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    • 2. 发明申请
    • Merocyanine derivatives for cosmetic use
    • 用于化妆品使用的花青衍生物
    • US20090175809A1
    • 2009-07-09
    • US12378566
    • 2009-02-17
    • Barbara WagnerThomas EhlisStefan Muller
    • Barbara WagnerThomas EhlisStefan Muller
    • A61K8/37C07C255/31C07C229/46C07D295/14C07D413/12C07D401/12C07D403/12A61Q17/04
    • C07D295/116A61K8/41A61K8/44A61K8/46A61K8/494A61K8/81A61Q17/00A61Q17/02C07C225/20C07C229/46C07C255/31C07C317/48C07C2601/14C07C2601/16C07D295/155
    • Described are merocyanine derivatives of formula wherein R2 is hydrogen; C1-C22alkyl; cyclo-C3-C8alkyl; unsubstituted or C1-C6alkyl- or C1-C6alkoxy-substituted C6-C20aryl; a cyano group; or R1 and R2 together with the nitrogen atom linking them form a —(CH2)m— ring which is optionally interrupted by —O— or by —NR7—; R4 is a cyano group; or -Q1-R5; Q1 is —COO—; —CONH—; —CO—; —SO2—; or —CONR6—; R5 is C1-C22alkyl; cyclo-C3-C8alkyl; or unsubstituted or C1-C6alkyl-substituted C6-C20aryl; R6 is hydrogen; C1-C22alkyl; cyclo-C3-C8alkyl; unsubstituted or C1-C6alkyl- or C1-C6alkoxy-substituted C6-C20aryl; R7 is hydrogen; C1-C22alkyl; cyclo-C3-C8alkyl; unsubstituted or C1-C6alkyl- or C1-C6alkoxy-substituted C6-C20aryl; the cyclohexene radical C is not substituted or substituted by one or more C1-C5alkyl; m is from 3 to 7; n is from 2 to 4; and o is from 2 to 4. Said merocyanine derivatives are useful in protecting human and animal hair and skin from UV radiation and to cosmetic compositions comprising said derivatives.
    • 描述的是下式的部花青衍生物其中R2是氢; C 1 -C 22烷基; 环-C 3 -C 8烷基; 未取代的或C 1 -C 6烷基 - 或C 1 -C 6烷氧基取代的C 6 -C 20芳基; 氰基; 或R 1和R 2与连接它们的氮原子一起形成 - (CH 2)m - 环,其任选被-O-或-NR 7 - 间隔; R4是氰基; 或-Q1-R5; Q1是-COO-; -CONH-; -CO-; -SO2-; 或-CONR6-; R5是C1-C22烷基; 环-C 3 -C 8烷基; 或未取代的或C 1 -C 6烷基取代的C 6 -C 20芳基; R6是氢; C 1 -C 22烷基; 环-C 3 -C 8烷基; 未取代的或C 1 -C 6烷基 - 或C 1 -C 6烷氧基取代的C 6 -C 20芳基; R7是氢; C 1 -C 22烷基; 环-C 3 -C 8烷基; 未取代的或C 1 -C 6烷基 - 或C 1 -C 6烷氧基取代的C 6 -C 20芳基; 环己烯基C不被一个或多个C 1 -C 5烷基取代或取代; m为3〜7; n为2〜4; 和o为2至4.所述的部花青衍生物可用于保护人和动物毛发和皮肤免受紫外线辐射和包含所述衍生物的化妆品组合物。
    • 5. 发明授权
    • Merocyanine derivatives for cosmetic use
    • 用于化妆品使用的花青衍生物
    • US07893292B2
    • 2011-02-22
    • US12378566
    • 2009-02-17
    • Barbara WagnerThomas EhlisStefan Müller
    • Barbara WagnerThomas EhlisStefan Müller
