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1. 发明申请

US20100113871A1 ANTIMICROBIAL COATING 审中-公开
标题翻译：抗菌涂料
公开(公告)号：US20100113871A1
公开(公告)日：2010-05-06
申请号：US12440543
申请日：2007-09-13
申请人： Aylvin Jorge Angelo Athanasius Dias , Edith Elisabeth M. Van Den Bosch , Astrid Franken
发明人： Aylvin Jorge Angelo Athanasius Dias , Edith Elisabeth M. Van Den Bosch , Astrid Franken
IPC分类号： A61L29/16 , A61L31/16 , A41D19/015 , A61L15/00 , A61L17/00
CPC分类号： C08F283/00 , A61L27/34 , A61L27/50 , A61L27/54 , A61L29/10 , A61L29/14 , A61L29/16 , A61L2300/102 , A61L2300/104 , A61L2300/404 , A61L2300/606 , A61L2300/624 , A61L2300/802 , C08F283/04 , C08G18/4833 , C08G18/4858 , C08G18/672 , C09D5/14 , C09D133/14 , C09D175/16 , C08G18/48
摘要： The invention relates to a formulation for preparing an antimicrobial lubricious hydrophilic coating, which formulation comprises a hydrophilic polymer; an initiator; particles comprising metallic silver (i.e. Ag°); and a carrier liquid. The invention further relates to an article comprising a hydrophilic coating on a surface wherein the coating comprises a cured hydrophilic polymer and particles comprising metallic silver.
摘要翻译：本发明涉及用于制备抗微生物润滑亲水涂层的制剂，该制剂包含亲水性聚合物; 发起者包含金属银（即Ag°）的颗粒; 和载液。本发明还涉及一种在表面上包含亲水涂层的制品，其中该涂层包含固化的亲水聚合物和包含金属银的颗粒。

2. 发明授权

US08828546B2 Coated medical device 有权
标题翻译：涂层医疗器械
公开(公告)号：US08828546B2
公开(公告)日：2014-09-09
申请号：US12440532
申请日：2007-09-13
申请人： Aylvin Jorge Angelo Athanasius Dias , Edith Elisabeth M. Van Den Bosch , Peter Bruin , Marnix Rooijmans , Rudolfus Antonius Theodorus Maria Van Benthem
发明人： Aylvin Jorge Angelo Athanasius Dias , Edith Elisabeth M. Van Den Bosch , Peter Bruin , Marnix Rooijmans , Rudolfus Antonius Theodorus Maria Van Benthem
IPC分类号： A61M25/00 , B32B27/08 , B32B27/26
CPC分类号： A61L31/10 , A61L29/085 , A61L29/10 , A61L29/14 , A61L31/14 , A61L2420/02 , A61L2420/06 , C08G65/3322 , C08G65/33324 , C08G2650/50 , C08L33/26 , C09D4/06 , C09D5/00 , C09D135/00 , C09D135/02 , C23C14/06 , C23C14/22 , Y10T428/1393 , Y10T428/24975 , Y10T428/31504 , Y10T428/31562 , Y10T428/31725 , Y10T428/31935
摘要： The invention relates to an article comprising a coating, which coating comprises at least two layers, of which the inner layer is a primer layer, comprising a supporting network comprising a supporting polymer, and the outer layer is a functional layer comprising a multifunctional polymerizable compound.
摘要翻译：本发明涉及一种包含涂层的制品，该涂层包括至少两层，其中内层为底漆层，其中包含支撑聚合物的支撑网，外层为包含多官能聚合性化合物的功能层。

3. 发明申请

US20100114042A1 COATED MEDICAL DEVICE 有权
标题翻译：涂层医疗器械
公开(公告)号：US20100114042A1
公开(公告)日：2010-05-06
申请号：US12440532
申请日：2007-09-13
申请人： Aylvin Jorge Angelo Athanasius Dias , Edith Elisabeth M> Van Den Bosch , Peter Bruin , Marnix Rooijmans , Rudolfus Antonius Theodorus Maria Van Benthem
发明人： Aylvin Jorge Angelo Athanasius Dias , Edith Elisabeth M> Van Den Bosch , Peter Bruin , Marnix Rooijmans , Rudolfus Antonius Theodorus Maria Van Benthem
IPC分类号： A61L29/14 , C08F2/46 , B05D3/10 , A61K8/72
CPC分类号： A61L31/10 , A61L29/085 , A61L29/10 , A61L29/14 , A61L31/14 , A61L2420/02 , A61L2420/06 , C08G65/3322 , C08G65/33324 , C08G2650/50 , C08L33/26 , C09D4/06 , C09D5/00 , C09D135/00 , C09D135/02 , C23C14/06 , C23C14/22 , Y10T428/1393 , Y10T428/24975 , Y10T428/31504 , Y10T428/31562 , Y10T428/31725 , Y10T428/31935
摘要： The invention relates to an article comprising a coating, which coating comprises at least two layers, of which the inner layer is a primer layer, comprising a supporting network comprising a supporting polymer, and the outer layer is a functional layer comprising a multifunctional polymerizable compound.
摘要翻译：本发明涉及一种包含涂层的制品，该涂层包括至少两层，其中内层为底漆层，其中包含支撑聚合物的支撑网，外层为包含多官能聚合性化合物的功能层。

