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1. 发明申请

US20130211182A1 Cardiac Patterning for Improving Diastolic Function 审中-公开
标题翻译：心脏图案改善舒张功能
公开(公告)号：US20130211182A1
公开(公告)日：2013-08-15
申请号：US13742322
申请日：2013-01-15
申请人： Hani N. Sabbah , Randall J. Lee , Andrew G. Hinson
发明人： Hani N. Sabbah , Randall J. Lee , Andrew G. Hinson
IPC分类号： A61F2/24
CPC分类号： A61F2/2478 , A61B17/00491 , A61B17/12022 , A61B17/12045 , A61B17/12122 , A61B17/12136 , A61B17/12181 , A61B17/12186 , A61B17/1219 , A61B2017/00243 , A61B2017/048 , A61B2017/1205 , A61B2017/12127 , A61F2/2481 , A61F2002/249 , A61F2250/0067 , A61L31/005
摘要： Cardiomyopathy may be treated by distributing a space-occupying diastole-assist agent within the myocardium or within the cardiac venous system in a pattern about one or more chambers of the heart, such that the space-modifying agent integrates into and thickens at least part of the cardiac wall about the chamber so as globally to reduce wall stress, stabilize or even reduce chamber size, and/or improve diastolic function. Some patterns also cause a beneficial global reshaping of the chamber. These changes occur quickly and are sustainable, and have a rapid and sustainable therapeutic effect on cardiac function. Patterns of distribution of space-occupying agent within the myocardium for global resizing may also be used or augmented to treat localized conditions such as myocardial infarctions, overt aneurysm of the ventricular wall as typically forms in response to large transmural myocardial infarctions, and mitral regurgitation due to a noncompliant mitral valve. These techniques may also be used to treat localized conditions that may not yet have progressed to cardiomyopathy.
摘要翻译：心肌病可以通过以围绕心脏的一个或多个腔室的模式在心肌内或心脏静脉系统内分布空间占据舒张辅助剂来治疗，使得空间改变剂整合入并增稠至少部分围绕腔室的心脏壁，以便全局地减小壁应力，稳定或甚至减小腔室尺寸，和/或改善舒张功能。一些模式也引起了对室的有益的全局整形。这些变化迅速发生并且是可持续的，并且对心脏功能具有快速和可持续的治疗作用。用于全局调整大小的心肌内的空间占位剂的分布模式也可以被使用或增加以治疗局部的情况，例如心肌梗死，通常形成响应于大的透壁性心肌梗死的心室壁的明显的动脉瘤和二尖瓣反流到不合规的二尖瓣。这些技术也可用于治疗可能尚未进展为心肌病的局部病症。

2. 发明申请

US20090012413A1 Cardiac patterning for improving diastolic function 审中-公开
标题翻译：用于改善舒张功能的心脏图案
公开(公告)号：US20090012413A1
公开(公告)日：2009-01-08
申请号：US12157711
申请日：2008-06-11
申请人： Hani N. Sabbah , Randall J. Lee , Andrew G. Hinson
发明人： Hani N. Sabbah , Randall J. Lee , Andrew G. Hinson
IPC分类号： A61K38/18 , A61K35/00 , A61M5/00 , A61B5/02 , A61M25/18 , A61P9/00
CPC分类号： A61F2/2478 , A61B17/00491 , A61B17/12022 , A61B17/12045 , A61B17/12122 , A61B17/12136 , A61B17/12181 , A61B17/12186 , A61B17/1219 , A61B2017/00243 , A61B2017/048 , A61B2017/1205 , A61B2017/12127 , A61F2/2481 , A61F2002/249 , A61F2250/0067 , A61L31/005
摘要： Cardiomyopathy may be treated by distributing a space-occupying diastole-assist agent within the myocardium or within the cardiac venous system in a pattern about one or more chambers of the heart, such that the space-modifying agent integrates into and thickens at least part of the cardiac wall about the chamber so as globally to reduce wall stress, stabilize or even reduce chamber size, and/or improve diastolic function. Some patterns also cause a beneficial global reshaping of the chamber. These changes occur quickly and are sustainable, and have a rapid and sustainable therapeutic effect on cardiac function. Patterns of distribution of space-occupying agent within the myocardium for global resizing may also be used or augmented to treat localized conditions such as myocardial infarctions, overt aneurysm of the ventricular wall as typically forms in response to large transmural myocardial infarctions, and mitral regurgitation due to a noncompliant mitral valve. These techniques may also be used to treat localized conditions that may not yet have progressed to cardiomyopathy.
摘要翻译：心肌病可以通过以围绕心脏的一个或多个腔室的模式在心肌内或心脏静脉系统内分布空间占据舒张辅助剂来治疗，使得空间改变剂整合入并增稠至少部分围绕腔室的心脏壁，以便全局地减小壁应力，稳定或甚至减小腔室尺寸，和/或改善舒张功能。一些模式也引起了对室的有益的全局整形。这些变化迅速发生并且是可持续的，并且对心脏功能具有快速和可持续的治疗作用。用于全局调整大小的心肌内的空间占位剂的分布模式也可以被使用或增加以治疗局部的情况，例如心肌梗死，通常形成响应于大的透壁性心肌梗死的心室壁的明显的动脉瘤和二尖瓣反流到不合规的二尖瓣。这些技术也可用于治疗可能尚未进展为心肌病的局部病症。

