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1. 发明授权

US07988685B2 Hydrogel compositions, devices, and microscale components 有权
标题翻译：水凝胶组合物，装置和微量元件
公开(公告)号：US07988685B2
公开(公告)日：2011-08-02
申请号：US10494119
申请日：2002-11-01
申请人： Babak Ziaie , Ronald A. Siegel , Yuandong Gu , Antonio Baldi , Gauri P. Misra , Paul E. Loftness , Ming Lei
发明人： Babak Ziaie , Ronald A. Siegel , Yuandong Gu , Antonio Baldi , Gauri P. Misra , Paul E. Loftness , Ming Lei
IPC分类号： A61M5/00 , H01L21/00 , H01L21/76
CPC分类号： A61K9/0024 , A61F2/022 , A61K47/34 , A61L29/145 , A61L29/16 , A61L31/145 , A61L2300/43 , A61L2300/602 , A61L2300/80
摘要： The invention provides hydrogel compositions, components, and hydrogel-actuated or mediated devices, and methods for the incorporation of hydrogel microscale components in microscale devices and systems. The methods and devices result in active microvalves that are useful in microfluidic applications, including analyte sensing, in process chemical and fermentation stream monitoring, and drug delivery. In particular, the devices are useful for controlled drug delivery either in response to a pre-determined stimulus or for pulsatile delivery.
摘要翻译：本发明提供水凝胶组合物，组分和水凝胶致动或介导的装置，以及用于在微尺度装置和系统中结合水凝胶微量元件的方法。这些方法和装置导致在微流体应用中有用的活性微血管，包括分析物感测，在过程化学和发酵流监测和药物递送。特别地，所述装置可用于响应于预先确定的刺激或用于脉动递送的受控药物递送。

2. 发明申请

US20130245402A1 SENSOR HAVING FERROGEL WITH MAGNETIC PARTICLES 有权
标题翻译：具有磁性颗粒的传感器
公开(公告)号：US20130245402A1
公开(公告)日：2013-09-19
申请号：US13800860
申请日：2013-03-13
申请人： Babak Ziaie , Ronald A. Siegel
发明人： Babak Ziaie , Ronald A. Siegel
IPC分类号： A61B5/145
CPC分类号： A61B5/14503 , A61B5/05 , A61B5/14532 , G01N27/72
摘要： A sensor for detecting a condition includes a hydrogel configured to change thickness or volume in response to the condition. Magnetic particles are arranged in the hydrogel so that a magnetic property of the hydrogel changes with changes of thickness or volume of the hydrogel. Some such sensors include a magnetic-field detector that measures the magnetic field of the hydrogel. Other such sensors include a device coil is arranged with respect to the hydrogel so that changes in the magnetic property modulate an electrical property of the sensor. A sensing system using such a sensor includes a reader spaced apart from the sensor and including a reader coil and a resonance detector coupled to the reader coil to detect a the resonant frequency of the sensor. Changes in the magnetic property detectably modulate the resonant frequency.
摘要翻译：用于检测状况的传感器包括水凝胶，其被配置成响应于该状况改变厚度或体积。磁性颗粒被布置在水凝胶中，使得水凝胶的磁性能随着水凝胶的厚度或体积的变化而变化。一些这样的传感器包括测量水凝胶磁场的磁场检测器。其他这样的传感器包括相对于水凝胶布置的装置线圈，使得磁性能的变化调节传感器的电性能。使用这种传感器的感测系统包括与传感器间隔开的读取器，并且包括读取器线圈和耦合到读取器线圈的谐振检测器，以检测传感器的谐振频率。磁性能的改变可以侦测地调制谐振频率。

