专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US08846737B2 Compound 有权
公开(公告)号：US08846737B2
公开(公告)日：2014-09-30
申请号：US13392206
申请日：2010-08-23
申请人： Lok Wai Lawrence Woo , Christian Bubert , Paul Michael Wood , Aurélien Putey , Atul Purohit , Barry Victor Lloyd Potter
发明人： Lok Wai Lawrence Woo , Christian Bubert , Paul Michael Wood , Aurélien Putey , Atul Purohit , Barry Victor Lloyd Potter
IPC分类号： C07D249/08
CPC分类号： C07D249/08 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12
摘要： There is provided a compound of formula I wherein Z is selected from N and CR22, wherein R22 is H or a bond with D; wherein D is selected from a bond, C═O, and linear or branched hydrocarbon groups having a carbon chain of from 1 to 6 carbon atoms, wherein the carbon chain optionally contains an oxy group (═O), an ether (—O—) or thioether (—S—) link, wherein R1 is selected from: triazolyl, imidazolyl, pyrimidinyl radical wherein each of R2 to R6 is independently selected from —H, NO2, halo, —CN, —N[(C═O)0-1R12][(C═O)0-1R13] and —(CH2)0-1R14, or two adjacent groups of R2 to R6, together with the carbon atoms to which they are attached, form a ring, wherein at least one of R2 to R6 is —CN, wherein (i) at least one of R2 to R6 is —(CH2)0-1R14, or (ii) at least one of R2 to R6 is —N[(C═O)0-1R12][(C═O)0-1R13], or (iii) at least two adjacent groups of R2 to R6 together with the carbon atoms to which they are attached, form a ring, or (iv) at least one of R2 to R6 is —(CH2)0-1—O—R′14, wherein R12 and R13 are independently selected from H, linear or branched hydrocarbon groups having a carbon chain of from 1 to 10 carbon atoms, or together with the atoms to which they are attached, may form a mono or bicyclic ring having from 5 to 14 ring members wherein R14 is selected from: aliphatic ring systems unsubstituted or substituted monocyclic aliphatic heterocycles; unsubstituted or substituted heteroaryl radical, and unsubstituted or substituted phenyl group; the group of formula wherein t is 1 or 2 wherein R′14 is a unsubstituted or substituted phenyl group; wherein each of R7 to R11 is independently selected from —H, NO2, halo, —O—(C1-C6)haloalkyl, (C1-C6)haloalkyl, (C1-C6)alkyl, —CN, —OH, —OPh, —OBn, -Ph, —OSO2NR15R16, —SO2R26, —SO2NR27R28, —O—(C1-C6)alkyl, —(C═O)0-1NR29R30 and —CO(O)0-1R31; wherein R15 and R16 are independently selected from H, alkyl, cycloalkyl, alkenyl, acyl and aryl, or combinations thereof, or together represent alkylene, wherein the or each alkyl or cycloalkyl or alkenyl optionally contain one or more hetero atoms or groups wherein each of R26 to R31 is independently selected from H, alkyl, cycloalkyl, alkenyl, acyl and aryl, or combinations thereof, or together represent alkylene, wherein the or each alkyl or cycloalkyl or alkenyl optionally contain one or more hetero atoms or groups; or any pharmaceutically acceptable salts thereof.

2. 发明授权

US08365095B2 System and method for assigning and scheduling activities 有权
标题翻译：用于分配和调度活动的系统和方法
公开(公告)号：US08365095B2
公开(公告)日：2013-01-29
申请号：US12871548
申请日：2010-08-30
申请人： Harish Bansal , Olivier Delerm , Atul Purohit , Chrisopher Scott Nash
发明人： Harish Bansal , Olivier Delerm , Atul Purohit , Chrisopher Scott Nash
IPC分类号： G06F3/048
CPC分类号： G06F3/0484 , G06Q10/06 , G06Q10/20 , Y10S715/963
摘要： Techniques to facilitate assignment and scheduling of activities. In accordance with a method, a chart showing a calendar of schedule for a number of available resources is provided in a first frame (or window) in a user interface menu, and a number of objects representative of a number of unplanned activities are provided in a second frame. A selection for an unplanned activity in the second frame (or a planned activity in the first frame) is received and, in response, selected ones of a number of objects in the chart are highlighted based on the selected activity. A request to assign the selected activity to a selected resource and to schedule the selected activity for a particular time duration is thereafter received. The requested assignment and scheduling may be accepted or rejected based on the requirements of the selected activity and the capabilities of the selected resource.
摘要翻译：促进活动分配和安排的技术。根据一种方法，在用户界面菜单中的第一帧（或窗口）中提供表示多个可用资源的日程表的图表，并且表示多个表示计划外活动的对象数目第二帧。接收对第二帧中的计划外活动（或第一帧中的计划活动）的选择，并且作为响应，基于所选择的活动突出显示图表中的多个对象中的选定的对象。此后接收到将所选择的活动分配给所选择的资源并且调度所选活动达特定持续时间的请求。可以基于所选活动的要求和所选资源的能力来接受或拒绝所请求的分配和调度。

