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1. 发明授权

US08148415B2 Sulfamic acid ester compounds useful in the inhibition of steroid sulphatase activity and aromatase activity 有权
标题翻译：用于抑制类固醇硫酸酯酶活性和芳香酶活性的氨基磺酸酯化合物
公开(公告)号：US08148415B2
公开(公告)日：2012-04-03
申请号：US11603941
申请日：2006-11-22
申请人： Barry Victor Lloyd Potter , Michael John Reed , Lok Wai Lawrence Woo , Atul Purohit , Christian Burbert , Paul Michael Wood , Oliver Brook Sutcliffe
发明人： Barry Victor Lloyd Potter , Michael John Reed , Lok Wai Lawrence Woo , Atul Purohit , Christian Burbert , Paul Michael Wood , Oliver Brook Sutcliffe
IPC分类号： A61K31/4192 , A61K31/4196 , C07D249/04 , C07D249/08
CPC分类号： C07D249/08
摘要： The present invention relates to steroid sulphatase and/or aromatase inhibitors of Formula III or Formula IV, wherein A is selected from H, OH, halogen and hydrocarbyl; D, E and F are each independently of each other an optional linker group; P, Q and R are independently of each other a ring system, wherein R4 and R5 are independently selected from H, alkyl, cycloalkyl, alkenyl, acyl and aryl, or combinations thereof, or together represent alkylene, wherein the or each alkyl or cycloalkyl or alkenyl or optionally contain one or more hetero atoms or groups, and which can be used in medicine.
摘要翻译：本发明涉及式III或式IV的类固醇硫酸酯酶和/或芳香酶抑制剂，其中A选自H，OH，卤素和烃基; D，E和F各自独立地为任选的连接基团; P，Q和R彼此独立地为环系，其中R4和R5独立地选自H，烷基，环烷基，烯基，酰基和芳基，或其组合，或一起表示亚烷基，其中烷基或环烷基或烯基或任选地含有一个或多个杂原子或基团，并且其可以用于医药中。

2. 发明申请

US20090111862A1 Compound 有权
标题翻译：复合
公开(公告)号：US20090111862A1
公开(公告)日：2009-04-30
申请号：US12056920
申请日：2008-03-27
申请人： Barry Victor Lloyd POTTER , Lok Wai Lawrence Woo , Atul Purohit , Michael John Reed , Oliver Brook Sutcliffe , Christian Bubert
发明人： Barry Victor Lloyd POTTER , Lok Wai Lawrence Woo , Atul Purohit , Michael John Reed , Oliver Brook Sutcliffe , Christian Bubert
IPC分类号： A61K31/4196 , A61P35/00
CPC分类号： C07D249/08 , C07D231/12 , C07D233/56 , C07D413/12 , C07D417/12
摘要： There is provided a compound of Formula I wherein each T is independently selected from H, hydrocarbyl, —F—R, and a bond with one of D, E, P or Q, or together with one of P and Q forms a ring; Z is a suitable atom the valency of which is m; D, E and F are each independently of each other an optional linker group, wherein when Z is nitrogen E is other than CH2 and C═O; P, Q and R are independently of each other a ring system; and at least Q comprises a sulphamate group.
摘要翻译：提供式I的化合物，其中每个T独立地选自H，烃基，-F-R和与D，E，P或Q之一的键，或与P和Q中的一个形成环; Z是一个合适的原子，其化合价是m; D，E和F各自独立地为任选的连接基团，其中当Z为氮时，E不是CH 2和C-O; P，Q和R彼此独立地是环系; 并且至少Q包含氨基磺酸酯基团。

