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1. 发明申请

US20070143878A1 Nucleic acid molecules and other molecules associated with the tocopherol pathway 有权
标题翻译：核酸分子和与生育酚途径相关的其它分子
公开(公告)号：US20070143878A1
公开(公告)日：2007-06-21
申请号：US11329160
申请日：2006-01-11
申请人： Barkur Bhat , Sekhar Boddupalli , Ganesh Kishore , Jingdong Liu , Shaukat Rangwala , Mylavarapu Venkatramesh
发明人： Barkur Bhat , Sekhar Boddupalli , Ganesh Kishore , Jingdong Liu , Shaukat Rangwala , Mylavarapu Venkatramesh
IPC分类号： A01H1/00 , C12Q1/68 , C07H21/04 , C12N9/10 , C07K16/40
CPC分类号： C12N15/8243 , C12N9/0069 , C12N15/8247 , C12Q1/6895 , C12Q2600/156
摘要： The present invention is in the field of plant biochemistry. More specifically the invention relates to nucleic acid sequences from plant cells, in particular, nucleic acid sequences from maize and soybean associated with the tocopherol synthesis pathway enzymes. The invention encompasses nucleic acid molecules that encode proteins and fragments of proteins. In addition, the invention also encompasses proteins and fragments of proteins so encoded and antibodies capable of binding these proteins or fragments. The invention also relates to methods of using the nucleic acid molecules, proteins and fragments of proteins and antibodies, for example for genome mapping, gene identification and analysis, plant breeding, preparation of constructs for use in plant gene expression and transgenic plants.
摘要翻译：本发明在植物生物化学领域。更具体地，本发明涉及来自植物细胞的核酸序列，特别是与生育酚合成途径酶相关的玉米和大豆的核酸序列。本发明包括编码蛋白质和蛋白质片段的核酸分子。此外，本发明还包括如此编码的蛋白质和蛋白质的片段以及能够结合这些蛋白质或片段的抗体。本发明还涉及使用核酸分子，蛋白质和蛋白质和抗体片段的方法，例如用于基因组图谱，基因鉴定和分析，植物育种，用于植物基因表达的构建体的制备和转基因植物。

2. 发明申请

US20050102716A1 Transgenic plants containing altered levels of sterol compounds and tocopherols 有权
标题翻译：含有改变水平的固醇化合物和生育酚的转基因植物
公开(公告)号：US20050102716A1
公开(公告)日：2005-05-12
申请号：US10647517
申请日：2004-01-16
申请人： Mylavarapu Venkatramesh , David Corbin , B. Bhat , Sekhar Boddupalli , Robert Grebenok , Ganesh Kishore , Kathryn Lardizabal , Michael Lassner , Shaukat Rangwala , Balsulojini Karunanandaa
发明人： Mylavarapu Venkatramesh , David Corbin , B. Bhat , Sekhar Boddupalli , Robert Grebenok , Ganesh Kishore , Kathryn Lardizabal , Michael Lassner , Shaukat Rangwala , Balsulojini Karunanandaa
IPC分类号： C12N9/02 , C12N15/53 , C12N15/54 , C12N15/82 , A01H1/00
CPC分类号： C12N9/001 , C12N15/8243
摘要： Provided are recombinant constructs comprising DNA sequences encoding enzymes effective in altering the biosynthesis and accumulation of sterol compounds and tocopherols in transgenic plants. Also provided are methods of using such constructs to produce transgenic plants, seeds of which contain elevated levels of sitostanol and/or sitostanol esters, and α-tocopherol, as well as reduced levels of campesterol and campestanol and their corresponding esters. These seeds also contain the novel sterol brassicastanol. Oil obtained from seeds of such transgenic plants is also provided. This oil can be used to prepare food and pharmaceutical compositions effective in lowering the level of low density lipoprotein cholesterol in blood serum. In addition, novel DNA sequences encoding plant steroid 5α-reductases are also disclosed.
摘要翻译：提供了包含编码有效改变转基因植物中甾醇化合物和生育酚的生物合成和积累的酶的DNA序列的重组构建体。还提供了使用这种构建体产生转基因植物的方法，其种子含有升高水平的谷甾烷醇和/或谷甾烷醇酯和α-生育酚，以及降低水平的菜油甾醇和菜油甾醇及其相应的酯。这些种子还含有新的甾醇黄豆糖醇。还提供了从这种转基因植物的种子获得的油。该油可用于制备有效降低血清中低密度脂蛋白胆固醇水平的食品和药物组合物。此外，还公开了编码植物类固醇5α-还原酶的新型DNA序列。

