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1. 发明授权

US07116423B2 Flow cell for optical detection having reduced sensitivity to refractive index variation 有权
$Flow cell for optical detection having reduced sensitivity to refractive index variation$
标题翻译：用于光学检测的流动池具有降低的对折射率变化的敏感性
公开(公告)号：US07116423B2
公开(公告)日：2006-10-03
申请号：US10700947
申请日：2003-10-31
申请人： Barbara A. Paldus , Alexander Katchanov , Robert Lodenkamper
发明人： Barbara A. Paldus , Alexander Katchanov , Robert Lodenkamper
IPC分类号： G01N21/00
CPC分类号： G01N21/39
摘要： An apparatus for cavity enhanced optical detection having an improved flow cell is provided. Sensitivity of the cavity resonance condition to changes in refractive index of an analyte flowing through the flow cell is reduced. More specifically, the round trip optical path defined by the resonant cavity intersects a curved cavity input mirror at a point. This point has a location on the input mirror that is substantially independent of the refractive index of the analyte. In this manner, changes in sample refractive index do not lead to misalignment of the resonant optical cavity.
摘要翻译：提供一种具有改进的流通池的腔增强光学检测装置。空腔共振条件对流过流动池的分析物的折射率变化的灵敏度降低。更具体地，由谐振腔定义的往返光路在一点与相交的曲面腔输入镜相交。这一点在输入镜上具有基本上独立于分析物的折射率的位置。以这种方式，样品折射率的变化不会导致共振光学腔的未对准。

2. 发明授权

US06970484B2 Laser tuning by spectrally dependent spatial filtering 失效
公开(公告)号：US06970484B2
公开(公告)日：2005-11-29
申请号：US11106000
申请日：2005-04-13
申请人： Barbara Paldus , Jinchun Xie , Robert Lodenkamper , David M. Adams , Eric Crosson , Alexander Katchanov , Grzegorz Pakulski , Chris W. Rella , Bruce A. Richman
发明人： Barbara Paldus , Jinchun Xie , Robert Lodenkamper , David M. Adams , Eric Crosson , Alexander Katchanov , Grzegorz Pakulski , Chris W. Rella , Bruce A. Richman
IPC分类号： H01S5/065 , H01S3/106 , H01S5/10 , H01S5/14 , H01S3/10
CPC分类号： H01S5/141 , H01S3/1068 , H01S5/101 , H01S5/1085 , H01S5/142
摘要： A tunable laser and laser tuning method, based on the interaction of a spectrally dependent beam distortion and a spatial filter within a laser cavity. One embodiment of this laser is an external cavity semiconductor laser in which broad tunability is obtained by the insertion of an acousto-optic tunable filter (AOTF) into the laser cavity such that the intra-cavity laser beam passes through the AOTF in zeroth order.

3. 发明申请

US20050175045A1 Laser tuning by spectrally dependent spatial filtering 失效
标题翻译：通过光谱依赖空间滤波进行激光调谐
公开(公告)号：US20050175045A1
公开(公告)日：2005-08-11
申请号：US11106000
申请日：2005-04-13
申请人： Barbara Paldus , Jinchun Xie , Robert Lodenkamper , David Adams , Eric Crosson , Alexander Katchanov , Grzegorz Pakulski , Chris Rella , Bruce Richman
发明人： Barbara Paldus , Jinchun Xie , Robert Lodenkamper , David Adams , Eric Crosson , Alexander Katchanov , Grzegorz Pakulski , Chris Rella , Bruce Richman
IPC分类号： H01S5/065 , H01S3/106 , H01S5/10 , H01S5/14 , H01S3/10
CPC分类号： H01S5/141 , H01S3/1068 , H01S5/101 , H01S5/1085 , H01S5/142
摘要： A tunable laser and laser tuning method, based on the interaction of a spectrally dependent beam distortion and a spatial filter within a laser cavity. One embodiment of this laser is an external cavity semiconductor laser in which broad tunability is obtained by the insertion of an acousto-optic tunable filter (AOTF) into the laser cavity such that the intra-cavity laser beam passes through the AOTF in zeroth order.
摘要翻译：基于频谱依赖的波束失真和激光腔内的空间滤波器的相互作用的可调激光和激光调谐方法。该激光器的一个实施例是外腔半导体激光器，其中通过将声光可调滤波器（AOTF）插入到激光腔中获得宽可调性，使得腔内激光束以零级顺序通过AOTF。