3. 发明授权

US07361677B2 Polycyclic sulphamate compounds suitable for use as inhibitors of aromatase and/or sulphatase 失效
标题翻译：适用于芳香酶和/或硫酸酯酶抑制剂的多环氨基磺酸盐化合物
公开(公告)号：US07361677B2
公开(公告)日：2008-04-22
申请号：US11209186
申请日：2005-08-22
申请人： Barry Victor Lloyd Potter , Lok Wai Lawrence Woo , Atul Purohit , Michael John Reed , Oliver Brook Sutcliffe , Christian Bubert
发明人： Barry Victor Lloyd Potter , Lok Wai Lawrence Woo , Atul Purohit , Michael John Reed , Oliver Brook Sutcliffe , Christian Bubert
IPC分类号： A61K31/4196 , C07D249/08
CPC分类号： C07D249/08 , C07D231/12 , C07D233/56 , C07D413/12 , C07D417/12
摘要： There is provided a compound of Formula I wherein each T is independently selected from H, hydrocarbyl, —F—R, and a bond with one of D, E, P or Q, or together with one of P and Q forms a ring; Z is a suitable atom the valency of which is m; D, E and F are each independently of each other an optional linker group, wherein when Z is nitrogen E is other than CH2 and C═O; P, Q and R are independently of each other a ring system; and at least Q comprises a sulphamate group.
摘要翻译：提供式I的化合物，其中每个T独立地选自H，烃基，-F-R和与D，E，P或Q之一的键，或与P和Q中的一个形成环; Z是一个合适的原子，其化合价是m; D，E和F各自独立地为任选的连接基团，其中当Z为氮时，E不是CH 2和C-O; P，Q和R彼此独立地是环系; 并且至少Q包含氨基磺酸酯基团。

4. 发明授权

US07745472B2 Compound 有权
标题翻译：复合
公开(公告)号：US07745472B2
公开(公告)日：2010-06-29
申请号：US12056920
申请日：2008-03-27
申请人： Barry Victor Lloyd Potter , Lok Wai Lawrence Woo , Atul Purohit , Michael John Reed , Oliver Brook Sutcliffe , Christian Bubert
发明人： Barry Victor Lloyd Potter , Lok Wai Lawrence Woo , Atul Purohit , Michael John Reed , Oliver Brook Sutcliffe , Christian Bubert
IPC分类号： A61K31/4196 , C07D249/08
CPC分类号： C07D249/08 , C07D231/12 , C07D233/56 , C07D413/12 , C07D417/12
摘要： There is provided a compound of Formula I wherein each T is independently selected from H, hydrocarbyl, —F—R, and a bond with one of D, E, P or Q, or together with one of P and Q forms a ring; Z is a suitable atom the valency of which is m; D, E and F are each independently of each other an optional linker group, wherein when Z is nitrogen E is other than CH2 and C═O; P, Q and R are independently of each other a ring system; and at least Q comprises a sulphamate group.
摘要翻译：提供式I的化合物，其中每个T独立地选自H，烃基，-F-R和与D，E，P或Q之一的键，或与P和Q中的一个形成环; Z是一个合适的原子，其化合价是m; D，E和F各自独立地为任选的连接基团，其中当Z为氮时，E不是CH 2且C = O; P，Q和R彼此独立地是环系; 并且至少Q包含氨基磺酸酯基团。

5. 发明授权

US07098343B2 Compound 有权
标题翻译：复合
公开(公告)号：US07098343B2
公开(公告)日：2006-08-29
申请号：US10300494
申请日：2002-11-20
申请人： Barry Victor Lloyd Potter , Lok Wai Lawrence Woo , Atul Purohit , Michael John Reed , Oliver Brook Sutcliffe , Christian Bubert
发明人： Barry Victor Lloyd Potter , Lok Wai Lawrence Woo , Atul Purohit , Michael John Reed , Oliver Brook Sutcliffe , Christian Bubert
IPC分类号： C07D249/08
CPC分类号： C07D249/08 , C07D231/12 , C07D233/56 , C07D413/12 , C07D417/12
摘要： There is provided a compound of Formula I wherein each T is independently selected from H, hydrocarbyl, —F—R, and a bond with one of D, E, P or Q, or together with one of P and Q forms a ring; Z is a suitable atom the valency of which is m; D, E and F are each independently of each other an optional linker group, wherein when Z is nitrogen E is other than CH2 and C═O; P, Q and R are independently of each other a ring system; and at least Q comprises a sulphamate group.
摘要翻译：提供式I的化合物，其中每个T独立地选自H，烃基，-F-R和与D，E，P或Q之一的键，或与P和Q中的一个一起形成环; Z是一个合适的原子，其化合价是m; D，E和F各自独立地为任选的连接基团，其中当Z为氮时，E不是CH 2和C-O; P，Q和R彼此独立地是环系; 并且至少Q包含氨基磺酸酯基团。