3. 发明授权

US09375313B2 Intramyocardial patterning for global cardiac resizing and reshaping 有权
标题翻译：用于全球心脏调整和重塑的心肌内图案
公开(公告)号：US09375313B2
公开(公告)日：2016-06-28
申请号：US11899962
申请日：2007-09-07
申请人： Hani N. Sabbah , Randall J. Lee , Andrew G. Hinson
发明人： Hani N. Sabbah , Randall J. Lee , Andrew G. Hinson
IPC分类号： A61M37/00 , A61F2/00 , A61F2/24 , A61L27/38
CPC分类号： A61F2/2451 , A61F2/2481 , A61F2002/249 , A61F2250/0067 , A61K9/0024 , A61L27/20 , A61L27/3873 , A61L27/52 , A61L2400/06 , A61M5/14 , A61M5/178 , A61M37/00 , A61M37/0069
摘要： Cardiomyopathy may be treated by distributing space-occupying agent within the myocardium in a pattern about one or more chambers of the heart, such that the space-modifying agent integrates into and thickens at least part of the cardiac wall about the chamber so as globally to reduce wall stress and stabilize or even reduce chamber size. Some patterns also cause a beneficial global reshaping of the chamber. These changes occur quickly and are sustainable, and have a rapid and sustainable therapeutic effect on cardiac function. Over time the relief of wall stress reduces oxygen consumption and promotes healing. Moreover, various long-term therapeutic effects may be realized depending on the properties of the space-occupying agent, including combinations with other therapeutic materials. These techniques may also be used to treat localized conditions, whether or not they have progressed to cardiomyopathy.
摘要翻译：心肌病可以通过以围绕心脏的一个或多个腔室的模式在心肌内分布空间占位剂来治疗，使得空间改变剂整合到腔室周围的至少部分心脏壁并使其增厚，降低壁面应力，稳定或甚至减小腔室尺寸。一些模式也引起了对室的有益的全局整形。这些变化迅速发生并且是可持续的，并且对心脏功能具有快速和可持续的治疗作用。随着时间的推移，墙壁压力的减轻会降低氧气消耗并促进愈合。此外，根据空间占据剂的特性，包括与其它治疗材料的组合，可以实现各种长期治疗效果。这些技术也可用于治疗局部的病症，无论其是否进展为心肌病。

