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1. 发明申请

US20120077740A1 Methods for making Apo-2 Ligand using divalent metal ions 审中-公开
标题翻译：使用二价金属离子制备Apo-2配体的方法
公开(公告)号：US20120077740A1
公开(公告)日：2012-03-29
申请号：US12928422
申请日：2010-12-10
申请人： Avi J. Ashkenazi , Sarah Hymowitz , Robert F. Kelley , Iphigenia Koumenis , Woon-Lam Susan Leung , Mark O'Connell , Roger Pai , Zahra Shahrokh , Laura Simmons
发明人： Avi J. Ashkenazi , Sarah Hymowitz , Robert F. Kelley , Iphigenia Koumenis , Woon-Lam Susan Leung , Mark O'Connell , Roger Pai , Zahra Shahrokh , Laura Simmons
IPC分类号： A61K38/19 , C12N15/19 , C12N15/63 , C12N1/21 , B01D15/36 , C07K1/14 , C07K1/18 , C07K1/20 , B01D15/32 , C12P21/02 , C07K14/52
CPC分类号： A61K9/19 , A61K9/0019 , A61K38/00 , A61K47/02 , C07K14/525 , C07K14/70575
摘要： Methods of making Apo-2 ligand and formulations of Apo-2 ligand using divalent metal ions are provided. Such divalent metal ions include zinc and cobalt which improve Apo-2 ligand trimer formation and stability. The crystal structure of Apo-2 ligand is also provided, along with Apo-2 ligand variant polypeptides identified using oligonucleotide-directed mutagenesis.
摘要翻译：提供使用二价金属离子制备Apo-2配体和Apo-2配体制剂的方法。这种二价金属离子包括改善Apo-2配体三聚体形成和稳定性的锌和钴。还提供了Apo-2配体的晶体结构，以及使用寡核苷酸定向突变鉴定的Apo-2配体变体多肽。

2. 发明授权

US07855066B1 Methods for making Apo-2 ligand using divalent metal ions 有权
标题翻译：使用二价金属离子制备Apo-2配体的方法
公开(公告)号：US07855066B1
公开(公告)日：2010-12-21
申请号：US11528948
申请日：2006-09-28
申请人： Avi J. Ashkenazi , Sarah Hymowitz , Robert F. Kelley , Iphigenia Koumenis , Woon-Lam Susan Leung , Mark O'Connell , Roger Pai , Zahra Shahrokh , Laura Simmons
发明人： Avi J. Ashkenazi , Sarah Hymowitz , Robert F. Kelley , Iphigenia Koumenis , Woon-Lam Susan Leung , Mark O'Connell , Roger Pai , Zahra Shahrokh , Laura Simmons
IPC分类号： C12N5/10 , C12N15/12 , C07K14/52
CPC分类号： A61K9/19 , A61K9/0019 , A61K38/00 , A61K47/02 , C07K14/525 , C07K14/70575
摘要： Methods of making Apo-2 ligand and formulations of Apo-2 ligand using divalent metal ions are provided. Such divalent metal ions include zinc and cobalt which improve Apo-2 ligand trimer formation and stability. The crystal structure of Apo-2 ligand is also provided, along with Apo-2 ligand variant polypeptides identified using oligonucleotide-directed mutagenesis.
摘要翻译：提供使用二价金属离子制备Apo-2配体和Apo-2配体制剂的方法。这种二价金属离子包括改善Apo-2配体三聚体形成和稳定性的锌和钴。还提供了Apo-2配体的晶体结构，以及使用寡核苷酸定向突变鉴定的Apo-2配体变体多肽。

3. 发明申请

US20070161564A1 Methods for making Apo-2 ligand using divalent metal ions 审中-公开
标题翻译：使用二价金属离子制备Apo-2配体的方法
公开(公告)号：US20070161564A1
公开(公告)日：2007-07-12
申请号：US11603584
申请日：2006-11-22
申请人： Avi Ashkenazi , Sarah Hymowitz , Robert Kelley , Iphigenia Koumenis , Woon-Lam Leung , Mark O'Connell , Roger Pai , Zahra Shahrokh , Laura Simmons
发明人： Avi Ashkenazi , Sarah Hymowitz , Robert Kelley , Iphigenia Koumenis , Woon-Lam Leung , Mark O'Connell , Roger Pai , Zahra Shahrokh , Laura Simmons
IPC分类号： A61K38/17
CPC分类号： A61K9/19 , A61K9/0019 , A61K38/00 , A61K47/02 , C07K14/525 , C07K14/70575
摘要： Methods of making Apo-2 ligand and formulations of Apo-2 ligand using divalent metal ions are provided. Such divalent metal ions include zinc and cobalt which improve Apo-2 ligand trimer formation and stability. The crystal structure of Apo-2 ligand is also provided, along with Apo-2 ligand variant polypeptides identified using oligonucleotide-directed mutagenesis.
摘要翻译：提供使用二价金属离子制备Apo-2配体和Apo-2配体制剂的方法。这种二价金属离子包括改善Apo-2配体三聚体形成和稳定性的锌和钴。还提供了Apo-2配体的晶体结构，以及使用寡核苷酸定向突变鉴定的Apo-2配体变体多肽。

