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1. 发明授权

US10279042B2 One-step processing of hydrogels for mechanically robust and chemically desired features 有权
公开(公告)号：US10279042B2
公开(公告)日：2019-05-07
申请号：US14604298
申请日：2015-01-23
申请人： Board of Regents, The University of Texas System
发明人： Sarah Mayes , Christine Schmidt
IPC分类号： A61K31/738 , A61K31/7008 , A61K31/734 , A61K31/728 , A61K47/36
摘要： The application of a highly controlled, micron-sized, branched, porous architecture to enhance the handling properties and degradation rate of hydrogels is described in the instant invention. A previously described pattern created through one-step nucleated crystallization in a hydrogel film creates tunable mechanical properties and/or chemical stability for use in tissue engineering applications. The bulk mechanical properties and the degradation rate of the material can be tuned easily by the addition or subtraction of crystalline structure or by the addition and subtraction of backfill material, making this useful for a variety of applications. Relevant mechanical properties that can be tuned through the application of this unique porosity are moduli, elasticity, tensile strength, and compression strength. The method of the present invention can be applied to biopolymers and natural materials as well as synthetic materials.

2. 发明申请

US20160237235A1 Dendritic Macroporous Hydrogels Prepared By Crystal Templating 有权
公开(公告)号：US20160237235A1
公开(公告)日：2016-08-18
申请号：US15135978
申请日：2016-04-22
申请人： BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
发明人： Scott Zawko , Christine Schmidt
IPC分类号： C08J9/26 , A61L27/56 , A61L27/26 , C08J5/18 , C08J3/24 , C08J5/10 , C08J3/28 , C08K5/21 , A61L27/52 , C08J3/075
CPC分类号： C08J9/26 , A61L26/0023 , A61L26/0095 , A61L27/52 , B01J13/0065 , C08B37/0015 , C08B37/003 , C08B37/0045 , C08B37/0072 , C08B37/0075 , C08B37/0084 , C08H1/06 , C08J3/075 , C08J3/24 , C08J3/242 , C08J3/26 , C08J3/28 , C08J5/10 , C08J5/18 , C08J2201/0424 , C08J2205/022 , C08J2205/04 , C08J2207/10 , C08J2305/00 , C08J2305/04 , C08J2305/08 , C08K5/0025 , C08K5/0083 , C08K5/21 , C08L5/00 , C08L5/04 , C08L5/10 , C08L5/16 , C08L89/06 , C08L5/06 , C08L5/08
摘要： The present invention includes a hydrogel and a method of making a porous hydrogel by preparing an aqueous mixture of an uncrosslinked polymer and a crystallizable molecule; casting the mixture into a vessel; allowing the cast mixture to dry to form an amorphous hydrogel film; seeding the cast mixture with a seed crystal of the crystallizable molecule; growing the crystallizable molecule into a crystal structure within the uncrosslinked polymer; crosslinking the polymer around the crystal structure under conditions in which the crystal structure within the crosslinked polymer is maintained; and dissolving the crystals within the crosslinked polymer to form the porous hydrogel.

3. 发明申请

US20220160877A1 One-Step Processing of Hydrogels for Mechanically Robust and Chemically Desired Features 有权
公开(公告)号：US20220160877A1
公开(公告)日：2022-05-26
申请号：US17669455
申请日：2022-02-11
申请人： Board of Regents, The University of Texas System
发明人： Sarah Mayes , Christine Schmidt
IPC分类号： A61K47/36 , A61K31/738
摘要： The application of a highly controlled, micron-sized, branched, porous architecture to enhance the handling properties and degradation rate of hydrogels is described in the instant invention. A previously described pattern created through one-step nucleated crystallization in a hydrogel film creates tunable mechanical properties and/or chemical stability for use in tissue engineering applications. The bulk mechanical properties and the degradation rate of the material can be tuned easily by the addition or subtraction of crystalline structure or by the addition and subtraction of backfill material, making this useful for a variety of applications. Relevant mechanical properties that can be tuned through the application of this unique porosity are moduli, elasticity, tensile strength, and compression strength. The method of the present invention can be applied to biopolymers and natural materials as well as synthetic materials.

