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1. 发明申请

US20110303760A1 APPARATUS AND METHOD FOR CONTROLLABLY RELEASING A SUBSTANCE 审中-公开
标题翻译：控制释放物质的装置和方法
公开(公告)号：US20110303760A1
公开(公告)日：2011-12-15
申请号：US12950053
申请日：2010-11-19
申请人： Ashok Joshi , Truman Wold , David Erekson , John Howard Gordon
发明人： Ashok Joshi , Truman Wold , David Erekson , John Howard Gordon
IPC分类号： A61L9/04
CPC分类号： A61L9/127 , A61L2209/131 , A61L2209/132
摘要： An apparatus for controllably releasing a substance is disclosed herein. In one embodiment, such an apparatus includes a chamber to store a non-gaseous fluid. An outlet communicates with a bottom of the chamber to dispense the non-gaseous fluid. An inlet communicates with a top of the chamber to enable gas to flow into the chamber. To regulate the flow of non-gaseous fluid through the outlet, a regulator element is coupled to the inlet to regulate the flow of gas into the chamber. In certain embodiments, to provide more consistent release rates, the chamber includes a short wide portion situated above a relatively long narrow portion. Such a configuration generates more consistent head pressure and thus more consistent release rates for the non-gaseous fluid. A corresponding method is also disclosed herein.
摘要翻译：本文公开了可控释放物质的装置。在一个实施例中，这种装置包括用于存储非气态流体的室。出口与室的底部连通以分配非气态流体。入口与室的顶部连通，以使气体能够流入腔室。为了调节通过出口的非气态流体的流动，调节器元件联接到入口以调节进入室的气体流。在某些实施例中，为了提供更一致的释放速率，腔室包括位于相对长的狭窄部分上方的短宽度部分。这种配置产生更一致的头部压力，从而产生非气态流体的更一致的释放速率。本文还公开了相应的方法。

2. 发明授权

US08113390B2 Gas generation dispenser apparatus and method for on-demand fluid delivery 有权
标题翻译：用于按需流体输送的气体分配装置和方法
公开(公告)号：US08113390B2
公开(公告)日：2012-02-14
申请号：US11923490
申请日：2007-10-24
申请人： Truman Wold , John Howard Gordon , Ashok Joshi
发明人： Truman Wold , John Howard Gordon , Ashok Joshi
IPC分类号： G01F11/00
CPC分类号： A61M5/14526 , A61L9/12 , A61L2209/132 , A61M5/14244 , A61M11/007 , A61M2005/14204 , A61M2005/14513 , A61M2205/3368 , A61M2205/8206 , A61M2205/8231 , B05B11/025 , B05B11/04 , B05B11/061
摘要： An on-demand fluid dispenser to dispense fluid in response to gas generation by a gas cell. The on-demand fluid dispenser includes an expandable gas chamber, a fluid chamber, and an on-demand gas cell. The expandable gas chamber includes a moveable plunger forming a wall of the expandable gas chamber. The moveable plunger also forms a wall of the fluid chamber. The on-demand gas cell is configured to generate the gas on demand. The on-demand gas cell is also configured to direct the gas to the expandable gas chamber to expand the expandable gas chamber. Expansion of the expandable gas chamber moves the moveable plunger to reduce a volume of the fluid chamber and to dispense an amount of fluid from the fluid chamber.
摘要翻译：一种按需流体分配器，用于响应气体生成气体而分配流体。按需流体分配器包括可膨胀气体室，流体室和按需气体室。可膨胀气体室包括形成可膨胀气体室的壁的活动柱塞。可移动柱塞还形成流体室的壁。按需气体电池被配置成根据需要产生气体。按需气体室还构造成将气体引导到可膨胀气体室以膨胀可膨胀气体室。可膨胀气体室的膨胀使可移动的柱塞移动以减小流体室的体积并从流体室分配一定量的流体。