3. 发明申请

US20120238550A1 COMPOUND 有权
公开(公告)号：US20120238550A1
公开(公告)日：2012-09-20
申请号：US13392206
申请日：2010-08-23
申请人： Lok Wai Lawrence Woo , Christian Bubert , Paul Michael Wood , Aurélien Putey , Atul Purohit , Barry Victor Lloyd Potter
发明人： Lok Wai Lawrence Woo , Christian Bubert , Paul Michael Wood , Aurélien Putey , Atul Purohit , Barry Victor Lloyd Potter
IPC分类号： A61K31/4196 , C07D409/12 , C07D403/12 , A61K31/55 , C07D401/12 , A61P35/00 , C07D413/12 , A61K31/5377 , A61K31/496 , A61K31/4439 , C07D405/12 , C07D249/08 , A61K31/454
CPC分类号： C07D249/08 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12
摘要： There is provided a compound of formula I wherein Z is selected from N and CR22, wherein R22 is H or a bond with D; wherein D is selected from a bond, C═O, and linear or branched hydrocarbon groups having a carbon chain of from 1 to 6 carbon atoms, wherein the carbon chain optionally contains an oxy group (═O), an ether (—O—) or thioether (—S—) link, wherein R1 is selected from: triazolyl, imidazolyl, pyrimidinyl radical wherein each of R2 to R6 is independently selected from —H, NO2, halo, —CN, —N[(C═O)0-1R12][(C═O)0-1R13] and —(CH2)0-1R14, or two adjacent groups of R2 to R6, together with the carbon atoms to which they are attached, form a ring, wherein at least one of R2 to R6 is —CN, wherein (i) at least one of R2 to R6 is —(CH2)0-1R14, or (ii) at least one of R2 to R6 is —N[(C═O)0-1R12][(C═O)0-1R13], or (iii) at least two adjacent groups of R2 to R6 together with the carbon atoms to which they are attached, form a ring, or (iv) at least one of R2 to R6 is —(CH2)0-1—O—R′14, wherein R12 and R13 are independently selected from H, linear or branched hydrocarbon groups having a carbon chain of from 1 to 10 carbon atoms, or together with the atoms to which they are attached, may form a mono or bicyclic ring having from 5 to 14 ring members wherein R14 is selected from: aliphatic ring systems unsubstituted or substituted monocyclic aliphatic heterocycles; unsubstituted or substituted heteroaryl radical, and unsubstituted or substituted phenyl group; the group of formula wherein t is 1 or 2 wherein R′14 is a unsubstituted or substituted phenyl group; wherein each of R7 to R11 is independently selected from —H, NO2, halo, —O—(C1-C6)haloalkyl, (C1-C6)haloalkyl, (C1-C6)alkyl, —CN, —OH, —OPh, —OBn, -Ph, —OSO2NR15R16, —SO2R26, —SO2NR27R28, —O—(C1-C6)alkyl, —(C═O)0-1NR29R30 and —CO(O)0-1R31; wherein R15 and R16 are independently selected from H, alkyl, cycloalkyl, alkenyl, acyl and aryl, or combinations thereof, or together represent alkylene, wherein the or each alkyl or cycloalkyl or alkenyl optionally contain one or more hetero atoms or groups wherein each of R26 to R31 is independently selected from H, alkyl, cycloalkyl, alkenyl, acyl and aryl, or combinations thereof, or together represent alkylene, wherein the or each alkyl or cycloalkyl or alkenyl optionally contain one or more hetero atoms or groups; or any pharmaceutically acceptable salts thereof.

