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1. 发明申请

US20060281874A1 Method of making a diisocyanate terminated macromer 有权
标题翻译：制备二异氰酸酯封端的大分子单体的方法
公开(公告)号：US20060281874A1
公开(公告)日：2006-12-14
申请号：US11476513
申请日：2006-06-28
申请人： Benjamin Fitz , Michael Justus , Christopher Westergom
发明人： Benjamin Fitz , Michael Justus , Christopher Westergom
IPC分类号： C08F20/00 , C08G59/14
CPC分类号： C08G18/4252 , C08G18/771 , C08G2230/00
摘要： A novel macromer or mixture thereof is described herein, comprising benzoyl isocyanate terminal moieties and at least two residues of a water-soluble polymer having a molecular weight ranging from 80 to 10,000 adjacent to the carbonyl group of the benzoyl isocyanate moieties, thereby forming at least two ester linkages in the macromer or mixture thereof. A method for making a diisocyanate macromer is also described herein.
摘要翻译：本文描述了一种新的大分子单体或其混合物，其包含苯甲酰异氰酸酯末端部分和与苯甲酰基异氰酸酯部分的羰基相邻的分子量范围为80至10,000的水溶性聚合物的至少两个残基，从而至少形成大分子单体或其混合物中的两个酯键。本文还描述了制备二异氰酸酯大分子单体的方法。

2. 发明申请

US20070167617A1 Method of making a diisocyanate terminated macromer 审中-公开
标题翻译：制备二异氰酸酯封端的大分子单体的方法
公开(公告)号：US20070167617A1
公开(公告)日：2007-07-19
申请号：US11333057
申请日：2006-01-17
申请人： Benjamin Fitz , Michael Justus
发明人： Benjamin Fitz , Michael Justus
IPC分类号： C08B11/193
CPC分类号： C09J175/08 , A61L24/046 , C07C265/14 , C08G18/10 , C08G18/4833 , C08G2190/00 , C08G2230/00 , C08L75/04 , C08G18/771
摘要： A method for making a polyisocyanate macromer is described herein.
摘要翻译：本文描述了制备多异氰酸酯大分子单体的方法。

3. 发明授权

US07005531B2 Method of making iron(III)gluconate complex 失效
标题翻译：制备葡萄糖酸铁（III）络合物的方法
公开(公告)号：US07005531B2
公开(公告)日：2006-02-28
申请号：US10991748
申请日：2004-11-18
申请人： Michael Justus , Rolf Hänseler
发明人： Michael Justus , Rolf Hänseler
IPC分类号： C07F15/02 , A61K31/295
CPC分类号： C07F15/025
摘要： The present invention refers to a method for making iron(III)gluconate complex, preferably alkali iron(III)gluconate complex. The method includes the following steps: (i) mixing a water soluble iron(III)salt in aqueous solution, simultaneously or in any desired sequence, with a member selected from gluconic acid, a water soluble salt of gluconic acid and combinations thereof, and a member selected from an alkali hydroxide, an alkali carbonate, an alkali hydrogen carbonate and combinations thereof, so that the reaction mixture has an acid value (pH-value) within the range of from 7.0 to 12, provided that when alkali hydroxide is used, gluconic acid or a water soluble salt of gluconic acid is provided at the beginning of the reaction or is added to the reaction mixture simultaneously with the alkali hydroxide; (ii) heating the reaction mixture until the iron(III)gluconate complex has formed; and (iii) adding an organic solvent which is miscible with water until the iron(III)gluconate complex is precipitated. The present invention also refers to pharmaceutical compositions including the iron(III)gluconate complex and methods of treating anemic conditions.
摘要翻译：本发明涉及制造葡萄糖酸铁（III）络合物，优选葡萄糖酸铁（III）络合物的方法。该方法包括以下步骤：（i）将水溶性铁（III）盐同时或以任何所需的顺序与选自葡糖酸，葡萄糖酸的水溶性盐及其组合的成员混合，以及选自碱金属氢氧化物，碱金属碳酸盐，碱金属氢氧化物及其组合的成员，使得反应混合物的酸值（pH值）在7.0至12的范围内，条件是当使用碱金属氢氧化物时葡萄糖酸或葡萄糖酸的水溶性盐在反应开始时提供，或者与碱金属氢氧化物同时加入到反应混合物中; （ii）加热反应混合物直到葡萄糖酸铁配合物形成; 和（iii）加入与水混溶的有机溶剂，直到铁（III）葡萄糖酸铁配合物沉淀。本发明还涉及包含葡萄糖酸铁（III）络合物和治疗贫血病症的方法的药物组合物。