3. 发明申请

US20130026194A1 GAS GENERATION DISPENSER APPARATUS FOR ON-DEMAND FLUID DELIVERY 审中-公开
标题翻译：用于需要流体输送的气体发生分配器装置
公开(公告)号：US20130026194A1
公开(公告)日：2013-01-31
申请号：US13323341
申请日：2011-12-12
申请人： Truman Wold , John Howard Gordon , Ashok V. Joshi
发明人： Truman Wold , John Howard Gordon , Ashok V. Joshi
IPC分类号： B65D83/76
CPC分类号： A61M5/14526 , A61L9/12 , A61L2209/132 , A61M5/14244 , A61M11/007 , A61M2005/14204 , A61M2005/14513 , A61M2205/3368 , A61M2205/8206 , A61M2205/8231 , B05B11/025 , B05B11/04 , B05B11/061
摘要： An on-demand fluid dispenser to dispense fluid in response to gas generation by a gas cell. The on-demand fluid dispenser includes an expandable gas chamber, a fluid chamber, and an on-demand gas cell. The expandable gas chamber includes a moveable plunger forming a wall of the expandable gas chamber. The moveable plunger also forms a wall of the fluid chamber. The on-demand gas cell is configured to generate the gas on demand. The on-demand gas cell is also configured to direct the gas to the expandable gas chamber to expand the expandable gas chamber. Expansion of the expandable gas chamber moves the moveable plunger to reduce a volume of the fluid chamber and to dispense an amount of fluid from the fluid chamber.
摘要翻译：一种按需流体分配器，用于响应气体生成气体而分配流体。按需流体分配器包括可膨胀气体室，流体室和按需气体室。可膨胀气体室包括形成可膨胀气体室的壁的活动柱塞。可移动柱塞还形成流体室的壁。按需气体电池被配置成根据需要产生气体。按需气体室还构造成将气体引导到可膨胀气体室以膨胀可膨胀气体室。可膨胀气体室的膨胀使可移动的柱塞移动以减小流体室的体积并从流体室分配一定量的流体。

4. 发明授权

US08240260B2 Apparatus for delivering beneficial liquids at steady rate 有权
标题翻译：用于以稳定的速率输送有益液体的装置
公开(公告)号：US08240260B2
公开(公告)日：2012-08-14
申请号：US13281282
申请日：2011-10-25
申请人： John Howard Gordon , Ashok V. Joshi , Truman Wold , Sai Bhavaraju
发明人： John Howard Gordon , Ashok V. Joshi , Truman Wold , Sai Bhavaraju
IPC分类号： A01C23/02
CPC分类号： A01M1/2044 , A61L9/12 , Y10T137/2931
摘要： An apparatus for delivering a beneficial agent is disclosed in one embodiment of the invention as including a water collection chamber. A water-transporting membrane is provided to communicate with the water collection chamber. An extraction chamber receives water through the water-transporting membrane, expanding the extraction chamber. A dispensing chamber, containing a beneficial agent, is configured to contract upon expanding the extraction chamber. This causes the dispensing chamber to expel the beneficial agent through a subterranean delivery channel, such as a rigid hollow spike. In certain embodiments, a rate adjustment mechanism may control the rate that water is received through the water-transporting membrane, thereby controlling the rate the beneficial agent is expelled. The water-transporting membrane has features that repel osmagent from passing through to the water collection chamber. The apparatus features steady rate performance without refreshing the water chamber and low temperature sensitivity.
摘要翻译：在本发明的一个实施例中公开了一种用于递送有益剂的装置，包括水收集室。提供水输送膜以与收集室连通。提取室通过水输送膜接收水，使提取室膨胀。包含有益剂的分配腔被构造成在膨胀提取室时收缩。这使得分配室通过地下输送通道（例如刚性中空尖峰）排出有益剂。在某些实施例中，速率调节机构可以控制通过水输送膜接收水的速率，从而控制有益剂被排出的速率。水输送膜具有排斥渗透到收集室的特征。该设备具有稳定的速率性能，无需刷新水室和低温灵敏度。