4. 发明授权

US06959024B2 Laser Tuning by spectrally dependent spatial filtering 有权
标题翻译：激光通过光谱依赖空间滤波进行调谐
公开(公告)号：US06959024B2
公开(公告)日：2005-10-25
申请号：US10308541
申请日：2002-12-02
申请人： Barbara Paldus , Jinchun Xie , Robert Lodenkamper , David M. Adams , Eric Crosson , Alexander Katchanov , Grzegorz Pakulski , Chris W. Rella , Bruce A. Richman , Serguei Koulikov
发明人： Barbara Paldus , Jinchun Xie , Robert Lodenkamper , David M. Adams , Eric Crosson , Alexander Katchanov , Grzegorz Pakulski , Chris W. Rella , Bruce A. Richman , Serguei Koulikov
IPC分类号： H01S5/065 , H01S3/106 , H01S5/10 , H01S5/14 , H01S3/10
CPC分类号： H01S5/141 , H01S3/1068 , H01S5/101 , H01S5/1085 , H01S5/142
摘要： A laser tuning mechanism which embodies “spectrally dependent spatial filtering” (SDSF) and contemplates two key elements of the tuning mechanism. The first element of the SDSF tuning mechanism is a spectrally dependent beam distortion (i.e. alteration of the amplitude and/or phase profile of the beam) provided by an SDSF tuning element in a laser cavity. The second element of the SDSF tuning mechanism is an intracavity spatial filter which makes the round trip cavity loss a sensitive function of both beam distortion and cavity alignment. Such a laser can be aligned so that a specific beam distortion, which is provided by the SDSF tuning element at a tunable wavelength, is required to obtain minimum round trip cavity loss, thereby providing tunable laser emission. A preferred embodiment of the SDSF tuning mechanism is an external cavity semiconductor laser having a zeroth order acousto-optic tuning element.
摘要翻译：激光调谐机制体现了“光谱依赖空间滤波”（SDSF），并考虑了调谐机制的两个关键要素。 SDSF调谐机构的第一要素是由激光腔中的SDSF调谐元件提供的频谱依赖的光束失真（即光束的振幅和/或相位分布的改变）。 SDSF调谐机构的第二个元素是腔内空间滤波器，其使得往返腔体损耗具有波束失真和腔体对准的敏感功能。这样的激光器可以对齐，使得由SDSF调谐元件提供的可调谐波长的特定光束失真是需要的，以获得最小的往返腔损耗，从而提供可调谐的激光发射。 SDSF调谐机构的优选实施例是具有零级声光调谐元件的外腔半导体激光器。

5. 发明申请

US20050243884A1 Laser tuning by spectrally dependent spatial filtering 审中-公开
标题翻译：通过光谱依赖空间滤波进行激光调谐
公开(公告)号：US20050243884A1
公开(公告)日：2005-11-03
申请号：US11176059
申请日：2005-07-07
申请人： Barbara Paldus , Jinchun Xie , Robert Lodenkamper , David Adams , Eric Crosson , Alexander Katchanov , Grzegorz Pakulski , Chris Rella , Bruce Richman , Serguei Koulikov
发明人： Barbara Paldus , Jinchun Xie , Robert Lodenkamper , David Adams , Eric Crosson , Alexander Katchanov , Grzegorz Pakulski , Chris Rella , Bruce Richman , Serguei Koulikov
IPC分类号： H01S5/065 , H01S3/106 , H01S5/10 , H01S5/14 , H01S3/093
CPC分类号： H01S5/141 , H01S3/1068 , H01S5/101 , H01S5/1085 , H01S5/142
摘要： A laser tuning mechanism which embodies “spectrally dependent spatial filtering” (SDSF) and contemplates two key elements of the tuning mechanism. The first element of the SDSF tuning mechanism is a spectrally dependent beam distortion (i.e. alteration of the amplitude and/or phase profile of the beam) provided by an SDSF tuning element in a laser cavity. The second element of the SDSF tuning mechanism is an intracavity spatial filter which makes the round trip cavity loss a sensitive function of both beam distortion and cavity alignment. Such a laser can be aligned so that a specific beam distortion, which is provided by the SDSF tuning element at a tunable wavelength, is required to obtain minimum round trip cavity loss, thereby providing tunable laser emission. A preferred embodiment of the SDSF tuning mechanism is an external cavity semiconductor laser having a zeroth order acousto-optic tuning element.
摘要翻译：激光调谐机制体现了“光谱依赖空间滤波”（SDSF），并考虑了调谐机制的两个关键要素。 SDSF调谐机构的第一要素是由激光腔中的SDSF调谐元件提供的频谱依赖的光束失真（即光束的振幅和/或相位分布的改变）。 SDSF调谐机构的第二个元素是腔内空间滤波器，其使得往返腔体损耗具有波束失真和腔体对准的敏感功能。这样的激光器可以对齐，使得由SDSF调谐元件提供的可调谐波长的特定光束失真是需要的，以获得最小的往返腔损耗，从而提供可调谐的激光发射。 SDSF调谐机构的优选实施例是具有零级声光调谐元件的外腔半导体激光器。

