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1. 发明授权

US06281355B1 Nitrogen-containing tetracyclic compounds 失效
标题翻译：含氮四环化合物
公开(公告)号：US06281355B1
公开(公告)日：2001-08-28
申请号：US09555570
申请日：2000-06-01
申请人： Atsuro Nakazato , Taketoshi Okubo , Toshihito Kumagai , Shigeyuki Chaki , Kazuyuki Tomisawa , Masashi Nagamine , Makoto Gotoh , Kuniaki Kondoh , Masanori Yoshida
发明人： Atsuro Nakazato , Taketoshi Okubo , Toshihito Kumagai , Shigeyuki Chaki , Kazuyuki Tomisawa , Masashi Nagamine , Makoto Gotoh , Kuniaki Kondoh , Masanori Yoshida
IPC分类号： A61K31403
CPC分类号： C07D471/04 , C07D495/04
摘要： A nitrogen-containing tetracyclic compound represented by the formula: wherein Y1—Y2—Y3 is N—C═N or a group represented by the formula: C═C—NR3 (wherein R3 is a hydrogen atom, a C1-5 alkyl group or a nitrogen-containing C2-10 alkyl group), Y4 is S, SO, SO2, CH2 or a group represented by the formula: NR4 (wherein R4 is a C1-5 alkanoyl group or a C1-5 alkyl group), R1 and R2 are the same or different, and are each a hydrogen atom, a C1-10 alkyl group, a C3-15 alkoxyalkyl group or a C3-15 alkylaminoalkyl group, or R1 and R2 taken together with the nitrogen atom to which they are attached form a cyclic amino group, X1 and X2 are the same or different, and are each a hydrogen atom, a C1-5 alkyl group, a C1-5 alkoxy group or a halogen atom, and n is 0, 1 or 2; or a pharmaceutically acceptable salt thereof.
摘要翻译：一种由下式表示的含氮四环化合物：其中Y1-Y2-Y3为NC = N或由下式表示的基团：C = C-NR3（其中R3为氢原子，C1-5烷基或含氮的C2-10烷基），Y4是S，SO，SO2，CH2或由下式表示的基团：NR4（其中R4是C1-5烷酰基或C1-5烷基），R1和R2 各自为氢原子，C 1-10烷基，C 3-15烷氧基烷基或C 3-15烷基氨基烷基，或者R 1和R 2与它们所连接的氮原子一起形成环状氨基，X1和X2相同或不同，分别为氢原子，C1-5烷基，C1-5烷氧基或卤素原子，n为0,1或2; 或其药学上可接受的盐。

