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1. 发明申请

US20080033563A1 TOTAL DISC IMPLANT 有权
标题翻译：总盘移植
公开(公告)号：US20080033563A1
公开(公告)日：2008-02-07
申请号：US11858016
申请日：2007-09-19
申请人： Ashok Khandkar , Darrel Brodke , Ramaswamy Lakshminarayanan
发明人： Ashok Khandkar , Darrel Brodke , Ramaswamy Lakshminarayanan
IPC分类号： A61F2/44 , A61B17/58
CPC分类号： A61F2/4425 , A61F2/30767 , A61F2002/30224 , A61F2002/30301 , A61F2002/30365 , A61F2002/30604 , A61F2002/30616 , A61F2002/30878 , A61F2002/30934 , A61F2002/443 , A61F2220/0033 , A61F2230/0069 , A61F2230/0095 , A61F2310/00023 , A61F2310/00029 , A61F2310/00317 , Y10S606/907
摘要： A total disc implant (TDI) is provided for total replacement of a spinal disc or discs in a human patient or other mammal, wherein the TDI is designed to maintain a substantially full range of natural motion (ROM) following implantation. The TDI generally comprises, in one preferred form, upper and lower end plates for affixation to adjacent vertebral bodies, with an intervening insert disposed therebetween. The end plates each include elongated part-cylindrical surfaces oriented generally perpendicular to each other, with one of said surfaces extending in an anterior-posterior direction and the other extending in a medial-lateral direction. The intervening insert defines concave upper and lower part-cylindrical seats oriented for respectively engaging these part-cylindrical surfaces, wherein these part-cylindrical seats are defined by offset radii to include a somewhat flattened central base region merging smoothly with upwardly curving radiused sides.
摘要翻译：全盘植入物（TDI）被提供用于人类患者或其他哺乳动物中的脊椎盘或椎间盘的完全替换，其中TDI被设计成在植入后保持基本上全部的自然运动范围（ROM）。在一个优选形式中，TDI通常包括用于固定到相邻椎体的上端板和下端板，其间设置插入插入件。端板各自包括大致垂直于彼此定向的细长部分圆柱形表面，其中一个表面沿前后方向延伸，另一个延伸在内侧方向上。中间插入件限定凹入的上部和下部圆柱形座，其定位成分别接合这些部分圆柱形表面，其中这些部分圆柱形座由偏移半径限定，以包括平滑地与向上弯曲的圆弧边合并的稍微平坦化的中心基部区域。

2. 发明申请

US20050177238A1 Radiolucent bone graft 审中-公开
标题翻译：放射性可透性骨移植
公开(公告)号：US20050177238A1
公开(公告)日：2005-08-11
申请号：US11040477
申请日：2005-01-20
申请人： Ashok Khandkar , Bret Berry , Darrel Brodke , Ramaswamy Lakshminarayanan , Mahendra Rao
发明人： Ashok Khandkar , Bret Berry , Darrel Brodke , Ramaswamy Lakshminarayanan , Mahendra Rao
IPC分类号： A61F2/00 , A61F2/28 , A61F2/30 , A61F2/44 , A61F2/46 , A61L27/10 , A61L27/30 , A61L27/32 , A61L27/38 , A61L27/56
CPC分类号： A61F2/30767 , A61F2/442 , A61F2/446 , A61F2/447 , A61F2/4611 , A61F2002/2835 , A61F2002/30011 , A61F2002/30016 , A61F2002/30064 , A61F2002/30153 , A61F2002/30158 , A61F2002/30166 , A61F2002/30179 , A61F2002/30224 , A61F2002/30235 , A61F2002/30261 , A61F2002/30266 , A61F2002/30271 , A61F2002/3028 , A61F2002/30329 , A61F2002/30616 , A61F2002/30677 , A61F2002/30733 , A61F2002/30774 , A61F2002/30777 , A61F2002/30789 , A61F2002/3082 , A61F2002/30822 , A61F2002/30827 , A61F2002/3085 , A61F2002/30881 , A61F2002/30891 , A61F2002/30892 , A61F2002/30896 , A61F2002/3092 , A61F2002/30968 , A61F2002/4475 , A61F2002/4623 , A61F2002/4629 , A61F2002/4648 , A61F2220/0025 , A61F2230/0019 , A61F2230/0026 , A61F2230/0028 , A61F2230/0058 , A61F2230/0063 , A61F2230/0069 , A61F2230/0082 , A61F2250/0019 , A61F2250/0023 , A61F2310/00203 , A61F2310/00239 , A61F2310/00796 , A61F2310/00928 , A61F2310/0097 , A61F2310/00976 , A61L27/10 , A61L27/30 , A61L27/32 , A61L27/3608 , A61L27/3695 , A61L27/3856 , A61L27/56 , A61L2430/02 , A61L2430/38
摘要： An improved bone graft is provided for human implantation, bone graft includes a substrate block of high strength biocompatible material having a selected size and shape to fit the anatomical space, and a controlled porosity analogous to natural bone. The substrate block may be coated with a bio-active surface coating material such as hydroxyapatite or a calcium phosphate to promote bone ingrowth and enhanced bone fusion. Upon implantation, the bone graft provides a spacer element having a desired combination of mechanical strength together with osteoconductivity and osteoinductivity to promote bone ingrowth and fusion, as well as radiolucency for facilitated post-operative monitoring. The bone graft may additionally carry one or more natural or synthetic therapeutic agents for further promoting bone ingrowth and fusion.
摘要翻译：提供改进的骨移植物用于人类植入，骨移植物包括具有选定尺寸和形状以适应解剖空间的高强度生物相容性材料的基底块，以及类似于天然骨的受控孔隙。衬底块可以涂覆有生物活性表面涂层材料，例如羟基磷灰石或磷酸钙，以促进骨向内生长和增强骨融合。植入后，骨移植物提供了具有机械强度与骨传导性和骨诱导性的期望组合的间隔元件，以促进骨向内生长和融合，以及便于术后监测的放射性。骨移植物还可携带一种或多种天然或合成治疗剂，用于进一步促进骨向内生长和融合。