3. 发明申请

US20050086713A1 Transgenic plants containing altered levels of steroid compounds 有权
标题翻译：含有改变水平的类固醇化合物的转基因植物
公开(公告)号：US20050086713A1
公开(公告)日：2005-04-21
申请号：US10862907
申请日：2004-06-07
申请人： Balasulojini Karunanandaa , Martha Post-Beittenmiller , Mylavarapu Venkatramesh , Ganesh Kishore , Gregory Thorne , John LeDeaux
发明人： Balasulojini Karunanandaa , Martha Post-Beittenmiller , Mylavarapu Venkatramesh , Ganesh Kishore , Gregory Thorne , John LeDeaux
IPC分类号： C12N9/02 , C12N9/04 , C12N9/10 , C12N15/82 , A01H1/00 , C12N5/04
CPC分类号： C12N9/0073 , C12N9/0006 , C12N9/0083 , C12N9/1007 , C12N15/8243 , C12N15/8247 , C12Y101/01034 , C12Y114/99007
摘要： Disclosed are constructs comprising sequences encoding 3-hydroxy-3methylglutaryl-Coenzyme A reductase and at least one other sterol synthesis pathway enzyme. Also disclosed are methods for using such constructs to alter sterol production and content in cells, plants, seeds and storage organs of plants. Also provided are oils and compositions containing altered sterol levels produced by use of the disclosed constructs. Novel nucleotide sequences useful in the alteration of sterol production are also provided. Also provided are cells, plants, seeds and storage organs of plants comprising sequences encoding 3-hydroxy-3methylglutaryl-Coenzyme A reductase, at least one other sterol synthesis pathway enzyme and at least one tocopherol synthesis enzyme.
摘要翻译：公开了包含编码3-羟基-3甲基戊二酰辅酶A还原酶和至少一种其它甾醇合成途径酶的序列的构建体。还公开了使用这种构建体来改变植物的细胞，植物，种子和储存器官中的固醇产生和含量的方法。还提供了含有通过使用所公开的构建体产生的改变的固醇水平的油和组合物。还提供了可用于改变甾醇生产的新型核苷酸序列。还提供了包含编码3-羟基-3甲基戊二酰辅酶A还原酶，至少一种其它甾醇合成途径酶和至少一种生育酚合成酶的序列的植物的细胞，植物，种子和储存器官。

4. 发明申请

US20100100987A1 NUCLEIC ACID MOLECULES AND OTHER MOLECULES ASSOCIATED WITH THE TOCOPHEROL PATHWAY 审中-公开
标题翻译：核酸分子和其他分子与TOCOPHEROL途径相关
公开(公告)号：US20100100987A1
公开(公告)日：2010-04-22
申请号：US12634356
申请日：2009-12-09
申请人： Barkur G. BHAT , Sekhar S. Boddupalli , Ganesh M. Kishore , Jingdong Liu , Shaukat H. Rangwala , Mylavarapu Venkatramesh
发明人： Barkur G. BHAT , Sekhar S. Boddupalli , Ganesh M. Kishore , Jingdong Liu , Shaukat H. Rangwala , Mylavarapu Venkatramesh
IPC分类号： A01H5/00 , C07H21/04 , A01C7/00
CPC分类号： C12N15/8243 , C12N9/0069 , C12N15/8247 , C12Q1/6895 , C12Q2600/156
摘要： The present invention is in the field of plant biochemistry. More specifically the invention relates to nucleic acid sequences from plant cells, in particular, nucleic acid sequences from maize and soybean associated with the tocopherol synthesis pathway enzymes. The invention encompasses nucleic acid molecules that encode proteins and fragments of proteins. In addition, the invention also encompasses proteins and fragments of proteins so encoded and antibodies capable of binding these proteins or fragments. The invention also relates to methods of using the nucleic acid molecules, proteins and fragments of proteins and antibodies, for example for genome mapping, gene identification and analysis, plant breeding, preparation of constructs for use in plant gene expression and transgenic plants.
摘要翻译：本发明在植物生物化学领域。更具体地，本发明涉及来自植物细胞的核酸序列，特别是与生育酚合成途径酶相关的玉米和大豆的核酸序列。本发明包括编码蛋白质和蛋白质片段的核酸分子。此外，本发明还包括如此编码的蛋白质和蛋白质的片段以及能够结合这些蛋白质或片段的抗体。本发明还涉及使用核酸分子，蛋白质和蛋白质和抗体片段的方法，例如用于基因组图谱，基因鉴定和分析，植物育种，用于植物基因表达的构建体的制备和转基因植物。