4. 发明申请

US20100291116A1 MICROPARTICLE COMPRISING CROSS-LINKED POLYMER 审中-公开
标题翻译：包含交联聚合物的微晶
公开(公告)号：US20100291116A1
公开(公告)日：2010-11-18
申请号：US12679132
申请日：2008-09-26
申请人： Aylvin Jorge Angelo Athanasius Dias , Bartholomeus Johannes Margretha Plum , Audrey Petit , Tristan Handels
发明人： Aylvin Jorge Angelo Athanasius Dias , Bartholomeus Johannes Margretha Plum , Audrey Petit , Tristan Handels
IPC分类号： A61K47/30 , C08G67/00 , B32B1/00 , A61K38/02 , A61K39/00 , A61K31/7088 , C08G73/00 , C08G75/00 , A61K31/573 , A61P31/00
CPC分类号： A61K9/1641 , A61K9/5031 , Y10T428/2982 , Y10T428/2998
摘要： Microparticle comprising a cross-linked polymer comprising (a) a cross-linker comprising two or more radically polymerizable groups, preferably selected from the group consisting of alkenes, sulfhydryl (SH), thioic, unsaturated esters, unsaturated urethanes, unsaturated ethers, and unsaturated amides; (b) a monofunctional reactive diluent comprising maximum one unsaturated C—C bond represented by the formula R0—C(R1)═CHR2 Formula (I) wherein —R0 is chosen depending on the structure of a selected active agent (c) to be loaded into the microparticle and is chosen to have a structure that when combined with the other components of the microparticle provides a higher affinity of the selected active agent (c) for the microparticle; —each R1 is chosen from hydrogen and substituted and unsubstituted, aliphatic, cycloaliphatic and aromatic hydrocarbon groups which groups optionally contain one or more moieties selected from the group of ester moieties, ether moieties, thioester moieties, thioether moieties, carbamate moieties, thiocarbamate moieties, amide moieties and other moieties comprising one or more heteroatoms, in particular one or more heteroatoms selected from S, O, P and N, each R5 in particular independently being chosen from the group of hydrogen and substituted and unsubstituted alkyl groups, which alkyl groups optionally contain one or more heteroatoms, in particular one or more heteroatoms selected from P, S, O and N; —each R2 is chosen from hydrogen, —COOCH3, —COOC2H5, —COOC3H7, and —COOC4H9.
摘要翻译：包含交联聚合物的微粒包括（a）包含两个或更多个可自由基聚合基团的交联剂，优选选自烯烃，巯基（SH），硫代，不饱和酯，不饱和氨基甲酸酯，不饱和醚和不饱和醚酰胺（b）单官能反应性稀释剂，其包含由式R 0 -C（R 1）= CHR 2式（I）表示的最大一个不饱和C-C键，其中-R 0根据所选活性剂（c）的结构选择加入到微粒中并被选择为具有当与微粒的其它组分组合时提供所选择的活性剂（c）对于微粒的较高亲合力的结构; - 每个R 1选自氢和取代和未取代的脂族，脂环族和芳族烃基，这些基团任选地含有一个或多个选自酯部分，醚部分，硫酯部分，硫醚部分，氨基甲酸酯部分，硫代氨基甲酸酯部分，酰胺部分和包含一个或多个杂原子，特别是一个或多个选自S，O，P和N的杂原子的其它部分，每个R 5特别地独立地选自氢和取代和未取代的烷基，该烷基任选地含有一个或多个杂原子，特别是一个或多个选自P，S，O和N的杂原子; - 每个R 2选自氢，-COOCH 3，-COOC 2 H 5，-COOC 3 H 7和-COOC 4 H 9。