2. 发明授权

US06329525B1 1,2-Dihydro-2-oxoquinoline derivatives 失效
标题翻译： 1,2-二氢-2-氧代喹啉衍生物
公开(公告)号：US06329525B1
公开(公告)日：2001-12-11
申请号：US09555568
申请日：2000-06-01
申请人： Atsuro Nakazato , Taketoshi Okubo , Toshihito Kumagai , Shigeyuki Chaki , Kazuyuki Tomisawa , Masashi Nagamine , Makoto Gotoh , Masanori Yoshida
发明人： Atsuro Nakazato , Taketoshi Okubo , Toshihito Kumagai , Shigeyuki Chaki , Kazuyuki Tomisawa , Masashi Nagamine , Makoto Gotoh , Masanori Yoshida
IPC分类号： C07D215227
CPC分类号： C07D401/06 , C07D215/54 , C07D241/44
摘要： A 1,2-dihydro-2-oxoquinoline derivative represented by the formula: wherein Ar is a pyridyl group or a group represented by the formula: (wherein X3 and X4 are the same or different, and are each a hydrogen atom, a halogen atom, a C1-5 alkyl group, a C1-5 alkoxy group, a hydroxyl group or a trifluoromethyl group), Y is a nitrogen atom, CH or C(OH), R1 and R2 are the same or different, and are each a hydrogen atom, a C1-10 alkyl group, a C3-15 alkoxyalkyl group or a C3-15 alkylaminoalkyl group, or R1 and R2 taken together with the nitrogen atom to which they are attached form a cyclic amino group, X1 and X2 are the same or different, and are each a hydrogen atom, a C1-5 alkyl group, a C1-5 alkoxy group or a halogen atom, or X1 and X2 taken together form an alkylenedioxy group, and n is an integer of 1 to 3; or a pharmaceutically acceptable salt thereof.
摘要翻译：由下式表示的1,2-二氢-2-氧代喹啉衍生物：其中Ar是吡啶基或由下式表示的基团：（其中X 3和X 4相同或不同，并且各自为氢原子，卤素原子，C 1-5烷基，C 1-5烷氧基，羟基或三氟甲基），Y是氮原子，CH或C（OH），R 1和R 2相同或不同，各自相同或不同氢原子，C 1-10烷基，C 3-15烷氧基烷基或C 3-15烷基氨基烷基，或者R 1和R 2与它们所连接的氮原子一起形成环状氨基，X 1和X 2是相同或不同，各自为氢原子，C1-5烷基，C1-5烷氧基或卤素原子，或X1和X2一起形成亚烷基二氧基，n为1〜3的整数 ; 或其药学上可接受的盐。

3. 发明授权

US06380384B1 1,2-dihydro-2-oxoquinoline derivatives 失效
标题翻译： 1,2-二氢-2-氧代喹啉衍生物
公开(公告)号：US06380384B1
公开(公告)日：2002-04-30
申请号：US09829203
申请日：2001-04-10
申请人： Atsuro Nakazato , Taketoshi Okubo , Toshihito Kumagai , Shigeyuki Chaki , Kazuyuki Tomisawa , Masashi Nagamine , Makoto Gotoh , Masanori Yoshida
发明人： Atsuro Nakazato , Taketoshi Okubo , Toshihito Kumagai , Shigeyuki Chaki , Kazuyuki Tomisawa , Masashi Nagamine , Makoto Gotoh , Masanori Yoshida
IPC分类号： C07D40106
CPC分类号： C07D401/06 , C07D215/54 , C07D241/44
摘要： A 1,2-dihydro-2-oxoquinoline derivative represented by the formula: wherein Ar is a pyridyl group or a group represented by the formula: (wherein X3 and X4 are the same or different, and are each a hydrogen atom, a halogen atom, a C1-5 alkyl group, a C1-5 alkoxy group, a hydroxyl group or a trifluoromethyl group), Y is a nitrogen atom, CH or C(OH), R1 and R2 are the same or different, and are each a hydrogen atom, a C1-10 alkyl group, a C3-15 alkoxyalkyl group or a C3-15 alkylaminoalkyl group, or R1 and R2 taken together with the nitrogen atom to which they are attached form a cyclic amino group, X1 and X2 are the same or different, and are each a hydrogen atom, a C1-5 alkyl group, a C1-5 alkoxy group or a halogen atom; or X1 and X2 taken together form an alkylenedioxy group, and n is an integer of 1 to 3; or a pharmaceutically acceptable salt thereof.
摘要翻译：由下式表示的1,2-二氢-2-氧代喹啉衍生物：其中Ar是吡啶基或由下式表示的基团：（其中X 3和X 4相同或不同，并且各自为氢原子，卤素原子，C 1-5烷基，C 1-5烷氧基，羟基或三氟甲基），Y是氮原子，CH或C（OH），R 1和R 2相同或不同，各自相同或不同氢原子，C 1-10烷基，C 3-15烷氧基烷基或C 3-15烷基氨基烷基，或者R 1和R 2与它们所连接的氮原子一起形成环状氨基，X 1和X 2是相同或不同，并且各自为氢原子，C1-5烷基，C1-5烷氧基或卤素原子; 或者X1和X2一起形成亚烷基二氧基，n为1〜3的整数。或其药学上可接受的盐。

