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1. 发明授权

US07728097B2 Method of making a diisocyanate terminated macromer 有权
标题翻译：制备二异氰酸酯封端的大分子单体的方法
公开(公告)号：US07728097B2
公开(公告)日：2010-06-01
申请号：US11476513
申请日：2006-06-28
申请人： Benjamin D. Fitz , Michael Justus , Christopher M. Westergom
发明人： Benjamin D. Fitz , Michael Justus , Christopher M. Westergom
IPC分类号： C08G18/08 , A61K47/00
CPC分类号： C08G18/4252 , C08G18/771 , C08G2230/00
摘要： A novel macromer or mixture thereof is described herein, comprising benzoyl isocyanate terminal moieties and at least two residues of a water-soluble polymer having a molecular weight ranging from 80 to 10,000 adjacent to the carbonyl group of the benzoyl isocyanate moieties, thereby forming at least two ester linkages in the macromer or mixture thereof. A method for making a diisocyanate macromer is also described herein.
摘要翻译：本文描述了一种新的大分子单体或其混合物，其包含苯甲酰异氰酸酯末端部分和与苯甲酰基异氰酸酯部分的羰基相邻的分子量范围为80至10,000的水溶性聚合物的至少两个残基，从而至少形成大分子单体或其混合物中的两个酯键。本文还描述了制备二异氰酸酯大分子单体的方法。

2. 发明申请

US20090222038A1 MEDICALLY ACCEPTABLE FORMULATION OF A DIISOCYANATE TERMINATED MACROMER FOR USE AS AN INTERNAL ADHESIVE OR SEALANT 有权
标题翻译：用作内部胶粘剂或密封剂的二异氰酸酯终止的MACROMER的医学上可接受的配方
公开(公告)号：US20090222038A1
公开(公告)日：2009-09-03
申请号：US12415155
申请日：2009-03-31
申请人： Benjamin D. Fitz , Elizabeth Vailhe , Joseph Zavatsky , Christopher M. Westergom
发明人： Benjamin D. Fitz , Elizabeth Vailhe , Joseph Zavatsky , Christopher M. Westergom
IPC分类号： A61B17/03 , C08L75/00
CPC分类号： A61L24/0042 , A61L24/043 , A61L31/041 , A61L31/148 , C08G18/10 , C08G18/42 , C08L75/04
摘要： The present invention is directed to a medically acceptable formulation comprising a diisocyanate terminated macromer or mixture thereof, and bio-absorbable desiccant comprising a hygroscopic and/or hydrophilic or combination thereof. The present invention is also directed to methods of use for such formulations for medical procedures.
摘要翻译：本发明涉及包含二异氰酸酯封端的大分子单体或其混合物的医学上可接受的制剂，以及包含吸湿性和/或亲水性或其组合的生物可吸收干燥剂。本发明还涉及用于这种制剂用于医疗过程的方法。

3. 发明授权

US08071663B2 Medically acceptable formulation of a diisocyanate terminated macromer for use as an internal adhesive or sealant 有权
标题翻译：用作内部粘合剂或密封剂的二异氰酸酯封端的大分子单体的医学上可接受的制剂
公开(公告)号：US08071663B2
公开(公告)日：2011-12-06
申请号：US12415155
申请日：2009-03-31
申请人： Benjamin D. Fitz , Elizabeth Vailhe , Joseph Zavatsky , Christopher M. Westergom
发明人： Benjamin D. Fitz , Elizabeth Vailhe , Joseph Zavatsky , Christopher M. Westergom
IPC分类号： A61L24/04 , A61F2/00 , C08G18/70 , C08G18/72 , C08G18/77 , C07C265/12
CPC分类号： A61L24/0042 , A61L24/043 , A61L31/041 , A61L31/148 , C08G18/10 , C08G18/42 , C08L75/04
摘要： The present invention is directed to a medically acceptable formulation comprising a diisocyanate terminated macromer or mixture thereof, and bio-absorbable desiccant comprising a hygroscopic and/or hydrophilic or combination thereof. The present invention is also directed to methods of use for such formulations for medical procedures.
摘要翻译：本发明涉及包含二异氰酸酯封端的大分子单体或其混合物的医学上可接受的制剂，以及包含吸湿性和/或亲水性或其组合的生物可吸收干燥剂。本发明还涉及用于这种制剂用于医疗过程的方法。

