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    • 8. 发明授权
    • Process for exchanging functional groups by halogen-metal exchange reaction
    • 通过卤素 - 金属交换反应交换官能团的方法
    • US07439535B2
    • 2008-10-21
    • US11077292
    • 2005-03-11
    • Takehiko IidaToshihiro WadaToshiaki Mase
    • Takehiko IidaToshihiro WadaToshiaki Mase
    • C07F3/02
    • C07D213/84C07C45/004C07C45/45C07D213/61C07D333/28C07F3/02C07F7/0827C07C47/55
    • A method by which a halogen atom of a halogen compound can be efficiently replaced with an electrophilic group.Also provided are: a reagent for converting a functional group through a halogen-metal exchange reaction, characterized by comprising either a mixture of a magnesium compound represented by the formula R1—Mg—X (I) (wherein R1 represents a halogen atom or an optionally substituted hydrocarbon residue; and X1 represents a halogen atom) and an organolithium compound represented by the formula R2—Li (II)(wherein R2 represents an optionally substituted hydrocarbon residue) or a product of the reaction of the magnesium compound with the organolithium compound; and a process for producing with the reagent a compound in which a halogen atom of a halogen compound has been replaced with an electrophilic group.
    • 可以用亲电子基团有效地代替卤素化合物的卤素原子的方法。 还提供:用于通过卤素 - 金属交换反应转化官能团的试剂,其特征在于包含由式R 1 -Mg-X(I)表示的镁化合物的混合物( 其中R 1表示卤素原子或任选取代的烃残基; X 1表示卤素原子)和由式R 2表示的有机锂化合物, (II)(其中R 2表示任选取代的烃残基)或镁化合物与有机锂化合物的反应的产物; 以及用该试剂制备其中卤素化合物的卤素原子已被亲电子基团取代的化合物的方法。