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1. 发明授权

US5840074A Method and apparatus for delivering first agent followed by second agent 失效
标题翻译：用于递送第一代理，后跟第二代理的方法和装置
公开(公告)号：US5840074A
公开(公告)日：1998-11-24
申请号：US852248
申请日：1992-06-02
申请人： Atul Devdatt Ayer , James B. Eckenhoff , Jeremy C. Wright , Anthony L. Kuczynski
发明人： Atul Devdatt Ayer , James B. Eckenhoff , Jeremy C. Wright , Anthony L. Kuczynski
IPC分类号： A61K9/00 , A61K9/22
CPC分类号： A61K9/0068 , A61K9/0004
摘要： The invention provides a dispensing device (10) comprising a loading dose (32) (first agent delivery device) for short-term and continuous delivery of agent, retained together with a long-term dispensing device (12) (second agent delivery device) capable of long-term and continuous delivery of agent. The combination of first and second agent delivery device provides a device in which a substantially constant dose of beneficial agent is delivered to the environment of use over time. A rapid delivery of beneficial agent is followed by continuous and prolonged delivery of agent. In a preferred embodiment the device includes (A) a loading dose chamber (30) and retaining device (16) retaining a loading dose (32) (short-term delivery device) for rapid and continuous delivery of agent to the environment of use; and (B) a long-term dispensing device (12) (long-term delivery device) comprising a semipermeable wall (14) which surrounds and defines an internal lumen (20), a driving source (22) (expansion device) in the lumen for expanding and occupying an increased volume of the lumen, a beneficial agent (24) in the lumen that provides a dispensable formulation to the environment of use, and an exit (28) in the device for delivery of the beneficial agent to the environment of use over time. A densifier (26) and/or a moveable barrier device (34) may also be included in the lumen of the long-term dispensing device.
摘要翻译： PCT No.PCT / US90 / 07598 Sec。 371日期：1992年6月2日 102（e）日期1992年6月2日PCT 1990年12月21日PCT PCT。出版物WO91 / 10423 日期1991年7月10日本发明提供一种分配装置（10），其包括与长期分配装置（12）保持在一起的用于短期和连续输送药剂的负荷剂量（32）（第一药剂输送装置）第二代理递送设备），能够长期和连续地递送代理。第一和第二药剂递送装置的组合提供了一种装置，其中基本上恒定剂量的有益药剂随时间递送到使用环境中。随后快速递送有益药剂，其次是持续和长期的药剂输送。在优选实施例中，装置包括（A）负载剂量室（30）和保持装置（16），保持装置（16）保持负载剂量（32）（短期输送装置），用于将药剂快速和连续地递送到使用环境中; 和（B）包括围绕并限定内腔（20）的半透壁（14）的长期分配装置（12）（长期输送装置），其中用于扩张和占据管腔体积增加的内腔，在内腔中的有益剂（24），其向使用环境提供可分配的配方，以及用于将有益剂递送至环境的装置中的出口（28）随着时间的推移使用。致密器（26）和/或可移动屏障装置（34）也可以包括在长期分配装置的内腔中。

2. 发明授权

US5045082A Long-term delivery device including loading dose 失效
标题翻译：长期输送装置，包括负荷剂量
公开(公告)号：US5045082A
公开(公告)日：1991-09-03
申请号：US463109
申请日：1990-01-10
申请人： Atul D. Ayer , James B. Eckenhoff , Jeremy C. Wright , Anthony L. Kuczynski
发明人： Atul D. Ayer , James B. Eckenhoff , Jeremy C. Wright , Anthony L. Kuczynski
IPC分类号： A61K9/00 , A61K9/22
CPC分类号： A61K9/0068 , A61K9/0004
摘要： The invention provides a long-term dispensing device comprising a first agent delivery means for short-term and continuous delivery of agent, retained together with a second agent delivery means capable of long-term and continuous delivery of agent. The combination of first and second agent delivery means provides a device in which a substantially constant dose of beneficial agent is delivered to the environment of use over time. A rapid delivery of beneficial agent is followed by continuous and prolonged delivery of agent. In a preferred embodiment the device includes (1) a short term delivery means for rapid and continuous delivery of agent to the environment of use; and (2) a long-term delivery means comprising a semipermeable wall which surrounds and defines an internal lumen; a means in the lumen for expanding and occupying an increased volume of the lumen; a beneficial agent in the lumen that provides a dispensable formulation to the environment of use; and a means in the device for delivery of the beneficial agent to the environment of use over time.
摘要翻译：本发明提供了一种长期分配装置，其包括用于短期和连续输送药剂的第一药剂递送装置，与能够长期和连续递送药剂的第二药剂递送装置保持在一起。第一和第二药剂递送装置的组合提供了一种装置，其中基本上恒定剂量的有益药剂随时间递送到使用环境中。随后快速递送有益药剂，其次是持续和长期的药剂输送。在优选实施例中，该装置包括（1）用于将药剂快速且连续地递送到使用环境的短期递送装置; 和（2）包括围绕并限定内腔的半透壁的长期递送装置; 用于扩张和占据体积增加的管腔中的一种装置; 内腔中的有益剂，为使用环境提供可分配的配方; 以及用于将有益剂递送到使用环境的装置中的装置。