4. 发明授权

US08335890B1 Associating an identifier with a content unit 有权
标题翻译：将标识符与内容单元相关联
公开(公告)号：US08335890B1
公开(公告)日：2012-12-18
申请号：US13301323
申请日：2011-11-21
申请人： Mark O'Connell , Michael Kilian
发明人： Mark O'Connell , Michael Kilian
IPC分类号： G06F13/00 , G06F13/28 , G06F12/00 , G06F17/30
CPC分类号： G06F12/1018
摘要： Embodiments of the invention relate to associating a source string with a target content unit stored on a content addressable storage (CAS) system. This may be accomplished, in some embodiments, by storing on the CAS system an associative content unit that includes the source string in its binding part and includes the target content unit in its non-binding part.
摘要翻译：本发明的实施例涉及将源字符串与存储在内容可寻址存储（CAS）系统上的目标内容单元相关联。这在一些实施例中可以通过在CAS系统上存储包括其绑定部分中的源字符串并且在其非约束部分中包括目标内容单元的关联内容单元来实现。

5. 发明授权

US07080102B2 Method and system for migrating data while maintaining hard links 有权
公开(公告)号：US07080102B2
公开(公告)日：2006-07-18
申请号：US10105976
申请日：2002-03-25
申请人： Mark O'Connell , Zhiling Zheng
发明人： Mark O'Connell , Zhiling Zheng
IPC分类号： G06F17/30
CPC分类号： G06F3/0601 , G06F2003/0697 , Y10S707/99952 , Y10S707/99953
摘要： Data is migrated from an original host storage system to another replacement host storage system. An original host storage system is connected directly to the replacement host storage system. Data migration occurs, and when data is transferred, hard links between files relating to the same data are also maintained.

6. 发明授权

US10019447B1 Methods and apparatus for managing objects in a storage environment 有权
公开(公告)号：US10019447B1
公开(公告)日：2018-07-10
申请号：US12800448
申请日：2010-05-14
申请人： Mark O'Connell
发明人： Mark O'Connell
IPC分类号： G06F7/00 , G06F17/30
CPC分类号： G06F16/10 , G06F16/14 , G06F16/1873 , G06F16/27
摘要： Some embodiments are directed to accessing a content unit stored in a storage environment that includes a plurality of storage clusters, wherein multiple versions of the content unit are stored on at least two different clusters in the storage environment. The storage environment and/or the requesting entity may identify the at least two storage clusters that store the content unit and select one of clusters as storing a valid version of the content unit.

7. 发明申请

US20050285748A1 Apparatus, system and method for monitoring a drying procedure 有权
标题翻译：用于监测干燥程序的装置，系统和方法
公开(公告)号：US20050285748A1
公开(公告)日：2005-12-29
申请号：US10877417
申请日：2004-06-25
申请人： Mark Pedraza , Richard Lubeski , Mark O'Connell
发明人： Mark Pedraza , Richard Lubeski , Mark O'Connell
IPC分类号： E04B1/70 , F26B25/22 , G08B21/00
CPC分类号： H04Q9/14 , E04B1/70 , F24F3/14 , F24F11/0008 , F24F11/30 , F24F2110/20 , F26B25/22 , G01D4/002
摘要： An apparatus, system, and method provide drying procedure information through a user interface. A monitoring device transmits drying procedure data measured by sensors within a structure undergoing the drying procedure to a server. In response to requests received through a communication network from a user interface, the server transmits the drying procedure information that is presented through the user interface. A variety of information and services related to the drying procedure may be provided through the user interface.
摘要翻译：装置，系统和方法通过用户界面提供干燥程序信息。监测装置将经由干燥过程的结构内的传感器测量的干燥程序数据传送到服务器。响应于从用户界面通过通信网络接收的请求，服务器发送通过用户界面呈现的干燥过程信息。可以通过用户界面提供与干燥过程相关的各种信息和服务。

