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1. 发明申请

US20090104134A1 ORGANOPHILIC CLAY FOR THICKENING ORGANIC SOLVENTS 审中-公开
标题翻译：有机溶剂用于增稠有机溶剂
公开(公告)号：US20090104134A1
公开(公告)日：2009-04-23
申请号：US12282377
申请日：2007-06-06
申请人： Ashoke K. SenGupta , David McGregor , Ralph Spindler , Kevin Cureton
发明人： Ashoke K. SenGupta , David McGregor , Ralph Spindler , Kevin Cureton
IPC分类号： A61K47/30 , C08K3/34 , C08K3/26 , A61Q1/04 , A61Q3/02 , A61Q17/04 , A61Q1/10 , A61Q11/00 , C08K3/22
CPC分类号： A61K8/11 , A61K8/26 , A61K8/37 , A61K8/86 , A61K2800/412 , A61Q3/02 , C01B33/44
摘要： An organophilic clay for thickening hydrophobic liquids comprising a layered silicate material, surfaces of said layered silicate material modified by an amphipathic copolymer prepared from a first comonomer that generates a hydrophilic homopolymer that is essentially insoluble in a hydrophobic liquid and a second comonomer that generates a hydrophobic homopolymer that is soluble in a hydrophobic liquid, said organophilic clay containing at least 10% by weight water, based on the dry weight of the layered silicate material.
摘要翻译：一种用于增稠疏水性液体的亲有机粘土，其包含层状硅酸盐材料，所述层状硅酸盐材料的表面由由第一共聚单体制备的两亲共聚物改性，所述两性共聚物由基本不溶于疏水性液体的亲水均聚物和产生疏水性液体的第二共聚单体制备可溶于疏水液体的均聚物，所述有机粘土含有至少10重量％的水，基于层状硅酸盐材料的干重。

2. 发明申请

US20100183688A1 Delivery System and Method of Manufacturing the Same 审中-公开
标题翻译：交付系统及其制造方法
公开(公告)号：US20100183688A1
公开(公告)日：2010-07-22
申请号：US12373769
申请日：2007-07-23
申请人： Limin Liu , Ralph Spindler , Stephen J. Urbanec , Gholam-Reza Vakili-Tahami , Ashoke K. Sengupta , Kevin Cureton
发明人： Limin Liu , Ralph Spindler , Stephen J. Urbanec , Gholam-Reza Vakili-Tahami , Ashoke K. Sengupta , Kevin Cureton
IPC分类号： A61K8/02 , A61K9/14 , A01N25/26 , A61Q15/00 , A61Q17/04 , A61Q11/00 , A61K31/60 , A61K33/00 , A61K31/23 , A61K31/355 , A61K31/341 , A61K31/327 , A61K31/555 , A61K31/12 , A61K31/222 , A61K31/19 , A61Q5/10
CPC分类号： A61Q5/06 , A61K8/0241 , A61K8/8129 , A61K8/8152 , A61K9/0014 , A61K9/5015 , A61K9/5089 , A61K47/32 , A61K2800/522 , A61K2800/56 , A61K2800/622 , A61K2800/654 , A61Q7/00 , A61Q15/00 , A61Q17/005 , A61Q17/04 , A61Q19/00 , A61Q19/04
摘要： A microparticle delivery system for an active compound which includes an active compound loaded onto polymeric microparticles, wherein the loaded microparticles are encased by a matrix material comprising about 68% to about 99%, by weight, of the microparticle delivery system. Compositions containing the microparticle delivery system, and methods of manufacturing the microparticle delivery system, also are disclosed.
摘要翻译：用于活性化合物的微粒递送系统，其包含负载在聚合物微粒上的活性化合物，其中负载的微粒被基质材料包裹，所述基质材料占微粒输送系统的约68％至约99％。还公开了包含微粒递送系统的组合物和制造微粒递送系统的方法。