    • C07C255/00A61K8/00A61K8/18A61K8/49A61K31/13A61K31/16A61Q17/04A01N33/00A01N33/02
    • C07D295/116A61K8/41A61K8/44A61K8/46A61K8/494A61K8/81A61Q17/00A61Q17/02C07C225/20C07C229/46C07C255/31C07C317/48C07C2601/14C07C2601/16C07D295/155
    • Described are merocyanine derivatives of formula wherein R2 is hydrogen; C1-C22alkyl; cyclo-C3-C8alkyl; unsubstituted or C1-C6alkyl- or C1-C6alkoxy-substituted C6-C20aryl; a cyano group; or R1 and R2 together with the nitrogen atom linking them form a —(CH2)m— ring which is optionally interrupted by —O— or by —NR7—; R4 is a cyano group; or -Q1-R5; Q1 is —COO—; —CONH—; —CO—; —SO2—; or —CONR6—; R5 is C1-C22alkyl; cyclo-C3-C8alkyl; or unsubstituted or C1-C6alkyl-substituted C6-C20aryl; R6 is hydrogen; C1-C22alkyl; cyclo-C3-C8alkyl; unsubstituted or C1-C6alkyl- or C1-C6alkoxy-substituted C6-C20aryl; R7 is hydrogen; C1-C22alkyl; cyclo-C3-C8alkyl; unsubstituted or C1-C6alkyl- or C1-C6alkoxy-substituted C6-C20aryl; the cyclohexene radical C is not substituted or substituted by one or more C1-C5alkyl; m is from 3 to 7; n is from 2 to 4; and o is from 2 to 4. Said merocyanine derivatives are useful in protecting human and animal hair and skin from UV radiation and to cosmetic compositions comprising said derivatives.
    • 描述的是下式的部花青衍生物其中R2是氢; C 1 -C 22烷基; 环-C 3 -C 8烷基; 未取代的或C 1 -C 6烷基 - 或C 1 -C 6烷氧基取代的C 6 -C 20芳基; 氰基; 或R 1和R 2与连接它们的氮原子一起形成 - (CH 2)m - 环,其任选被-O-或-NR 7 - 间隔; R4是氰基; 或-Q1-R5; Q1是-COO-; -CONH-; -CO-; -SO2-; 或-CONR6-; R5是C1-C22烷基; 环C 3 -C 8烷基; 或未取代的或C 1 -C 6烷基取代的C 6 -C 20芳基; R6是氢; C 1 -C 22烷基; 环-C 3 -C 8烷基; 未取代的或C 1 -C 6烷基 - 或C 1 -C 6烷氧基取代的C 6 -C 20芳基; R7是氢; C 1 -C 22烷基; 环-C 3 -C 8烷基; 未取代的或C 1 -C 6烷基 - 或C 1 -C 6烷氧基取代的C 6 -C 20芳基; 环己烯基C不被一个或多个C 1 -C 5烷基取代或取代; m为3〜7; n为2〜4; 和o为2至4.所述的部花青衍生物可用于保护人和动物毛发和皮肤免受紫外线辐射和包含所述衍生物的化妆品组合物。
    • 6. 发明授权
    • Merocyanine derivatives
    • US07772242B2
    • 2010-08-10
    • US11630489
    • 2005-06-20
    • Barbara WagnerFrank BienewaldHeinz WollebOlof WallquistBernd HerzogThomas EhlisJürg Haase
    • Barbara WagnerFrank BienewaldHeinz WollebOlof WallquistBernd HerzogThomas EhlisJürg Haase
    • A61K31/519A61K31/445A61K31/16A61K31/165
    • A61K8/498A61K8/4913A61K8/494A61Q17/04
