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1. 发明授权

US08900624B2 Antimicrobial silver compositions 有权
标题翻译：抗微生物银组合物
公开(公告)号：US08900624B2
公开(公告)日：2014-12-02
申请号：US11194951
申请日：2005-08-01
申请人： Bhalchandra M. Karandikar , Bruce L. Gibbins , Ken A. Cornell
发明人： Bhalchandra M. Karandikar , Bruce L. Gibbins , Ken A. Cornell
IPC分类号： A61K33/38 , A61K9/70 , A61L15/18 , D06M16/00 , D06M11/83 , D06M23/08 , A61L15/46 , A61L29/16 , A01N59/16
CPC分类号： A01N59/16 , A01N25/34 , A61K33/38 , A61L15/18 , A61L15/42 , A61L15/46 , A61L27/306 , A61L27/54 , A61L29/106 , A61L29/16 , A61L2300/104 , A61L2300/404 , A61L2300/624 , A61L2400/12 , C08J7/04 , C08J2323/12 , C08J2327/06 , C08J2327/18 , C08J2375/04 , C08J2377/02 , C23C18/1637 , C23C18/1639 , C23C18/1641 , C23C18/1646 , C23C18/1689 , C23C18/44 , D06M11/83 , D06M16/00 , D06M23/08 , Y10S977/906 , A01N25/02 , A01N25/10 , A01N25/22 , A01N25/30 , A01N2300/00 , A01N37/06 , A01N43/50 , A01N43/80
摘要： The present invention comprises methods and compositions for antimicrobial silver compositions comprising silver nanoparticles. The present invention further comprises compositions for preparing silver nanoparticles comprising at least one stabilizing agent, one or more silver compounds, at least one reducing agent and a solvent. In one aspect, the stabilizing agent comprises a surfactant or a polymer. The polymer may comprise polymers such as polyacrylamides, polyurethanes, and polyamides. In one aspect, the silver compound comprises a salt comprising a silver cation and an anion. The anion may comprise saccharinate derivatives, long chain fatty acids, and alkyl dicarboxylates. The methods of the present invention comprise treating devices with the silver nanoparticle compositions, including, but not limited to, such devices as woven wound care materials, catheters, patient care devices, and collagen matrices. The present invention further comprises treatment of humans and animals wacr6ith the antimicrobial devices described herein.
摘要翻译：本发明包括包含银纳米颗粒的抗微生物银组合物的方法和组合物。本发明还包括用于制备包含至少一种稳定剂，一种或多种银化合物，至少一种还原剂和溶剂的银纳米颗粒的组合物。一方面，稳定剂包括表面活性剂或聚合物。聚合物可以包括聚合物，例如聚丙烯酰胺，聚氨酯和聚酰胺。在一个方面，银化合物包括包含银阳离子和阴离子的盐。阴离子可以包含糖精衍生物，长链脂肪酸和二羧酸烷基酯。本发明的方法包括用银纳米颗粒组合物处理装置，包括但不限于诸如编织伤口护理材料，导管，患者护理装置和胶原基质之类的装置。本发明还包括用本文所述的抗微生物装置处理人和动物。