3. 发明申请

US20050049706A1 Radiolucent spinal fusion cage 审中-公开
标题翻译：放射性可透性脊柱融合器
公开(公告)号：US20050049706A1
公开(公告)日：2005-03-03
申请号：US10941620
申请日：2004-09-14
申请人： Darrel Brodke , Bret Berry , Ashok Khandkar , Ramaswamy Lakshminarayanan , Mahendra Rao
发明人： Darrel Brodke , Bret Berry , Ashok Khandkar , Ramaswamy Lakshminarayanan , Mahendra Rao
IPC分类号： A61F2/00 , A61F2/28 , A61F2/30 , A61F2/44 , A61F2/46 , A61L27/10 , A61L27/30 , A61L27/32 , A61L27/38 , A61L27/56
CPC分类号： A61L27/3804 , A61F2/30767 , A61F2/442 , A61F2/446 , A61F2/447 , A61F2/4611 , A61F2002/2835 , A61F2002/30011 , A61F2002/30016 , A61F2002/30064 , A61F2002/30153 , A61F2002/30158 , A61F2002/30166 , A61F2002/30179 , A61F2002/30224 , A61F2002/30235 , A61F2002/30261 , A61F2002/30266 , A61F2002/30271 , A61F2002/3028 , A61F2002/30329 , A61F2002/30616 , A61F2002/30677 , A61F2002/30733 , A61F2002/30774 , A61F2002/30777 , A61F2002/30789 , A61F2002/3082 , A61F2002/30822 , A61F2002/30827 , A61F2002/3085 , A61F2002/30881 , A61F2002/30891 , A61F2002/30892 , A61F2002/30896 , A61F2002/3092 , A61F2002/30968 , A61F2002/4475 , A61F2002/4623 , A61F2002/4627 , A61F2002/4629 , A61F2002/4648 , A61F2220/0025 , A61F2230/0019 , A61F2230/0026 , A61F2230/0028 , A61F2230/0058 , A61F2230/0063 , A61F2230/0069 , A61F2230/0082 , A61F2250/0019 , A61F2250/0023 , A61F2310/00203 , A61F2310/00239 , A61F2310/00796 , A61F2310/00928 , A61F2310/0097 , A61F2310/00976 , A61L27/10 , A61L27/30 , A61L27/32 , A61L27/3608 , A61L27/365 , A61L27/3847 , A61L27/56 , A61L2430/02 , A61L2430/38
摘要： An improved bone graft is provided for human implantation, particularly such as a spinal fusion cage for implantation into the inter-vertebral space between two adjacent vertebrae. The improved spinal fusion cage includes a substrate block of high strength biocompatible material having a selected size and shape to fit the anatomical space, and a controlled porosity analogous to natural bone. The substrate block may be coated with a bio-active surface coating material such as hydroxyapatite or a calcium phosphate to promote bone in growth and enhanced bone fusion. Upon implantation, the fusion cage provides a spacer element having a desired combination of mechanical strength together with osteoconductivity and osteoinductivity to promote bone ingrowth and fusion, as well as radiolucency for facilitated post-operative monitoring. The fusion cage may additionally carry one or more natural or synthetic therapeutic agents for further promoting bone ingrowth and fusion.
摘要翻译：提供改进的骨移植物用于人类植入，特别是例如用于植入到两个相邻椎骨之间的椎间空间中的脊柱融合器。改进的脊柱融合器包括具有选定尺寸和形状以适应解剖空间的高强度生物相容性材料的基底块，以及类似于天然骨的受控孔隙。衬底块可以涂覆有生物活性表面涂层材料，例如羟基磷灰石或磷酸钙，以促进骨骼生长和增强骨融合。植入后，融合笼提供了具有机械强度与骨传导性和骨诱导性的期望组合的间隔元件，以促进骨向内生长和融合，以及便于手术后监测的放射性。融合笼可另外携带一种或多种天然或合成治疗剂，用于进一步促进骨向内生长和融合。