6. 发明申请

US20050094158A1 Flow cell for optical detection having reduced sensitivity to refractive index variation 有权
$Flow cell for optical detection having reduced sensitivity to refractive index variation$
标题翻译：用于光学检测的流动池具有降低的对折射率变化的敏感性
公开(公告)号：US20050094158A1
公开(公告)日：2005-05-05
申请号：US10700947
申请日：2003-10-31
申请人： Barbara Paldus , Alexander Katchanov , Robert Lodenkamper
发明人： Barbara Paldus , Alexander Katchanov , Robert Lodenkamper
IPC分类号： G01N21/39 , G01B9/02
CPC分类号： G01N21/39
摘要： An apparatus for cavity enhanced optical detection comprising: a) a source of optical radiation b) a resonant optical cavity which provides a round trip path for said optical radiation the cavity comprising: i) a plurality of mirrors, the first mirror being an input mirror which receives the optical radiation and inputs it into the cavity; ii) a flow cell positioned within said cavity, said flow cell comprising at least a first analysis channel which accommodates a flow of analyte fluid there through, iii) a second mirror, which second mirror receives the radiation from the optical source after its passage through both said input mirror and said analysis channel and reflects said received radiation. The resonant optical cavity provides a round trip path for analyte fluid having at least two different refractive index values and the location of the point at which said reflected radiation impinges on said input mirror remains substantially the same as the point from which said first mirror inputs said radiation into said cavity notwithstanding changes in the refractive index of the analyte fluid or the wavelength of the optical radiation.
摘要翻译：一种用于空腔增强光学检测的装置，包括：a）光辐射源; b）谐振光学腔，其为所述光辐射提供所述光辐射的往返路径，所述光腔包括：i）多个反射镜，所述第一反射镜是输入镜其接收光辐射并将其输入到腔中; ii）位于所述空腔内的流动池，所述流动池包括至少第一分析通道，其容纳其中通过的分析物流体流，iii）第二反射镜，所述第二反射镜在其通过之后接收来自光源的辐射所述输入反射镜和所述分析通道都反映所述接收的辐射。谐振光学腔提供具有至少两个不同折射率值的分析物流体的往返路径，并且所述反射辐射照射在所述输入反射镜上的点的位置保持与所述第一反射镜从其输入所述输入反射镜的点大致相同尽管分析物流体的折射率或光辐射的波长发生变化，但是辐射进入所述腔。

