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    • 9. 发明申请
    • Cardiac Patterning for Improving Diastolic Function
    • 心脏图案改善舒张功能
    • US20130211182A1
    • 2013-08-15
    • US13742322
    • 2013-01-15
    • Hani N. SabbahRandall J. LeeAndrew G. Hinson
    • Hani N. SabbahRandall J. LeeAndrew G. Hinson
    • A61F2/24
    • A61F2/2478A61B17/00491A61B17/12022A61B17/12045A61B17/12122A61B17/12136A61B17/12181A61B17/12186A61B17/1219A61B2017/00243A61B2017/048A61B2017/1205A61B2017/12127A61F2/2481A61F2002/249A61F2250/0067A61L31/005
    • Cardiomyopathy may be treated by distributing a space-occupying diastole-assist agent within the myocardium or within the cardiac venous system in a pattern about one or more chambers of the heart, such that the space-modifying agent integrates into and thickens at least part of the cardiac wall about the chamber so as globally to reduce wall stress, stabilize or even reduce chamber size, and/or improve diastolic function. Some patterns also cause a beneficial global reshaping of the chamber. These changes occur quickly and are sustainable, and have a rapid and sustainable therapeutic effect on cardiac function. Patterns of distribution of space-occupying agent within the myocardium for global resizing may also be used or augmented to treat localized conditions such as myocardial infarctions, overt aneurysm of the ventricular wall as typically forms in response to large transmural myocardial infarctions, and mitral regurgitation due to a noncompliant mitral valve. These techniques may also be used to treat localized conditions that may not yet have progressed to cardiomyopathy.
    • 心肌病可以通过以围绕心脏的一个或多个腔室的模式在心肌内或心脏静脉系统内分布空间占据舒张辅助剂来治疗,使得空间改变剂整合入并增稠至少部分 围绕腔室的心脏壁,以便全局地减小壁应力,稳定或甚至减小腔室尺寸,和/或改善舒张功能。 一些模式也引起了对室的有益的全局整形。 这些变化迅速发生并且是可持续的,并且对心脏功能具有快速和可持续的治疗作用。 用于全局调整大小的心肌内的空间占位剂的分布模式也可以被使用或增加以治疗局部的情况,例如心肌梗死,通常形成响应于大的透壁性心肌梗死的心室壁的明显的动脉瘤和二尖瓣反流 到不合规的二尖瓣。 这些技术也可用于治疗可能尚未进展为心肌病的局部病症。