4. 发明授权

US6166033A 2-carbonylthiazole derivatives and use of the same 失效
标题翻译： 2-羰基噻唑衍生物及其用途
公开(公告)号：US6166033A
公开(公告)日：2000-12-26
申请号：US269021
申请日：1999-11-05
申请人： Atsuro Nakazato , Toshihito Kumagai , Shigeyuki Chaki , Kazuyuki Tomisawa , Masashi Nagamine , Makoto Gotoh , Masanori Yoshida
发明人： Atsuro Nakazato , Toshihito Kumagai , Shigeyuki Chaki , Kazuyuki Tomisawa , Masashi Nagamine , Makoto Gotoh , Masanori Yoshida
IPC分类号： A61K31/425 , C07D417/06 , A61K31/4535 , A61K31/496 , C07D211/70 , C07D401/14 , C07D413/06
CPC分类号： C07D417/06
摘要： This invention provides a 2-carbonylthiazole derivative represented by formula (I): ##STR1## wherein each of Ar.sup.1 and Ar.sup.2 represents a phenyl group or a substituted phenyl group; R.sup.1 represents an alkoxy group having 1 to 5 carbon atoms, a hydroxyl group or an amino group; Y.sup.1 --Y.sup.2 represents CH--CO or C.dbd.CR.sup.2, wherein R.sup.2 represents a hydrogen atom or an alkyl group having 1 to 5 carbon atoms; and n is an integer of from 1 to 4, or a pharmaceutically acceptable salt thereof. The disclosed compounds are useful as drugs for preventing and treating dopamine D receptor-related morbid states such as schizophrenia and problematic behavior caused by cerebrovascular accidents and senile dementia and do not induce extrapyramidal disorders as side effects.
摘要翻译： PCT No.PCT / JP97 / 03342 Sec。 371日期1999年11月5日 102（e）1999年11月5日PCT PCT 1997年9月19日PCT公布。公开号WO98 / 12195 日期：1998年3月26日本发明提供由式（I）表示的2-羰基噻唑衍生物：其中Ar1和Ar2各自表示苯基或取代的苯基; R1表示碳原子数1〜5的烷氧基，羟基或氨基。 Y1-Y2表示CH-CO或C = CR2，其中R2表示氢原子或具有1至5个碳原子的烷基; 和n为1〜4的整数，或其药学上可接受的盐。所公开的化合物可用作预防和治疗多巴胺D受体相关的病态，如精神分裂症和由脑血管意外和老年痴呆引起的问题行为的药物，并且不诱导锥体外系疾病作为副作用。

5. 发明授权

US06806275B2 Arylpiperidine derivatives and use thereof 失效
标题翻译：芳基哌啶衍生物及其用途
公开(公告)号：US06806275B2
公开(公告)日：2004-10-19
申请号：US10120408
申请日：2002-04-12
申请人： Masashi Nagamine , Makoto Gotoh , Masanori Yoshida , Atsuro Nakazato , Toshihito Kumagai , Shigeyuki Chaki , Kazuyuki Tomisawa
发明人： Masashi Nagamine , Makoto Gotoh , Masanori Yoshida , Atsuro Nakazato , Toshihito Kumagai , Shigeyuki Chaki , Kazuyuki Tomisawa
IPC分类号： A61K31505
CPC分类号： C07D401/14 , C07D409/14 , C07D417/14
摘要： The present invention provides an arylpiperidine derivative of the formula (I) or a pharmaceutically acceptable salt thereof, which has antipsychotic effect: wherein D is a carbon atom or a nitrogen atom, E is a CH group or a nitrogen atom, G is an oxygen atom, a sulfur atom, a nitrogen atom or an NH group, Y1 is a hydrogen atom or a halogen atom, n is an integer of 1 to 4, and R1 is a group represented by any of the formulas (i) to (iv) defined in the specification.
摘要翻译：本发明提供具有抗精神病作用的式（I）的芳基哌啶衍生物或其药学上可接受的盐，其中D为碳原子或氮原子，E为CH基或氮原子，G为氧原子，硫原子，氮原子或NH基，Y 1为氢原子或卤素原子，n为1〜4的整数，R 1为由式（i）至（iv）。

