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1. 发明申请

US20080033563A1 TOTAL DISC IMPLANT 有权
标题翻译：总盘移植
公开(公告)号：US20080033563A1
公开(公告)日：2008-02-07
申请号：US11858016
申请日：2007-09-19
申请人： Ashok Khandkar , Darrel Brodke , Ramaswamy Lakshminarayanan
发明人： Ashok Khandkar , Darrel Brodke , Ramaswamy Lakshminarayanan
IPC分类号： A61F2/44 , A61B17/58
CPC分类号： A61F2/4425 , A61F2/30767 , A61F2002/30224 , A61F2002/30301 , A61F2002/30365 , A61F2002/30604 , A61F2002/30616 , A61F2002/30878 , A61F2002/30934 , A61F2002/443 , A61F2220/0033 , A61F2230/0069 , A61F2230/0095 , A61F2310/00023 , A61F2310/00029 , A61F2310/00317 , Y10S606/907
摘要： A total disc implant (TDI) is provided for total replacement of a spinal disc or discs in a human patient or other mammal, wherein the TDI is designed to maintain a substantially full range of natural motion (ROM) following implantation. The TDI generally comprises, in one preferred form, upper and lower end plates for affixation to adjacent vertebral bodies, with an intervening insert disposed therebetween. The end plates each include elongated part-cylindrical surfaces oriented generally perpendicular to each other, with one of said surfaces extending in an anterior-posterior direction and the other extending in a medial-lateral direction. The intervening insert defines concave upper and lower part-cylindrical seats oriented for respectively engaging these part-cylindrical surfaces, wherein these part-cylindrical seats are defined by offset radii to include a somewhat flattened central base region merging smoothly with upwardly curving radiused sides.
摘要翻译：全盘植入物（TDI）被提供用于人类患者或其他哺乳动物中的脊椎盘或椎间盘的完全替换，其中TDI被设计成在植入后保持基本上全部的自然运动范围（ROM）。在一个优选形式中，TDI通常包括用于固定到相邻椎体的上端板和下端板，其间设置插入插入件。端板各自包括大致垂直于彼此定向的细长部分圆柱形表面，其中一个表面沿前后方向延伸，另一个延伸在内侧方向上。中间插入件限定凹入的上部和下部圆柱形座，其定位成分别接合这些部分圆柱形表面，其中这些部分圆柱形座由偏移半径限定，以包括平滑地与向上弯曲的圆弧边合并的稍微平坦化的中心基部区域。

2. 发明申请

US20050240273A1 Total disc implant 失效
标题翻译：全盘植入
公开(公告)号：US20050240273A1
公开(公告)日：2005-10-27
申请号：US11149627
申请日：2005-06-09
申请人： Ashock Khandkar , Darrel Brodke , Ramaswamy Lakshminarayanan
发明人： Ashock Khandkar , Darrel Brodke , Ramaswamy Lakshminarayanan
IPC分类号： A61F20060101 , A61F2/00 , A61F2/30 , A61F2/44
CPC分类号： A61F2/4425 , A61F2/30767 , A61F2002/30224 , A61F2002/30301 , A61F2002/30365 , A61F2002/30604 , A61F2002/30616 , A61F2002/30878 , A61F2002/30934 , A61F2002/443 , A61F2220/0033 , A61F2230/0069 , A61F2230/0095 , A61F2310/00023 , A61F2310/00029 , A61F2310/00317 , Y10S606/907
摘要： A total disc implant (TDI) is provided for total replacement of a spinal disc or discs in a human patient or other mammal, wherein the TDI is designed to maintain a substantially full range of natural motion (ROM) following implantation. The TDI generally comprises, in one preferred form, upper and lower end plates for affixation to adjacent vertebral bodies, with an intervening insert disposed therebetween. The end plates each include elongated part-cylindrical surfaces oriented generally perpendicular to each other, with one of said surfaces extending in an anterior-posterior direction and the other extending in a medial-lateral direction. The intervening insert defines concave upper and lower part-cylindrical seats oriented for respectively engaging these part-cylindrical surfaces, wherein these part-cylindrical seats are defined by offset radii to include a somewhat flattened central base region merging smoothly with upwardly curving radiused sides.
摘要翻译：全盘植入物（TDI）被提供用于人类患者或其他哺乳动物中的脊椎盘或椎间盘的完全替换，其中TDI被设计成在植入后保持基本上全部的自然运动范围（ROM）。在一个优选形式中，TDI通常包括用于固定到相邻椎体的上端板和下端板，其间设置插入插入件。端板各自包括大致垂直于彼此定向的细长部分圆柱形表面，其中一个表面沿前后方向延伸，另一个延伸在内侧方向上。中间插入件限定凹入的上部和下部圆柱形座，其定位成分别接合这些部分圆柱形表面，其中这些部分圆柱形座由偏移半径限定，以包括平滑地与向上弯曲的圆弧边合并的稍微平坦化的中心基部区域。