4. 发明申请

US20180163012A1 Dendritic Macroporous Hydrogels Prepared By Crystal Templating 审中-公开
公开(公告)号：US20180163012A1
公开(公告)日：2018-06-14
申请号：US15890719
申请日：2018-02-07
申请人： BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
发明人： Scott Zawko , Christine Schmidt
IPC分类号： C08J9/26 , C08L89/06 , A61L26/00 , C08L5/10 , C08L5/04 , C08L5/00 , C08K5/21 , C08K5/00 , C08L5/16 , A61L27/52 , B01J13/00 , C08B37/16 , C08B37/08 , C08B37/00 , C08J5/18 , C08J5/10 , C08J3/28 , C08J3/24 , C08J3/075 , C08H1/06 , C08J3/26
CPC分类号： C08J9/26 , A61L26/0023 , A61L26/0095 , A61L27/52 , B01J13/0065 , C08B37/0015 , C08B37/003 , C08B37/0045 , C08B37/0072 , C08B37/0075 , C08B37/0084 , C08H1/06 , C08J3/075 , C08J3/24 , C08J3/242 , C08J3/26 , C08J3/28 , C08J5/10 , C08J5/18 , C08J2201/0424 , C08J2205/022 , C08J2205/04 , C08J2207/10 , C08J2305/00 , C08J2305/04 , C08J2305/08 , C08K5/0025 , C08K5/0083 , C08K5/21 , C08L5/00 , C08L5/04 , C08L5/10 , C08L5/16 , C08L89/06 , C08L5/06 , C08L5/08
摘要： The present invention includes a hydrogel and a method of making a porous hydrogel by preparing an aqueous mixture of an uncrosslinked polymer and a crystallizable molecule; casting the mixture into a vessel; allowing the cast mixture to dry to form an amorphous hydrogel film; seeding the cast mixture with a seed crystal of the crystallizable molecule; growing the crystallizable molecule into a crystal structure within the uncrosslinked polymer; crosslinking the polymer around the crystal structure under conditions in which the crystal structure within the crosslinked polymer is maintained; and dissolving the crystals within the crosslinked polymer to form the porous hydrogel.

5. 发明申请

US20150133377A1 One-Step Processing of Hydrogels for Mechanically Robust and Chemically Desired Features 审中-公开
标题翻译：用于机械稳定和化学需要的特征的水凝胶的一步加工
公开(公告)号：US20150133377A1
公开(公告)日：2015-05-14
申请号：US14604298
申请日：2015-01-23
申请人： Board of Regents, The University of Texas System
发明人： Sarah Mayes , Christine Schmidt
IPC分类号： A61K47/36
CPC分类号： A61K47/36 , A61K31/738
摘要： The application of a highly controlled, micron-sized, branched, porous architecture to enhance the handling properties and degradation rate of hydrogels is described in the instant invention. A previously described pattern created through one-step nucleated crystallization in a hydrogel film creates tunable mechanical properties and/or chemical stability for use in tissue engineering applications. The bulk mechanical properties and the degradation rate of the material can be tuned easily by the addition or subtraction of crystalline structure or by the addition and subtraction of backfill material, making this useful for a variety of applications. Relevant mechanical properties that can be tuned through the application of this unique porosity are moduli, elasticity, tensile strength, and compression strength. The method of the present invention can be applied to biopolymers and natural materials as well as synthetic materials.
摘要翻译：在本发明中描述了高度控制的微米尺寸的支化多孔结构的应用以增强水凝胶的处理性能和降解速率。在水凝胶膜中通过一步成核结晶产生的先前描述的图案产生用于组织工程应用的可调谐的机械性能和/或化学稳定性。材料的体积机械性能和降解速率可以通过加入或减少晶体结构或通过添加和减少回填材料来轻松调整，使其适用于各种应用。通过应用这种独特的孔隙可以调节的相关机械性能是模量，弹性，拉伸强度和抗压强度。本发明的方法可以应用于生物聚合物和天然材料以及合成材料。