6. 发明授权

US06291467B1 Heteroaromatic derivatives 失效
标题翻译：杂芳族衍生物
公开(公告)号：US06291467B1
公开(公告)日：2001-09-18
申请号：US09646309
申请日：2000-09-15
申请人： Atsuro Nakazato , Toshihito Kumagai , Shigeyuki Chaki , Kazuyuki Tomisawa , Masashi Nagamine , Makoto Gotoh , Masanori Yoshida
发明人： Atsuro Nakazato , Toshihito Kumagai , Shigeyuki Chaki , Kazuyuki Tomisawa , Masashi Nagamine , Makoto Gotoh , Masanori Yoshida
IPC分类号： C07D41706
CPC分类号： C07D231/12 , C07D401/06 , C07D417/06
摘要： An aromaheterocyclic derivative represented by the formula: wherein Z is a group represented by the following formula: wherein Ar1 is a phenyl group or a phenyl group substituted with a halogen atom or an alkyl group of 1 to 5 carbon atoms, R2 is an alkyl group of 1 to 5 carbon atoms, Y is a hydrogen atom, a mercapto group, an alkylthio group of 1 to 5 carbon atoms, an amino group or an amino group substituted with one or two alkyl groups having 1 to 5 carbon atoms, Ar2 is a phenyl group of one or two substituents selected from the group consisting of a halogen atom, an alkyl group of 1 to 5 carbon atoms, an alkoxy group of 1 to 5 carbon atoms, a hydroxyl group and a trifluoromethyl group, or a phenyl group, B1-B2 is CH—CO or C═C(R1) (wherein R1 is a hydrogen atom or an alkyl group of 1 to 5 carbon atoms), and n is an integer of 1 to 4, or a pharmaceutically acceptable salt thereof, which is a dopamine D4 receptor antagonist compound having an antipsychotic action without causing extrapyramidal diseases.
摘要翻译：由下式表示的芳族杂环衍生物：其中Z为下式表示的基团：其中Ar1为苯基或被卤素原子或1〜5个碳原子的烷基取代的苯基，R2为烷基 1〜5个碳原子，Y为氢原子，巯基，1〜5个碳原子的烷硫基，氨基或被一个或两个碳原子数为1〜5的烷基取代的氨基，Ar2为选自卤素原子，1〜5个碳原子的烷基，1〜5个碳原子的烷氧基，羟基和三氟甲基，或苯基中的一个或两个取代基的苯基，B1-B2为CH-CO或C = C（R1）（其中R1为氢原子或1〜5个碳原子的烷基），n为1〜4的整数，或其药学上可接受的盐，其是具有抗精神病作用而不引起外敷的多巴胺D4受体拮抗剂化合物痉挛性疾病

