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1. 发明申请

US20080026996A1 Selective Vpac2 Receptor Reptide Agonists 审中-公开
标题翻译：选择性Vpac2受体Repeide激动剂
公开(公告)号：US20080026996A1
公开(公告)日：2008-01-31
申请号：US11569258
申请日：2005-05-19
申请人： Bengt Bokvist , Jesper Gromada , Robert Cummins , Wolfgang Glaesner , John Mayer , Lianshan Zhang , Jorge Alsina-Fernandez
发明人： Bengt Bokvist , Jesper Gromada , Robert Cummins , Wolfgang Glaesner , John Mayer , Lianshan Zhang , Jorge Alsina-Fernandez
IPC分类号： C07K14/475 , A61K38/18 , A61P3/10
CPC分类号： C07K14/57563
摘要： The present invention encompasses peptides that selectively activate the VPAC2 receptor and are useful in the treatment of diabetes.
摘要翻译：本发明包括选择性活化VPAC2受体并可用于治疗糖尿病的肽。

2. 发明申请

US20070105759A1 Melanocortin receptor 4 (mc4) agonists and their uses 审中-公开
标题翻译：黑皮质素受体4（mc4）激动剂及其用途
公开(公告)号：US20070105759A1
公开(公告)日：2007-05-10
申请号：US10556689
申请日：2004-06-17
申请人： David Flora , Mark Heiman , JeAnne Hertel , Hansen Hsiung , John Mayer , David Smiley , Liang Yan , Lianshan Zhang
发明人： David Flora , Mark Heiman , JeAnne Hertel , Hansen Hsiung , John Mayer , David Smiley , Liang Yan , Lianshan Zhang
IPC分类号： A61K38/12 , C07K7/64
CPC分类号： C07K14/68 , A61K38/12
摘要： The present invention relates to peptide agonists of the MC4 receptor, and as such are useful in the treatment of disorders responsive to the activation of this receptor, such as obesity, diabetes mellitus and male and/or female sexual dysfunction.
摘要翻译：本发明涉及MC4受体的肽激动剂，因此可用于治疗对该受体的活化有响应的病症，例如肥胖症，糖尿病和男性和/或女性性功能障碍。

3. 发明申请

US20060293223A1 Uses of melanocortin-3 receptor (mc3r) agonist peptides 审中-公开
标题翻译：黑皮质素-3受体（mc3r）激动剂肽的使用
公开(公告)号：US20060293223A1
公开(公告)日：2006-12-28
申请号：US10556690
申请日：2004-06-17
申请人： Robert Gadski , Mark Heiman , Hansen Hsiung , John Mayer , Liang Yan
发明人： Robert Gadski , Mark Heiman , Hansen Hsiung , John Mayer , Liang Yan
IPC分类号： A61K38/12
CPC分类号： A61K38/12
摘要： The present invention provides methods of treating metabolic disorders, including, for example, obesity, diabetes mellitus, cachexia, sarcopenia, and cardiovascular disorders, methods of inducing weight loss and increasing muscle mass in a patient, by administration of MC3R agonist peptides. Furthermore, the present invention provides the use of an MC3R agonist peptide for the manufacture of a medicament for the treatment of metabolic disorders, including, for example, obesity, diabetes mellitus, cachexia, sarcopenia, and cardiovascular disorders, inducing weight loss and increasing muscle mass in a patient.
摘要翻译：本发明提供了通过施用MC3R激动剂肽来治疗代谢紊乱的方法，包括例如肥胖症，糖尿病，恶病质，肌营养不良和心血管疾病，诱导患者体重减轻和增加肌肉质量的方法。此外，本发明提供了MC3R激动剂肽用于制备用于治疗代谢紊乱的药物的用途，所述代谢紊乱包括例如肥胖，糖尿病，恶病质，肌营养不良和心血管疾病，引起体重减轻和增加肌肉在病人身上。