    • Disclosed is the use of the compounds of formula  wherein Q is —OH; —OR7; —NH2; —NHR7; —NR7R8; or —N═R9; T is —COR5; —CN; or —SO2—(C6-C12)aryl; R1 is hydrogen; —OR7, —SR7; —NHR7; —NR7R8; C1-C22alkyl; C2-C12Alkenyl; C2-C12alkinyl; C3-C12cycloalkyl; C3-C12cycloalkenyl; C7-C12aralkyl; C1-C12heteroalkyl, C2-C11heteroaralkyl; C6-C10aryl; or C1-C9heteroaryl; R2 and R3 independently from each other are C1-C22alkyl; C2-C12alkenyl; C2-C12alkinyl; C3-C12cycloalkyl, C3-C12cycloalkenyl; C7-C12aralkyl; C1-C12heteroalkyl; C3-C12cycloheteroalkyl; C2-C11heteroaralkyl, C6-C10aryl; or C1-C9heteroaryl; R4 is cyano; COR7, COOR7; CONH2; CONHR7; CONR7R8; SO2(C6-C12)aryl, C2-C12alk-1 -enyl; C3-C12cycloalk-1-enyl; C2-C12alk-1-inyl; C2-C12heteroalkyl, C3-C5heterocycloalkyl, C6-C10aryl; or C1-C9heteroaryl; R5 is —COR7; —COOR7; —OR7; —SR7, —NHR7, —NR7R8; C1-C22alkyl; C2-C12alkenyl; C2-C12alkinyl; C3-C12cycloalkyl; C3-C12cycloalkenyl; C7-C12aralkyl; C1-C12alkylphenyl; C1-C12alkoxy-C6-C10aryl; C1-C12heteroalkyl; C2-C11heteroaralkyl; C3-C12cycloheteroalkyl; C6-C10aryl; C1-C12alkoxy-C6-C10aryl or C1-C9heteroaryl; R6, R7 and R8 independently from each other are hydrogen; C1-C22alkyl; C2-C12alkenyl; C2-C12alkinyl; C3-C12cycloalkyl; C3-C12cycloalkenyl; C7-C12aralkyl; C1-C12heteroalkyl; C2-C11heteroaralkyl; C6-C10aryl; o-C6-C10aryl; or C1-C9heteroaryl; R9 is a (C1-C6)alkylidene radical; or R1 and R2, R1 and Q, R1 and R4, R1 and R6, R2 and R3, R3 and Q, R6 and Q, T and Q, each independently, are linked together, so that 1, 2, 3 or 4 carbocyclic or N, O and/or S-heterocyclic rings are formed, wherein each of them, independently from each other, may be condensed with an aromatic or heteroaromatic ring, and/or more N-, O- and/or S-heterocycic rings, and each N atom in a N-heterocyclic ring may be substituted by C1-C22alkyl; and n is a number from 1 to 4; for protecting of human hair and skin against the damaging effect of UV radiation.
    • 10. 发明授权
    • Merocyanine derivatives
    • 梅花菁衍生物
    • US08044058B2
    • 2011-10-25
    • US12715839
    • 2010-03-02
    • Barbara WagnerFrank BienewaldHeinz WollebOlof WallquistBernd HerzogThomas EhlisJürg Haase
    • Barbara WagnerFrank BienewaldHeinz WollebOlof WallquistBernd HerzogThomas EhlisJürg Haase
    • A61K31/517A61K31/445A61K31/16
    • A61K8/498A61K8/4913A61K8/494A61Q17/04