7. 发明授权

US06407121B1 Arylpiperidine derivatives and use thereof 失效
标题翻译：芳基哌啶衍生物及其用途
公开(公告)号：US06407121B1
公开(公告)日：2002-06-18
申请号：US09646080
申请日：2000-09-13
申请人： Masashi Nagamine , Makoto Gotoh , Masanori Yoshida , Atsuro Nakazato , Toshihito Kumagai , Shigeyuki Chaki , Kazuyuki Tomisawa
发明人： Masashi Nagamine , Makoto Gotoh , Masanori Yoshida , Atsuro Nakazato , Toshihito Kumagai , Shigeyuki Chaki , Kazuyuki Tomisawa
IPC分类号： A61K31445
CPC分类号： C07D401/14 , C07D405/14 , C07D417/14
摘要： The present invention provides an arylpiperidine derivative of the formula (I) or a pharmaceutically acceptable salt thereof, which has antipsychotic effect: wherein D is a carbon atom or a nitrogen atom, E is a CH group or a nitrogen atom, G is an oxygen atom, a sulfur atom, a nitrogen atom or an NH group, Y1 is a hydrogen atom or a halogen atom, n is an integer of 1 to 4, and R1 is a group represented by any of the formulas (i) to (iv) defined in the specification.
摘要翻译：本发明提供具有抗精神病作用的式（I）的芳基哌啶衍生物或其药学上可接受的盐，其中D为碳原子或氮原子，E为CH基或氮原子，G为氧原子，硫原子，氮原子或NH基，Y1是氢原子或卤素原子，n是1〜4的整数，R1是由式（i）〜（iv）中的任一个表示的基团）。

8. 发明授权

US06469003B1 Pyridazinone derivatives 失效
标题翻译：哒嗪酮衍生物
公开(公告)号：US06469003B1
公开(公告)日：2002-10-22
申请号：US09762877
申请日：2001-02-14
申请人： Makoto Gotoh , Koji Umimoto , Masanobu Onishi , Akiyuki Satoh , Yoshitami Oshita , Masashi Nagamine
发明人： Makoto Gotoh , Koji Umimoto , Masanobu Onishi , Akiyuki Satoh , Yoshitami Oshita , Masashi Nagamine
IPC分类号： A61K3150
CPC分类号： C07D401/04 , C07D237/14 , C07D237/18 , C07D237/24 , C07D237/28 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D409/04 , C07D409/12 , C07D417/04 , C07D471/12
摘要： A pyridazinone derivative represented by formula (I): a pharmaceutically acceptable salt thereof, or a derivative thereof, or a pharmaceutical composition comprising as an active ingredient the derivative or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier or diluent.
摘要翻译：由式（I）表示的哒嗪酮衍生物：其药学上可接受的盐或其衍生物，或包含其衍生物或药学上可接受的盐和药学上可接受的载体或稀释剂作为活性成分的药物组合物。