4. 发明授权

US09782258B2 Intramyocardial patterning for global cardiac resizing and reshaping 有权
公开(公告)号：US09782258B2
公开(公告)日：2017-10-10
申请号：US11900005
申请日：2007-09-07
申请人： Hani N. Sabbah , Randall J. Lee , Andrew G. Hinson
发明人： Hani N. Sabbah , Randall J. Lee , Andrew G. Hinson
IPC分类号： A61M37/00 , A61F2/24 , A61L27/38 , A61K9/00 , A61L27/20 , A61L27/52 , A61M5/14 , A61M5/178
CPC分类号： A61F2/2451 , A61F2/2481 , A61F2002/249 , A61F2250/0067 , A61K9/0024 , A61L27/20 , A61L27/3873 , A61L27/52 , A61L2400/06 , A61M5/14 , A61M5/178 , A61M37/00 , A61M37/0069
摘要： Cardiomyopathy may be treated by distributing space-occupying agent within the myocardium in a pattern about one or more chambers of the heart, such that the space-modifying agent integrates into and thickens at least part of the cardiac wall about the chamber so as globally to reduce wall stress and stabilize or even reduce chamber size. Some patterns also cause a beneficial global reshaping of the chamber. These changes occur quickly and are sustainable, and have a rapid and sustainable therapeutic effect on cardiac function. Over time the relief of wall stress reduces oxygen consumption and promotes healing. Moreover, various long-term therapeutic effects may be realized depending on the properties of the space-occupying agent, including combinations with other therapeutic materials. Specific cardiac conditions treatable by these systems and methods include, for example, dilated cardiomyopathy (with or without overt aneurismal formations), congestive heart failure, and ventricular arrhythmias. Patterns of distribution of space-occupying agent within the myocardium for global resizing may also be used or augmented to treat localized conditions such as myocardial infarctions, overt aneurysm of the ventricular wall as typically forms in response to large transmural myocardial infarctions, and mitral regurgitation due to a noncompliant mitral valve. These techniques may also be used to treat localized conditions that may not yet have progressed to cardiomyopathy.

5. 发明申请

US20160338831A1 INTRAMYOCARDIAL PATTERNING FOR GLOBAL CARDIAC RESIZING AND RESHAPING 审中-公开
标题翻译：用于全球心脏重塑和重塑的内分泌方案
公开(公告)号：US20160338831A1
公开(公告)日：2016-11-24
申请号：US15161255
申请日：2016-05-22
申请人： Hani N. Sabbah , Randall J. Lee , Andrew G. Hinson
发明人： Hani N Sabbah , Randall J. Lee , Andrew G. Hinson
IPC分类号： A61F2/24 , A61M5/14 , A61K9/00 , A61L27/52 , A61L27/20 , A61M37/00 , A61M5/178
CPC分类号： A61F2/2451 , A61F2/2481 , A61F2002/249 , A61F2250/0067 , A61K9/0024 , A61L27/20 , A61L27/3873 , A61L27/52 , A61L2400/06 , A61M5/14 , A61M5/178 , A61M37/00 , A61M37/0069
摘要： Cardiomyopathy may be treated by distributing space-occupying agent within the myocardium in a pattern about one or more chambers of the heart, such that the space-modifying agent integrates into and thickens at least part of the cardiac wall about the chamber so as globally to reduce wall stress and stabilize or even reduce chamber size. Some patterns also cause a beneficial global reshaping of the chamber. These changes occur quickly and are sustainable, and have a rapid and sustainable therapeutic effect on cardiac function. Over time the relief of wall stress reduces oxygen consumption and promotes healing. Moreover, various long-term therapeutic effects may be realized depending on the properties of the space-occupying agent, including combinations with other therapeutic materials. Specific cardiac conditions treatable by these systems and methods include, for example, dilated cardiomyopathy (with or without overt aneurismal formations), congestive heart failure, and ventricular arrhythmias. Patterns of distribution of space-occupying agent within the myocardium for global resizing may also be used or augmented to treat localized conditions such as myocardial infarctions, overt aneurysm of the ventricular wall as typically forms in response to large transmural myocardial infarctions, and mitral regurgitation due to a noncompliant mitral valve. These techniques may also be used to treat localized conditions that may not yet have progressed to cardiomyopathy.
摘要翻译：心肌病可以通过以围绕心脏的一个或多个腔室的模式在心肌内分布空间占位剂来治疗，使得空间改变剂整合到腔室周围的至少部分心脏壁并使其增厚，降低壁面应力，稳定或甚至减小腔室尺寸。一些模式也引起了对室的有益的全局整形。这些变化迅速发生并且是可持续的，并且对心脏功能具有快速和可持续的治疗作用。随着时间的推移，墙壁压力的减轻会降低氧气消耗并促进愈合。此外，根据空间占据剂的特性，包括与其它治疗材料的组合，可以实现各种长期治疗效果。可通过这些系统和方法治疗的特异性心脏病症包括例如扩张型心肌病（有或没有明显的动脉瘤形成），充血性心力衰竭和室性心律失常。用于全局调整大小的心肌内的空间占位剂的分布模式也可以被使用或增加以治疗局部的情况，例如心肌梗死，通常形成响应于大的透壁性心肌梗死的心室壁的明显的动脉瘤和二尖瓣反流到不合规的二尖瓣。这些技术也可用于治疗可能尚未进展为心肌病的局部病症。

