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1. 发明授权

US06324531B1 System and method for identifying the geographic origin of a fresh commodity 失效
标题翻译：识别新鲜商品的地理来源的制度和方法
公开(公告)号：US06324531B1
公开(公告)日：2001-11-27
申请号：US09210358
申请日：1998-12-11
申请人： Kim A. Anderson , Brian Smith , Bernadene Magnuson
发明人： Kim A. Anderson , Brian Smith , Bernadene Magnuson
IPC分类号： G06N302
CPC分类号： G06N3/0454 , G06K9/62 , G06K2209/17
摘要： The detection method includes generating a plurality of neural network models. Each model has as a training set a data set from a plurality of samples of a commodity of known origins. Each sample has been analyzed for a plurality of elemental concentrations. Each neural network model is presented for classification a test data set from a plurality of samples of a commodity of unknown origins. As with the training set, the samples have been analyzed for the same plurality of elemental concentrations. Next a bootstrap aggregating strategy is employed to combine the results of the classifications for each sample in the test data set made by each neural network model. Finally, a determination is made from the bootstrap aggregating strategy as to a final classification of each sample in the test data set. This final classification is indicative of the geographical origin of the commodity. The system includes software for generating the neural network models and a software routine for performing the bootstrap aggregating strategy.
摘要翻译：检测方法包括生成多个神经网络模型。每个模型都具有从已知来源的商品的多个样本中设置数据集的训练。已经分析了每个样品的多种元素浓度。呈现每个神经网络模型，用于对来自未知来源的商品的多个样本进行分类测试数据集。与训练集一样，已经分析了相同多个元素浓度的样品。接下来，采用引导聚合策略将每个样本的分类结果与由每个神经网络模型进行的测试数据集相结合。最后，从引导聚合策略中确定测试数据集中每个样本的最终分类。这种最终分类表明商品的地理来源。该系统包括用于生成神经网络模型的软件和用于执行引导聚合策略的软件例程。

2. 发明申请

US20060024392A1 Compositions and methods for enhancing the effectiveness of a chemotherapeutic agent 审中-公开
标题翻译：用于增强化学治疗剂有效性的组合物和方法
公开(公告)号：US20060024392A1
公开(公告)日：2006-02-02
申请号：US11106240
申请日：2005-04-14
申请人： Bernadene Magnuson , Tao Yu
发明人： Bernadene Magnuson , Tao Yu
IPC分类号： A61K36/45
CPC分类号： A61K31/4178 , A61K31/35 , A61K31/513 , A61K36/73 , A61K45/06 , A61K2300/00
摘要： This invention relates to food components such as phytochemicals including anthocyanins that can enhance the effectiveness of a chemotherapeutic agent in treating a cell proliferative disorder and/or reduce chemotherapy-induced side effects during treatment of a cell proliferative disorder.
摘要翻译：本发明涉及包括花色素苷的植物化学物质的食品成分，其可以在治疗细胞增殖性疾病期间增强化学治疗剂在治疗细胞增殖性病症和/或降低化学疗法诱发的副作用的有效性。

3. 发明申请

US20050013880A1 Anthocyanin-rich compositions and methods for inhibiting cancer cell growth 审中-公开
标题翻译：富含花青素的组合物和抑制癌细胞生长的方法
公开(公告)号：US20050013880A1
公开(公告)日：2005-01-20
申请号：US10795967
申请日：2004-03-08
申请人： Bernadene Magnuson , M. Giusti , Minnie Malik , Cuiwei Zhao
发明人： Bernadene Magnuson , M. Giusti , Minnie Malik , Cuiwei Zhao
IPC分类号： A61K31/353 , A61K31/7048 , A61K36/45 , A61K36/73 , A61K36/87 , A61K35/78
CPC分类号： A61K31/7048 , A61K31/353 , A61K36/45 , A61K36/73 , A61K36/87 , A61K2300/00
摘要： The present invention provides compositions and methods for inhibiting the growth and cell cycle progression in carcinoma cells comprising the step of contacting the cells with an anthocyanin rich extract (ARE) in an amount effective to inhibit the growth and cell cycle progression of the carcinoma cells without effecting the growth and cell cycle progression on normal cells. The invention further provides therapeutic compositions and methods of inhibiting the growth and cell cycle progression of carcinoma cells in a patient comprising administering to a patient a therapeutically effective amount of an anthocyanin-rich extract with the proviso that the anthocyanin rich extract does not effect the growth and cell cycle progression of normal cells in the patient. In preferred embodiments, the anthocyanin-rich extract useful in the compositions and methods of the invention are derived from chokeberry, bilberry, grape or combinations thereof. In preferred embodiments the carcinoma cells are colon carcinoma cells.
摘要翻译：本发明提供用于抑制癌细胞生长和细胞周期进展的组合物和方法，包括使细胞与富含花青素的提取物（ARE）接触的步骤，所述提取物（ARE）有效抑制癌细胞的生长和细胞周期进程，而没有影响正常细胞的生长和细胞周期进程。本发明进一步提供了抑制患者癌细胞生长和细胞周期进程的治疗组合物和方法，其包括向患者施用治疗有效量的富含花青素的提取物，条件是富含花青素的提取物不影响生长以及患者正常细胞的细胞周期进程。在优选的实施方案中，可用于本发明的组合物和方法的富含花青素的提取物衍生自苦瓜，越桔，葡萄或其组合。在优选的实施方案中，癌细胞是结肠癌细胞。