3. 发明申请

US20150087945A1 LASER-SCRIBED FERROGEL SENSOR WITH MAGNETIC PARTICLES 有权
标题翻译：具有磁性颗粒的激光雷达传感器
公开(公告)号：US20150087945A1
公开(公告)日：2015-03-26
申请号：US14557247
申请日：2014-12-01
申请人： Babak Ziaie , Ronald A. Siegel
发明人： Babak Ziaie , Ronald A. Siegel
IPC分类号： A61B5/05 , G01R3/00 , A61B5/145
CPC分类号： A61B5/05 , A61B5/0031 , A61B5/14503 , A61B5/14532 , A61B5/14539 , A61K9/0009 , A61K9/06 , A61K47/32 , G01R3/00 , Y10T29/49155
摘要： A method of making a sensor includes depositing a layer of hydrogel over a substrate, the hydrogel configured to change thickness or volume in response to a selected condition and including a plurality of magnetic particles disposed in the hydrogel so that a magnetic property of the hydrogel changes with changes of thickness or volume of the hydrogel. The hydrogel is sacrificed in selected region(s) of the layer so that the hydrogel outside the selected region(s) forms a plurality of spaced-apart islands of the hydrogel. The islands of the hydrogel are enclosed in an enclosure at least partly permeable to a selected fluid. A sensor for detecting a condition includes the substrate, islands, and a device coil arranged with respect to the hydrogel so that changes in the magnetic property modulate an electrical property of the sensor. A system includes the substrate, islands, and a magnetic-field detector.
摘要翻译：一种制造传感器的方法包括在衬底上沉积一层水凝胶，该水凝胶被配置成响应于所选择的条件改变厚度或体积，并且包括设置在水凝胶中的多个磁性颗粒，使得水凝胶的磁性变化随着水凝胶的厚度或体积的变化。将水凝胶在层的选定区域中处死，使得所选区域外的水凝胶形成多个间隔开的水凝胶岛。水凝胶的岛被封闭在至少部分可渗透选定流体的外壳中。用于检测条件的传感器包括相对于水凝胶布置的衬底，岛和器件线圈，使得磁性的变化调节传感器的电性能。系统包括基板，岛和磁场检测器。

4. 发明授权

US09173994B2 Touch-actuated micropump for transdermal drug delivery and method of use 有权
标题翻译：用于透皮药物递送的触摸式微型泵和使用方法
公开(公告)号：US09173994B2
公开(公告)日：2015-11-03
申请号：US13214990
申请日：2011-08-22
申请人： Babak Ziaie , Manuel Ochoa , Charilaos Mousoulis
发明人： Babak Ziaie , Manuel Ochoa , Charilaos Mousoulis
IPC分类号： A61M5/142 , A61M5/145 , A61M37/00
CPC分类号： A61M5/14248 , A61M5/14586 , A61M5/14593 , A61M2037/0023 , A61M2037/003
摘要： A micropump device. The micropump device includes a first layer forming a first chamber configured to store a working material, a second chamber defined by a deflectable membrane in fluid communication with the first chamber and configured to deflect in response to a pressure increase in the first chamber in response to a volume increase in the first chamber, the second chamber configured to store a drug compound to be delivered to a subject's vascular system, and at least one needle in fluid communication with the second chamber and configured to penetrate a subject's skin to pump the drug compound in response to the deflection of the deflectable membrane.
摘要翻译：微型泵装置。微型泵装置包括形成第一室的第一层，其被配置为存储工作材料，第二室由可偏转膜限定，与第一室流体连通，并且被配置为响应于第一室中的压力增加而响应于所述第一室中的体积增加，所述第二室被配置为储存要输送到受试者的血管系统的药物化合物，以及至少一个与所述第二室流体连通的针，并且构造成穿透受试者的皮肤以泵送药物组合物响应于可偏转膜的偏转。

5. 发明申请

US20090069648A1 INTRA-OCCULAR PRESSURE SENSOR 有权
标题翻译：内部压力传感器
公开(公告)号：US20090069648A1
公开(公告)日：2009-03-12
申请号：US12196534
申请日：2008-08-22
申请人： Pedro P. Irazoqui , Eric Y. Chow , William J. Chappell , Chin-Lung Yang , Babak Ziaie
发明人： Pedro P. Irazoqui , Eric Y. Chow , William J. Chappell , Chin-Lung Yang , Babak Ziaie
IPC分类号： A61B3/16 , A61B5/03 , A61B5/07
CPC分类号： A61B3/16 , A61B5/0004 , A61B5/0028 , A61B5/0031 , A61B5/03 , A61B5/6803 , A61B5/686 , A61B2562/0247
摘要： A system is provided for monitoring intraocular pressure, the system comprising: a sensor package configured to be disposed in the suprachoroidal space of a patient's eye; a pressure sensor; a wireless transceiver disposed within the sensor package and coupled to the pressure sensor; an external transceiver, the external receiver being wirelessly coupled to the wireless transceiver when the transceiver is disposed proximate to the patient's eye.
摘要翻译：提供了一种用于监测眼内压的系统，所述系统包括：传感器封装，其被配置为设置在患者眼睛的脉络膜上空间中; 压力传感器; 布置在所述传感器封装内并耦合到所述压力传感器的无线收发器; 外部收发器，当收发器被布置成靠近病人的眼睛时，外部接收器无线耦合到无线收发器。