6. 发明申请

US20120121599A1 COMPOSITIONS AND METHODS FOR STEM CELL DELIVERY 审中-公开
标题翻译：用于干细胞递送的组合物和方法
公开(公告)号：US20120121599A1
公开(公告)日：2012-05-17
申请号：US13355258
申请日：2012-01-20
申请人： Lawrence G. Lum , Randall J. Lee
发明人： Lawrence G. Lum , Randall J. Lee
IPC分类号： A61K47/42 , C07K16/46
CPC分类号： A61K39/3955 , A61K47/6901 , A61K2035/124 , A61K2039/505 , C07K16/2803 , C07K16/2809 , C07K16/2821 , C07K16/2836 , C07K2317/31
摘要： This invention provides compositions of matter, articles of manufacture and methods for delivering and/or affixing a stem cell to a target tissue. This invention also provides related nucleic acids, vectors, cells, methods of production, and kits.
摘要翻译：本发明提供了物质组合物，制品和用于将干细胞递送和/或附着于靶组织的方法。本发明还提供了相关的核酸，载体，细胞，生产方法和试剂盒。

7. 发明申请

US20120076786A1 BISPECIFIC ANTIBODIES 审中-公开
标题翻译：双重抗体
公开(公告)号：US20120076786A1
公开(公告)日：2012-03-29
申请号：US13306888
申请日：2011-11-29
申请人： Randall J. Lee , James Larrick , Lawrence G. Lum
发明人： Randall J. Lee , James Larrick , Lawrence G. Lum
IPC分类号： A61K39/395 , C12N5/07 , A61P9/00 , C07K16/28
CPC分类号： C07K16/18 , A61K2039/505 , C07K16/289 , C07K2317/31
摘要： The present invention provides compositions and methods for targeting stem cells to injured cardiac tissue.
摘要翻译：本发明提供了将干细胞靶向损伤的心脏组织的组合物和方法。

8. 发明申请

US20080288008A1 Cardiac Stimulation System and Method 审中-公开
标题翻译：心脏刺激系统及方法
公开(公告)号：US20080288008A1
公开(公告)日：2008-11-20
申请号：US11941893
申请日：2007-11-16
申请人： Randall J. Lee
发明人： Randall J. Lee
IPC分类号： A61N1/362
CPC分类号： A61N1/056 , A61N1/0568 , A61N1/30 , A61N2001/0585
摘要： A cardiac stimulation assembly includes an energy source coupled to an energy emitter that extends form a delivery member into a region of tissue in the heart. An array of the emitters are adapted to extend from a delivery assembly and into unique locations along the region of tissue, such as by use of extendable, pre-shaped needles. A volume of conductive agent is delivered into the region and enhances stimulation of the region with the energy emitter. The agent may be an injectable preparation of living cells that express production of connexin, e.g. connexin 43, and may be genetically modified to over-express such production. The agent may include a non-living material, such as conductive polymer or metal or combination thereof. The combination of energy emitters and conductive agent enhances stimulation of the region. Delivering the stimulation assembly and conductive agent into the interventricular septum allows for improved biventricular septal pacing.
摘要翻译：心脏刺激组件包括耦合到能量发射器的能量源，能量发射器从形成递送构件延伸到心脏中的组织区域。发射器的阵列适于从输送组件延伸并且沿着组织区域延伸到独特的位置，例如通过使用可延伸的预成形针。导电剂的体积被输送到该区域中并且增强了与能量发射体的区域的刺激。该试剂可以是表达连接蛋白生产的活细胞的可注射制剂，例如连接蛋白43，并且可以进行基因修饰以过度表达这种生产。试剂可以包括非活性材料，例如导电聚合物或金属或其组合。能量发射器和导电剂的组合增强了该区域的刺激。将刺激组件和导电剂递送到室间隔可允许改善双室间隔起搏。