5. 发明授权

US07655777B2 Nucleic acid molecules associated with the tocopherol pathway 有权
标题翻译：与生育酚途径相关的核酸分子
公开(公告)号：US07655777B2
公开(公告)日：2010-02-02
申请号：US11329160
申请日：2006-01-11
申请人： Barkur G. Bhat , Sekhar S. Boddupalli , Ganesh M. Kishore , Jingdong Liu , Shaukat H. Rangwala , Mylavarapu Venkatramesh
发明人： Barkur G. Bhat , Sekhar S. Boddupalli , Ganesh M. Kishore , Jingdong Liu , Shaukat H. Rangwala , Mylavarapu Venkatramesh
IPC分类号： C07H21/02 , C12Q1/66
CPC分类号： C12N15/8243 , C12N9/0069 , C12N15/8247 , C12Q1/6895 , C12Q2600/156
摘要： The present invention is in the field of plant biochemistry. More specifically the invention relates to nucleic acid sequences from plant cells, in particular, nucleic acid sequences from maize and soybean associated with the tocopherol synthesis pathway enzymes. The invention encompasses nucleic acid molecules that encode proteins and fragments of proteins. In addition, the invention also encompasses proteins and fragments of proteins so encoded and antibodies capable of binding these proteins or fragments. The invention also relates to methods of using the nucleic acid molecules, proteins and fragments of proteins and antibodies, for example for genome mapping, gene identification and analysis, plant breeding, preparation of constructs for use in plant gene expression and transgenic plants.
摘要翻译：本发明在植物生物化学领域。更具体地，本发明涉及来自植物细胞的核酸序列，特别是与生育酚合成途径酶相关的玉米和大豆的核酸序列。本发明包括编码蛋白质和蛋白质片段的核酸分子。此外，本发明还包括如此编码的蛋白质和蛋白质的片段以及能够结合这些蛋白质或片段的抗体。本发明还涉及使用核酸分子，蛋白质和蛋白质和抗体片段的方法，例如用于基因组图谱，基因鉴定和分析，植物育种，用于植物基因表达的构建体的制备和转基因植物。

6. 发明授权

US07709666B2 Transgenic plants containing altered levels of sterol compounds and tocopherols 有权
标题翻译：含有改变水平的固醇化合物和生育酚的转基因植物
公开(公告)号：US07709666B2
公开(公告)日：2010-05-04
申请号：US10647517
申请日：2004-01-16
申请人： Mylavarapu Venkatramesh , David R. Corbin , B. Ganesh Bhat , Sekhar S. Boddupalli , Robert J. Grebenok , Ganesh M. Kishore , Kathryn D. Lardizabal , Michael W. Lassner , Shaukat H. Rangwala , Balasulojini Karunanandaa
发明人： Mylavarapu Venkatramesh , David R. Corbin , B. Ganesh Bhat , Sekhar S. Boddupalli , Robert J. Grebenok , Ganesh M. Kishore , Kathryn D. Lardizabal , Michael W. Lassner , Shaukat H. Rangwala , Balasulojini Karunanandaa
IPC分类号： C07C59/147
CPC分类号： C12N9/001 , C12N15/8243
摘要： Provided are recombinant constructs comprising DNA sequences encoding enzymes effective in altering the biosynthesis and accumulation of sterol compounds and tocopherols in transgenic plants. Also provided are methods of using such constructs to produce transgenic plants, seeds of which contain elevated levels of sitostanol and/or sitostanol esters, and α-tocopherol, as well as reduced levels of campesterol and campestanol and their corresponding esters. These seeds also contain the novel sterol brassicastanol. Oil obtained from seeds of such transgenic plants is also provided. This oil can be used to prepare food and pharmaceutical compositions effective in lowering the level of low density lipoprotein cholesterol in blood serum. In addition, novel DNA sequences encoding plant steroid 5α-reductases are also disclosed.
摘要翻译：提供了包含编码有效改变转基因植物中甾醇化合物和生育酚的生物合成和积累的酶的DNA序列的重组构建体。还提供了使用这种构建体产生转基因植物的方法，其种子含有升高水平的谷甾烷醇和/或谷甾烷醇酯和α-生育酚，以及降低水平的菜油甾醇和菜油甾醇及其相应的酯。这些种子还含有新的甾醇黄豆糖醇。还提供了从这种转基因植物的种子获得的油。该油可用于制备有效降低血清中低密度脂蛋白胆固醇水平的食品和药物组合物。此外，还公开了编码植物类固醇5α-还原酶的新型DNA序列。