4. 发明公开

US20230218859A1 Tamper-Evident Enclosure for PICC Line 审中-公开
公开(公告)号：US20230218859A1
公开(公告)日：2023-07-13
申请号：US18187565
申请日：2023-03-21
申请人： Michael Justus , Jesse Justus , Katherine Justus
发明人： Michael Justus , Jesse Justus , Katherine Justus
IPC分类号： A61M25/00 , A61M39/10
CPC分类号： A61M25/002 , A61M39/1011
摘要： A catheter enclosure device for locking an intravenous catheter therein with tamper-evident features to deter unauthorized use. The catheter enclosure device may be particularly useful for peripherally inserted central catheters (PICC). The enclosure device comprises an open-top box and a removable lid for covering the box. The open-top box has a compartment for holding the proximal end of an intravenous catheter. The lid comprises a panel for covering the open portion of the open-top box and a folding wing that overhangs the forward end of the box when covering the box. The folding wing further comprises a retaining anchor. When the folding wing is folded down, the retaining anchor inserts into a locking slot on the forward end of the box, thereby preventing the lid from being removed off the box. Also disclosed are methods for using the catheter enclosure device.

5. 发明授权

US07915421B2 Method for preparing phenyl acetic acid derivatives 失效
标题翻译：制备苯乙酸衍生物的方法
公开(公告)号：US07915421B2
公开(公告)日：2011-03-29
申请号：US10556268
申请日：2004-05-13
申请人： Rainer Heck , Michael Justus , Roland Müller , Thomas Otten , Martin Rettig
发明人： Rainer Heck , Michael Justus , Roland Müller , Thomas Otten , Martin Rettig
IPC分类号： C07D295/12
CPC分类号： C07D295/135 , Y02P20/55
摘要： Method for preparing (S)(+)phenyl acetic acid derivatives having the general formula (I): wherein R1 is a linear or branched alkyl group with 1-6 carbon atoms or substituted benzyl group, and R2 is methyl, ethyl or propyl group said method, characterised in that a compound of the general formula (II): wherein R1 is as given above, and R3 is a nucleofuge, or a suitable salt of a compound of the general formula (II) is reacted with a compound having the general formula (III): wherein R2 is as given above, and R4 is hydrogen or a nucleofuge that can be removed hydrolytically, and the protective group R4 that may be present, may be subsequently removed hydrolytically.
摘要翻译：制备具有通式（I）的（S）（+）苯基乙酸衍生物的方法：其中R1是具有1-6个碳原子的直链或支链烷基或取代的苄基，R2是甲基，乙基或丙基所述方法的特征在于通式（II）的化合物：其中R 1如上所定义，并且R 3是核离去，或通式（II）的化合物的合适的盐与具有通式（III）：其中R 2如上所定义，并且R 4是氢或可以水解除去的核苷，并且可以存在的保护基R 4可以随后被水解除去。

6. 发明申请

US20080167266A1 Process For Preparing An Iron Saccharose Complex 审中-公开
标题翻译：制备铁蔗糖复合物的方法
公开(公告)号：US20080167266A1
公开(公告)日：2008-07-10
申请号：US11569477
申请日：2005-05-20
申请人： Michael Justus
发明人： Michael Justus
IPC分类号： A61K31/7016 , C07H1/00 , C07H1/06 , A61P7/06 , C07H3/04
CPC分类号： C07H23/00
摘要： Process for the preperation of iron-sucrose complex, in which (a) an iron salt in aqueous solution is mixed with sucrose and an inorganic base, simultaneously or in any order, at a low temperature, in such a way that the reaction mixture has an acidity (pH) in the range 3
摘要翻译：其中（a）水溶液中的铁盐与蔗糖和无机碱同时或以任何顺序在低温下混合，使得反应混合物具有在3