9. 发明授权

US06875768B1 Phthalamide derivatives, intermediates in the production thereof, and agricultural/horticultural insecticides and method for using the same 失效
标题翻译：邻苯二甲酰胺衍生物，其生产中的中间体和农业/园艺杀虫剂及其使用方法
公开(公告)号：US06875768B1
公开(公告)日：2005-04-05
申请号：US10018464
申请日：2000-07-04
申请人： Kouzou Machiya , Kazuyoshi Endoh , Takashi Furuya , Hayami Nakao , Makoto Gotoh , Eiji Kohno , Masanori Tohnishi , Kazuyuki Sakata , Masayuki Morimoto , Akira Seo
发明人： Kouzou Machiya , Kazuyoshi Endoh , Takashi Furuya , Hayami Nakao , Makoto Gotoh , Eiji Kohno , Masanori Tohnishi , Kazuyuki Sakata , Masayuki Morimoto , Akira Seo
IPC分类号： A01N43/08 , A01N43/10 , A01N43/34 , A01N43/36 , A01N43/40 , A01N43/50 , A01N43/54 , A01N43/56 , A01N43/58 , A01N43/60 , A01N43/647 , A01N43/76 , A01N43/78 , A01N43/80 , A01N43/82 , C07D207/34 , C07D213/73 , C07D213/75 , C07D231/40 , C07D233/88 , C07D239/42 , C07D241/20 , C07D249/02 , C07D249/14 , C07D261/14 , C07D263/48 , C07D271/04 , C07D271/10 , C07D271/113 , C07D275/02 , C07D275/03 , C07D277/44 , C07D277/50 , C07D277/82 , C07D285/06 , C07D285/08 , C07D285/12 , C07D285/135 , C07D307/66 , C07D333/36 , C07D401/12 , C07D401/14
CPC分类号： C07D213/73 , A01N43/08 , A01N43/10 , A01N43/34 , A01N43/36 , A01N43/40 , A01N43/50 , A01N43/54 , A01N43/56 , A01N43/58 , A01N43/60 , A01N43/647 , A01N43/76 , A01N43/78 , A01N43/80 , A01N43/82 , C07D207/34 , C07D213/75 , C07D231/40 , C07D233/88 , C07D239/42 , C07D241/20 , C07D249/02 , C07D249/14 , C07D261/14 , C07D263/48 , C07D271/04 , C07D271/113 , C07D275/03 , C07D277/50 , C07D277/82 , C07D285/06 , C07D285/08 , C07D285/135 , C07D307/66 , C07D333/36
摘要： Heterocyclic amine derivatives represented by general formula (I): wherein R1, R2 and R3 represent each H, optionally halogenated C3-6 cycloalkyl, etc.; Q represents an optionally substituted heterocycle containing O, S or N; X represents halogeno, cyano, halo(C1-6)alkyl, etc.; n is from 1 to 4; and Z1 and Z2 represent each O or S; and intermediates thereof represented by the following general formula (IV′): Q′—NH2 wherein Q′ represents a definite heterocycle selected from among those represented by Q. Agricultural/horticultural insecticides having a remarkable effect of controlling pest insects of crops such as rice, fruit trees and vegetables, as well as various agricultural, forestry, horticultural and stored grain pest insects.
摘要翻译：由通式（I）表示的杂环胺衍生物：其中R 1，R 2和R 3各自表示H，任选卤代的C 3-6环烷基等; Q表示任选取代的含有O，S或N的杂环; X表示卤代，氰基，卤代（C 1-6）烷基等; n为1至4; Z 1和Z 2分别表示O或S; 及其中间体：Q'-NH 2，其中Q'表示选自Q表示的定义杂环。具有显着效果的农业/园艺杀虫剂对作物如稻米的害虫具有显着作用果树，蔬菜，以及各种农，林，园艺和储粮害虫。

10. 发明授权

US5362325A Apparatus for growing crystals in an environment in which opportunity for accessing is limited 失效
标题翻译：用于在存取机会有限的环境中生长晶体的装置
公开(公告)号：US5362325A
公开(公告)日：1994-11-08
申请号：US171971
申请日：1993-12-23
申请人： Atsushi Shiraishi , Koji Asano , Makoto Gotoh , Kotaro Oka
发明人： Atsushi Shiraishi , Koji Asano , Makoto Gotoh , Kotaro Oka
IPC分类号： C30B29/58 , C07K1/00 , C30B7/00 , C30B30/08 , B01D9/00
CPC分类号： C30B30/08 , C30B29/58 , C30B7/00 , Y10S117/901 , Y10T117/1004 , Y10T117/1012
摘要： A material processing apparatus includes a plurality of syringes provided detachable on a base member and containing fluids that are used for processing a material; A processing chamber is provided detachable on the base member for causing the material processing: An actuation mechanism actuates the plurality of syringes to supply the fluids in the syringes to the processing chamber; An interconnection fixture connects the plurality of syringes to the processing chamber for transporting the fluids in the plurality of syringes to the processing chamber. The plurality of syringes are provided detachable with respect to the interconnection fixture, and the processing chamber is provided detachable with respect to the interconnection fixture.
摘要翻译：一种材料处理设备包括多个注射器，其可拆卸地安装在基底构件上并且包含用于处理材料的流体; 一种处理室，其可拆卸地设置在基座构件上用于引起材料处理：致动机构致动多个注射器以将注射器中的流体供应到处理室; 互连夹具将多个注射器连接到处理室，用于将多个注射器中的流体输送到处理室。多个注射器相对于互连夹具可拆卸地设置，并且处理室设置成相对于互连夹具可拆卸。

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