7. 发明申请

US20080244790A1 METHYL-D-ERYTHRITOL PHOSPHATE PATHWAY GENES 审中-公开
标题翻译：甲基-D-谷维素磷酸盐路径基因
公开(公告)号：US20080244790A1
公开(公告)日：2008-10-02
申请号：US12101833
申请日：2008-04-11
申请人： Albert Boronat , Narciso Campos , Manual Rodriguez-Concepcion , Michel Rohmer , Myriam Seemann , Henry E. Valentin , Tyamagondlu V. Venkatesh , Mylavarapu Venkatramesh
发明人： Albert Boronat , Narciso Campos , Manual Rodriguez-Concepcion , Michel Rohmer , Myriam Seemann , Henry E. Valentin , Tyamagondlu V. Venkatesh , Mylavarapu Venkatramesh
IPC分类号： C12N15/29 , C07K16/00 , C12N5/10 , A01H5/00
CPC分类号： C12N15/8243 , C12N15/52 , C12N15/825
摘要： The present invention provides and includes nucleic acids, proteins and antibodies associated with novel genes in the MEP pathway. The invention further encompasses methods utilizing such molecules, for example in gene isolation, gene analysis and the production of transgenic plants. The present invention also includes transgenic plants modified to express proteins associated with the MEP pathway.
摘要翻译：本发明提供并包括与MEP途径中的新基因相关的核酸，蛋白质和抗体。本发明还包括利用这种分子的方法，例如在基因分离，基因分析和转基因植物的生产中。本发明还包括被修饰以表达与MEP途径相关的蛋白质的转基因植物。

8. 发明申请

US20050223435A1 Methyl-D-erythritol phosphate pathway genes 有权
公开(公告)号：US20050223435A1
公开(公告)日：2005-10-06
申请号：US10974559
申请日：2004-10-27
申请人： Albert Boronat , Narciso Campos , Manual Rodriguez-Concepcion , Michel Rohmer , Myriam Seemann , Henry Valentin , Tyamagondlu Venkatesh , Mylavarapu Venkatramesh
发明人： Albert Boronat , Narciso Campos , Manual Rodriguez-Concepcion , Michel Rohmer , Myriam Seemann , Henry Valentin , Tyamagondlu Venkatesh , Mylavarapu Venkatramesh
IPC分类号： C12N15/52 , C12N15/82 , A01H5/00
CPC分类号： C12N15/8243 , C12N15/52 , C12N15/825
摘要： The present invention provides and includes nucleic acids, proteins and antibodies associated with novel genes in the MEP pathway. The invention further encompasses methods utilizing such molecules, for example in gene isolation, gene analysis and the production of transgenic plants. The present invention also includes transgenic plants modified to express proteins associated with the MEP pathway.