6. 发明授权

US12031008B2 Dendritic macroporous hydrogels prepared by crystal templating 有权
公开(公告)号：US12031008B2
公开(公告)日：2024-07-09
申请号：US18361981
申请日：2023-07-31
申请人： BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
发明人： Scott Zawko , Christine Schmidt
IPC分类号： C08J9/26 , A61L26/00 , A61L27/52 , B01J13/00 , C08B37/00 , C08B37/08 , C08B37/16 , C08H1/06 , C08J3/075 , C08J3/24 , C08J3/28 , C08J5/10 , C08J5/18 , C08K5/00 , C08K5/21 , C08L5/00 , C08L5/04 , C08L5/10 , C08L5/16 , C08L89/06 , C08J3/26
CPC分类号： C08J9/26 , A61L26/0023 , A61L26/0095 , A61L27/52 , B01J13/0065 , C08B37/0015 , C08B37/003 , C08B37/0045 , C08B37/0072 , C08B37/0075 , C08B37/0084 , C08H1/06 , C08J3/075 , C08J3/24 , C08J3/28 , C08J5/10 , C08J5/18 , C08K5/0025 , C08K5/0083 , C08K5/21 , C08L5/00 , C08L5/04 , C08L5/10 , C08L5/16 , C08L89/06 , C08J3/242 , C08J3/26 , C08J2201/0424 , C08J2205/022 , C08J2205/04 , C08J2207/10 , C08J2305/00 , C08J2305/04 , C08J2305/08 , C08L5/00 , C08K5/0025 , C08L5/06 , C08K5/0025 , C08L5/08 , C08K5/0025 , C08L5/04 , C08K5/0025 , C08L5/10 , C08K5/0025 , C08K5/0025 , C08L5/00 , C08K5/0025 , C08L5/06 , C08K5/0025 , C08L5/08 , C08K5/0025 , C08L5/04 , C08K5/0025 , C08L5/10
摘要： The present invention includes a hydrogel and a method of making a porous hydrogel by preparing an aqueous mixture of an uncrosslinked polymer and a crystallizable molecule; casting the mixture into a vessel; allowing the cast mixture to dry to form an amorphous hydrogel film; seeding the cast mixture with a seed crystal of the crystallizable molecule; growing the crystallizable molecule into a crystal structure within the uncrosslinked polymer; crosslinking the polymer around the crystal structure under conditions in which the crystal structure within the crosslinked polymer is maintained; and dissolving the crystals within the crosslinked polymer to form the porous hydrogel.

7. 发明公开

US20230383086A1 Dendritic Macroporous Hydrogels Prepared By Crystal Templating 审中-公开
公开(公告)号：US20230383086A1
公开(公告)日：2023-11-30
申请号：US18361981
申请日：2023-07-31
申请人： BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
发明人： Scott Zawko , Christine Schmidt
IPC分类号： C08J9/26 , C08K5/00 , C08B37/08 , C08B37/00 , C08J3/075 , C08J3/24 , C08J3/28 , B01J13/00 , C08B37/16 , C08H1/06 , C08L5/16 , C08L89/06 , A61L26/00 , A61L27/52 , C08J5/10 , C08J5/18 , C08K5/21 , C08L5/00 , C08L5/04 , C08L5/10
CPC分类号： C08J9/26 , C08K5/0025 , C08B37/0072 , C08B37/0084 , C08J3/075 , C08J3/24 , C08J3/28 , C08K5/0083 , B01J13/0065 , C08B37/0015 , C08B37/003 , C08B37/0045 , C08B37/0075 , C08H1/06 , C08L5/16 , C08L89/06 , A61L26/0023 , A61L26/0095 , A61L27/52 , C08J5/10 , C08J5/18 , C08K5/21 , C08L5/00 , C08L5/04 , C08L5/10 , C08J3/242 , C08J3/26
摘要： The present invention includes a hydrogel and a method of making a porous hydrogel by preparing an aqueous mixture of an uncrosslinked polymer and a crystallizable molecule; casting the mixture into a vessel; allowing the cast mixture to dry to form an amorphous hydrogel film; seeding the cast mixture with a seed crystal of the crystallizable molecule; growing the crystallizable molecule into a crystal structure within the uncrosslinked polymer; crosslinking the polymer around the crystal structure under conditions in which the crystal structure within the crosslinked polymer is maintained; and dissolving the crystals within the crosslinked polymer to form the porous hydrogel.

8. 发明申请

US20190216933A1 One-Step Processing of Hydrogels for Mechanically Robust and Chemically Desired Features 审中-公开
公开(公告)号：US20190216933A1
公开(公告)日：2019-07-18
申请号：US16358948
申请日：2019-03-20
申请人： Board of Regents, The University of Texas System
发明人： Sarah Mayes , Christine Schmidt
IPC分类号： A61K47/36 , A61K31/738
CPC分类号： A61K47/36 , A61K31/738
摘要： The application of a highly controlled, micron-sized, branched, porous architecture to enhance the handling properties and degradation rate of hydrogels is described in the instant invention. A previously described pattern created through one-step nucleated crystallization in a hydrogel film creates tunable mechanical properties and/or chemical stability for use in tissue engineering applications. The bulk mechanical properties and the degradation rate of the material can be tuned easily by the addition or subtraction of crystalline structure or by the addition and subtraction of backfill material, making this useful for a variety of applications. Relevant mechanical properties that can be tuned through the application of this unique porosity are moduli, elasticity, tensile strength, and compression strength. The method of the present invention can be applied to biopolymers and natural materials as well as synthetic materials.

