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    • 1. 发明申请
    • Anthocyanin-rich compositions and methods for inhibiting cancer cell growth
    • 富含花青素的组合物和抑制癌细胞生长的方法
    • US20060159781A1
    • 2006-07-20
    • US11388163
    • 2006-03-23
    • Bernadene MagnusonM. GiustiMinnie MalikCuiwei Zhao
    • Bernadene MagnusonM. GiustiMinnie MalikCuiwei Zhao
    • A61K36/45
    • A61K31/7048A61K31/353A61K36/45A61K36/73A61K36/87A61K2300/00
    • The present invention provides compositions and methods for inhibiting the growth and cell cycle progression in carcinoma cells comprising the step of contacting the cells with an anthocyanin rich extract (ARE) in an amount effective to inhibit the growth and cell cycle progression of the carcinoma cells without effecting the growth and cell cycle progression on normal cells. The invention further provides therapeutic compositions and methods of inhibiting the growth and cell cycle progression of carcinoma cells in a patient comprising administering to a patient a therapeutically effective amount of an anthocyanin-rich extract with the proviso that the anthocyanin rich extract does not effect the growth and cell cycle progression of normal cells in the patient. In preferred embodiments, the anthocyanin-rich extract useful in the compositions and methods of the invention are derived from chokeberry, bilberry, grape or combinations thereof. In preferred embodiments the carcinoma cells are colon carcinoma cells.
    • 本发明提供用于抑制癌细胞生长和细胞周期进展的组合物和方法,包括使细胞与富含花青素的提取物(ARE)接触的步骤,所述提取物(ARE)有效抑制癌细胞的生长和细胞周期进程,而没有 影响正常细胞的生长和细胞周期进程。 本发明进一步提供了治疗组合物和抑制患者癌细胞生长和细胞周期进程的方法,包括向患者施用治疗有效量的富含花青素的提取物,条件是富含花青素的提取物不影响生长 以及患者正常细胞的细胞周期进程。 在优选的实施方案中,可用于本发明的组合物和方法的富含花青素的提取物衍生自苦瓜,越桔,葡萄或其组合。 在优选的实施方案中,癌细胞是结肠癌细胞。
    • 2. 发明申请
    • Anthocyanin-rich compositions and methods for inhibiting cancer cell growth
    • 富含花青素的组合物和抑制癌细胞生长的方法
    • US20050013880A1
    • 2005-01-20
    • US10795967
    • 2004-03-08
    • Bernadene MagnusonM. GiustiMinnie MalikCuiwei Zhao
    • Bernadene MagnusonM. GiustiMinnie MalikCuiwei Zhao
    • A61K31/353A61K31/7048A61K36/45A61K36/73A61K36/87A61K35/78
    • A61K31/7048A61K31/353A61K36/45A61K36/73A61K36/87A61K2300/00
    • The present invention provides compositions and methods for inhibiting the growth and cell cycle progression in carcinoma cells comprising the step of contacting the cells with an anthocyanin rich extract (ARE) in an amount effective to inhibit the growth and cell cycle progression of the carcinoma cells without effecting the growth and cell cycle progression on normal cells. The invention further provides therapeutic compositions and methods of inhibiting the growth and cell cycle progression of carcinoma cells in a patient comprising administering to a patient a therapeutically effective amount of an anthocyanin-rich extract with the proviso that the anthocyanin rich extract does not effect the growth and cell cycle progression of normal cells in the patient. In preferred embodiments, the anthocyanin-rich extract useful in the compositions and methods of the invention are derived from chokeberry, bilberry, grape or combinations thereof. In preferred embodiments the carcinoma cells are colon carcinoma cells.
    • 本发明提供用于抑制癌细胞生长和细胞周期进展的组合物和方法,包括使细胞与富含花青素的提取物(ARE)接触的步骤,所述提取物(ARE)有效抑制癌细胞的生长和细胞周期进程,而没有 影响正常细胞的生长和细胞周期进程。 本发明进一步提供了抑制患者癌细胞生长和细胞周期进程的治疗组合物和方法,其包括向患者施用治疗有效量的富含花青素的提取物,条件是富含花青素的提取物不影响生长 以及患者正常细胞的细胞周期进程。 在优选的实施方案中,可用于本发明的组合物和方法的富含花青素的提取物衍生自苦瓜,越桔,葡萄或其组合。 在优选的实施方案中,癌细胞是结肠癌细胞。