4. 发明授权

US08470954B2 Diisocyanate terminated macromer and formulation thereof for use as an internal adhesive or sealant 有权
标题翻译：二异氰酸酯封端的大分子单体及其制剂用作内部粘合剂或密封剂
公开(公告)号：US08470954B2
公开(公告)日：2013-06-25
申请号：US11772401
申请日：2007-07-02
申请人： Christopher M. Westergom , Benjamin D. Fitz
发明人： Christopher M. Westergom , Benjamin D. Fitz
IPC分类号： C08G18/10
CPC分类号： C08G18/771 , A61L24/046 , C08G18/10 , C08G18/4252 , C08L75/04 , C08G18/42
摘要： A novel macromer or mixture thereof is described herein, comprising benzoyl isocyanate terminal moieties and at least two residues of a water-soluble polymer having a molecular weight ranging from 80 to 10,000 adjacent to the carbonyl group of the benzoyl isocyanate moieties, thereby forming at least two ester linkages in the macromer or mixture thereof. A method for making a polyisocyanate macromer is also described herein.
摘要翻译：本文描述了一种新的大分子单体或其混合物，其包含苯甲酰异氰酸酯末端部分和与苯甲酰基异氰酸酯部分的羰基相邻的分子量范围为80至10,000的水溶性聚合物的至少两个残基，从而至少形成大分子单体或其混合物中的两个酯键。本文还描述了制备多异氰酸酯大分子单体的方法。

5. 发明授权

US07968668B2 Diisocyanate terminated macromer and formulation thereof for use as an internal adhesive or sealant 有权
标题翻译：二异氰酸酯封端的大分子单体及其制剂用作内部粘合剂或密封剂
公开(公告)号：US07968668B2
公开(公告)日：2011-06-28
申请号：US11476512
申请日：2006-06-28
申请人： Benjamin D. Fitz , Christopher M. Westergom
发明人： Benjamin D. Fitz , Christopher M. Westergom
IPC分类号： C08G18/00 , C09J4/00
CPC分类号： C08G18/771 , A61L24/046 , C07C265/14 , C08G18/10 , C08G18/4236 , C08G18/4252 , C08G18/4833 , C08G18/4887 , C08G18/7657 , C08G2190/00 , C08G2220/00 , C08G2230/00 , C09J175/06 , C09J175/08 , C08L75/04 , C08G18/307
摘要： A novel macromer or mixture thereof is described herein, comprising benzoyl isocyanate terminal moieties and at least two residues of a water-soluble polymer having a molecular weight ranging from 80 to 10,000 adjacent to the carbonyl group of the benzoyl isocyanate moieties, thereby forming at least two ester linkages in the macromer or mixture thereof. A method for making a polyisocyanate macromer is also described herein.
摘要翻译：本文描述了一种新的大分子单体或其混合物，其包含苯甲酰异氰酸酯末端部分和与苯甲酰基异氰酸酯部分的羰基相邻的分子量范围为80至10,000的水溶性聚合物的至少两个残基，从而至少形成大分子单体或其混合物中的两个酯键。本文还描述了制备多异氰酸酯大分子单体的方法。