4. 发明申请

US20050273176A1 Hip prosthesis with monoblock ceramic acetabular cup 失效
标题翻译：髋关节假体与整体陶瓷髋臼杯
公开(公告)号：US20050273176A1
公开(公告)日：2005-12-08
申请号：US11203047
申请日：2005-08-12
申请人： K. Ely , Ashok Khandkar , Ramaswamy Lakshminarayanan , Aaron Hofmann
发明人： K. Ely , Ashok Khandkar , Ramaswamy Lakshminarayanan , Aaron Hofmann
IPC分类号： A61F2/00 , A61F2/30 , A61F2/32 , A61F2/34 , A61F2/36 , A61L27/10
CPC分类号： A61F2/32 , A61F2/30767 , A61F2/34 , A61F2/36 , A61F2/3662 , A61F2002/30011 , A61F2002/30324 , A61F2002/30332 , A61F2002/30685 , A61F2002/30934 , A61F2002/349 , A61F2002/3611 , A61F2002/3625 , A61F2002/365 , A61F2220/0033 , A61F2250/0023 , A61F2250/0036 , A61F2310/00011 , A61F2310/00029 , A61F2310/00179 , A61F2310/00203 , A61F2310/00239 , A61F2310/00317 , A61L27/10
摘要： An improved hip prosthesis includes an acetabular cup bearing component constructed from a relatively hard and high strength ceramic material for articulation with a ball-shaped femoral head component which may be constructed from a compatible ceramic or metal material. In one form, the acetabular cup further includes a ceramic porous bone ingrowth surface adhered thereto for secure ingrowth attachment to natural patient bone.
摘要翻译：改进的髋关节假体包括由相对较硬和高强度的陶瓷材料构成的髋臼杯支承部件，用于与可相容的陶瓷或金属材料构成的球形股骨头部件铰接。在一种形式中，髋臼杯还包括粘附到其上的陶瓷多孔骨向内生长表面，用于固定地向内植入天然患者骨。

5. 发明申请

US20060276788A1 Osteoconductive spinal fixation system 审中-公开
标题翻译：骨诱导性脊柱固定系统
公开(公告)号：US20060276788A1
公开(公告)日：2006-12-07
申请号：US11139126
申请日：2005-05-26
申请人： Bret Berry , Ashok Khandkar , Ramaswamy Lakshminarayanan
发明人： Bret Berry , Ashok Khandkar , Ramaswamy Lakshminarayanan
IPC分类号： A61F2/30
CPC分类号： A61B17/863 , A61B17/7005 , A61B17/7011 , A61B17/7037 , A61B17/7059 , A61B17/866 , A61B2017/00004 , A61F2/0077 , A61F2310/00592 , A61F2310/00796
摘要： An improved spinal fixation system is provided for human implantation, including a set of screws with interconnecting rods for implantation into the pedicle and between two adjacent vertebrae or a plate with screws for fixating two adjacent vertebrae. The screws, rods, and plates include a substrate portion of high strength biocompatible material and a controlled porosity analogous to natural bone. The substrate portion may be coated with a bio-active surface coating material such as hydroxyapatite or a calcium phosphate to promote bone ingrowth and enhanced bone fusion. Upon implantation, the fixation system provides a desired combination of mechanical strength together with osteoconductivity and bio-activity to promote bone ingrowth and fusion, as well as radiolucency for facilitated post-operative monitoring. The fixation system may additionally carry one or more natural or synthetic therapeutic agents for further promoting bone ingrowth and fusion.
摘要翻译：提供了一种改进的脊柱固定系统，用于人类植入，包括一组螺钉，其具有用于植入椎弓根的相互连接的杆和两个相邻椎骨之间的螺钉或具有用于固定两个相邻椎骨的螺钉的板。螺钉，杆和板包括高强度生物相容性材料的基底部分和类似于天然骨的受控孔隙。衬底部分可以涂覆有生物活性表面涂层材料，例如羟基磷灰石或磷酸钙，以促进骨向内生长和增强骨融合。植入后，固定系统提供机械强度与骨传导性和生物活性的期望组合，以促进骨向内生长和融合，以及便于手术后监测的放射性。固定系统可另外携带一种或多种天然或合成治疗剂，用于进一步促进骨向内生长和融合。