4. 发明申请

US20070212283A1 Apparatus for deactivating instruments and devices 有权
标题翻译：用于停用仪器和设备的设备
公开(公告)号：US20070212283A1
公开(公告)日：2007-09-13
申请号：US11714044
申请日：2007-03-05
申请人： Jeffrey Horacek , Donald Sargent , Alan Solomon , John Mayer , Christopher Jethrow , Karl Ludwig
发明人： Jeffrey Horacek , Donald Sargent , Alan Solomon , John Mayer , Christopher Jethrow , Karl Ludwig
IPC分类号： A61L2/16
CPC分类号： A61L2/186 , A61B50/33 , A61B2050/006 , A61B2050/3011 , A61L2/04 , A61L2/06 , A61L2/18 , A61L2/208 , A61L2/22 , A61L2/24 , A61L2202/121 , A61L2202/122 , A61L2202/14 , A61L2202/182 , A61L2202/21 , A61L2202/24
摘要： An apparatus for deactivating medical instruments and devices. The apparatus has a housing structure and a drawer disposed in the housing structure. The drawer has a recess formed therein and a planar surface formed about the periphery of the recess. The recess is dimensioned to receive medical instruments and devices to be microbially deactivated. A circulation system is provided within the housing structure to circulate a microbial deactivation fluid through the recess. A drawer-sealing assembly is located in the housing structure. The drawer-sealing assembly is operable to engage the drawer assembly and fluidly seal the recess to create a decontamination chamber.
摘要翻译：一种用于停用医疗器械和装置的装置。该装置具有壳体结构和布置在壳体结构中的抽屉。抽屉具有形成在其中的凹部和围绕凹部的周边形成的平面。凹槽的尺寸被设计成接收将被微生物停用的医疗仪器和装置。在壳体结构内设置循环系统，以使微生物去活化液体通过凹槽循环。抽屉密封组件位于壳体结构中。抽屉密封组件可操作以接合抽屉组件并且流体地密封凹部以产生净化室。

5. 发明申请

US20070212280A1 Apparatus for deactivating instruments and devices 有权
标题翻译：用于停用仪器和设备的设备
公开(公告)号：US20070212280A1
公开(公告)日：2007-09-13
申请号：US11714046
申请日：2007-03-05
申请人： Jeffrey Horacek , Donald Sargent , Alan Solomon , John Mayer , Christopher Jethrow , Karl Ludwig , Jude Kral
发明人： Jeffrey Horacek , Donald Sargent , Alan Solomon , John Mayer , Christopher Jethrow , Karl Ludwig , Jude Kral
IPC分类号： A61L2/00
CPC分类号： A61L2/186 , A61B50/33 , A61B2050/006 , A61B2050/3011 , A61L2/04 , A61L2/06 , A61L2/18 , A61L2/208 , A61L2/22 , A61L2/24 , A61L2202/121 , A61L2202/122 , A61L2202/14 , A61L2202/182 , A61L2202/21 , A61L2202/24
摘要： An apparatus for deactivating medical instruments and devices comprised of a deactivation chamber movable between a loading position and a deactivation position. A circulation system is provided to circulate a deactivating fluid through the deactivation chamber. The circulation system is connectable to the deactivation chamber when the deactivation chamber is in the deactivation position.
摘要翻译：一种用于停用医疗器械和装置的装置，包括可在加载位置和停用位置之间移动的停用室。提供循环系统以使失活流体循环通过去活化室。当停用室处于停用位置时，循环系统可连接到停用室。