5. 发明授权

US08871869B2 Hydrophilic coating 有权
标题翻译：亲水涂层
公开(公告)号：US08871869B2
公开(公告)日：2014-10-28
申请号：US12096096
申请日：2006-12-11
申请人： Aylvin Jorge Angelo Athanasius Dias , Guido Joseph Elisabeth Hensen , Johannes Wilhelmus Belt , Marnix Rooijmans , Nicolaes Hubertus Maria de Bont , Edwin Peter Kennedy Currie
发明人： Aylvin Jorge Angelo Athanasius Dias , Guido Joseph Elisabeth Hensen , Johannes Wilhelmus Belt , Marnix Rooijmans , Nicolaes Hubertus Maria de Bont , Edwin Peter Kennedy Currie
IPC分类号： C08L33/24 , A61L33/00 , B05D3/00 , A61L29/08 , C08J7/04 , C09D5/00
CPC分类号： A61L29/085 , C08J7/047 , C09D5/00 , Y10T428/264 , Y10T428/31504 , Y10T428/31533 , C08L39/06 , C08L71/02
摘要： The invention relates to a hydrophilic coating formulation which when cured results in a hydrophilic coating, wherein the hydrophilic coating formulation comprises a polyelectrolyte and a non-ionic hydrophilic polymer. The invention further relates to a coating system, a hydrophilic coating, a lubricious coating, use of a polyelectrolyte and a non-ionic hydrophilic polymer in a lubricious coating, an article, a medical device or component and a method of forming on a substrate a hydrophilic coating.
摘要翻译：本发明涉及亲水性涂料制剂，其在固化时产生亲水涂层，其中亲水性涂料制剂包含聚电解质和非离子亲水性聚合物。本发明还涉及一种涂层系统，亲水涂层，润滑涂层，在光滑涂层中使用聚电解质和非离子亲水性聚合物，制品，医疗装置或部件以及在基材上形成的方法亲水涂层。

6. 发明申请

US20090156707A1 Polymers comprising thioester bonds 失效
标题翻译：包含硫酯键的聚合物
公开(公告)号：US20090156707A1
公开(公告)日：2009-06-18
申请号：US11991016
申请日：2006-09-07
申请人： Aylvin Jorge Angelo Athanasius Dias , Mark Johannes Boerakker , Atze Jan Nijenhuis
发明人： Aylvin Jorge Angelo Athanasius Dias , Mark Johannes Boerakker , Atze Jan Nijenhuis
IPC分类号： C08J3/28 , C08G63/688 , C08L33/02
CPC分类号： C08G63/6882 , C08G63/6888 , C08G63/912
摘要： This invention is in the field of polymer chemistry. More in particular it provides a method to produce polymers such as block copolymers or cross-linked networks that are suitable for medical applications. The invention also provides degradable materials that may degrade completely when used in the human or animal body, minimizing residual components that may be toxic or otherwise undesirable.
摘要翻译：本发明在聚合物化学领域。更具体地，其提供了生产适合于医疗应用的聚合物如嵌段共聚物或交联网络的方法。本发明还提供了当在人或动物体内使用时可完全降解的可降解材料，使可能具有毒性或其他不希望的残留成分最小化。

7. 发明授权

US08304468B2 Polymers comprising thioester bonds 失效
标题翻译：包含硫酯键的聚合物
公开(公告)号：US08304468B2
公开(公告)日：2012-11-06
申请号：US11991016
申请日：2006-09-07
申请人： Aylvin Jorge Angelo Athanasius Dias , Mark Johannes Boerakker , Atze Jan Nijenhuis
发明人： Aylvin Jorge Angelo Athanasius Dias , Mark Johannes Boerakker , Atze Jan Nijenhuis
IPC分类号： C08J3/28 , C08G63/68 , C08G63/688
CPC分类号： C08G63/6882 , C08G63/6888 , C08G63/912
摘要： This invention is in the field of polymer chemistry. More in particular it provides a method to produce polymers such as block copolymers or cross-linked networks that are suitable for medical applications. The invention also provides degradable materials that may degrade completely when used in the human or animal body, minimizing residual components that may be toxic or otherwise undesirable.
摘要翻译：本发明在聚合物化学领域。更具体地，其提供了生产适合于医疗应用的聚合物如嵌段共聚物或交联网络的方法。本发明还提供了当在人或动物体内使用时可完全降解的可降解材料，使可能具有毒性或其他不希望的残留成分最小化。