6. 发明申请

US20050107888A1 Metal-ceramic composite articulation 有权
标题翻译：金属陶瓷复合铰接
公开(公告)号：US20050107888A1
公开(公告)日：2005-05-19
申请号：US11020424
申请日：2004-12-21
申请人： Ashok Khandkar , Aaron Hofmann , Ramaswamy Lakshminarayanan
发明人： Ashok Khandkar , Aaron Hofmann , Ramaswamy Lakshminarayanan
IPC分类号： A61L27/04 , A61L27/10 , A61L27/42 , A61F2/30
CPC分类号： A61L27/045 , A61F2/32 , A61F2/34 , A61F2002/3611 , A61F2310/00317 , A61L27/10 , A61L27/42 , A61L27/427 , A61L2430/24
摘要： A ceramic-metal composite articulation is provided with substantial elimination of wear debris, wherein a ceramic material is provided with superior mechanical properties tailored for articulating with ceramic articulations having high flexural strength (greater than about 700 MPa), high fracture toughness (greater than about 7 MPam1/2) and a high Weibull modulus (greater than about 20), in comparison with presently available bio-ceramics such as alumina or zirconia. The mechanical property enhancement enables ceramic materials with greater reliability and significantly reduced in-vivo fracture risk to be obtained. Preliminary in-vitro wear performance, to several million cycles using established test protocols, of head/cup components in a prosthetic hip joint made from these ceramics also demonstrates the ultra low wear characteristics. These material properties substantially eliminate polyethylene (PE) wear debris mediated implant failures by offering an optimal combination of bio-mechanical safety and reliability with ultra low wear performance.
摘要翻译：陶瓷 - 金属复合铰链提供了大量消除磨损碎屑，其中陶瓷材料具有优良的机械性能，适合于与具有高弯曲强度（大于约700MPa），高断裂韧性（大于约700MPa）与目前可获得的生物陶瓷如氧化铝或氧化锆相比，具有较高的威布尔模量（大于约20）。机械性能的提高使陶瓷材料具有更高的可靠性和显着降低的体内断裂风险。由这些陶瓷制成的假体髋关节中的头部/杯部件的初步体外磨损性能，使用已建立的测试方案达数百万次循环，也表现出超低磨损特性。通过提供生物机械安全性和可靠性与超低磨损性能的最佳组合，这些材料性质基本上消除了聚乙烯（PE）磨损碎片介导的植入物失效。

7. 发明申请

US20050090903A1 Metal-ceramic composite articulation 有权
标题翻译：金属陶瓷复合铰接
公开(公告)号：US20050090903A1
公开(公告)日：2005-04-28
申请号：US10987415
申请日：2004-11-12
申请人： Ashok Khandkar , Aaron Hofmann , Ramaswamy Lakshminarayanan
发明人： Ashok Khandkar , Aaron Hofmann , Ramaswamy Lakshminarayanan
IPC分类号： A61L27/04 , A61L27/10 , A61L27/42 , A61F2/32 , A61F2/28 , A61F2/30
CPC分类号： A61L27/045 , A61F2/32 , A61F2/34 , A61F2002/3611 , A61F2310/00317 , A61L27/10 , A61L27/42 , A61L27/427 , A61L2430/24
摘要： A ceramic-metal composite articulation is provided with substantial elimination of wear debris, wherein a ceramic material is provided with superior mechanical properties tailored for articulating with ceramic articulations having high flexural strength (greater than about 700 MPa), high fracture toughness (greater than about 7 MPam1/2) and a high Weibull modulus (greater than about 20), in comparison with presently available bio-ceramics such as alumina or zirconia. The mechanical property enhancement enables ceramic materials with greater reliability and significantly reduced in-vivo fracture risk to be obtained. Preliminary in-vitro wear performance, to several million cycles using established test protocols, of head/cup components in a prosthetic hip joint made from these ceramics also demonstrates the ultra low wear characteristics. These material properties substantially eliminate PE wear debris mediated implant failures by offering an optimal combination of bio-mechanical safety and reliability with ultra low wear performance.
摘要翻译：陶瓷 - 金属复合铰链提供了大量消除磨损碎屑，其中陶瓷材料具有优良的机械性能，适合于与具有高弯曲强度（大于约700MPa），高断裂韧性（大于约700MPa）与目前可获得的生物陶瓷如氧化铝或氧化锆相比，具有较高的威布尔模量（大于约20）。机械性能的提高使陶瓷材料具有更高的可靠性和显着降低的体内断裂风险。由这些陶瓷制成的假体髋关节中的头部/杯部件的初步体外磨损性能，使用已建立的测试方案达数百万次循环，也表现出超低磨损特性。通过提供生物机械安全性和可靠性与超低磨损性能的最佳组合，这些材料性质基本上消除了PE磨损碎片介导的植入物失效。