3. 发明申请

US20050177238A1 Radiolucent bone graft 审中-公开
标题翻译：放射性可透性骨移植
公开(公告)号：US20050177238A1
公开(公告)日：2005-08-11
申请号：US11040477
申请日：2005-01-20
申请人： Ashok Khandkar , Bret Berry , Darrel Brodke , Ramaswamy Lakshminarayanan , Mahendra Rao
发明人： Ashok Khandkar , Bret Berry , Darrel Brodke , Ramaswamy Lakshminarayanan , Mahendra Rao
IPC分类号： A61F2/00 , A61F2/28 , A61F2/30 , A61F2/44 , A61F2/46 , A61L27/10 , A61L27/30 , A61L27/32 , A61L27/38 , A61L27/56
CPC分类号： A61F2/30767 , A61F2/442 , A61F2/446 , A61F2/447 , A61F2/4611 , A61F2002/2835 , A61F2002/30011 , A61F2002/30016 , A61F2002/30064 , A61F2002/30153 , A61F2002/30158 , A61F2002/30166 , A61F2002/30179 , A61F2002/30224 , A61F2002/30235 , A61F2002/30261 , A61F2002/30266 , A61F2002/30271 , A61F2002/3028 , A61F2002/30329 , A61F2002/30616 , A61F2002/30677 , A61F2002/30733 , A61F2002/30774 , A61F2002/30777 , A61F2002/30789 , A61F2002/3082 , A61F2002/30822 , A61F2002/30827 , A61F2002/3085 , A61F2002/30881 , A61F2002/30891 , A61F2002/30892 , A61F2002/30896 , A61F2002/3092 , A61F2002/30968 , A61F2002/4475 , A61F2002/4623 , A61F2002/4629 , A61F2002/4648 , A61F2220/0025 , A61F2230/0019 , A61F2230/0026 , A61F2230/0028 , A61F2230/0058 , A61F2230/0063 , A61F2230/0069 , A61F2230/0082 , A61F2250/0019 , A61F2250/0023 , A61F2310/00203 , A61F2310/00239 , A61F2310/00796 , A61F2310/00928 , A61F2310/0097 , A61F2310/00976 , A61L27/10 , A61L27/30 , A61L27/32 , A61L27/3608 , A61L27/3695 , A61L27/3856 , A61L27/56 , A61L2430/02 , A61L2430/38
摘要： An improved bone graft is provided for human implantation, bone graft includes a substrate block of high strength biocompatible material having a selected size and shape to fit the anatomical space, and a controlled porosity analogous to natural bone. The substrate block may be coated with a bio-active surface coating material such as hydroxyapatite or a calcium phosphate to promote bone ingrowth and enhanced bone fusion. Upon implantation, the bone graft provides a spacer element having a desired combination of mechanical strength together with osteoconductivity and osteoinductivity to promote bone ingrowth and fusion, as well as radiolucency for facilitated post-operative monitoring. The bone graft may additionally carry one or more natural or synthetic therapeutic agents for further promoting bone ingrowth and fusion.
摘要翻译：提供改进的骨移植物用于人类植入，骨移植物包括具有选定尺寸和形状以适应解剖空间的高强度生物相容性材料的基底块，以及类似于天然骨的受控孔隙。衬底块可以涂覆有生物活性表面涂层材料，例如羟基磷灰石或磷酸钙，以促进骨向内生长和增强骨融合。植入后，骨移植物提供了具有机械强度与骨传导性和骨诱导性的期望组合的间隔元件，以促进骨向内生长和融合，以及便于术后监测的放射性。骨移植物还可携带一种或多种天然或合成治疗剂，用于进一步促进骨向内生长和融合。