3. 发明授权

US08298562B2 Sustained delivery of an active agent using an implantable system 有权
标题翻译：使用可植入系统持续递送活性剂
公开(公告)号：US08298562B2
公开(公告)日：2012-10-30
申请号：US13116970
申请日：2011-05-26
申请人： John R. Peery , Keith E. Dionne , James B. Eckenhoff , Bonnie J. Eckenhoff, legal representative , Felix A. Landrau , Scott D. Lautenbach , Judy A. Magruder , Jeremy C. Wright
发明人： John R. Peery , Keith E. Dionne , James B. Eckenhoff , Felix A. Landrau , Scott D. Lautenbach , Judy A. Magruder , Jeremy C. Wright
IPC分类号： A61K9/20 , A61K9/22 , A61K9/24 , A61F2/00
CPC分类号： A61M5/14526 , A61K9/0004 , A61K9/0024 , A61K38/09 , A61M2005/14513 , A61M2206/10
摘要： The invention is directed to a device for delivering an active agent formulation for a predetermined administration period. An impermeable reservoir is divided into a water-swellable agent chamber and an active agent formulation chamber. Fluid from the environment is imbibed through a semipermeable plug into the water-swellable agent chamber and the active agent formulation is released through a back-diffusion regulating outlet. Delivery periods of up to 2 years are achieved.
摘要翻译：本发明涉及一种用于在预定给药期间递送活性剂制剂的装置。不可渗透的储存器分为水溶胀剂室和活性剂配制室。来自环境的流体通过半渗透塞吸入水溶胀剂室中，活性剂制剂通过反向扩散调节出口释放。交付期限达2年。

4. 发明授权

US6068850A Aqueous formulations of peptides 有权
标题翻译：肽的水性制剂
公开(公告)号：US6068850A
公开(公告)日：2000-05-30
申请号：US248286
申请日：1999-02-11
申请人： Cynthia L. Stevenson , Sally A. Tao , Steven J. Prestrelski , James B. Eckenhoff, deceased , Jeremy C. Wright , John J. Leonard, Jr.
发明人： Cynthia L. Stevenson , Sally A. Tao , Steven J. Prestrelski , James B. Eckenhoff, deceased , Jeremy C. Wright , John J. Leonard, Jr.
IPC分类号： A61K47/16 , A61K9/00 , A61K9/08 , A61K38/00 , A61K38/04 , A61K38/08 , A61K38/09 , A61K38/22 , A61K38/24 , A61K38/27 , A61K38/38 , A61K47/02 , A61K47/08 , A61K47/18 , A61K47/20 , A61P35/00 , A61P43/00 , A61F2/02
CPC分类号： A61K38/09 , A61K9/0019 , A61K9/0024 , A61K9/08 , A61K47/20
摘要： This invention relates to stable liquid aqueous formulations of peptide compounds at high concentrations. These stable formulations comprise at least about 10% peptide in water. They may be stored at elevated temperatures for long periods of time and are especially useful in implantable delivery devices for long term delivery of drug.
摘要翻译：本发明涉及高浓度肽化合物的稳定液体含水制剂。这些稳定的制剂包含至少约10％的水中的肽。它们可以在升高的温度下长时间储存，并且在用于长期递送药物的可植入递送装置中特别有用。