    • Disclosed is the use of merocyanine derivatives of formula Q is hydrogen; C1-C22alkyl; —OH; —OR7; —NR7R8; or —N═R9; R1 is hydrogen; C1-C22alkyl; —OR7, —SR7; —NR7R8; C1-C22alkyl; C2-C12 alkenyl; C2-C12alkinyl; C3-C12cycloalkyl; C3-C12cycloalkenyl; C7-C12aralkyl; C1-C12heteroalkyl, C2-C11heteroaralkyl; C6-C10aryl; or C1-C9heteroaryl; R4 is cyano; COR7, COOR7; CONR7R8; SO2(C6-C12)aryl; C2-C12alk-1-enyl; C3-C12cycloalk-1-enyl; C2-C12alk-1-inyl; C2-C12heteroalkyl; C3-C5heterocycloalkyl; C6-C10aryl; or C1-C9heteroaryl; R5 is —COR7; —COOR7; —OR7; —SR7, —NHR7, —NR7R8; C1-C22alkyl; C2-C12alkenyl; C2-C12alkinyl; C3-C12cycloalkyl; C3-C12cycloalkenyl; C7-C12aralkyl; C1-C12alkylphenyl; C1-C12alkoxy-C6-C10aryl; C1-C12heteroalkyl; C2-C11heteroaralkyl; C3-C12cycloheteroalkyl; C6-C10aryl; C1-C12alkoxy-C6-C10aryl; or C1-C9heteroaryl; R6 is hydrogen; C1-C22alkyl; C1-C22alkoxy; or COR7; R7 and R8 independently from each other are hydrogen; C1-C22alkyl; C2-C12alkenyl; C2-C12alkinyl; C3-C12cycloalkyl; C3-C12cycloalkenyl; —(CH2)tCOOH; C7-C12aralkyl; C1-C12heteroalkyl; C2-C11heteroaralkyl; C6-C10aryl; C1-C9heteroaryl; Si—R10R11R12; Si(OR10)(OR11)(OR12); SiR10(OR11)(OR12); SiR10R11(OR12); —(CH2)u—O—(CH2)v—SiR10R11R12; or a radical X-Sil; t, u and v, independently from each other are a number from 1 to 5; R9 is a (C1-C6)alkylidene radical; R10, R11, R12 independently form each other are C1-C22alkyl; X is a linker; for protecting of human hair and skin against the damaging effect of UV radiation.
    • 披露式Q的部花青衍生物的用途是氢; C 1 -C 22烷基; -哦; -OR7; -NR7R8; 或-N = R9; R1是氢; C 1 -C 22烷基; -OR7,-SR7; -NR7R8; C 1 -C 22烷基; C 2 -C 12烯基; C 2 -C 12炔基; C 3 -C 12环烷基; C3-C12环烯基; C7-C12芳烷基; C 1 -C 12杂烷基,C 2 -C 11杂芳烷基; C6-C10芳基; 或C 1 -C 9杂芳基; R4是氰基; COR7,COOR7; CONR7R8; SO2(C6-C12)芳基; C2-C12烷-1-烯基; C 3 -C 12环烯-1-烯基; C2-C12alk-1-inyl; C 2 -C 12杂烷基; C3-C5杂环烷基; C6-C10芳基; 或C 1 -C 9杂芳基; R5为-COR7; -COOR7; -OR7; -SR 7,-NHR 7,-NR 7 R 8; C 1 -C 22烷基; C 2 -C 12烯基; C 2 -C 12炔基; C 3 -C 12环烷基; C3-C12环烯基; C7-C12芳烷基; C 1 -C 12烷基苯基; C 1 -C 12烷氧基-C 6 -C 10芳基; C 1 -C 12杂烷基; C 2 -C 11杂芳烷基; C 3 -C 12环杂烷基; C6-C10芳基; C 1 -C 12烷氧基-C 6 -C 10芳基; 或C 1 -C 9杂芳基; R6是氢; C 1 -C 22烷基; C1-C22烷氧基; 或COR7; R 7和R 8彼此独立地是氢; C 1 -C 22烷基; C 2 -C 12烯基; C 2 -C 12炔基; C 3 -C 12环烷基; C3-C12环烯基; - (CH 2)t COOH; C7-C12芳烷基; C 1 -C 12杂烷基; C 2 -C 11杂芳烷基; C6-C10芳基; C1-C9杂芳基; Si-R10R11R12; Si(OR10)(OR11)(OR12); SiR10(OR11)(OR12); SiR10R11(OR12); - (CH 2)u -O-(CH 2)v -SiR 10 R 11 R 12; 或基团X-Sil; t,u和v彼此独立地为1至5的数; R9是(C1-C6)亚烷基; R 10,R 11,R 12彼此独立地为C 1 -C 22烷基; X是一个连接子; 用于保护人的头发和皮肤免受紫外线辐射的破坏作用。