4. 发明申请

US20070198093A1 SPINAL IMPLANT WITH OFFSET KEELS 审中-公开
标题翻译：脊柱植入与偏心牙科
公开(公告)号：US20070198093A1
公开(公告)日：2007-08-23
申请号：US11307701
申请日：2006-02-17
申请人： Darrel Brodke , John Bernero
发明人： Darrel Brodke , John Bernero
IPC分类号： A61F2/44
CPC分类号： A61F2/442 , A61F2/4425 , A61F2/4611 , A61F2002/3082 , A61F2002/30884 , A61F2002/3092 , A61F2002/449 , A61F2310/00011 , A61F2310/00179
摘要： An improved spinal implant includes vertically offset keels for mechanically interlocking respectively with overlying and underlying vertebral bone structures when implanted therebetween. At least one upper keel projects upwardly for close-fit reception into a prepared slot formed in the overlying vertebral structure, and at least one lower keel projects downwardly for similar close-fit reception into a prepared slot formed in the underlying vertebral structure. The upper and lower keels are misaligned or offset from each other to preclude creation of a common stress line extending therethrough, thereby significantly reducing risk of vertebral fracture.
摘要翻译：改进的脊柱植入物包括垂直偏移的龙骨，用于在植入其间时与上覆和下面的椎骨结构机械互锁。至少一个上龙骨向上突出，用于紧密接合到形成在上覆脊椎结构中的预备槽中，并且至少一个下龙骨向下突出以类似的紧密接合接合到形成在下面的椎骨结构中的预备槽中。上龙骨和下龙骨彼此不对准或偏移，以防止产生延伸穿过其中的共同应力线，从而显着降低椎骨骨折的风险。

5. 发明申请

US20050228388A1 DOUBLE LEAD BONE SCREW 审中-公开
标题翻译：双铅骨头螺丝
公开(公告)号：US20050228388A1
公开(公告)日：2005-10-13
申请号：US10708881
申请日：2004-03-30
申请人： Darrel Brodke , G. Kumar , Michael Varieur
发明人： Darrel Brodke , G. Kumar , Michael Varieur
IPC分类号： A61B17/58 , A61B17/86
CPC分类号： A61B17/863
摘要： A bone screw is provided having a head and a shank with opposed first and second helical threads extending there around. In one embodiment, the shank has a proximal portion with a constant minor diameter, and a distal portion with a minor diameter that decreases in a proximal-to-distal direction to form a taper. The opposed first and second helical threads preferably define a thread depth that remains constant along the length of the shank. In an exemplary embodiment, a major diameter of the shank at a distal tip of the shank is equal to or less than the minor diameter of the proximal portion of the shank.
摘要翻译：提供了具有头部和柄部的骨螺钉，其具有在其周围延伸的相对的第一和第二螺旋形螺纹。在一个实施例中，柄具有具有恒定小直径的近端部分，以及具有小直径的远端部分，其在近端至远端方向上减小以形成锥形。相对的第一和第二螺旋螺纹优选地限定沿着柄的长度保持恒定的螺纹深度。在示例性实施例中，柄部的远侧末端处的柄的大直径等于或小于柄的近端部分的小直径。