8. 发明授权

US08133580B2 Coating composition for a urinary catheter 有权
标题翻译：用于导尿管的涂层组合物
公开(公告)号：US08133580B2
公开(公告)日：2012-03-13
申请号：US12096623
申请日：2006-12-11
申请人： Aylvin Jorge Angelo Athanasius Dias , Guido Joseph Elisabeth Hensen , Johannes Wilhelmus Belt , Marnix Rooijmans , Nicolaes Hubertus Maria De Bont , Edwin Peter Kennedy Currie
发明人： Aylvin Jorge Angelo Athanasius Dias , Guido Joseph Elisabeth Hensen , Johannes Wilhelmus Belt , Marnix Rooijmans , Nicolaes Hubertus Maria De Bont , Edwin Peter Kennedy Currie
IPC分类号： B32B27/08 , B32B9/04
CPC分类号： A61L29/085 , C08J7/047 , C09D5/00 , Y10T428/264 , Y10T428/31504 , Y10T428/31533 , C08L39/06 , C08L71/02
摘要： The invention relates to an article comprising a coating, which coating comprises at least two layers, of which the inner layer is a primer layer, comprising a supporting polymer network which is composed of a supporting polymer selected from the group consisting of polyethers and polythioethers, including copolymers thereof, the supporting network optionally comprising a functional non-ionic hydrophilic polymer entangled in the supporting polymer network; and the outer layer is a functional layer comprising a functional non-ionic hydrophilic polymer and a polyelectrolyte.
摘要翻译：本发明涉及一种包括涂层的制品，该涂层包括至少两层，其中内层是底漆层，其包含支撑聚合物网络，其由选自聚醚和聚硫醚的支撑聚合物组成，包括其共聚物，所述支持网络任选地包含缠结在支持聚合物网络中的功能非离子亲水性聚合物; 并且外层是包含功能性非离子亲水聚合物和聚电解质的功能层。

9. 发明申请

US20100311130A1 ENZYMATIC ESTER HYDROLYSIS 审中-公开
标题翻译：酶催化水解
公开(公告)号：US20100311130A1
公开(公告)日：2010-12-09
申请号：US12664452
申请日：2008-06-19
申请人： Peter Jan Leonard Mario Quaedflieg , Claudia Cusan , Bas Ritzen , Aylvin Jorge Angelo Athanasius Dias
发明人： Peter Jan Leonard Mario Quaedflieg , Claudia Cusan , Bas Ritzen , Aylvin Jorge Angelo Athanasius Dias
IPC分类号： C12P13/02
CPC分类号： C12P13/00 , C12P7/02 , C12P7/40
摘要： The present invention relates to a method for selectively hydrolysing a pendant ester bond formed by an unsubstituted or substituted hydrocarbon group—optionally comprising one or more heteroatoms—and a pendant carboxylate moiety, which carboxylate moiety is part of a polymer or a polymerisable compound, which polymer or polymerisable compound comprises at least one other hydrolysable group, wherein the method comprises contacting the polymer or polymerisable compound with a hydrolytic enzyme.
摘要翻译：本发明涉及一种选择性水解由未取代或取代的烃基形成的侧链酯键的方法 - 任选地包含一个或多个杂原子和羧酸侧基部分，羧酸酯部分是聚合物或可聚合化合物的一部分，聚合物或可聚合化合物包含至少一种其它可水解基团，其中该方法包括使聚合物或可聚合化合物与水解酶接触。

10. 发明授权

US09737637B2 Method for reducing the amount of migrateables of polymer coatings 有权
公开(公告)号：US09737637B2
公开(公告)日：2017-08-22
申请号：US11791488
申请日：2005-11-28
申请人： Aylvin Jorge Angelo Athanasius Dias , Marnix Rooijmans , Victor Litvinov , Edwin Peter Kennedy Currie , Erwin Johannes Elisabeth Houben
发明人： Aylvin Jorge Angelo Athanasius Dias , Marnix Rooijmans , Victor Litvinov , Edwin Peter Kennedy Currie , Erwin Johannes Elisabeth Houben
IPC分类号： B05D3/02 , A61L29/08 , A61L27/34 , A61L31/10
CPC分类号： A61L29/085 , A61L27/34 , A61L31/10
摘要： This invention relates to an improved process for obtaining a cross-linked polymer coating on a surface. The invention also relates to coatings obtainable by that process and objects coated therewith. The invention also relates to medical devices comprising a coating, in particular to coils coated with an improved lubricious coating.

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