2. 发明授权

US08361553B2 Methods and compositions for metal nanoparticle treated surfaces 有权
标题翻译：金属纳米粒子处理表面的方法和组成
公开(公告)号：US08361553B2
公开(公告)日：2013-01-29
申请号：US11704167
申请日：2007-02-08
申请人： Bhalchandra M. Karandikar , Bruce L. Gibbins
发明人： Bhalchandra M. Karandikar , Bruce L. Gibbins
IPC分类号： B05D3/00
CPC分类号： B05D5/12 , A01N59/16 , A01N59/20 , B05D5/00 , B22F1/0022 , B22F7/08 , B22F9/24 , B32B15/01 , B82Y30/00 , C08J7/06 , C08J2300/26 , C09D5/14 , C09D5/1681 , C09D7/67 , H01B1/02 , Y10S977/773 , Y10T428/12063 , Y10T428/12111 , Y10T428/13 , Y10T428/31507 , Y10T428/31605 , Y10T428/31663 , Y10T428/31678 , Y10T428/31681 , Y10T428/31688 , Y10T428/31692 , Y10T428/31699 , Y10T428/31707 , A01N25/02
摘要： The present invention comprises methods and compositions comprising metal nanoparticles. The invention comprises metal nanoparticles and surfaces treated with a metal nanoparticle coating. The present invention further comprises compositions for preparing nanoparticles comprising at least one stabilizing agent, one or more metal compounds, at least one reducing agent and a solvent. In one aspect, the stabilizing agent comprises a surfactant or a polymer. The polymer may comprise polymers such as polyacrylamides, polyurethanes, and polyamides. In one aspect, the metal compound comprises a salt comprising a metal cation and an anion. The anion may comprise saccharinate derivatives, long chain fatty acids, and alkyl dicarboxylates.
摘要翻译：本发明包括包含金属纳米颗粒的方法和组合物。本发明包括金属纳米颗粒和用金属纳米颗粒涂层处理的表面。本发明还包括用于制备包含至少一种稳定剂，一种或多种金属化合物，至少一种还原剂和溶剂的纳米颗粒的组合物。一方面，稳定剂包括表面活性剂或聚合物。聚合物可以包括聚合物，例如聚丙烯酰胺，聚氨酯和聚酰胺。一方面，金属化合物包括含有金属阳离子和阴离子的盐。阴离子可以包含糖精衍生物，长链脂肪酸和二羧酸烷基酯。

3. 发明授权

US09289378B2 Antimicrobial amorphous compositions 有权
标题翻译：抗菌无定形组合物
公开(公告)号：US09289378B2
公开(公告)日：2016-03-22
申请号：US11663236
申请日：2005-09-19
申请人： Bhalchandra M. Karandikar , Bruce L. Gibbins
发明人： Bhalchandra M. Karandikar , Bruce L. Gibbins
IPC分类号： A61K9/107 , A61K31/28 , A61K33/38 , A61K47/06 , A61K47/10 , A61K47/26 , A61K47/38 , A61P17/02 , A61P31/00 , A61K9/00 , A61K45/06
CPC分类号： A61K9/0014 , A61K9/006 , A61K9/0063 , A61K9/06 , A61K9/107 , A61K31/28 , A61K33/38 , A61K45/06 , A61K47/02 , A61K47/06 , A61K47/10 , A61K47/12 , A61K47/18 , A61K47/26 , A61K47/32 , A61K47/38 , A61K51/00 , A61K2300/00
摘要： The present invention comprises compositions and methods for providing antimicrobial compositions. The antimicrobial compositions comprise gel delivery vehicles comprising stabilized silver, wherein ionic silver is provided to a site for antimicrobial purposes. Methods of making and using such compositions are taught, including application of the silver-containing gel compositions to wounds, burns, abrasions, cuts, surgical incision, sites where skin or organ integrity has been breached, and other sites to supply an antimicrobial environment.
摘要翻译：本发明包括用于提供抗微生物组合物的组合物和方法。抗微生物组合物包含凝胶输送载体，其包含稳定的银，其中将离子银提供到用于抗微生物目的的部位。教导了制备和使用这些组合物的方法，包括将含银凝胶组合物施加到伤口，烧伤，擦伤，切口，手术切口，已经破坏皮肤或器官完整性的位置以及其它供应抗微生物环境的部位。