6. 发明授权

US06725180B2 Environmental monitoring system 有权
标题翻译：环境监测系统
公开(公告)号：US06725180B2
公开(公告)日：2004-04-20
申请号：US09759890
申请日：2001-01-12
申请人： John Mayer , James E. Van't Slot , Daniel Rawlings
发明人： John Mayer , James E. Van't Slot , Daniel Rawlings
IPC分类号： G06F1132
CPC分类号： B01D53/30 , G01K1/026 , G01N33/0063 , G01N33/02
摘要： A system for monitoring conditions relating to the status of items such as perishable food products stored in enclosed spaces has a number of sensors mounted in the spaces. Tables maintained by the system hold a description of the spaces to be monitored and the location and identity of the sensors within each space. The values detected by each sensor are periodically recorded and tested against benchmark values established for the stored items adjacent to the sensor. Values outside of the benchmark values create an alarm condition, and a set of alarm messages are displayed on a display unit. The alarm messages include suggested corrective actions. The user has the opportunity to signal to the system the corrective actions taken, and the system stores a record of these corrective actions in association with the corrective actions and the alarm condition.
摘要翻译：用于监测与封闭空间中存储的易腐食品等物品状态相关的条件的系统具有安装在空间中的多个传感器。由系统维护的表保存要监视的空间的描述以及每个空间内传感器的位置和身份。根据与传感器相邻的存储项目建立的基准值，定期记录和测试由每个传感器检测的值。基准值以外的值会产生报警条件，并在显示单元上显示一组报警信息。警报消息包括建议的纠正措施。用户有机会向系统发出纠正措施，系统存储与纠正措施和报警条件相关联的这些纠正措施的记录。

7. 发明申请

US20080109070A1 BIODEGRADABLE ELASTOMERIC SCAFFOLDS CONTAINING MICROINTEGRATED CELLS 审中-公开
标题翻译：含有微生物细胞的可生物降解的弹性蛋白酶
公开(公告)号：US20080109070A1
公开(公告)日：2008-05-08
申请号：US11837235
申请日：2007-08-10
申请人： William Wagner , John Stankus , Jianjun Guan , Kazuro Fujimoto , Alejandro Nieponice , Lorenzo Soletti , David Vorp , Michael Sacks , Todd Courtney , John Mayer
发明人： William Wagner , John Stankus , Jianjun Guan , Kazuro Fujimoto , Alejandro Nieponice , Lorenzo Soletti , David Vorp , Michael Sacks , Todd Courtney , John Mayer
IPC分类号： A61F2/06 , A61F2/08 , A61F2/24
CPC分类号： A61L27/3843 , A61F2/2415 , A61L27/54 , A61L27/56 , A61L2300/236 , A61L2300/41 , A61L2300/414 , A61L2300/42 , A61L2300/602
摘要： Described herein are elastomeric materials, and in particular porous biodegradable elastomeric materials which optionally may have microintegrated cells. Also described herein are bioprosthetic devices that can be manufactured using the biodegradable elastomeric materials, non-limiting examples of such devices including pulmonary valves, vocal chords, and blood vessels.
摘要翻译：本文描述的是弹性体材料，特别是多孔可生物降解的弹性体材料，其任选地可以具有微结合的细胞。本文还描述了可以使用可生物降解的弹性体材料制造的生物假体装置，这种装置的非限制性实例包括肺动脉瓣，声带和血管。