9. 发明授权

US09896561B2 Dendritic macroporous hydrogels prepared by crystal templating 有权
公开(公告)号：US09896561B2
公开(公告)日：2018-02-20
申请号：US15135978
申请日：2016-04-22
申请人： BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
发明人： Scott Zawko , Christine Schmidt
IPC分类号： C08J9/26 , A61L27/56 , A61L27/26 , C08J5/18 , C08J3/24 , C08J5/10 , C08J3/28 , C08K5/21 , A61L27/52 , C08J3/075 , C08B37/08 , C08B37/00 , C08K5/00 , B01J13/00 , C08B37/16 , C08H1/06 , C08L5/16 , C08L89/06 , A61L26/00 , C08J3/26
CPC分类号： C08J9/26 , A61L26/0023 , A61L26/0095 , A61L27/52 , B01J13/0065 , C08B37/0015 , C08B37/003 , C08B37/0045 , C08B37/0072 , C08B37/0075 , C08B37/0084 , C08H1/06 , C08J3/075 , C08J3/24 , C08J3/242 , C08J3/26 , C08J3/28 , C08J5/10 , C08J5/18 , C08J2201/0424 , C08J2205/022 , C08J2205/04 , C08J2207/10 , C08J2305/00 , C08J2305/04 , C08J2305/08 , C08K5/0025 , C08K5/0083 , C08K5/21 , C08L5/00 , C08L5/04 , C08L5/10 , C08L5/16 , C08L89/06 , C08L5/06 , C08L5/08
摘要： The present invention includes a hydrogel and a method of making a porous hydrogel by preparing an aqueous mixture of an uncrosslinked polymer and a crystallizable molecule; casting the mixture into a vessel; allowing the cast mixture to dry to form an amorphous hydrogel film; seeding the cast mixture with a seed crystal of the crystallizable molecule; growing the crystallizable molecule into a crystal structure within the uncrosslinked polymer; crosslinking the polymer around the crystal structure under conditions in which the crystal structure within the crosslinked polymer is maintained; and dissolving the crystals within the crosslinked polymer to form the porous hydrogel.

10. 发明授权

US11760858B2 Dendritic macroporous hydrogels prepared by crystal templating 有权
公开(公告)号：US11760858B2
公开(公告)日：2023-09-19
申请号：US17231653
申请日：2021-04-15
申请人： BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
发明人： Scott Zawko , Christine Schmidt
IPC分类号： C08J9/26 , C08K5/00 , C08B37/08 , C08B37/00 , C08J3/075 , C08J3/24 , C08J3/28 , B01J13/00 , C08B37/16 , C08H1/06 , C08L5/16 , C08L89/06 , A61L26/00 , A61L27/52 , C08J5/10 , C08J5/18 , C08K5/21 , C08L5/00 , C08L5/04 , C08L5/10 , C08J3/26
CPC分类号： C08J9/26 , A61L26/0023 , A61L26/0095 , A61L27/52 , B01J13/0065 , C08B37/003 , C08B37/0015 , C08B37/0045 , C08B37/0072 , C08B37/0075 , C08B37/0084 , C08H1/06 , C08J3/075 , C08J3/24 , C08J3/28 , C08J5/10 , C08J5/18 , C08K5/0025 , C08K5/0083 , C08K5/21 , C08L5/00 , C08L5/04 , C08L5/10 , C08L5/16 , C08L89/06 , C08J3/242 , C08J3/26 , C08J2201/0424 , C08J2205/022 , C08J2205/04 , C08J2207/10 , C08J2305/00 , C08J2305/04 , C08J2305/08 , C08L5/00 , C08K5/0025 , C08L5/06 , C08K5/0025 , C08L5/08 , C08K5/0025 , C08L5/04 , C08K5/0025 , C08L5/10 , C08K5/0025 , C08K5/0025 , C08L5/00 , C08K5/0025 , C08L5/06 , C08K5/0025 , C08L5/08 , C08K5/0025 , C08L5/04 , C08K5/0025 , C08L5/10
摘要： The present invention includes a hydrogel and a method of making a porous hydrogel by preparing an aqueous mixture of an uncrosslinked polymer and a crystallizable molecule; casting the mixture into a vessel; allowing the cast mixture to dry to form an amorphous hydrogel film; seeding the cast mixture with a seed crystal of the crystallizable molecule; growing the crystallizable molecule into a crystal structure within the uncrosslinked polymer; crosslinking the polymer around the crystal structure under conditions in which the crystal structure within the crosslinked polymer is maintained; and dissolving the crystals within the crosslinked polymer to form the porous hydrogel.

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