4. 发明授权

US08093279B2 Compound 有权
标题翻译：复合
公开(公告)号：US08093279B2
公开(公告)日：2012-01-10
申请号：US12555342
申请日：2009-09-08
申请人： Lok Wai Lawrence Woo , Toby Jackson , Atul Purohit , Michael John Reed , Gillian Reed, legal representative , Barry Victor Lloyd Potter
发明人： Lok Wai Lawrence Woo , Toby Jackson , Atul Purohit , Michael John Reed , Barry Victor Lloyd Potter
IPC分类号： A61K31/44 , C07D249/00
CPC分类号： C07D249/08 , C07D405/10
摘要： There is provided a compound of Formula I wherein R3, R4, R5, R6 and R7 are independently selected from H and —Y—R8; wherein each R8 is independently selected from —OH, hydrocarbyl groups, oxyhydrocarbyl groups, cyano (—CN), nitro (—NO2), H-bond acceptors, and halogens; wherein at least one of R3, R4, R5, R6 and R7 is —Y—R8 wherein R8 is selected from substituted and unsubstituted heterocyclic rings and amino substituted phenyl groups, wherein X is a bond or a linker group; wherein Y is an optional linker group; and wherein ring A is optionally further substituted; wherein R9 is selected from H, —OH and —OSO2NR1R2; wherein R1 and R2 are independently selected from H and hydrocarbyl; wherein (a) X is a bond and at least one of R3, R4, R5, R6 and R7 is —Y—R8; OR (b) R9 is —OSO2NR1R2 or —OH and four of R3, R4, R5, R6 and R7 are H and one of R3, R4, R5, R6 and R7 is —Y—R8.
摘要翻译：提供式I的化合物，其中R 3，R 4，R 5，R 6和R 7独立地选自H和-Y-R 8; 其中每个R 8独立地选自-OH，烃基，羟基烃基，氰基（-CN），硝基（-NO 2），H-键受体和卤素; 其中R 3，R 4，R 5，R 6和R 7中的至少一个是-Y-R 8，其中R 8选自取代和未取代的杂环和氨基取代的苯基，其中X是键或连接基团; 其中Y是任选的连接基团; 并且其中环A任选进一步被取代; 其中R9选自H，-OH和-OSO2NR1R2; 其中R1和R2独立地选自H和烃基; 其中（a）X是键，并且R 3，R 4，R 5，R 6和R 7中的至少一个是-Y-R 8; 或（b）R9为-OSO2NR1R2或-OH，R3，R4，R5，R6和R7中的4个为H，R3，R4，R5，R6和R7之一为-Y-R8。

5. 发明授权

US07968561B2 Steroidal compounds as steroid sulphatase inhibitors 失效
标题翻译：甾类化合物作为类固醇硫酸酯酶抑制剂
公开(公告)号：US07968561B2
公开(公告)日：2011-06-28
申请号：US12200252
申请日：2008-08-28
申请人： Barry Victor Lloyd Potter , Michael John Reed , Lok Wai Lawrence Woo , Atul Purohit , Paul Foster
发明人： Barry Victor Lloyd Potter , Michael John Reed , Lok Wai Lawrence Woo , Atul Purohit , Paul Foster
IPC分类号： A01N43/42 , A61K31/44 , C07D221/18 , C07D221/22
CPC分类号： C07J63/00
摘要： There is provided a compound having Formula I wherein G is a fluorocarbyl group, and wherein R1 is any one of a sulphamate group, a phosphonate group, a thiophosphonate group, a sulphonate group or a sulphonamide group.
摘要翻译：提供具有式I的化合物，其中G是氟代羰基，其中R 1是氨基磺酸酯基，膦酸酯基，硫代膦酸酯基，磺酸酯基或磺酰胺基中的任何一个。