6. 发明申请

US20050049706A1 Radiolucent spinal fusion cage 审中-公开
标题翻译：放射性可透性脊柱融合器
公开(公告)号：US20050049706A1
公开(公告)日：2005-03-03
申请号：US10941620
申请日：2004-09-14
申请人： Darrel Brodke , Bret Berry , Ashok Khandkar , Ramaswamy Lakshminarayanan , Mahendra Rao
发明人： Darrel Brodke , Bret Berry , Ashok Khandkar , Ramaswamy Lakshminarayanan , Mahendra Rao
IPC分类号： A61F2/00 , A61F2/28 , A61F2/30 , A61F2/44 , A61F2/46 , A61L27/10 , A61L27/30 , A61L27/32 , A61L27/38 , A61L27/56
CPC分类号： A61L27/3804 , A61F2/30767 , A61F2/442 , A61F2/446 , A61F2/447 , A61F2/4611 , A61F2002/2835 , A61F2002/30011 , A61F2002/30016 , A61F2002/30064 , A61F2002/30153 , A61F2002/30158 , A61F2002/30166 , A61F2002/30179 , A61F2002/30224 , A61F2002/30235 , A61F2002/30261 , A61F2002/30266 , A61F2002/30271 , A61F2002/3028 , A61F2002/30329 , A61F2002/30616 , A61F2002/30677 , A61F2002/30733 , A61F2002/30774 , A61F2002/30777 , A61F2002/30789 , A61F2002/3082 , A61F2002/30822 , A61F2002/30827 , A61F2002/3085 , A61F2002/30881 , A61F2002/30891 , A61F2002/30892 , A61F2002/30896 , A61F2002/3092 , A61F2002/30968 , A61F2002/4475 , A61F2002/4623 , A61F2002/4627 , A61F2002/4629 , A61F2002/4648 , A61F2220/0025 , A61F2230/0019 , A61F2230/0026 , A61F2230/0028 , A61F2230/0058 , A61F2230/0063 , A61F2230/0069 , A61F2230/0082 , A61F2250/0019 , A61F2250/0023 , A61F2310/00203 , A61F2310/00239 , A61F2310/00796 , A61F2310/00928 , A61F2310/0097 , A61F2310/00976 , A61L27/10 , A61L27/30 , A61L27/32 , A61L27/3608 , A61L27/365 , A61L27/3847 , A61L27/56 , A61L2430/02 , A61L2430/38
摘要： An improved bone graft is provided for human implantation, particularly such as a spinal fusion cage for implantation into the inter-vertebral space between two adjacent vertebrae. The improved spinal fusion cage includes a substrate block of high strength biocompatible material having a selected size and shape to fit the anatomical space, and a controlled porosity analogous to natural bone. The substrate block may be coated with a bio-active surface coating material such as hydroxyapatite or a calcium phosphate to promote bone in growth and enhanced bone fusion. Upon implantation, the fusion cage provides a spacer element having a desired combination of mechanical strength together with osteoconductivity and osteoinductivity to promote bone ingrowth and fusion, as well as radiolucency for facilitated post-operative monitoring. The fusion cage may additionally carry one or more natural or synthetic therapeutic agents for further promoting bone ingrowth and fusion.
摘要翻译：提供改进的骨移植物用于人类植入，特别是例如用于植入到两个相邻椎骨之间的椎间空间中的脊柱融合器。改进的脊柱融合器包括具有选定尺寸和形状以适应解剖空间的高强度生物相容性材料的基底块，以及类似于天然骨的受控孔隙。衬底块可以涂覆有生物活性表面涂层材料，例如羟基磷灰石或磷酸钙，以促进骨骼生长和增强骨融合。植入后，融合笼提供了具有机械强度与骨传导性和骨诱导性的期望组合的间隔元件，以促进骨向内生长和融合，以及便于手术后监测的放射性。融合笼可另外携带一种或多种天然或合成治疗剂，用于进一步促进骨向内生长和融合。

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