：US09806212B2
公开(公告)日：2017-10-31
申请号：US14419768
申请日：2013-08-09
申请人： University of Kansas , Bing Li , Liang-huan Feng
发明人： Judy Z. Wu , Bing Li , Liang-huan Feng
IPC分类号： H01L31/0352 , H01L31/0392 , H01L31/073 , B82Y20/00 , H01L31/0296 , H01L31/0336 , H01L31/18
CPC分类号： H01L31/035236 , B82Y20/00 , H01L31/0296 , H01L31/0336 , H01L31/03925 , H01L31/073 , H01L31/18 , H01L31/1828 , Y02E10/543
摘要： Disclosed are ultrathin layers of group II-VI semiconductors, group II-VI semiconductor superlattice structures, photovoltaic devices incorporating the layers and superlattice structures and related methods. The superlattice structures comprise an ultrathin layer of a first group II-VI semiconductor alternating with an ultrathin layer of at least one additional semiconductor, e.g., a second group II-VI semiconductor, or a group IV semiconductor, or a group III-V semiconductor.

10. 发明申请

US20150284411A1 NOVEL AZABENZIMIDAZOLE HEXAHYDROFURO[E,2-B]FURAN DERIVATIVES 有权
标题翻译：新型亚氨基二咪唑六氢呋喃[E，2-B]呋喃衍生物
公开(公告)号：US20150284411A1
公开(公告)日：2015-10-08
申请号：US14419774
申请日：2013-08-19
申请人： James M. APGAR , Ashok ARASAPPAN , Tesfaye BIFTU , Ping CHEN , Danqing FENG , Erin GUIDRY , Jacqueline HICKS , Ahmet KEKEC , Kenneth LEAVITT , Bing LI , Troy MCCRACKEN , Iyassu SEBHAT , Xiaoxia QIAN , Lan WEI , Robert WILKENING , Zhicai WU , Merck Sharp & Dohme Corp.
发明人： James M. Apgar , Ashok Arasappan , Tesfaye Biftu , Ping Chen , Danqing Feng , Erin Guidry , Jacqueline D. Hicks , Ahmet Kekec , Kenneth J. Leavitt , Bing Li , Troy McCracken , Iyassu Sebhat , Xiaoxia Qian , Lan Wei , Robert R. Wilkening , Zhicai Wu
IPC分类号： C07D519/00 , A61K31/438 , A61K45/06 , A61K31/501 , A61K31/5377 , A61K31/541 , A61K31/437 , A61K31/506
CPC分类号： C07D519/00 , A61K31/366 , A61K31/397 , A61K31/437 , A61K31/438 , A61K31/4985 , A61K31/501 , A61K31/506 , A61K31/5377 , A61K31/541 , A61K45/06 , A61K2300/00
摘要： Novel compounds of the structural formula (I) are activators of AMP-protein kinase and may be useful in the treatment, prevention and suppression of diseases mediated by the AMPK activated protein kinase. The compounds of the present invention may be useful in the treatment of Type 2 diabetes, hyperglycemia, metabolic syndrome, obesity, hypercholesterolemia, and hypertension.
摘要翻译：结构式（I）的新型化合物是AMP-蛋白激酶的活化剂，可用于治疗，预防和抑制AMPK活化蛋白激酶介导的疾病。本发明的化合物可用于治疗2型糖尿病，高血糖症，代谢综合征，肥胖症，高胆固醇血症和高血压。

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