6. 发明授权

US07893284B2 Oestrogen derivatives as inhibitors of steroid sulphatase 失效
标题翻译：雌激素衍生物作为类固醇硫酸酯酶的抑制剂
公开(公告)号：US07893284B2
公开(公告)日：2011-02-22
申请号：US11233945
申请日：2005-09-23
申请人： Matthew Leese , Atul Purohit , Michael John Reed , Simon Paul Newman , Surinder Kuman Chander , Fabrice Jourdan , Barry Victor Lloyd Potter
发明人： Matthew Leese , Atul Purohit , Michael John Reed , Simon Paul Newman , Surinder Kuman Chander , Fabrice Jourdan , Barry Victor Lloyd Potter
IPC分类号： C07J3/00 , C07J1/00
CPC分类号： C07J43/00 , C07J41/00
摘要： The present invention provides a compound comprising a steroidal ring system and an optional group R1 selected from any one of —OH, a sulphamate group, a phosphonate group, a thiophosphonate group, a sulphonate group or a sulphonamide group; wherein the D ring of the steroidal ring system is substituted by a group R2 of the formula -L-R3, wherein L is an optional linker group and R3 is selected from groups which are or which comprise one of a nitrite group, an alcohol, an ester, an ether, an amine and an alkene, provided that when R3 is or comprises an alcohol, L is present; and wherein the A ring of the steroidal ring system is substituted at position 2 or 4 with a group R4, wherein R4 is a hydrocarbyl group.
摘要翻译：本发明提供了包含甾族环系统和选自-OH，氨基磺酸盐基团，膦酸盐基团，硫代膦酸盐基团，磺酸盐基团或磺酰胺基团中的任何一个的任选基团R1的化合物; 其中甾族环体系的D环被式-L-R3的基团R 2取代，其中L是任选的连接基团，并且R 3选自亚硝酸根基团，醇，酯，醚，胺和烯烃，条件是当R3是或包含醇时，存在L; 并且其中所述甾族环系统的A环在位置2或4与基团R 4取代，其中R 4是烃基。

7. 发明申请

US20100325582A1 System and Method for Assigning and Scheduling Activities 有权
标题翻译：分配和调度活动的系统和方法
公开(公告)号：US20100325582A1
公开(公告)日：2010-12-23
申请号：US12871548
申请日：2010-08-30
申请人： Harish Bansal , Olivier Delerm , Atul Purohit , Chrisopher Scott Nash
发明人： Harish Bansal , Olivier Delerm , Atul Purohit , Chrisopher Scott Nash
IPC分类号： G06F3/048
CPC分类号： G06F3/0484 , G06Q10/06 , G06Q10/20 , Y10S715/963
摘要： Techniques to facilitate assignment and scheduling of activities. In accordance with a method, a chart showing a calendar of schedule for a number of available resources is provided in a first frame (or window) in a user interface menu, and a number of objects representative of a number of unplanned activities are provided in a second frame. A selection for an unplanned activity in the second frame (or a planned activity in the first frame) is received and, in response, selected ones of a number of objects in the chart are highlighted based on the selected activity. A request to assign the selected activity to a selected resource and to schedule the selected activity for a particular time duration is thereafter received. The requested assignment and scheduling may be accepted or rejected based on the requirements of the selected activity and the capabilities of the selected resource.
摘要翻译：促进活动分配和安排的技术。根据一种方法，在用户界面菜单中的第一帧（或窗口）中提供表示多个可用资源的日程表的图表，并且表示多个表示计划外活动的对象数目第二帧。接收对第二帧中的计划外活动（或第一帧中的计划活动）的选择，并且作为响应，基于所选择的活动突出显示图表中的多个对象中的选定的对象。此后接收到将所选择的活动分配给所选择的资源并且调度所选活动达特定持续时间的请求。可以基于所选活动的要求和所选资源的能力来接受或拒绝所请求的分配和调度。

8. 发明授权

US07745472B2 Compound 有权
标题翻译：复合
公开(公告)号：US07745472B2
公开(公告)日：2010-06-29
申请号：US12056920
申请日：2008-03-27
申请人： Barry Victor Lloyd Potter , Lok Wai Lawrence Woo , Atul Purohit , Michael John Reed , Oliver Brook Sutcliffe , Christian Bubert
发明人： Barry Victor Lloyd Potter , Lok Wai Lawrence Woo , Atul Purohit , Michael John Reed , Oliver Brook Sutcliffe , Christian Bubert
IPC分类号： A61K31/4196 , C07D249/08
CPC分类号： C07D249/08 , C07D231/12 , C07D233/56 , C07D413/12 , C07D417/12
摘要： There is provided a compound of Formula I wherein each T is independently selected from H, hydrocarbyl, —F—R, and a bond with one of D, E, P or Q, or together with one of P and Q forms a ring; Z is a suitable atom the valency of which is m; D, E and F are each independently of each other an optional linker group, wherein when Z is nitrogen E is other than CH2 and C═O; P, Q and R are independently of each other a ring system; and at least Q comprises a sulphamate group.
摘要翻译：提供式I的化合物，其中每个T独立地选自H，烃基，-F-R和与D，E，P或Q之一的键，或与P和Q中的一个形成环; Z是一个合适的原子，其化合价是m; D，E和F各自独立地为任选的连接基团，其中当Z为氮时，E不是CH 2且C = O; P，Q和R彼此独立地是环系; 并且至少Q包含氨基磺酸酯基团。