3. 发明授权

US06716418B2 Multifunctional particulate additive for personal care and cosmetic compositions, and the process of making the same 有权
标题翻译：用于个人护理和化妆品组合物的多功能颗粒添加剂及其制备方法
公开(公告)号：US06716418B2
公开(公告)日：2004-04-06
申请号：US10277470
申请日：2002-10-22
申请人： Ashoke K. SenGupta , Ralph Spindler , Jerald W. Darlington, Jr.
发明人： Ashoke K. SenGupta , Ralph Spindler , Jerald W. Darlington, Jr.
IPC分类号： A61K742
CPC分类号： A61K8/04 , A61K8/06 , A61K8/26 , A61K8/27 , A61K8/29 , A61K8/72 , A61Q1/02 , A61Q17/04 , A61Q19/00
摘要： Cosmetic and personal care compositions can be manufactured using the multifunctional-additive compositions of the present invention. Such an additive preferably contains one or more particulate-based thickeners, such as a smectite clay, colloidal silica, laponite, and/or alumina, and most preferably one or more smectite clays. According to one important embodiment of the present invention, the thickener particles are co-dispersed with particles of one or more particulate UVR-filters such as titanium dioxide, zinc oxide, or SUNSPHERE (available from International Specialty Chemicals, ISP), and most preferably with the natural particulate sunscreens such as the metal oxides. Another important component of the multifunctional-additive compositions is a dispersant or surface-modifier for the foregoing particulate materials, selected from the family of polyphenolic, natural polymers such as lignosulfonates, lignins, humates, tannates, and derivatives thereof. In addition, these compositions optionally include one or more of the following components: electrolytes, defoamers, humectants, emollients for cosmetics, preservatives, whiteners, and the like.
摘要翻译：可以使用本发明的多功能添加剂组合物制造化妆品和个人护理组合物。这种添加剂优选含有一种或多种颗粒基增稠剂，例如蒙脱石粘土，胶体二氧化硅，锂辉石和/或氧化铝，最优选一种或多种绿土粘土。根据本发明的一个重要实施方案，增稠剂颗粒与一种或多种微粒UVR-过滤器如二氧化钛，氧化锌或SUNSPHERE（可得自International Specialty Chemicals，ISP）的颗粒共分散，最优选与天然颗粒防晒剂如金属氧化物。多功能添加剂组合物的另一重要组分是用于上述颗粒材料的分散剂或表面改性剂，其选自多酚，天然聚合物如木素磺酸盐，木质素，腐殖酸盐，鞣酸盐及其衍生物。此外，这些组合物任选地包括一种或多种以下组分：电解质，消泡剂，保湿剂，化妆品的润肤剂，防腐剂，增白剂等。

4. 发明申请

US20090022818A1 HIGH-FOAMING, VISCOUS CLEANSER COMPOSITION WITH A SKIN CARE AGENT 审中-公开
标题翻译：高发泡，粘性清洁剂组合物与皮肤护理剂
公开(公告)号：US20090022818A1
公开(公告)日：2009-01-22
申请号：US12172784
申请日：2008-07-14
申请人： Ashoke K. SenGupta , Limin Liu , Gholam-Reza Vakili-Tahami , Ralph Spindler
发明人： Ashoke K. SenGupta , Limin Liu , Gholam-Reza Vakili-Tahami , Ralph Spindler
IPC分类号： A61K31/60 , C11D3/16 , A61K33/04 , A61K31/05 , A61K31/07 , A61K31/135 , A61K31/7056 , A61K31/194 , A61K31/192 , A61P17/10
CPC分类号： A61Q19/10 , A61K8/0279 , A61K8/046 , A61K8/39 , A61K8/73 , A61K8/8147 , A61K8/8152 , A61K2800/56 , A61K2800/594 , A61K2800/654
摘要： A liquid cleansing composition comprising a cleansing surfactant, an adsorbed skin-care agent, adsorptive polymeric particles having an adsorption capacity of at least 2 g of skin care agent per gm of dry polymeric particles, a polymeric thickening agent having a molecular weight in the range of 500,000-10,000,000 Dalton, a water-soluble polymer having a molecular weight in the range of 200-50,000 Dalton, and a hydrophilic liquid, the said cleansing composition having the following features i) the low molecular weight, water-soluble polymer component functions as a foam-boosting and thixotropy-boosting agent; ii) the ratio of the Brookfield viscosity at 1 rpm of spindle speed to the Brookfield viscosity at 100 rpm of spindle speed is at least 10; and iii) the foam-volume is at least 20% higher with the water-soluble, polymeric, foam-boosting component than without it.
摘要翻译：一种液体清洁组合物，其包含清洁表面活性剂，吸附的护肤剂，每克干性聚合物颗粒具有至少2g护肤剂吸附能力的吸附聚合物颗粒，分子量在该范围内的聚合物增稠剂 500,000-10,000,000道尔顿，分子量为200-50,000道尔顿的水溶性聚合物和亲水性液体，所述清洁组合物具有以下特征：i）低分子量水溶性聚合物组分的功能作为泡沫促进和触变增效剂; ii）主轴速度1rpm下的布鲁克菲尔德粘度与主轴速度在100rpm下的布鲁克菲尔德粘度之比为至少10; 和iii）泡沫体积与水溶性，聚合物，泡沫增强组分相比不高于20％。