5. 发明授权

US5922353A Interlocking couplings for osmotic delivery devices 失效
标题翻译：用于渗透输送装置的联锁联轴器
公开(公告)号：US5922353A
公开(公告)日：1999-07-13
申请号：US947110
申请日：1997-10-08
申请人： Judy A. Magruder , James B. Eckenhoff, deceased , Richard Cortese , Jeremy C. Wright , John R. Peery , Edward V. Bourneuf , James B. Pike , Urano A. Robinson , John M. Sharockman , Jonathan P. Smith
发明人： Judy A. Magruder , James B. Eckenhoff, deceased , Richard Cortese , Jeremy C. Wright , John R. Peery , Edward V. Bourneuf , James B. Pike , Urano A. Robinson , John M. Sharockman , Jonathan P. Smith
IPC分类号： A61K9/00 , A61K9/52 , A61K9/24
CPC分类号： A61K9/0004
摘要： A delivery system is disclosed for delivering a fluid-sensitive active agent such as a somatotropin, or an analogue or derivative thereof, to an animal such as a bovine. The delivery system comprises a first wall section, a second wall section and a locking coupling therebetween. The coupled wall sections define a compartment, enclosing an active agent and an expandable driving member. Various embodiments of the locking coupling are disclosed.
摘要翻译：公开了用于将诸如生长激素或其类似物或衍生物的流体敏感活性剂递送到动物如牛的递送系统。输送系统包括第一壁部分，第二壁部分和它们之间的锁定联接。耦合的壁部分限定了隔室，包围活性剂和可扩展的驱动构件。公开了锁定联接器的各种实施例。

6. 发明授权

US5728088A Osmotic system for delivery of fluid-sensitive somatotropins to bovine animals 失效
标题翻译：用于将流体敏感生长激素递送至牛类动物的渗透系统
公开(公告)号：US5728088A
公开(公告)日：1998-03-17
申请号：US269596
申请日：1994-07-01
申请人： Judy A. Magruder , James B. Eckenhoff , Richard Cortese , Jeremy C. Wright , John R. Peery , James B. Pike , Urano A. Robinson , Jonathan P. Smith , Lyle E. Ziemann
发明人： Judy A. Magruder , James B. Eckenhoff , Richard Cortese , Jeremy C. Wright , John R. Peery , James B. Pike , Urano A. Robinson , Jonathan P. Smith , Lyle E. Ziemann
IPC分类号： A61D7/00 , A61K9/00 , A61K9/22 , A61K9/52 , A61M31/00
CPC分类号： A61K9/0004 , A61D7/00 , A61M31/002
摘要： A delivery system is disclosed for delivering a fluid-sensitive beneficial agent such as a somatotropin, or an analogue or derivative thereof, to an animal such as a bovine. The delivery system comprises a wall that surrounds an internal compartment, said wall comprising a first wall section that limits the passage of fluid into the system and a second wall section that permits the passage of fluid into the system. The wall may further comprise an end cap which may include means for adapting the end cap for ultrasonic welding to the first wall section and means for maintaining the beneficial agent in contact with exit means. The compartment comprises a beneficial agent and an expandable means. The delivery system comprises exit means for delivering the beneficial agent to the animal. The exit means may include means for compensating for slight variations in the efflux rate of the beneficial agent and means for maintaining for a sufficient velocity or efflux rate of beneficial agent outward from the device while minimizing diffusion of fluids from the external environment back into the device.
摘要翻译：公开了一种递送系统，用于将诸如生长激素或其类似物或衍生物的流体敏感的有益药物递送到动物例如牛。输送系统包括围绕内部隔室的壁，所述壁包括限制流体进入系统的第一壁部分和允许流体进入系统的第二壁部分。所述壁还可以包括端盖，所述端盖可以包括用于使用于超声波焊接的端盖适配到第一壁部分的装置和用于保持有益剂与出口装置接触的装置。隔室包括有益剂和可膨胀装置。递送系统包括用于将有益剂递送到动物的出口装置。出口装置可以包括用于补偿有益剂的流出速率的轻微变化的装置和用于维持有益剂从装置向外的足够的速度或流出速率的装置，同时最小化流体从外部环境扩散回装置。

7. 发明授权

US5215753A Delivery system with thermoresponsive composition comprising means for controlling internal pressure 失效
标题翻译：具有热敏组合物的输送系统包括用于控制内部压力的装置
公开(公告)号：US5215753A
公开(公告)日：1993-06-01
申请号：US849841
申请日：1992-03-12
申请人： Jeremy C. Wright , James B. Eckenhoff , Frederick H. Maruyama , John R. Peery
发明人： Jeremy C. Wright , James B. Eckenhoff , Frederick H. Maruyama , John R. Peery
IPC分类号： A61J3/07 , A61D7/00 , A61J1/00 , A61J3/00 , A61K9/00 , A61K9/22 , A61K9/52 , A61M31/00 , B65D83/00 , B67D7/08
CPC分类号： A61K9/0068 , A61K9/0004
摘要： A dispensing device is disclosed for delivering a beneficial agent. The device comprises (1) a semipermeable housing defining a internal space, (2) an optional and presently preferred in the space, (3) a heat responsive composition comprising a beneficial agent in the space, (4) a space consuming member in the device, (5) a non-toxic compound blended with the heat responsive composition for enhancing its viscosity; (6) an exit port in the wall for increasing the internal pressure of the dispenser and for simultaneously letting the beneficial agent exit through said port from the device, and (7) an embodiment comprising a prehydrating fluid for fastening the start-up of delivery from the delivery system.
摘要翻译：公开了用于递送有益剂的分配装置。该装置包括（1）限定内部空间的半透明壳体，（2）在该空间中任选且目前优选的;（3）在该空间中包含有益剂的热响应组合物，（4）空间消耗构件装置，（5）与热响应组合物混合的无毒化合物以增强其粘度; （6）壁中的出口，用于增加分配器的内部压力并且同时使有益剂从所述装置排出所述端口;以及（7）包括预水化流体的实施方案，用于紧固输送启动从送货系统。