5. 发明申请

US20120037242A1 APPARATUS FOR DELIVERING BENEFICIAL LIQUIDS AT STEADY RATE 有权
标题翻译：以稳定的速度递送受益液体的装置
公开(公告)号：US20120037242A1
公开(公告)日：2012-02-16
申请号：US13281282
申请日：2011-10-25
申请人： John Howard Gordon , Ashok V. Joshi , Truman Wold , Sai Bhavaraju
发明人： John Howard Gordon , Ashok V. Joshi , Truman Wold , Sai Bhavaraju
IPC分类号： B67D7/72
CPC分类号： A01M1/2044 , A61L9/12 , Y10T137/2931
摘要： An apparatus for delivering a beneficial agent is disclosed in one embodiment of the invention as including a water collection chamber. A water-transporting membrane is provided to communicate with the water collection chamber. An extraction chamber receives water through the water-transporting membrane, expanding the extraction chamber. A dispensing chamber, containing a beneficial agent, is configured to contract upon expanding the extraction chamber. This causes the dispensing chamber to expel the beneficial agent through a subterranean delivery channel, such as a rigid hollow spike. In certain embodiments, a rate adjustment mechanism may control the rate that water is received through the water-transporting membrane, thereby controlling the rate the beneficial agent is expelled. The water-transporting membrane has features that repel osmagent from passing through to the water collection chamber. The apparatus features steady rate performance without refreshing the water chamber and low temperature sensitivity.
摘要翻译：在本发明的一个实施例中公开了一种用于递送有益剂的装置，包括水收集室。提供水输送膜以与收集室连通。提取室通过水输送膜接收水，使提取室膨胀。包含有益剂的分配腔被构造成在膨胀提取室时收缩。这使得分配室通过地下输送通道（例如刚性中空尖峰）排出有益剂。在某些实施例中，速率调节机构可以控制通过水输送膜接收水的速率，从而控制有益剂被排出的速率。水输送膜具有排斥渗透到收集室的特征。该设备具有稳定的速率性能，无需刷新水室和低温灵敏度。

6. 发明申请

US20100022993A1 APPARATUS AND METHOD FOR DELIVERING BENEFICIAL LIQUIDS AT STEADY RATE 有权
标题翻译：用于以稳定速率递送受益液体的装置和方法
公开(公告)号：US20100022993A1
公开(公告)日：2010-01-28
申请号：US12550050
申请日：2009-08-28
申请人： John Howard Gordon , Ashok V. Joshi , Truman Wold , Sai Bhavaraju
发明人： John Howard Gordon , Ashok V. Joshi , Truman Wold , Sai Bhavaraju
IPC分类号： A61M5/142
CPC分类号： A01M1/2044 , A61L9/12 , Y10T137/2931
摘要： An apparatus for delivering a beneficial agent is disclosed in one embodiment of the invention as including a water collection chamber. A water-transporting membrane is provided to communicate with the water collection chamber. An extraction chamber receives water through the water-transporting membrane, expanding the extraction chamber. A dispensing chamber, containing a beneficial agent, is configured to contract upon expanding the extraction chamber. This causes the dispensing chamber to expel the beneficial agent through a subterranean delivery channel, such as a rigid hollow spike. In certain embodiments, a rate adjustment mechanism may control the rate that water is received through the water-transporting membrane, thereby controlling the rate the beneficial agent is expelled. The water-transporting membrane has features that repel osmagent from passing through to the water collection chamber. The apparatus features steady rate performance without refreshing the water chamber and low temperature sensitivity.
摘要翻译：在本发明的一个实施例中公开了一种用于递送有益剂的装置，包括水收集室。提供水输送膜以与收集室连通。提取室通过水输送膜接收水，使提取室膨胀。包含有益剂的分配腔被构造成在膨胀提取室时收缩。这使得分配室通过地下输送通道（例如刚性中空尖峰）排出有益剂。在某些实施例中，速率调节机构可以控制通过水输送膜接收水的速率，从而控制有益剂被排出的速率。水输送膜具有排斥渗透到收集室的特征。该设备具有稳定的速率性能，无需刷新水室和低温灵敏度。