5. 发明授权

US06500411B2 Multifunctional particulate additive for personal care and cosmetic compositions, and the process of making the same 有权
标题翻译：用于个人护理和化妆品组合物的多功能颗粒添加剂及其制备方法
公开(公告)号：US06500411B2
公开(公告)日：2002-12-31
申请号：US10068268
申请日：2002-02-05
申请人： Ashoke K. SenGupta , Ralph Spindler , Jerald W. Darlington, Jr.
发明人： Ashoke K. SenGupta , Ralph Spindler , Jerald W. Darlington, Jr.
IPC分类号： A61K700
CPC分类号： A61K8/04 , A61K8/06 , A61K8/26 , A61K8/27 , A61K8/29 , A61K8/72 , A61Q1/02 , A61Q17/04 , A61Q19/00
摘要： Cosmetic and personal care compositions can be manufactured using the multifunctional-additive compositions of the present invention. Such an additive preferably contains one or more particulate-based thickeners, such as a smectite clay, colloidal silica, laponite, and/or alumina, and most preferably one. or more smectite clays. According to one important embodiment of the present invention, the thickener particles are co-dispersed with particles of one or more particulate UVR-filters such as titanium dioxide, zinc oxide, or SUNSPHERE (available from International Specialty Chemicals, ISP), and most preferably with the natural particulate sunscreens such as the metal oxides. Another important component of the multifunctional-additive compositions is a dispersant or surface-modifier for the foregoing particulate materials, selected from the family of polyphenolic, natural polymers such as lignosulfonates, lignins, humates, tannates, and derivatives thereof. In addition, these compositions optionally include one or more of the following components: electrolytes, defoamers, humectants, emollients for cosmetics, preservatives, whiteners, and the like.
摘要翻译：可以使用本发明的多功能添加剂组合物制造化妆品和个人护理组合物。这种添加剂优选含有一种或多种基于颗粒的增稠剂，例如蒙脱石粘土，胶体二氧化硅，锂铝锂合金和/或氧化铝，最优选一种。或更多的绿土粘土。根据本发明的一个重要实施方案，增稠剂颗粒与一种或多种微粒UVR-过滤器如二氧化钛，氧化锌或SUNSPHERE（可得自International Specialty Chemicals，ISP）的颗粒共分散，最优选与天然颗粒防晒剂如金属氧化物。多功能添加剂组合物的另一重要组分是用于前述颗粒材料的分散剂或表面改性剂，其选自多酚，天然聚合物如木素磺酸盐，木质素，腐殖酸盐，鞣酸盐及其衍生物。此外，这些组合物任选地包括一种或多种以下组分：电解质，消泡剂，保湿剂，化妆品的润肤剂，防腐剂，增白剂等。

6. 发明申请

US20120014888A1 Matte Skin Finish Compositions 审中-公开
标题翻译：哑光皮肤成分
公开(公告)号：US20120014888A1
公开(公告)日：2012-01-19
申请号：US13145490
申请日：2010-01-25
申请人： Limin Liu , Ralph Spindler , Kevin Cureton
发明人： Limin Liu , Ralph Spindler , Kevin Cureton
IPC分类号： A61K8/30 , A61K8/06 , A61Q17/04 , A61Q19/02 , A61Q15/00
CPC分类号： A61Q19/008 , A61K8/02 , A61K8/8152 , A61K9/0014 , A61K2800/412 , A61Q1/02
摘要： A composition and method for reducing the shine of human skin is disclosed. The composition imparts a topical matte finish to the skin for an extended time period. The composition contains polymeric microparticles, optionally loaded with a cosmetic or therapeutic skin care compound.
摘要翻译：公开了一种用于减少人体皮肤光泽的组合物和方法。该组合物在皮肤上长时间给予局部消光。该组合物含有聚合物微粒，任选地装有化妆品或治疗性护肤化合物。