8. 发明授权

US10709800B2 Radio-opaque writing instruments and methods of use 有权
公开(公告)号：US10709800B2
公开(公告)日：2020-07-14
申请号：US16103870
申请日：2018-08-14
申请人： Prataprai R. Chowdhary , Ashok Khandkar
发明人： Prataprai R. Chowdhary , Ashok Khandkar
IPC分类号： B43K29/00 , A61K49/04 , A61B90/00 , B43K5/00 , B43K8/14
摘要： A radio-opaque composition is formulated to enable a clinician to apply custom markings to a surface, such as a patient's skin or a surgical drape on the patient. More specifically, the radio-opaque composition may be used to write on the surface. The markings may be well-defined and contrast with the surface to which they are applied. Such a composition may include a liquid radio-opaque component that includes one or more radio-opaque materials that have been dissolved in a solvent, as well as a solid radio-opaque component with particles of one or more radio-opaque materials dispersed throughout a carrier, such as the solvent of the liquid radio-opaque component. Marking apparatuses that may be used to write with the radio-opaque composition are also disclosed, as are methods for using the radio-opaque composition.

9. 发明授权

US11369696B1 Radio-opaque writing instruments and methods of use 有权
公开(公告)号：US11369696B1
公开(公告)日：2022-06-28
申请号：US16928863
申请日：2020-07-14
申请人： Prataprai R. Chowdhary , Ashok Khandkar
发明人： Prataprai R. Chowdhary , Ashok Khandkar
IPC分类号： B43K29/00 , A61K49/04 , A61B90/00 , B43K5/00 , B43K8/14
摘要： A radio-opaque composition is formulated to enable a clinician to apply custom markings to a surface, such as a patient's skin or a surgical drape on the patient. More specifically, the radio-opaque composition may be used to write on the surface. The markings may be well-defined and contrast with the surface to which they are applied. Such a composition may include a liquid radio-opaque component that includes one or more radio-opaque materials that have been dissolved in a solvent, as well as a solid radio-opaque component with particles of one or more radio-opaque materials dispersed throughout a carrier, such as the solvent of the liquid radio-opaque component. Marking apparatuses that may be used to write with the radio-opaque composition are also disclosed, as are methods for using the radio-opaque composition.

10. 发明申请

US20190046666A1 RADIO-OPAQUE WRITING INSTRUMENTS AND METHODS OF USE 审中-公开
公开(公告)号：US20190046666A1
公开(公告)日：2019-02-14
申请号：US16103870
申请日：2018-08-14
申请人： Prataprai R. Chowdhary , Ashok Khandkar
发明人： Prataprai R. Chowdhary , Ashok Khandkar
IPC分类号： A61K49/04 , A61B90/00 , B43K5/00
摘要： A radio-opaque composition is formulated to enable a clinician to apply custom markings to a surface, such as a patient's skin or a surgical drape on the patient. More specifically, the radio-opaque composition may be used to write on the surface. The markings may be well-defined and contrast with the surface to which they are applied. Such a composition may include a liquid radio-opaque component that includes one or more radio-opaque materials that have been dissolved in a solvent, as well as a solid radio-opaque component with particles of one or more radio-opaque materials dispersed throughout a carrier, such as the solvent of the liquid radio-opaque component. Marking apparatuses that may be used to write with the radio-opaque composition are also disclosed, as are methods for using the radio-opaque composition.

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