6. 发明申请

US20120170050A1 Reflective Diffractometric Hydrogel Sensor for Biological and Chemical Detection 有权
$Reflective Diffractometric Hydrogel Sensor for Biological and Chemical Detection$
标题翻译：用于生物和化学检测的反射衍射水凝胶传感器
公开(公告)号：US20120170050A1
公开(公告)日：2012-07-05
申请号：US13311307
申请日：2011-12-05
申请人： Cagri Savran , Chun-Li Chang , Zhenwen Ding , Babak Ziaie , Andrew Ellington , Venkata Naga Lakshmi Rekha Patchigolla
发明人： Cagri Savran , Chun-Li Chang , Zhenwen Ding , Babak Ziaie , Andrew Ellington , Venkata Naga Lakshmi Rekha Patchigolla
IPC分类号： G01B11/02
CPC分类号： G01B11/14 , B82Y35/00
摘要： A reflective diffractometric hydrogel sensor includes an upper layer, including a microfluidic chamber formed from a substantially transparent material and configured to contain a solution, a reflective diffraction grating positioned within the microfluidic chamber, the diffraction grating including a plurality of hydrogel strips configured to change in dimension in response to a stimulus, each hydrogel strip having a top surface coated with a reflective material and a bottom surface in contact with the upper layer substrate, and a reflective surface below the reflective diffraction grating wherein when a coherent light is incident upon and reflected from the upper layer at an angle substantially normal to the upper layer an interference diffraction pattern results, including a first diffraction mode, a light intensity of which indicates the relative distance between the top surfaces of the plurality of hydrogel strips and the reflective surface.
摘要翻译：反射衍射水凝胶传感器包括上层，包括由基本上透明的材料形成的微流体室，并且被构造为容纳溶液，位于微流体室内的反射衍射光栅，衍射光栅包括多个水凝胶条，其被配置为在每个水凝胶条具有涂覆有反射材料的顶表面和与上层基底接触的底表面，以及反射衍射光栅下方的反射表面，其中当相干光入射并反射时导致基本垂直于上层的角度从上层开始产生干涉衍射图案，其包括第一衍射模式，其第一衍射模式的光强表示多个水凝胶条带的顶表面与反射表面之间的相对距离。

7. 发明申请

US20050107674A1 DC offset cancellation techniques 审中-公开
标题翻译：直流偏移消除技术
公开(公告)号：US20050107674A1
公开(公告)日：2005-05-19
申请号：US10953080
申请日：2004-09-29
申请人： Jayant Parthasarathy , Babak Ziaie , Aaron Redish , Arthur Erdman , Rahul Venkateswaran
发明人： Jayant Parthasarathy , Babak Ziaie , Aaron Redish , Arthur Erdman , Rahul Venkateswaran
IPC分类号： A61B5/04 , A61B5/05
CPC分类号： A61B5/04004 , A61B5/04001
摘要： The invention provides an electro-physiological system and various techniques for substantially canceling direct current (DC) offset while amplifying low frequency biological signals, e.g. local field potentials. In particular, the measured results of the invention show a DC offset rejection ratio of approximately greater than 100 dB. In one embodiment, the invention provides a method comprising receiving a biological signal including a frequency component and a DC (direct current) component, attenuating the frequency component of the biological signal to generate a second signal, and subtracting the second signal from the biological signal to generate a third signal.
摘要翻译：本发明提供了一种电生理系统和用于基本上消除直流（DC）偏移同时放大低频生物信号的各种技术，例如，局部场势。特别地，本发明的测量结果示出了大约大于100dB的DC偏移抑制比。在一个实施例中，本发明提供了一种方法，包括接收包括频率分量和DC（直流）分量的生物信号，衰减生物信号的频率分量以产生第二信号，以及从生物信号中减去第二信号以产生第三信号。