7. 发明申请

US20110189249A1 Low pH Retinoid Topical Compositions 有权
标题翻译：低pH维甲酸主题组合物
公开(公告)号：US20110189249A1
公开(公告)日：2011-08-04
申请号：US13062021
申请日：2009-09-09
申请人： Limin Liu , Ralph Spindler , Gholam-Reza Vakili-Tahami
发明人： Limin Liu , Ralph Spindler , Gholam-Reza Vakili-Tahami
IPC分类号： A61K8/67 , A61K8/02 , A61Q19/08
CPC分类号： A61K9/0014 , A61K8/06 , A61K8/064 , A61K8/11 , A61K8/671 , A61K9/107 , A61K9/1623 , A61K9/1635 , A61K9/1694 , A61K9/5084 , A61K47/02 , A61K47/10 , A61K47/14 , A61K2800/412 , A61K2800/56 , A61Q19/08
摘要： A low pH composition containing a retinol and a method for treating skin is disclosed. The composition contains (a) a retinoid and (b) an active acid, like an alpha-hydroxy acid or a beta-hydroxy acid, and has a pH of less than 5.
摘要翻译：公开了含有视黄醇的低pH组合物和治疗皮肤的方法。组合物包含（a）类视黄醇和（b）活性酸，如α-羟基酸或β-羟基酸，并且具有小于5的pH。

8. 发明申请

US20080286318A1 Oral Care Compositions 审中-公开
标题翻译：口腔护理组合
公开(公告)号：US20080286318A1
公开(公告)日：2008-11-20
申请号：US11815672
申请日：2006-02-24
申请人： Ralph Spindler , Stephen J. Urbanec , Nataliya V. Larionova
发明人： Ralph Spindler , Stephen J. Urbanec , Nataliya V. Larionova
IPC分类号： A61K9/14 , A61K8/21 , A61K8/24 , A61K8/22 , A61Q11/00
CPC分类号： A61Q11/00 , A61K8/0241 , A61K8/20 , A61K8/22 , A61K8/24 , A61K8/347 , A61K8/4926 , A61K8/8152 , A61K2800/56
摘要： An oral care composition containing polymeric microparticles highly loaded with an oral care compound is disclosed.
摘要翻译：公开了含有高度负荷口腔护理化合物的聚合物微粒的口腔护理组合物。

9. 发明申请

US20050089486A1 Self-tanning compositions and method of using the same 审中-公开
标题翻译：自鞣组合物及其使用方法
公开(公告)号：US20050089486A1
公开(公告)日：2005-04-28
申请号：US10948657
申请日：2004-09-23
申请人： Ralph Spindler , Ray Vakili , Stephen Urbanec
发明人： Ralph Spindler , Ray Vakili , Stephen Urbanec
IPC分类号： A61K8/04 , A61K8/34 , A61Q19/04 , A61K7/42 , A61K31/715
CPC分类号： A61K8/35 , A61K8/0279 , A61K8/41 , A61K8/44 , A61K2800/56 , A61Q19/04
摘要： A composition and method of enhancing the tanning rate of a self-tanning composition is disclosed. The self-tanning composition contains an amine potentiator loaded onto a microparticle delivery system.
摘要翻译：公开了提高自晒黑组合物的鞣制速度的组合物和方法。自鞣组合物含有负载在微粒输送系统上的胺增强剂。

10. 发明授权

US06491953B1 Controlled release compositions and method 有权
标题翻译：控制释放组合物和方法
公开(公告)号：US06491953B1
公开(公告)日：2002-12-10
申请号：US09479764
申请日：2000-01-07
申请人： Milan F. Sojka , Ralph Spindler
发明人： Milan F. Sojka , Ralph Spindler
IPC分类号： A61K914
CPC分类号： A61K9/5021 , A61K9/5015 , Y10S514/844 , Y10S514/963 , Y10S514/964 , Y10S514/965
摘要： A controlled release composition comprising an adsorbent polymer, an active agent, and a release retardant is disclosed. The composition has an improved ability to release the active agent over an extended time period.
摘要翻译：公开了一种包含吸附剂聚合物，活性剂和释放阻滞剂的控释组合物。该组合物在延长的时间内具有改善的释放活性剂的能力。

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