7. 发明申请

US20120267389A1 APPARATUS AND METHOD FOR DELIVERING BENEFICIAL LIQUIDS AT A CONSISTENT RATE 审中-公开
标题翻译：用于以一致性递送受益液体的装置和方法
公开(公告)号：US20120267389A1
公开(公告)日：2012-10-25
申请号：US13523015
申请日：2012-06-14
申请人： John Howard Gordon , Ashok V. Joshi , Truman Wold , Sai Bhavaraju
发明人： John Howard Gordon , Ashok V. Joshi , Truman Wold , Sai Bhavaraju
IPC分类号： B67D7/76
CPC分类号： A01M1/2044 , A61L9/12 , C02F1/001 , C02F1/28 , C02F1/44 , C02F1/68 , C02F1/686
摘要： An apparatus for providing controlled delivery of a beneficial agent is disclosed. In one embodiment, such an apparatus includes a water chamber and a filter to produce filtered water by removing impurities from water introduced into the water chamber. A water-transporting membrane transports filtered water from the water chamber to an extraction chamber, thereby expanding the extraction chamber. The extraction chamber contains an osmagent that provides the driving force to pull the filtered water through the water-transporting membrane. As the extraction chamber expands, a dispensing chamber containing a beneficial agent contracts. This causes the beneficial agent to be expelled through a port in communication with the dispensing chamber. A corresponding method is also disclosed.
摘要翻译：公开了一种用于提供有益药物受控输送的装置。在一个实施例中，这种装置包括水室和过滤器，以通过从引入水室的水中除去杂质来产生过滤水。水输送膜将过滤的水从水室输送到提取室，从而使提取室膨胀。提取室包含一个渗透剂，其提供驱动力以将过滤的水拉过水输送膜。当提取室膨胀时，含有有益代理的分配室合同。这使得有益剂通过与分配室连通的端口排出。还公开了相应的方法。

8. 发明申请

US20120037658A1 METHOD FOR DELIVERING BENEFICIAL LIQUIDS AT STEADY RATE 有权
标题翻译：以稳定速度递送受益液体的方法
公开(公告)号：US20120037658A1
公开(公告)日：2012-02-16
申请号：US13281288
申请日：2011-10-25
申请人： John Howard Gordon , Ashok V. Joshi , Truman Wold , Sai Bhavaraju
发明人： John Howard Gordon , Ashok V. Joshi , Truman Wold , Sai Bhavaraju
IPC分类号： B67D7/16
CPC分类号： A01M1/2044 , A61L9/12 , Y10T137/2931
摘要： A method for delivering a beneficial agent is disclosed in one embodiment of the invention as including a water collection chamber. A water-transporting membrane is provided to communicate with the water collection chamber. An extraction chamber receives water through the water-transporting membrane, expanding the extraction chamber. A dispensing chamber, containing a beneficial agent, is configured to contract upon expanding the extraction chamber. This causes the dispensing chamber to expel the beneficial agent through a subterranean delivery channel, such as a rigid hollow spike. In certain embodiments, a rate adjustment mechanism may control the rate that water is received through the water-transporting membrane, thereby controlling the rate the beneficial agent is expelled. The water-transporting membrane has features that repel osmagent from passing through to the water collection chamber. The method features steady rate performance without refreshing the water chamber and low temperature sensitivity.
摘要翻译：在本发明的一个实施例中公开了一种递送有益剂的方法，包括一个收水室。提供水输送膜以与收集室连通。提取室通过水输送膜接收水，使提取室膨胀。包含有益剂的分配腔被构造成在膨胀提取室时收缩。这使得分配室通过地下输送通道（例如刚性中空尖峰）排出有益剂。在某些实施例中，速率调节机构可以控制通过水输送膜接收水的速率，从而控制有益剂被排出的速率。水输送膜具有排斥渗透到收集室的特征。该方法具有稳定的速率性能，无需刷新水箱和低温灵敏度。