8. 发明申请

US20070212279A1 Apparatus for deactivating instruments and devices 有权
标题翻译：用于停用仪器和设备的设备
公开(公告)号：US20070212279A1
公开(公告)日：2007-09-13
申请号：US11714045
申请日：2007-03-05
申请人： John Mayer , Christopher Jethrow , Karl Ludwig
发明人： John Mayer , Christopher Jethrow , Karl Ludwig
IPC分类号： A61L2/16
CPC分类号： A61L2/186 , A61B50/33 , A61B2050/006 , A61B2050/3011 , A61L2/04 , A61L2/06 , A61L2/18 , A61L2/208 , A61L2/22 , A61L2/24 , A61L2202/121 , A61L2202/122 , A61L2202/14 , A61L2202/182 , A61L2202/21 , A61L2202/24
摘要： An apparatus for deactivating medical instruments and devices having a circulation system for circulating fluids through the apparatus and a chemical delivery assembly for generating a deactivation fluid to circulate through the circulation system. The chemical delivery assembly is comprised of a chemistry housing that has a first receptacle and a second receptacle formed therein. A first fluid inlet communicates with the first receptacle. A second fluid inlet communicates with the second receptacle. A first fluid outlet is disposed near an upper portion of the first receptacle to establish a predetermined fluid level in the first receptacle when fluid is introduced into the first receptacle. A second fluid outlet is disposed near an upper portion of the second receptacle to establish a predetermined fluid level in the second receptacle when fluid is introduced into the second receptacle. A lid is attached to the chemistry housing. The lid is movable between a first position and a second position. The lid seals the chemistry housing and isolates the first receptacle from the second receptacle when the lid is in the first position. The first receptacle and the second receptacle are accessible when the lid is in the second position.
摘要翻译：一种用于停用具有循环系统的医疗仪器和装置的装置，所述循环系统用于使流体循环通过所述装置，以及化学输送组件，用于产生通过所述循环系统循环的去活化流体。化学品输送组件包括化学外壳，其具有形成在其中的第一容器和第二容器。第一流体入口与第一容器连通。第二流体入口与第二容器连通。第一流体出口设置在第一容器的上部附近，以在流体被引入到第一容器中时在第一容器中建立预定的液面。第二流体出口设置在第二容器的上部附近，以在流体被引入到第二容器中时在第二容器中建立预定的液位。盖子连接到化学外壳。盖可在第一位置和第二位置之间移动。当盖处于第一位置时，盖密封化学壳体并将第一容器与第二容器隔离。当盖处于第二位置时，第一容器和第二容器可接近。

9. 发明申请

US20070212252A1 Method for generating a microbial deactivation fluid in an apparatus for deactivating instruments and devices 有权
标题翻译：在用于去激活仪器和装置的装置中产生微生物去活化液的方法
公开(公告)号：US20070212252A1
公开(公告)日：2007-09-13
申请号：US11714035
申请日：2007-03-05
申请人： Christopher Jethrow , John Mayer , Dana Hall , Donald Rosenhamer
发明人： Christopher Jethrow , John Mayer , Dana Hall , Donald Rosenhamer
IPC分类号： A61L2/18
CPC分类号： A61L2/186 , A61B50/33 , A61B2050/006 , A61B2050/3011 , A61L2/04 , A61L2/06 , A61L2/18 , A61L2/208 , A61L2/22 , A61L2/24 , A61L2202/121 , A61L2202/122 , A61L2202/14 , A61L2202/182 , A61L2202/21 , A61L2202/24
摘要： A method of generating a microbial deactivation fluid to circulate through an apparatus that has a decontamination chamber for holding medical instruments and devices, comprising the steps of: (a) providing a first compartment and a second compartment in the circulation system; (b) providing a chemical reagent in the first compartment and a builder composition in the second compartment; (c) causing a fluid to flow through the second compartment to mix with the builder composition to create an alkaline fluid; (d) when the alkaline fluid has reached a predetermined pH level, causing the alkaline fluid to flow through the first compartment to mix with the chemical reagent to dissolve the chemical reagent to generate a microbial deactivation fluid; and (e) continuing steps (c) and (d) to continue the generation of the microbial deactivation fluid.
摘要翻译：一种产生微生物灭活液的方法，其通过具有用于保持医疗器械和装置的净化室的装置循环，包括以下步骤：（a）在所述循环系统中提供第一隔室和第二隔室; （b）在第一隔室中提供化学试剂和在第二隔室中提供助洗剂组合物; （c）使流体流过所述第二隔室以与所述助洗剂组合物混合以产生碱性流体; （d）当碱性流体达到预定的pH值时，使碱性流体流过第一隔室以与化学试剂混合以溶解化学试剂以产生微生物去活化液; 和（e）继续步骤（c）和（d）以继续产生微生物灭活液。

10. 外观设计

USD538436S1 Reprocessor for decontaminating medical, dental and veterinary instruments and articles 有权
标题翻译：用于去除医疗，牙科和兽医器械和物品的再处理器
公开(公告)号：USD538436S1
公开(公告)日：2007-03-13
申请号：US29255245
申请日：2006-03-06
申请人： Sona Patadia , John Mayer
设计人： Sona Patadia , John Mayer

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