9. 发明授权

US07317950B2 Cardiac stimulation system with delivery of conductive agent 有权
标题翻译：心脏刺激系统配有导电剂
公开(公告)号：US07317950B2
公开(公告)日：2008-01-08
申请号：US10374899
申请日：2003-02-24
申请人： Randall J. Lee
发明人： Randall J. Lee
IPC分类号： A61N1/05 , A61N1/362 , A61N1/39
CPC分类号： A61N1/056 , A61N1/0568 , A61N1/30 , A61N2001/0585
摘要： A cardiac stimulation assembly includes an energy source coupled to an energy emitter that extends form a delivery member into a region of tissue in the heart. An array of the emitters are adapted to extend from a delivery assembly and into unique locations along the region of tissue, such as by use of extendable, pre-shaped needles. A volume of conductive agent is delivered into the region and enhances stimulation of the region with the energy emitter. The agent may be an injectable preparation of living cells that express production of connexin, e.g. connexin 43, and may be genetically modified to over-express such production. The agent may include a non-living material, such as conductive polymer or metal or combination thereof. The combination of energy emitters and conductive agent enhances stimulation of the region. Delivering the stimulation assembly and conductive agent into the interventricular septum allows for improved biventricular septal pacing.
摘要翻译：心脏刺激组件包括耦合到能量发射器的能量源，能量发射器从形成递送构件延伸到心脏中的组织区域。发射器的阵列适于从输送组件延伸并且沿着组织区域延伸到独特的位置，例如通过使用可延伸的预成形针。导电剂的体积被输送到该区域中并且增强了与能量发射体的区域的刺激。该试剂可以是表达连接蛋白生产的活细胞的可注射制剂，例如连接蛋白43，并且可以进行基因修饰以过度表达这种生产。试剂可以包括非活性材料，例如导电聚合物或金属或其组合。能量发射器和导电剂的组合增强了该区域的刺激。将刺激组件和导电剂递送到室间隔可允许改善双室间隔起搏。

10. 发明授权

US6059726A Method for locating the atrio-ventricular (AV) junction of the heart and injecting active substances therein 失效
标题翻译：用于定位心脏的心房（AV）交界处并在其中注射活性物质的方法
公开(公告)号：US6059726A
公开(公告)日：2000-05-09
申请号：US933915
申请日：1997-09-23
申请人： Randall J. Lee , Michael D. Lesh
发明人： Randall J. Lee , Michael D. Lesh
IPC分类号： A61B5/042 , A61B8/12 , A61M25/00 , A61M25/01
CPC分类号： A61B8/12 , A61B5/042 , A61M25/0084
摘要： A method for locating the AV junction in the heart and injecting pharmacological or biological compounds into the AV junction for purposes of enhancing or retarding electrical conduction within the AV junction. The AV junction is identified using a combination of echocardiographs and intracardiac electrograms and, once, a catheter with an injection needle and infusion port is positioned into the AV junction for purposes of direct infusion of biologically active compounds to enhance or retard atrioventricular conduction of electrical impulses.
摘要翻译：用于定位心脏中的AV结并将药理学或生物化学物质注入AV结的方法，用于增强或延缓AV结内的电传导。使用超声心动图和心内电图的组合来识别AV结，并且一旦将具有注射针和输注端口的导管定位到AV结中，以便直接输注生物活性化合物以增强或延缓房室传导电脉冲。

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