7. 发明申请

US20060069276A1 Method of making iron(III)gluconate complex 审中-公开
公开(公告)号：US20060069276A1
公开(公告)日：2006-03-30
申请号：US11273183
申请日：2005-11-14
申请人： Michael Justus , Rolf Hanseler
发明人： Michael Justus , Rolf Hanseler
IPC分类号： C07F15/02
CPC分类号： C07F15/025
摘要： The present invention refers to a method for making iron(III)gluconate complex, preferably alkali iron(III)gluconate complex. The method includes the following steps: (i) mixing a water soluble iron(III)salt in aqueous solution, simultaneously or in any desired sequence, with a member selected from gluconic acid, a water soluble salt of gluconic acid and combinations thereof, and a member selected from an alkali hydroxide, an alkali carbonate, an alkali hydrogen carbonate and combinations thereof, so that the reaction mixture has an acid value (pH-value) within the range of from 7.0 to 12, provided that when alkali hydroxide is used, gluconic acid or a water soluble salt of gluconic acid is provided at the beginning of the reaction or is added to the reaction mixture simultaneously with the alkali hydroxide; (ii) heating the reaction mixture until the iron(III)gluconate complex has formed; and (iii) adding an organic solvent which is miscible with water until the iron(III)gluconate complex is precipitated. The present invention also refers to pharmaceutical compositions including the iron(III)gluconate complex and methods of treating anemic conditions.

8. 发明授权

US06515130B1 Process for preparing [S-(R*,S*)]-&bgr;-[[[1-[1-oxo-3(4-piperidinyl)propyl]-3-piperidinyl]carbonyl]amino]-3-pyridinepropanoic acid and derivatives 有权
标题翻译：制备[S-（R *，S *）]-β - [[[1- [1-氧代-3（4-哌啶基）丙基] -3-哌啶基]羰基]氨基] -3-吡啶丙酸和衍生品
公开(公告)号：US06515130B1
公开(公告)日：2003-02-04
申请号：US09532375
申请日：2000-03-21
申请人： Judith H. Cohen , Michael Justus , Cynthia A. Maryanoff , Armin Rössler , Fridtjof Schröder , Kirk L. Sorgi , Frank J. Villani, Jr. , Christian Weh
发明人： Judith H. Cohen , Michael Justus , Cynthia A. Maryanoff , Armin Rössler , Fridtjof Schröder , Kirk L. Sorgi , Frank J. Villani, Jr. , Christian Weh
IPC分类号： C07D40112
CPC分类号： C07D401/14
摘要： A process for preparing a compound of formula I wherein R1 and R2 are independently selected from the group consisting of hydrogen, lower alkyl and halogen
摘要翻译：制备式I化合物的方法，其中R1和R2独立地选自氢，低级烷基和卤素

9. 发明授权

US11607522B2 Tamper-evident enclosure for PICC line 有权
公开(公告)号：US11607522B2
公开(公告)日：2023-03-21
申请号：US16774680
申请日：2020-01-28
申请人： Michael Justus , Jesse Justus , Katherine Justus
发明人： Michael Justus , Jesse Justus , Katherine Justus
IPC分类号： A61M25/00 , A61M39/10
摘要： A catheter enclosure device for locking an intravenous catheter therein with tamper-evident features to deter unauthorized use. The catheter enclosure device may be particularly useful for peripherally inserted central catheters (PICC). The enclosure device comprises an open-top box and a removable lid for covering the box. The open-top box has a compartment for holding the proximal end of an intravenous catheter. The lid comprises a panel for covering the open portion of the open-top box and a folding wing that overhangs the forward end of the box when covering the box. The folding wing further comprises a retaining anchor. When the folding wing is folded down, the retaining anchor inserts into a locking slot on the forward end of the box, thereby preventing the lid from being removed off the box. Also disclosed are methods for using the catheter enclosure device.

10. 发明授权

US07728097B2 Method of making a diisocyanate terminated macromer 有权
标题翻译：制备二异氰酸酯封端的大分子单体的方法
公开(公告)号：US07728097B2
公开(公告)日：2010-06-01
申请号：US11476513
申请日：2006-06-28
申请人： Benjamin D. Fitz , Michael Justus , Christopher M. Westergom
发明人： Benjamin D. Fitz , Michael Justus , Christopher M. Westergom
IPC分类号： C08G18/08 , A61K47/00
CPC分类号： C08G18/4252 , C08G18/771 , C08G2230/00
摘要： A novel macromer or mixture thereof is described herein, comprising benzoyl isocyanate terminal moieties and at least two residues of a water-soluble polymer having a molecular weight ranging from 80 to 10,000 adjacent to the carbonyl group of the benzoyl isocyanate moieties, thereby forming at least two ester linkages in the macromer or mixture thereof. A method for making a diisocyanate macromer is also described herein.
摘要翻译：本文描述了一种新的大分子单体或其混合物，其包含苯甲酰异氰酸酯末端部分和与苯甲酰基异氰酸酯部分的羰基相邻的分子量范围为80至10,000的水溶性聚合物的至少两个残基，从而至少形成大分子单体或其混合物中的两个酯键。本文还描述了制备二异氰酸酯大分子单体的方法。

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