6. 发明授权

US08093279B2 Compound 有权
标题翻译：复合
公开(公告)号：US08093279B2
公开(公告)日：2012-01-10
申请号：US12555342
申请日：2009-09-08
申请人： Lok Wai Lawrence Woo , Toby Jackson , Atul Purohit , Michael John Reed , Gillian Reed, legal representative , Barry Victor Lloyd Potter
发明人： Lok Wai Lawrence Woo , Toby Jackson , Atul Purohit , Michael John Reed , Barry Victor Lloyd Potter
IPC分类号： A61K31/44 , C07D249/00
CPC分类号： C07D249/08 , C07D405/10
摘要： There is provided a compound of Formula I wherein R3, R4, R5, R6 and R7 are independently selected from H and —Y—R8; wherein each R8 is independently selected from —OH, hydrocarbyl groups, oxyhydrocarbyl groups, cyano (—CN), nitro (—NO2), H-bond acceptors, and halogens; wherein at least one of R3, R4, R5, R6 and R7 is —Y—R8 wherein R8 is selected from substituted and unsubstituted heterocyclic rings and amino substituted phenyl groups, wherein X is a bond or a linker group; wherein Y is an optional linker group; and wherein ring A is optionally further substituted; wherein R9 is selected from H, —OH and —OSO2NR1R2; wherein R1 and R2 are independently selected from H and hydrocarbyl; wherein (a) X is a bond and at least one of R3, R4, R5, R6 and R7 is —Y—R8; OR (b) R9 is —OSO2NR1R2 or —OH and four of R3, R4, R5, R6 and R7 are H and one of R3, R4, R5, R6 and R7 is —Y—R8.
摘要翻译：提供式I的化合物，其中R 3，R 4，R 5，R 6和R 7独立地选自H和-Y-R 8; 其中每个R 8独立地选自-OH，烃基，羟基烃基，氰基（-CN），硝基（-NO 2），H-键受体和卤素; 其中R 3，R 4，R 5，R 6和R 7中的至少一个是-Y-R 8，其中R 8选自取代和未取代的杂环和氨基取代的苯基，其中X是键或连接基团; 其中Y是任选的连接基团; 并且其中环A任选进一步被取代; 其中R9选自H，-OH和-OSO2NR1R2; 其中R1和R2独立地选自H和烃基; 其中（a）X是键，并且R 3，R 4，R 5，R 6和R 7中的至少一个是-Y-R 8; 或（b）R9为-OSO2NR1R2或-OH，R3，R4，R5，R6和R7中的4个为H，R3，R4，R5，R6和R7之一为-Y-R8。

7. 发明授权

US07968561B2 Steroidal compounds as steroid sulphatase inhibitors 失效
标题翻译：甾类化合物作为类固醇硫酸酯酶抑制剂
公开(公告)号：US07968561B2
公开(公告)日：2011-06-28
申请号：US12200252
申请日：2008-08-28
申请人： Barry Victor Lloyd Potter , Michael John Reed , Lok Wai Lawrence Woo , Atul Purohit , Paul Foster
发明人： Barry Victor Lloyd Potter , Michael John Reed , Lok Wai Lawrence Woo , Atul Purohit , Paul Foster
IPC分类号： A01N43/42 , A61K31/44 , C07D221/18 , C07D221/22
CPC分类号： C07J63/00
摘要： There is provided a compound having Formula I wherein G is a fluorocarbyl group, and wherein R1 is any one of a sulphamate group, a phosphonate group, a thiophosphonate group, a sulphonate group or a sulphonamide group.
摘要翻译：提供具有式I的化合物，其中G是氟代羰基，其中R 1是氨基磺酸酯基，膦酸酯基，硫代膦酸酯基，磺酸酯基或磺酰胺基中的任何一个。