8. 发明授权

US5112614A Implantable delivery dispenser 失效
标题翻译：可搬运分配器
公开(公告)号：US5112614A
公开(公告)日：1992-05-12
申请号：US407489
申请日：1989-09-14
申请人： Judy A. Magruder , James B. Eckenhoff , Jeremy C. Wright
发明人： Judy A. Magruder , James B. Eckenhoff , Jeremy C. Wright
IPC分类号： A61K9/00 , A61K9/22
CPC分类号： A61K9/0004
摘要： An implantable dispenser is enclosed comprising a wall surrounding a compartment containing a first composition comprising a beneficial agent, an oil, a cosolvent and a polymer gellant, a second expandable composition, a third boundary maintaining composition between the first and second composition, and an exit port.
摘要翻译：封闭的可植入分配器包括围绕包含第一组合物的隔室的壁，第一组合物包含有益剂，油，助溶剂和聚合物胶凝剂，第二可膨胀组合物，第一和第二组合物之间的第三边界保持组合物，以及出口港口。

9. 发明授权

US5110596A Delivery system comprising means for delivering agent to livestock 失效
标题翻译：输送系统包括用于将药物递送给家畜的装置
公开(公告)号：US5110596A
公开(公告)日：1992-05-05
申请号：US513330
申请日：1990-04-20
申请人： Judy A. Magruder , James B. Eckenhoff , Richard Cortese , Jeremy C. Wright , John R. Peery
发明人： Judy A. Magruder , James B. Eckenhoff , Richard Cortese , Jeremy C. Wright , John R. Peery
IPC分类号： A61K9/00 , A61M31/00
CPC分类号： A61K9/0004 , A61M31/002
摘要： A delivery system is disclosed for delivering a beneficial agent to an animal. The delivery system comprises a wall that surrounds a lumen, said wall comprising a composition that limits the passage of fluid into the system and a composition that permits the passage of fluid into the system. The lumen comprises a beneficial agent and an expandable member. The delivery system comprises an exit means for delivering the beneficial agent.
摘要翻译：公开了用于将有益剂递送到动物的递送系统。递送系统包括围绕内腔的壁，所述壁包括限制流体进入系统的组合物和允许流体进入系统的组合物。管腔包括有益剂和可膨胀构件。递送系统包括用于递送有益剂的出口装置。

10. 发明申请

US20100114074A1 Sustained delivery of an active agent using an implantable system 有权
标题翻译：使用可植入系统持续递送活性剂
公开(公告)号：US20100114074A1
公开(公告)日：2010-05-06
申请号：US12655399
申请日：2009-12-29
申请人： John R. Perry , Keith E. Dionne , James B. Eckenhoff , Felix A. Landrau , Scott D. Lautenbach , Judy A, Magruder , Jeremy C. Wright
发明人： John R. Perry , Keith E. Dionne , James B. Eckenhoff , Felix A. Landrau , Scott D. Lautenbach , Judy A, Magruder , Jeremy C. Wright
IPC分类号： A61M37/00 , B23P17/04
CPC分类号： A61M5/14526 , A61K9/0004 , A61K9/0024 , A61K38/09 , A61M2005/14513 , A61M2206/10
摘要： The invention is directed to a device for delivering an active agent formulation for a predetermined administration period. An impermeable reservoir is divided into a water-swellable agent chamber and an active agent formulation chamber. Fluid from the environment is imbibed through a semipermeable plug into the water-swellable agent chamber and the active agent formulation is released through a back-diffusion regulating outlet. Delivery periods of up to 2 years are achieved.
摘要翻译：本发明涉及一种用于在预定给药期间递送活性剂制剂的装置。不可渗透的储存器分为水溶胀剂室和活性剂配制室。来自环境的流体通过半渗透塞吸入水溶胀剂室中，活性剂制剂通过反向扩散调节出口释放。交付期限达2年。

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