4. 发明申请

US20100190004A1 ANTIMICROBIAL LAMINATE CONSTRUCTS 审中-公开
标题翻译：抗微生物层压结构
公开(公告)号：US20100190004A1
公开(公告)日：2010-07-29
申请号：US12625263
申请日：2009-11-24
申请人： Bruce L. Gibbins , Bhalchandra M. Karandikar
发明人： Bruce L. Gibbins , Bhalchandra M. Karandikar
IPC分类号： A61F13/02 , B05D5/10 , B32B15/04
CPC分类号： A61F13/02 , A61F13/00063 , A61F13/0276 , A61L15/46 , A61L2300/104 , A61L2300/404 , A61L2300/608 , C08K3/015 , C09J7/20 , C09J7/40 , C09J2205/106 , Y10T428/28 , Y10T428/2813 , Y10T428/2878 , Y10T428/2891 , Y10T428/2896 , Y10T428/31678
摘要： The present invention comprises methods for making and using antimicrobial laminate constructs comprising an antimicrobial layer and optionally, an adhesive layer. The present invention comprises methods for making medical devices, surfaces that may be in contact with medical equipment, personnel or patients, or treatment areas antimicrobial comprising, for example, applying an antimicrobial laminate construct.
摘要翻译：本发明包括制备和使用包含抗微生物层和任选的粘合剂层的抗微生物层压结构的方法。本发明包括用于制造医疗装置的方法，可能与医疗设备，人员或患者接触的表面或抗微生物的治疗区域，包括例如施用抗微生物层压构造物。

5. 发明申请

US20090035342A1 Antimicrobial Devices and Compositions 审中-公开
标题翻译：抗微生物装置和组合物
公开(公告)号：US20090035342A1
公开(公告)日：2009-02-05
申请号：US11572899
申请日：2005-08-01
申请人： Bhalchandra M. Karandikar , Bruce L. Gibbins , Ken A. Cornell
发明人： Bhalchandra M. Karandikar , Bruce L. Gibbins , Ken A. Cornell
IPC分类号： A01N25/34 , A01N59/16 , A01N59/26 , A61K31/28 , A61K33/38 , A61K9/00 , A01P1/00 , A61P31/00
CPC分类号： A01N25/34 , A01N59/16 , A61L15/46 , A61L27/54 , A61L29/16 , A61L2300/102 , A61L2300/104 , A61L2300/404 , A01N59/20 , A01N25/04 , A01N43/80
摘要： The present invention comprises methods and compositions for antimicrobial devices comprising metal containing compositions which are resistant to heat and light discoloration. The metal containing compositions may comprise salts or complexes of silver, copper or zinc. In one aspect the compositions comprise silver salts. In another aspect, the compositions comprise silver complexes. In one aspect, the metal salts may comprise metal salts of saccharin, acesulfame, long chain fatty acids, and alkyl dicarboxylic acids. The compositions further comprise polymers which form salts or complexes with silver, copper or zinc. The methods of the present invention comprise treating devices with the metal containing compositions, including, but not limited to, such devices as woven wound care materials, catheters, patient care devices, and collagen matrices. The present invention further comprises treatment of humans and animals with the antimicrobial devices described herein.
摘要翻译：本发明包括用于抗微生物装置的方法和组合物，其包含耐热和轻的变色的含有金属的组合物。含金属的组合物可以包含银，铜或锌的盐或络合物。在一个方面，组合物包含银盐。另一方面，组合物包含银络合物。一方面，金属盐可以包括糖精，乙酰磺胺酸盐，长链脂肪酸和烷基二羧酸的金属盐。组合物还包含与银，铜或锌形成盐或络合物的聚合物。本发明的方法包括用含金属的组合物处理装置，包括但不限于诸如编织伤口护理材料，导管，患者护理装置和胶原基质之类的装置。本发明还包括用本文所述的抗微生物装置处理人和动物。