6. 发明授权

US08236904B2 Bioabsorbable polymer compositions exhibiting enhanced crystallization and hydrolysis rates 有权
标题翻译：表现出增强的结晶和水解速率的生物可吸收聚合物组合物
公开(公告)号：US08236904B2
公开(公告)日：2012-08-07
申请号：US12107569
申请日：2008-04-22
申请人： Sasa Andjelic , Benjamin D. Fitz , Jianguo Jack Zhou
发明人： Sasa Andjelic , Benjamin D. Fitz , Jianguo Jack Zhou
IPC分类号： C08L67/04
CPC分类号： A61L31/06 , A61L27/18 , A61L27/58 , A61L31/148 , B29C71/00 , B29D7/00 , C08L67/04 , C08L69/00 , C08L101/16 , C08L2203/02 , C08L2205/02 , D01D5/0985 , D01F6/625 , D01F6/68 , D01F6/86 , D04H1/56 , Y10T442/609 , C08L2666/18
摘要： A bimodal bioabsorbable polymer composition. The composition includes a first amount of a bioabsorbable polymer polymerized so as to have a first molecular weight distribution; a second amount of said bioabsorbable polymer polymerized so as to have a second molecular weight distribution having a weight average molecular weight between about 10,000 to about 50,000 Daltons, the weight average molecular weight ratio of said first molecular weight distribution to said second molecular weight distribution is at least about two to one; wherein a substantially homogeneous blend of said first and second amounts of said bioabsorbable polymer is formed in a ratio of between about 50/50 to about 95/5 weight/weight percent. Also disclosed are a medical device, a method of making a medical device and a method of melt blowing a semi-crystalline polymer blend.
摘要翻译：双峰生物可吸收聚合物组合物。所述组合物包含第一量聚合以具有第一分子量分布的生物可吸收聚合物; 所述第二量的所述生物可吸收聚合物被聚合以具有重均分子量在约10,000至约50,000道尔顿之间的第二分子量分布，所述第一分子量分布与所述第二分子量分布的重均分子量比为至少约二比一; 其中所述第一和第二量的所述生物可吸收聚合物的基本均匀的共混物以约50/50至约95/5重量/重量％的比例形成。还公开了医疗装置，制造医疗装置的方法和熔融吹制半结晶聚合物共混物的方法。

7. 发明授权

US07310145B2 Apparatus and method for determining optical retardation and birefringence 有权
标题翻译：用于确定光学延迟和双折射的装置和方法
公开(公告)号：US07310145B2
公开(公告)日：2007-12-18
申请号：US10784573
申请日：2004-02-23
申请人： Ferass Abuzaina , Sa{tilde over (s)}a Andjelić , Benjamin D. Fitz
发明人： Ferass Abuzaina , Sa{tilde over (s)}a Andjelić , Benjamin D. Fitz
IPC分类号： G01J4/00
CPC分类号： G01N21/23
摘要： A method for determining the optical retardation and birefringence values of an anisotropic material utilizing a Fourier transform near infrared spectrophotometer operated in at least a portion of the range of wavenumbers between about 4,000 to about 10,000 cm−1.
摘要翻译：一种利用傅里叶变换近红外分光光度计确定各向异性材料的光学延迟和双折射值的方法，所述傅里叶变换在波数范围的至少一部分中操作，其范围在约4000至约10,000cm -1之间。

8. 发明授权

US06416745B1 Dental composition for treating hypersensitive teeth 失效
标题翻译：用于治疗过敏牙齿的牙科组合物
公开(公告)号：US06416745B1
公开(公告)日：2002-07-09
申请号：US09848138
申请日：2001-05-03
申请人： Kenneth J. Markowitz , Benjamin D. Fitz
发明人： Kenneth J. Markowitz , Benjamin D. Fitz
IPC分类号： A61K716
CPC分类号： A61K8/55 , A61K9/127 , A61Q11/00
摘要： The present invention provides dental compositions and methods for treating dentinal hypersensitivity teeth based on the discovery that anionic liposomes possess the capacity to induce mineral formation in the dentinal tubules which partially or fully block them. The subject compositions comprise the liposomes and a suitable carrier and are advantageous in that they can deliver additional agents useful in the treatment of dentinal hypersensitivity, particularly nerve desensitizing agents, to the tubules. The liposomes of the invention are further advantageous in that they are stable to conventional sources of fluoride ion conventionally used as anti-caries agents. The methods of the present invention utilize the subject composition to effect blocking of the dentinal tubules and to simultaneously deliver other treatment agents such as nerve desensitizing agents for the combined benefits thereof.
摘要翻译：本发明提供了牙科组合物和治疗牙本质过敏牙齿的方法，基于这样的发现，即阴离子脂质体具有在部分或完全阻断它们的牙质小管中诱导矿物形成的能力。主题组合物包含脂质体和合适的载体，并且有利的是它们可以递送可用于治疗牙质超敏反应的其它试剂，特别是神经脱敏剂。本发明的脂质体的进一步的优点在于它们对常规用作抗龋剂的氟离子的常规来源是稳定的。本发明的方法利用受试者组合物来实现牙本质小管的阻断并且同时递送其它治疗剂如神经脱敏剂以获得其组合的益处。