9. 发明申请

US20100144652A1 COMPOSITION COMPRISING A GLYCOLYTIC INHIBITOR AND A RING SYSTEM COMPRISING A SULPHAMATE GROUP FOR THE TREATMENT OF CANCER 审中-公开
标题翻译：包含糖尿病抑制剂和包含用于治疗癌症的磺酰胺类的环系统的组合物
公开(公告)号：US20100144652A1
公开(公告)日：2010-06-10
申请号：US12526398
申请日：2008-02-07
申请人： Sarah Louise Claire Tagg , Paul Alexander Foster , Simon Paul Newman , John Michael Reed , Atul Purohit , Barry Victor Lloyd Potter
发明人： Sarah Louise Claire Tagg , Paul Alexander Foster , Simon Paul Newman , John Michael Reed , Atul Purohit , Barry Victor Lloyd Potter
IPC分类号： A61K31/7004 , A61K31/70 , A61P35/00
CPC分类号： A61K31/33 , A61K31/565 , A61K31/7004 , A61K45/06 , A61K2300/00
摘要： The present invention provides a composition comprising (a) a glycolytic inhibitor (b) a compound comprising a ring system substituted with at least one of a suiphamate group and an alkoxy group; wherein (a) and (b) are different.
摘要翻译：本发明提供一种组合物，其包含（a）糖酵解抑制剂（b）包含被至少一个磺酸酯基和烷氧基取代的环系的化合物; 其中（a）和（b）不同。

10. 发明授权

US08030296B2 Oestrogen-17-sulphamates as inhibitors of steroid sulphatase 有权
标题翻译：雌激素-17-磺酰胺酸盐作为类固醇硫酸酯酶的抑制剂
公开(公告)号：US08030296B2
公开(公告)日：2011-10-04
申请号：US11368367
申请日：2006-03-03
申请人： Barry Victor Lloyd Potter , Michael John Reed , Lok Wai Lawrence Woo , Hatem Hejaz , Bertrand Leblond , Matthew Paul Leese , Atul Purohit
发明人： Barry Victor Lloyd Potter , Michael John Reed , Lok Wai Lawrence Woo , Hatem Hejaz , Bertrand Leblond , Matthew Paul Leese , Atul Purohit
IPC分类号： A61K31/56 , C07J1/00
CPC分类号： A61K31/565 , A61K31/37
摘要： There is provided a compound of Formula I wherein X is a ring system; R1 is any one of a sulphamate group, a phosphonate group, a thiophosphonate group, a sulphonate group or a sulphonamide group; R2 is any one of a sulphamate group, a phosphonate group, a thiophosphonate group, a sulphonate group or a sulphonamide group; wherein when X is a steroidal structure and both of R1 and R2 are sulphamate groups, the steroidal ring system (X) represents an oestrogen; and wherein said compound is capable of inhibiting steroid sulphatase (STS) activity and/or is capable of acting as a modulator of cell cycling and/or as a modulator of apoptosis and/or as a modulator of cell growth. There is also provided a compound of Formula VIII wherein R2 is any one of a sulphamate group, a phosphonate group, a thiophosphonate group, a sulphonate group or a sulphonamide group; and wherein said compound is capable of inhibiting steroid sulphatase (STS) activity and/or is capable of acting as a modulator of cell cycling and/or as a modulator of apoptosis and/or as a modulator of cell growth.
摘要翻译：提供式I的化合物，其中X是环系; R1是氨基磺酸酯基，膦酸酯基，硫代膦酸酯基，磺酸酯基或磺酰胺基中的任何一个; R2是氨基磺酸酯基，膦酸酯基，硫代膦酸酯基，磺酸酯基或磺酰胺基中的任何一个; 其中当X是甾体结构且R 1和R 2均为氨基磺酸酯基团时，甾体环体系（X）代表雌激素; 并且其中所述化合物能够抑制类固醇硫酸酯酶（STS）活性和/或能够充当细胞循环的调节剂和/或作为凋亡调节剂和/或细胞生长调节剂。还提供了式VIII的化合物，其中R 2是氨基磺酸酯基，膦酸酯基，硫代膦酸酯基，磺酸酯基或磺酰胺基中的任何一个; 并且其中所述化合物能够抑制类固醇硫酸酯酶（STS）活性和/或能够充当细胞循环的调节剂和/或作为凋亡调节剂和/或细胞生长调节剂。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式