7. 发明申请

US20050134836A1 Cavity enhanced optical detector 有权
标题翻译：腔增强型光检测器
公开(公告)号：US20050134836A1
公开(公告)日：2005-06-23
申请号：US10738599
申请日：2003-12-17
申请人： Barbara Paldus , Robert Provencal , Alexander Katchanov
发明人： Barbara Paldus , Robert Provencal , Alexander Katchanov
IPC分类号： G01J3/42 , G01J3/44 , G01N21/39 , G01N21/64 , G01N21/00
CPC分类号： G01N21/658 , G01J3/10 , G01J3/42 , G01J3/44 , G01N21/39 , G01N21/6402 , G01N2021/651 , G01N2021/655
摘要： A cavity enhanced optical detector comprising: i) a source of continuous wave laser light; ii) a high finesse resonant cavity comprising at least three spaced apart, high-reflectivity mirrors positioned to receive light from the laser light source; iii) at least one photo-detector for measuring the extinction coefficient of an analyte that is positioned in the resonant cavity; and iv) one or more additional photo-detectors for measuring the intensity of fluorescence emission and/or Raman scattering from the analyte.
摘要翻译：一种空腔增强型光学检测器，包括：i）连续波激光源; ii）高精细谐振腔，包括至少三个间隔开的高反射率反射镜，其被定位成接收来自激光光源的光; iii）至少一个光检测器，用于测量位于谐振腔中的分析物的消光系数; 和iv）一个或多个额外的光检测器，用于测量来自分析物的荧光发射强度和/或拉曼散射。

8. 发明授权

US07154595B2 Cavity enhanced optical detector 有权
标题翻译：腔增强型光检测器
公开(公告)号：US07154595B2
公开(公告)日：2006-12-26
申请号：US10738599
申请日：2003-12-17
申请人： Barbara Paldus , Alexander Katchanov , Robert Provencal
发明人： Barbara Paldus , Alexander Katchanov , Robert Provencal
IPC分类号： G01N21/00
CPC分类号： G01N21/658 , G01J3/10 , G01J3/42 , G01J3/44 , G01N21/39 , G01N21/6402 , G01N2021/651 , G01N2021/655
摘要： A cavity enhanced optical detector comprising: i) a source of continuous wave laser light; ii) a high finesse resonant cavity comprising at least three spaced apart, high-reflectivity mirrors positioned to receive light from the laser light source; iii) at least one photo-detector for measuring the extinction coefficient of an analyte that is positioned in the resonant cavity; and iv) one or more additional photo-detectors for measuring the intensity of fluorescence emission and/or Raman scattering from the analyte.
摘要翻译：一种空腔增强型光学检测器，包括：i）连续波激光源; ii）高精细谐振腔，包括至少三个间隔开的高反射率反射镜，其被定位成接收来自激光光源的光; iii）至少一个光检测器，用于测量位于谐振腔中的分析物的消光系数; 和iv）一个或多个额外的光检测器，用于测量来自分析物的荧光发射强度和/或拉曼散射。

9. 发明授权

US06859284B2 Apparatus and method for determining wavelength from coarse and fine measurements 失效
标题翻译：用于从粗细测量确定波长的装置和方法
公开(公告)号：US06859284B2
公开(公告)日：2005-02-22
申请号：US10308779
申请日：2002-12-02
申请人： Chris W. Rella , Alexander Katchanov
发明人： Chris W. Rella , Alexander Katchanov
IPC分类号： G01J3/26 , G01J9/02 , G01B9/02
CPC分类号： G01J9/0246
摘要： The present invention provides an apparatus for determining a wavelength of an optical signal by determining a coarse wavelength response and a fine wavelength response. The coarse wavelength response is achieved by utilizing an optical filter. A suitable detector detects the wavelength-dependent response and conveys the determined coarse wavelength response to the processing logic. The fine wavelength response is achieved by utilizing an interferometer that is capable of generating an interference pattern. Two detectors are disposed in the interference pattern at a quadrature separation from each other and detect the intensity responses at their respective locations. The intensity responses are conveyed to a unit that determines the fine wavelength response. Finally, the processing logic determines the wavelength utilizing the determined coarse wavelength response and the determined fine wavelength response.
摘要翻译：本发明提供一种通过确定粗略的波长响应和精细的波长响应来确定光信号的波长的装置。通过利用光学滤波器实现粗略的波长响应。合适的检测器检测与波长相关的响应，并将确定的粗波长响应传送到处理逻辑。通过利用能够产生干涉图案的干涉仪来实现良好的波长响应。两个检测器以干涉图案彼此正交分离地设置并检测其各自位置处的强度响应。强度响应被传送到确定精细波长响应的单元。最后，处理逻辑使用所确定的粗略波长响应和确定的精细波长响应来确定波长。

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