8. 发明授权

US06922761B2 Method and system for migrating data 有权
标题翻译：用于迁移数据的方法和系统
公开(公告)号：US06922761B2
公开(公告)日：2005-07-26
申请号：US10105821
申请日：2002-03-25
申请人： Mark O'Connell , Zhiling Zheng
发明人： Mark O'Connell , Zhiling Zheng
IPC分类号： G06F12/00 , H04L1/22
CPC分类号： G06F17/30067
摘要： Data is migrated from an original host storage system to another replacement host storage system with minimal client impact on a network. An original host storage system is connected directly to the replacement host storage system which is in turn connected to the network. Data migration occurs while allowing a client to access data in the original host storage system. When access is requested, the replacement host storage system determines if it resides locally or in the original host storage system. Depending on where the data resides, either the replacement host storage system acts on it or obtains it from the original host storage system.
摘要翻译：数据从原始主机存储系统迁移到另一个替代主机存储系统，对网络的影响最小。原始主机存储系统直接连接到替代主机存储系统，替代主机存储系统又连接到网络。数据迁移发生在允许客户端访问原始主机存储系统中的数据时。当请求访问时，替换主机存储系统确定它是驻留在本地还是驻留在原始主机存储系统中。取决于数据所在的位置，替换主机存储系统作用于其上或从原始主机存储系统获取。

9. 发明授权

US08478936B1 Spin down of storage resources in an object addressable storage system 有权
标题翻译：在对象可寻址存储系统中减少存储资源
公开(公告)号：US08478936B1
公开(公告)日：2013-07-02
申请号：US12649113
申请日：2009-12-29
申请人： Stephen J. Todd , Mark O'Connell
发明人： Stephen J. Todd , Mark O'Connell
IPC分类号： G06F12/02
CPC分类号： G06F17/30982 , Y02D10/45
摘要： Aspects of the invention relate to spin down of storage devices on an object addressable storage (OAS) system. One or more of the storage devices in object addressable storage system may be spun down to achieve a power savings, while other storage devices in the OAS system remain in an active state.
摘要翻译：本发明的方面涉及在对象可寻址存储（OAS）系统上的存储设备的旋转。对象可寻址存储系统中的一个或多个存储设备可以被降低以实现功率节省，而OAS系统中的其他存储设备保持在活动状态。

10. 发明授权

US09135016B1 Methods and apparatus for managing replication of objects in a storage environment 有权
标题翻译：管理存储环境中对象复制的方法和装置
公开(公告)号：US09135016B1
公开(公告)日：2015-09-15
申请号：US12800399
申请日：2010-05-14
申请人： Mark O'Connell
发明人： Mark O'Connell
IPC分类号： G06F12/00 , G06F9/38 , G06F11/07 , G06F3/06 , G06F17/30
CPC分类号： G06F9/3891 , G06F3/0619 , G06F3/0631 , G06F3/067 , G06F11/0769 , G06F11/14 , G06F11/2094 , G06F17/30215
摘要： Some embodiments are directed to replicating a content unit stored in a first storage environment comprising a first plurality of storage clusters to a second storage environment comprising a second plurality of storage clusters. The first storage environment may employ a replication policy, instituted at a first time, that specifies to which one of the second plurality of storage clusters content units stored in the first storage environment are to be replicated. The creation time of the first content unit may be determined and it may be determined when the creation time is before the time at which the first storage environment instituted the replication policy. If the creation time is not before the first time, one of the second plurality of storage clusters may be selected to which to replicate the first content unit based on the replication policy, and the content unit may be replicated to the selected one of the second plurality of storage clusters.
摘要翻译：一些实施例旨在将存储在包括第一多个存储集群的第一存储环境中的内容单元复制到包括第二多个存储集群的第二存储环境。第一存储环境可以采用指定第一存储环境中存储的第二多个存储集群内容单元中哪一个将被复制的第一次建立的复制策略。可以确定第一内容单元的创建时间，并且可以确定创建时间何时在第一存储环境设置复制策略的时间之前。如果创建时间不是在第一次之前，则可以基于复制策略来选择第二多个存储集群中的一个来复制第一内容单元，并且内容单元可以被复制到第二个多个存储集群。

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