6. 发明授权

US10251392B2 Antimicrobial devices and compositions 有权
公开(公告)号：US10251392B2
公开(公告)日：2019-04-09
申请号：US11572899
申请日：2005-08-01
申请人： Bhalchandra M. Karandikar , Bruce L. Gibbins , Ken A. Cornell
发明人： Bhalchandra M. Karandikar , Bruce L. Gibbins , Ken A. Cornell
IPC分类号： A01N25/04 , A01N25/34 , A01N43/80 , A01N59/16 , A01N59/20 , A61L15/46 , A61L27/54 , A61L29/16
摘要： The present invention comprises methods and compositions for antimicrobial devices comprising metal containing compositions which are resistant to heat and light discoloration. The metal containing compositions may comprise salts or complexes of silver, copper or zinc. In one aspect the compositions comprise silver salts. In another aspect, the compositions comprise silver complexes. In one aspect, the metal salts may comprise metal salts of saccharin, acesulfame, long chain fatty acids, and alkyl dicarboxylic acids. The compositions further comprise polymers which form salts or complexes with silver, copper or zinc. The methods of the present invention comprise treating devices with the metal containing compositions, including, but not limited to, such devices as woven wound care materials, catheters, patient care devices, and collagen matrices. The present invention further comprises treatment of humans and animals with the antimicrobial devices described herein.

7. 发明授权

US09381269B2 Biosorbable wound treatment device, process for making, and method of using the same 有权
标题翻译：生物可收缩伤口治疗装置，制造方法及其使用方法
公开(公告)号：US09381269B2
公开(公告)日：2016-07-05
申请号：US13428370
申请日：2012-03-23
申请人： Bhalchandra M. Karandikar , Sophie Truc Lam
发明人： Bhalchandra M. Karandikar , Sophie Truc Lam
IPC分类号： A61L15/42 , A61L15/44 , A61L15/60
CPC分类号： A61L15/425 , A61L15/44 , A61L15/60 , A61L2300/11 , C08L5/04 , C08L5/08 , C08L3/04 , C08L67/04
摘要： A biosorbable oxygen-delivery wound treatment device that includes a biosorbable matrix for delivering oxygen. The biosorbable matrix includes a water swellable, cross-linked biosorbable polymer network. A plurality of gas-permeable, elastic, closed cells is defined by the cross-linked biosorbable polymer network. According to the invention, these closed cells may be produced from a reaction between a catalyst and a second reactant. Deliverable oxygen is contained within the elastic closed cells such that when the device is used to treat a wound, oxygen is delivered from the closed cells. A process for making a biosorbable oxygen-delivery wound treatment device that includes a biosorbable matrix for delivering oxygen as well as a method of using an oxygen-delivery wound treatment device is disclosed.
摘要翻译：一种生物可吸收氧传递伤口治疗装置，其包括用于输送氧气的生物可吸收基质。生物可吸收的基质包括水可溶胀的交联的可生物吸收的聚合物网络。通过交联的生物可吸收聚合物网络限定多个透气的，弹性的闭孔。根据本发明，这些闭孔可以由催化剂和第二反应物之间的反应产生。可弹性的氧被包含在弹性封闭的细胞内，使得当该装置用于治疗伤口时，从封闭的细胞输送氧气。本发明公开了一种生产可吸收的氧传递伤口治疗装置的方法，该装置包括用于输送氧的生物可吸收基质以及使用氧传递伤口治疗装置的方法。