8. 发明申请

US20140147346A1 LASER TREATMENT OF A MEDIUM FOR MICROFLUIDS AND VARIOUS OTHER APPLICATIONS 审中-公开
标题翻译：用于微血管和各种其他应用的中等程度的中性粒子的激光治疗
公开(公告)号：US20140147346A1
公开(公告)日：2014-05-29
申请号：US13818081
申请日：2011-08-22
申请人： Girish Chitnis , Babak Ziaie , Zhenwen Ding
发明人： Girish Chitnis , Babak Ziaie , Zhenwen Ding
IPC分类号： B01L3/00 , B23K26/08 , B23K26/36
CPC分类号： B01L3/502707 , B23K26/082 , B23K26/361 , B81B2201/058 , B81C1/00119 , B81C2201/0143 , G01N27/44791 , H01L51/0023
摘要： A patterned circuit, including a hydrophilic substrate, a hydrophobic layer formed on the hydrophilic substrate, and a pattern formed in the hydrophobic layer to expose the hydrophilic substrate.
摘要翻译：包括亲水基底，形成在亲水基底上的疏水层的图案化电路，以及形成在疏水层中以露出亲水基底的图案。

9. 发明授权

US08663563B2 Reflective diffractometric hydrogel sensor for biological and chemical detection 有权
$Reflective diffractometric hydrogel sensor for biological and chemical detection$
标题翻译：用于生物和化学检测的反射衍射水凝胶传感器
公开(公告)号：US08663563B2
公开(公告)日：2014-03-04
申请号：US13311307
申请日：2011-12-05
申请人： Cagri Savran , Chun-Li Chang , Zhenwen Ding , Babak Ziaie , Andrew Ellington , Venkata Naga Lakshmi Rekha Patchigolla
发明人： Cagri Savran , Chun-Li Chang , Zhenwen Ding , Babak Ziaie , Andrew Ellington , Venkata Naga Lakshmi Rekha Patchigolla
IPC分类号： G01B11/02
CPC分类号： G01B11/14 , B82Y35/00
摘要： A reflective diffractometric hydrogel sensor includes an upper layer, including a microfluidic chamber formed from a substantially transparent material and configured to contain a solution, a reflective diffraction grating positioned within the microfluidic chamber, the diffraction grating including a plurality of hydrogel strips configured to change in dimension in response to a stimulus, each hydrogel strip having a top surface coated with a reflective material and a bottom surface in contact with the upper layer substrate, and a reflective surface below the reflective diffraction grating wherein when a coherent light is incident upon and reflected from the upper layer at an angle substantially normal to the upper layer an interference diffraction pattern results, including a first diffraction mode, a light intensity of which indicates the relative distance between the top surfaces of the plurality of hydrogel strips and the reflective surface.
摘要翻译：反射衍射水凝胶传感器包括上层，包括由基本上透明的材料形成的微流体室，并且被构造为容纳溶液，位于微流体室内的反射衍射光栅，衍射光栅包括多个水凝胶条，其被配置为在每个水凝胶条具有涂覆有反射材料的顶表面和与上层基底接触的底表面，以及反射衍射光栅下方的反射表面，其中当相干光入射并反射时导致基本垂直于上层的角度从上层开始产生干涉衍射图案，其包括第一衍射模式，其第一衍射模式的光强表示多个水凝胶条带的顶表面与反射表面之间的相对距离。

10. 发明申请

US20200088701A1 DEVICES, SYSTEMS, AND METHODS FOR DETECTING TARGETED COMPOUNDS 审中-公开
公开(公告)号：US20200088701A1
公开(公告)日：2020-03-19
申请号：US16085523
申请日：2017-01-19
申请人： Byunghoo Jung , Babak Ziaie , Wuyang Yu , Weeseong Seo
发明人： Byunghoo Jung , Babak Ziaie , Wuyang Yu , Weeseong Seo
IPC分类号： G01N31/22 , A61F13/42 , G01N33/52
摘要： Systems, devices, kits, and methods for detecting and quantifying targeted compounds within a liquid (such as urine) are provided. Such systems, devices, and methods may be autonomous, noninvasive, and provide quick and accurate results. The systems and devices are at least partially disposable (single-use) and configured to be embedded within or applied to a conventional diaper or the like. Methods for using the systems and devices hereof include receiving a liquid to be tested within a portion of a disposable device, allowing the liquid to traverse through one or more channels defined within the device in a controlled fashion, reacting the liquid with one or more chemical reagents, using a sensing unit to collect photocurrent data regarding the chemical reach on(s), and wirelessly transmitting that data to a computing unit for storage and quantitative analysis.

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