9. 发明授权

US08061280B2 Apparatus and method for delivering beneficial liquids at steady rate 有权
标题翻译：以稳定的速度输送有益液体的装置和方法
公开(公告)号：US08061280B2
公开(公告)日：2011-11-22
申请号：US12550050
申请日：2009-08-28
申请人： John Howard Gordon , Ashok V. Joshi , Truman Wold , Sai Bhavaraju
发明人： John Howard Gordon , Ashok V. Joshi , Truman Wold , Sai Bhavaraju
IPC分类号： A01C23/02
CPC分类号： A01M1/2044 , A61L9/12 , Y10T137/2931
摘要： An apparatus for delivering a beneficial agent is disclosed in one embodiment of the invention as including a water collection chamber. A water-transporting membrane is provided to communicate with the water collection chamber. An extraction chamber receives water through the water-transporting membrane, expanding the extraction chamber. A dispensing chamber, containing a beneficial agent, is configured to contract upon expanding the extraction chamber. This causes the dispensing chamber to expel the beneficial agent through a subterranean delivery channel, such as a rigid hollow spike. In certain embodiments, a rate adjustment mechanism may control the rate that water is received through the water-transporting membrane, thereby controlling the rate the beneficial agent is expelled. The water-transporting membrane has features that repel osmagent from passing through to the water collection chamber. The apparatus features steady rate performance without refreshing the water chamber and low temperature sensitivity.
摘要翻译：在本发明的一个实施例中公开了一种用于递送有益剂的装置，包括水收集室。提供水输送膜以与收集室连通。提取室通过水输送膜接收水，使提取室膨胀。包含有益剂的分配腔被构造成在膨胀提取室时收缩。这使得分配室通过地下输送通道（例如刚性中空尖峰）排出有益剂。在某些实施例中，速率调节机构可以控制通过水输送膜接收水的速率，从而控制有益剂被排出的速率。水输送膜具有排斥渗透到收集室的特征。该设备具有稳定的速率性能，无需刷新水室和低温灵敏度。

10. 发明授权

US08353426B2 Gas generation dispenser method for on-demand fluid delivery 有权
标题翻译：用于按需流体输送的气体分配器方法
公开(公告)号：US08353426B2
公开(公告)日：2013-01-15
申请号：US13323332
申请日：2011-12-12
申请人： Truman Wold , John Howard Gordon , Ashok V. Joshi
发明人： Truman Wold , John Howard Gordon , Ashok V. Joshi
IPC分类号： G01F11/00
CPC分类号： A61M5/14526 , A61L9/12 , A61L2209/132 , A61M5/14244 , A61M11/007 , A61M2005/14204 , A61M2005/14513 , A61M2205/3368 , A61M2205/8206 , A61M2205/8231 , B05B11/025 , B05B11/04 , B05B11/061
摘要： A method of dispensing a fluid comprising generating a gas from a liquid, directing the gas to an expandable gas chamber to expand a volume of the expandable gas chamber, reducing a volume of a fluid chamber in response to expansion of the expandable gas chamber to dispense an amount of the fluid from the fluid chamber, and removing the gas from the expandable gas chamber to collapse the expandable gas chamber.
摘要翻译：一种分配流体的方法，包括从液体产生气体，将气体引导到可膨胀气体室以膨胀可膨胀气体室的体积，响应于可扩张气体室的扩张而减少流体室的体积以分配来自流体室的流体的量，以及从可膨胀气体室移除气体以使可膨胀气体室折叠。

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