9. 发明授权

US08450431B2 Bioabsorbable polymer compositions exhibiting enhanced crystallization and hydrolysis rates 有权
公开(公告)号：US08450431B2
公开(公告)日：2013-05-28
申请号：US13567813
申请日：2012-08-06
申请人： Sasa Andjelic , Benjamin D. Fitz
发明人： Sasa Andjelic , Benjamin D. Fitz
IPC分类号： C08L67/04
CPC分类号： A61L31/06 , A61L27/18 , A61L27/58 , A61L31/148 , B29C71/00 , B29D7/00 , C08L67/04 , C08L69/00 , C08L101/16 , C08L2203/02 , C08L2205/02 , D01D5/0985 , D01F6/625 , D01F6/68 , D01F6/86 , D04H1/56 , Y10T442/609 , C08L2666/18
摘要： A bimodal bioabsorbable polymer composition. The composition includes a first amount of a bioabsorbable polymer polymerized so as to have a first molecular weight distribution; a second amount of said bioabsorbable polymer polymerized so as to have a second molecular weight distribution having a weight average molecular weight between about 10,000 to about 50,000 Daltons, the weight average molecular weight ratio of said first molecular weight distribution to said second molecular weight distribution is at least about two to one; wherein a substantially homogeneous blend of said first and second amounts of said bioabsorbable polymer is formed in a ratio of between about 50/50 to about 95/5 weight/weight percent. Also disclosed are a medical device, a method of making a medical device and a method of melt blowing a semi-crystalline polymer blend.

10. 发明授权

US08962784B2 Isocyanate terminated macromer and formulation thereof for use as an internal adhesive or sealant 有权
标题翻译：异氰酸酯封端的大分子单体及其制剂用作内部粘合剂或密封剂
公开(公告)号：US08962784B2
公开(公告)日：2015-02-24
申请号：US12339142
申请日：2008-12-19
申请人： Chetan Anirudh Khatri , Benjamin D. Fitz , Joseph Zavatsky
发明人： Chetan Anirudh Khatri , Benjamin D. Fitz , Joseph Zavatsky
IPC分类号： C08G18/10 , C08G18/08 , C08G18/77 , A61L24/04 , C08G18/42
CPC分类号： C08G18/771 , A61L24/046 , A61L2400/06 , C08G18/10 , C08G18/42 , C08G18/4238 , C08L75/04
摘要： A novel macromer or mixture thereof is described herein, comprising isocyanatophenyl ether terminal moieties and at least two residues of a water-soluble polymer having a molecular weight ranging from 80 to 10,000 adjacent to the ether group of the isocyanatophenyl ether terminal isocyanate moieties, thereby forming at least two ether linkages in the macromer or mixture thereof. A method for making a polyisocyanate macromer is also described herein.
摘要翻译：本文描述了一种新的大分子单体或其混合物，其包含异氰酸酯基苯基醚末端部分和与异氰酸酯基醚末端异氰酸酯部分的醚基相邻的分子量为80至10,000的水溶性聚合物的至少两个残基，由此形成大分子单体或其混合物中的至少两个醚键。本文还描述了制备多异氰酸酯大分子单体的方法。

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