8. 发明申请

US20150313912A1 ANTIMICROBIAL COMPOSITIONS AND METHODS OF MAKING THE SAME 有权
标题翻译：抗微生物组合物及其制备方法
公开(公告)号：US20150313912A1
公开(公告)日：2015-11-05
申请号：US14652730
申请日：2014-04-29
申请人： Bhalchandra M. KARANDIKAR
发明人： Bhalchandra M. Karandikar
IPC分类号： A61K31/555 , A61K47/02 , A61K47/38 , A61K9/00 , A61L15/28 , A61L15/20 , A61L15/44 , A61K9/70 , A61K9/06 , A61K47/10
CPC分类号： A61K31/555 , A01N59/16 , A61F13/00063 , A61K9/0014 , A61K9/06 , A61K9/7007 , A61K33/38 , A61K47/02 , A61K47/10 , A61K47/38 , A61L15/20 , A61L15/28 , A61L15/44 , A61L15/46 , A61L15/60 , A61L26/0066 , A61L26/008 , A61L27/52 , A61L27/54 , A61L2300/104 , A61L2300/404 , A01N25/04 , A01N25/14 , A01N25/22 , A01N43/66
摘要： The present disclosure comprises antimicrobial compositions and devices comprising silver compounds that resist heat and light discoloration. In one aspect, the said compounds comprise silver and at least one s-triazine ring or moiety. In another aspect, the antimicrobial compositions are hydrogels that are effective against broad spectrum of common pathogens including MRSA and VRE and are suitable for treating human or animal wounds and burns. The methods of the present disclosure comprise treating medical and non-medical devices and articles with compositions comprising the silver compounds to impart antimicrobial property.
摘要翻译：本公开内容包括抗微生物组合物和包含抵抗热和光变色的银化合物的装置。在一个方面，所述化合物包含银和至少一个s-三嗪环或部分。另一方面，抗微生物组合物是对包括MRSA和VRE在内的广谱常见病原体有效的水凝胶，并且适用于治疗人或动物伤口和烧伤。本公开的方法包括用包含银化合物的组合物处理医疗和非医疗装置和制品以赋予抗微生物性质。

9. 发明授权

US09181093B2 Two part oxygen generating system 有权
标题翻译：两部分氧气发生系统
公开(公告)号：US09181093B2
公开(公告)日：2015-11-10
申请号：US13555336
申请日：2012-07-23
申请人： Bhalchandra M. Karandikar , Sunita J. Macwana , Zhongju Liu Zhao
发明人： Bhalchandra M. Karandikar , Sunita J. Macwana , Zhongju Liu Zhao
IPC分类号： B65D83/68 , A61K8/02 , A61K8/04 , A61K8/19 , A61K8/22 , C01B13/02 , A61Q19/08 , A61K8/18 , A61L2/16 , A61L2/20 , A61L12/08 , A61L12/12 , B01J8/18 , B01J23/34
CPC分类号： C01B13/0214 , A61K8/0241 , A61K8/046 , A61K8/19 , A61K8/22 , A61K2800/22 , A61K2800/413 , A61K2800/882 , A61Q19/08
摘要： There is provided a two part spray for the liberation and delivery of oxygen through the use of a first part that is a peroxide-containing solution and a second part that is a nanoparticle manganese dioxide catalyst. When the two parts are mixed together, the ensuing reaction results in the liberation of oxygen.
摘要翻译：通过使用作为含过氧化物的溶液的第一部分和作为纳米颗粒二氧化锰催化剂的第二部分，提供了用于释放和输送氧气的两部分喷雾。当两部分混合在一起时，随后的反应导致氧的释放。

10. 发明授权

US06689494B1 Light emissive materials for organic light emitting devices (OLED) and OLED based thereupon 失效
标题翻译：有机发光器件（OLED）和基于OLED的光发射材料
公开(公告)号：US06689494B1
公开(公告)日：2004-02-10
申请号：US10241351
申请日：2002-09-11
申请人： Bhalchandra M. Karandikar
发明人： Bhalchandra M. Karandikar
IPC分类号： H05B3314
CPC分类号： C09K11/06 , C09K2211/1055 , H01L51/0079 , H01L51/5012 , Y10S428/917
摘要： Organic light emitting device (OLED) assemblies having light emitting layers made from boron atom rigidized monomethine cyanines are disclosed. OLED assemblies are constructed by conventional vapor deposition technique as well as by solution spin coating method. The OLED assemblies disclosed are expected to emit blue light and have improved color saturation because of smaller spectral width of the light emissive materials used.
摘要翻译：公开了具有由硼原子硬化的单甲基花青制成的发光层的有机发光器件（OLED）组件。 OLED组件通过常规蒸镀技术以及溶液旋涂法构成。由于所使用的光发射材料的光谱宽度较小，所公开的OLED组件预期发出蓝光并具有改善的色饱和度。

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