4. 发明授权

US07130834B2 Identification system and method for determining the geographic origin of a fresh commodity 有权
公开(公告)号：US07130834B2
公开(公告)日：2006-10-31
申请号：US09995257
申请日：2001-11-27
申请人： Kim A. Anderson , Brian Smith , Bernadene Magnuson
发明人： Kim A. Anderson , Brian Smith , Bernadene Magnuson
IPC分类号： G06N3/02
CPC分类号： G06K9/62 , G06K2209/17 , G06N3/0454
摘要： The detection method includes generating a plurality of neural network models. Each model has as a training set a data set from a plurality of samples of a commodity of known origins. Each sample has been analyzed for a plurality of elemental concentrations. Each neural network model is presented for classification a test data set from a plurality of samples of a commodity of unknown origins. As with the training set, the samples have been analyzed for the same plurality of elemental concentrations. Next a bootstrap aggregating strategy is employed to combine the results of the classifications for each sample in the test data set made by each neural network model. Finally, a determination is made from the bootstrap aggregating strategy as to a final classification of each sample in the test data set. This final classification is indicative of the geographical origin of the commodity. The system includes software for generating the neural network models and a software routine for performing the bootstrap aggregating strategy.

5. 发明申请

US20060159781A1 Anthocyanin-rich compositions and methods for inhibiting cancer cell growth 失效
标题翻译：富含花青素的组合物和抑制癌细胞生长的方法
公开(公告)号：US20060159781A1
公开(公告)日：2006-07-20
申请号：US11388163
申请日：2006-03-23
申请人： Bernadene Magnuson , M. Giusti , Minnie Malik , Cuiwei Zhao
发明人： Bernadene Magnuson , M. Giusti , Minnie Malik , Cuiwei Zhao
IPC分类号： A61K36/45
CPC分类号： A61K31/7048 , A61K31/353 , A61K36/45 , A61K36/73 , A61K36/87 , A61K2300/00
摘要： The present invention provides compositions and methods for inhibiting the growth and cell cycle progression in carcinoma cells comprising the step of contacting the cells with an anthocyanin rich extract (ARE) in an amount effective to inhibit the growth and cell cycle progression of the carcinoma cells without effecting the growth and cell cycle progression on normal cells. The invention further provides therapeutic compositions and methods of inhibiting the growth and cell cycle progression of carcinoma cells in a patient comprising administering to a patient a therapeutically effective amount of an anthocyanin-rich extract with the proviso that the anthocyanin rich extract does not effect the growth and cell cycle progression of normal cells in the patient. In preferred embodiments, the anthocyanin-rich extract useful in the compositions and methods of the invention are derived from chokeberry, bilberry, grape or combinations thereof. In preferred embodiments the carcinoma cells are colon carcinoma cells.
摘要翻译：本发明提供用于抑制癌细胞生长和细胞周期进展的组合物和方法，包括使细胞与富含花青素的提取物（ARE）接触的步骤，所述提取物（ARE）有效抑制癌细胞的生长和细胞周期进程，而没有影响正常细胞的生长和细胞周期进程。本发明进一步提供了治疗组合物和抑制患者癌细胞生长和细胞周期进程的方法，包括向患者施用治疗有效量的富含花青素的提取物，条件是富含花青素的提取物不影响生长以及患者正常细胞的细胞周期进程。在优选的实施方案中，可用于本发明的组合物和方法的富含花青素的提取物衍生自苦瓜，越桔，葡萄或其组合。在优选的实施方案中，癌细胞是结肠癌细胞。

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