9. 发明授权

US06822142B2 Transgenic plants containing altered levels of steroid compounds 有权
标题翻译：含有改变水平的类固醇化合物的转基因植物
公开(公告)号：US06822142B2
公开(公告)日：2004-11-23
申请号：US09885723
申请日：2001-06-20
申请人： Balasulojini Karunanandaa , Martha Post-Beittenmiller , Mylavarapu Venkatramesh , Ganesh M. Kishore , Gregory M. Thorne , John R. LeDeaux
发明人： Balasulojini Karunanandaa , Martha Post-Beittenmiller , Mylavarapu Venkatramesh , Ganesh M. Kishore , Gregory M. Thorne , John R. LeDeaux
IPC分类号： C12N1509
CPC分类号： C12N9/0073 , C12N9/0006 , C12N9/0083 , C12N9/1007 , C12N15/8243 , C12N15/8247 , C12Y101/01034 , C12Y114/99007
摘要： Disclosed are constructs comprising sequences encoding 3-hydroxy-3methylglutaryl-Coenzyme A reductase and at least one other sterol synthesis pathway enzyme. Also disclosed are methods for using such constructs to alter sterol production and content in cells, plants, seeds and storage organs of plants. Also provided are oils and compositions containing altered sterol levels produced by use of the disclosed constructs. Novel nucleotide sequences useful in the alteration of sterol production are also provided. Also provided are cells, plants, seeds and storage organs of plants comprising sequences encoding 3-hydroxy-3methylglutaryl-Coenzyme A reductase, at least one other sterol synthesis pathway enzyme and at least one tocopherol synthesis enzyme.
摘要翻译：公开了包含编码3-羟基-3甲基戊二酰辅酶A还原酶和至少一种其它甾醇合成途径酶的序列的构建体。还公开了使用这种构建体来改变植物的细胞，植物，种子和储存器官中的固醇产生和含量的方法。还提供了含有通过使用所公开的构建体产生的改变的固醇水平的油和组合物。还提供了可用于改变甾醇生产的新型核苷酸序列。还提供了包含编码3-羟基-3甲基戊二酰辅酶A还原酶，至少一种其它甾醇合成途径酶和至少一种生育酚合成酶的序列的植物的细胞，植物，种子和储存器官。

10. 发明授权

US08642340B2 Plant cell culture for production of natural products with reduced glucosinolate contamination 失效
标题翻译：用于生产具有降低的硫代葡萄糖苷污染的天然产物的植物细胞培养物
公开(公告)号：US08642340B2
公开(公告)日：2014-02-04
申请号：US13140381
申请日：2009-12-17
申请人： Helena V. Mathews , Sung-Yong Yoon , Mylavarapu Venkatramesh
发明人： Helena V. Mathews , Sung-Yong Yoon , Mylavarapu Venkatramesh
IPC分类号： C12N5/00
CPC分类号： C12P17/06 , A01H4/00 , C12N5/04
摘要： Disclosed are methods for obtaining a natural product preparation with reduced glucosinolate contamination from a plant of Brassicaceae. The methods can include cultivating a plant callus from a plant capable of producing a desired natural product, selecting a callus with reduced glucosinolate production, and cultivating the selected callus in a liquid medium. The method can also include recovering the natural product from the culture. Also disclosed are methods for obtaining cabbage anthocyanin with reduced glucosinolate contamination. The methods can include cultivating a red cabbage plant callus with reduced glucosinolate production in a liquid medium to obtain a suspension culture and cultivating the suspension culture in a medium lacking a nitrogen source. The method can also include recovering the anthocyanin with reduced glucosinolate contamination from the culture. Finally, several specific low-glucosinolate cell lines are described.
摘要翻译：本发明公开了一种从甘蓝科植物获得具有降低的硫代葡萄糖苷污染的天然产物制剂的方法。所述方法可以包括从能够产生所需天然产物的植物培养植物愈伤组织，选择具有降低的硫代葡萄糖苷产生的愈伤组织，以及在液体培养基中培养所选择的愈伤组织。该方法还可以包括从培养物中回收天然产物。还公开了获得具有降低的硫代葡萄糖苷污染的甘蓝花青素的方法。该方法可以包括在液体培养基中培养具有降低的硫代葡萄糖苷产量的红甘蓝植物愈伤组织以获得悬浮培养物，并在不含氮源的培养基中培养悬浮培养物。该方法还可以包括从培养物中降低芥子油苷污染来回收花青素。最后，描述了几种特异性低硫代葡萄糖苷酸细胞系。

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