8. 发明授权

US08030296B2 Oestrogen-17-sulphamates as inhibitors of steroid sulphatase 有权
标题翻译：雌激素-17-磺酰胺酸盐作为类固醇硫酸酯酶的抑制剂
公开(公告)号：US08030296B2
公开(公告)日：2011-10-04
申请号：US11368367
申请日：2006-03-03
申请人： Barry Victor Lloyd Potter , Michael John Reed , Lok Wai Lawrence Woo , Hatem Hejaz , Bertrand Leblond , Matthew Paul Leese , Atul Purohit
发明人： Barry Victor Lloyd Potter , Michael John Reed , Lok Wai Lawrence Woo , Hatem Hejaz , Bertrand Leblond , Matthew Paul Leese , Atul Purohit
IPC分类号： A61K31/56 , C07J1/00
CPC分类号： A61K31/565 , A61K31/37
摘要： There is provided a compound of Formula I wherein X is a ring system; R1 is any one of a sulphamate group, a phosphonate group, a thiophosphonate group, a sulphonate group or a sulphonamide group; R2 is any one of a sulphamate group, a phosphonate group, a thiophosphonate group, a sulphonate group or a sulphonamide group; wherein when X is a steroidal structure and both of R1 and R2 are sulphamate groups, the steroidal ring system (X) represents an oestrogen; and wherein said compound is capable of inhibiting steroid sulphatase (STS) activity and/or is capable of acting as a modulator of cell cycling and/or as a modulator of apoptosis and/or as a modulator of cell growth. There is also provided a compound of Formula VIII wherein R2 is any one of a sulphamate group, a phosphonate group, a thiophosphonate group, a sulphonate group or a sulphonamide group; and wherein said compound is capable of inhibiting steroid sulphatase (STS) activity and/or is capable of acting as a modulator of cell cycling and/or as a modulator of apoptosis and/or as a modulator of cell growth.
摘要翻译：提供式I的化合物，其中X是环系; R1是氨基磺酸酯基，膦酸酯基，硫代膦酸酯基，磺酸酯基或磺酰胺基中的任何一个; R2是氨基磺酸酯基，膦酸酯基，硫代膦酸酯基，磺酸酯基或磺酰胺基中的任何一个; 其中当X是甾体结构且R 1和R 2均为氨基磺酸酯基团时，甾体环体系（X）代表雌激素; 并且其中所述化合物能够抑制类固醇硫酸酯酶（STS）活性和/或能够充当细胞循环的调节剂和/或作为凋亡调节剂和/或细胞生长调节剂。还提供了式VIII的化合物，其中R 2是氨基磺酸酯基，膦酸酯基，硫代膦酸酯基，磺酸酯基或磺酰胺基中的任何一个; 并且其中所述化合物能够抑制类固醇硫酸酯酶（STS）活性和/或能够充当细胞循环的调节剂和/或作为凋亡调节剂和/或细胞生长调节剂。

9. 发明申请

US20100105764A1 USE 审中-公开
标题翻译：使用
公开(公告)号：US20100105764A1
公开(公告)日：2010-04-29
申请号：US12475910
申请日：2009-06-01
申请人： Michael John Reed , Atul Purohit , Paul Alexander Foster , Simon Paul Newman , Lok Wai Lawrence Woo , Barry Victor Lloyd Potter , Gillian Reed
发明人： Michael John Reed , Atul Purohit , Paul Alexander Foster , Simon Paul Newman , Lok Wai Lawrence Woo , Barry Victor Lloyd Potter , Gillian Reed
IPC分类号： A61K31/366 , A61P35/00
CPC分类号： A61K31/37
摘要： There is provided a method for the manufacture of a medicament for the treatment of cancer comprising a compound capable of inhibiting a steroid sulphatase enzyme (E.C.3.1.6.2), wherein the cancer is of a type, in which the cancer cells overexpress aromatase enzyme.
摘要翻译：提供了一种制备用于治疗癌症的药物的方法，其包括能够抑制类固醇硫酸酯酶的化合物（E.C.3.1.6.2），其中所述癌症是癌细胞过度表达芳香酶的类型。

10. 发明申请

US20080146656A1 Use of a steroid sulphatase inhibitor for inhibiting the synthesis of androstenedione and/or testosterone 审中-公开
标题翻译：使用类固醇硫酸酯酶抑制剂抑制雄烯二酮和/或睾酮的合成
公开(公告)号：US20080146656A1
公开(公告)日：2008-06-19
申请号：US11948102
申请日：2007-11-30
申请人： Michael John Reed , Atul Purohit , Lok Wai Lawrence Woo , Barry Victor Lloyd Potter
发明人： Michael John Reed , Atul Purohit , Lok Wai Lawrence Woo , Barry Victor Lloyd Potter
IPC分类号： A61K31/352 , A61P3/00
CPC分类号： A61K31/37
摘要： There is provided use of a compound capable of inhibiting a steroid sulphatase enzyme (E.C.3.1.6.2) in the manufacture of a medicament for inhibiting in vivo synthesis of at least one of androstenedione and testosterone, which may be useful for the treatment of hirsutism, excess sebum production, benign breast disease, benign ovarian disease, polycystic ovarian disease and female infertility among others.
摘要翻译：提供能够抑制类固醇硫酸酯酶（EC3.1.6.2）的化合物在制备用于抑制体内合成雄烯二酮和睾酮中的至少一种的药物中的用途，其可用于治疗多毛症，过多的皮脂产生，良性乳腺疾病，良性卵巢疾病，多囊卵巢病和女性不育症等。

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